The flexibility of Apicomplexa parasites in lipid metabolism
Shunmugam, Serena, Arnold, Christophe-Sébastien, Dass, Sheena, Katris, Nicholas J, Botté, Cyrille Y
Published in PLoS pathogens (17.03.2022)
Published in PLoS pathogens (17.03.2022)
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Journal Article
The acyl-CoA synthetase TgACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions
Charital, Sarah, Shunmugam, Serena, Dass, Sheena, Alazzi, Anna Maria, Arnold, Christophe-Sébastien, Katris, Nicholas J., Duley, Samuel, Quansah, Nyamekye A., Pierrel, Fabien, Govin, Jérôme, Yamaryo-Botté, Yoshiki, Botté, Cyrille Y.
Published in mBio (10.04.2024)
Published in mBio (10.04.2024)
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A Plasmodium falciparum lysophospholipase regulates host fatty acid flux via parasite lipid storage to enable controlled asexual schizogony
Sheokand, Pradeep Kumar, Yamaryo-Botté, Yoshiki, Narwal, Monika, Arnold, Christophe-Sébastien, Thakur, Vandana, Islam, Md Muzahidul, Banday, Mudassir M., Asad, Mohd, Botté, Cyrille Y., Mohmmed, Asif
Published in Cell reports (Cambridge) (25.04.2023)
Published in Cell reports (Cambridge) (25.04.2023)
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Antiplasmodial 2-thiophenoxy-3-trichloromethyl quinoxalines target the apicoplast of Plasmodium falciparum
Amrane, Dyhia, Primas, Nicolas, Arnold, Christophe-Sébastien, Hutter, Sébastien, Louis, Béatrice, Sanz-Serrano, Julen, Azqueta, Amaya, Amanzougaghene, Nadia, Tajeri, Shahin, Mazier, Dominique, Verhaeghe, Pierre, Azas, Nadine, Botté, Cyrille, Vanelle, Patrice
Published in European journal of medicinal chemistry (15.11.2021)
Published in European journal of medicinal chemistry (15.11.2021)
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Journal Article
2-Phenoxy-3-Trichloromethylquinoxalines Are Antiplasmodial Derivatives with Activity against the Apicoplast of Plasmodium falciparum
Amrane, Dyhia, Arnold, Christophe-Sébastien, Hutter, Sébastien, Sanz-Serrano, Julen, Collia, Miguel, Azqueta, Amaya, Paloque, Lucie, Cohen, Anita, Amanzougaghene, Nadia, Tajeri, Shahin, Franetich, Jean-François, Mazier, Dominique, Benoit-Vical, Françoise, Verhaeghe, Pierre, Azas, Nadine, Vanelle, Patrice, Botté, Cyrille, Primas, Nicolas
Published in Pharmaceuticals (Basel, Switzerland) (26.07.2021)
Published in Pharmaceuticals (Basel, Switzerland) (26.07.2021)
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Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites
Ashraf, Kutub, Tajeri, Shahin, Arnold, Christophe-Sébastien, Amanzougaghene, Nadia, Franetich, Jean-François, Vantaux, Amélie, Soulard, Valérie, Bordessoulles, Mallaury, Cazals, Guillaume, Bousema, Teun, van Gemert, Geert-Jan, Le Grand, Roger, Dereuddre-Bosquet, Nathalie, Barale, Jean-Christophe, Witkowski, Benoit, Snounou, Georges, Duval, Romain, Botté, Cyrille Y, Mazier, Dominique
Published in Life science alliance (01.03.2022)
Published in Life science alliance (01.03.2022)
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Journal Article
Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
Dass, Sheena, Shunmugam, Serena, Berry, Laurence, Arnold, Christophe-Sebastien, Katris, Nicholas J., Duley, Samuel, Pierrel, Fabien, Cesbron-Delauw, Marie-France, Yamaryo-Botté, Yoshiki, Botté, Cyrille Y.
Published in Nature communications (17.05.2021)
Published in Nature communications (17.05.2021)
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Journal Article
Division and Adaptation to Host Environment of Apicomplexan Parasites Depend on Apicoplast Lipid Metabolic Plasticity and Host Organelle Remodeling
Amiar, Souad, Katris, Nicholas J., Berry, Laurence, Dass, Sheena, Duley, Samuel, Arnold, Christophe-Sebastien, Shears, Melanie J., Brunet, Camille, Touquet, Bastien, McFadden, Geoffrey I., Yamaryo-Botté, Yoshiki, Botté, Cyrille Y.
Published in Cell reports (Cambridge) (17.03.2020)
Published in Cell reports (Cambridge) (17.03.2020)
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Journal Article
The flexibility of Apicomplexa parasites in lipid metabolism
Serena Shunmugam, Christophe-Sébastien Arnold, Sheena Dass, Nicholas J. Katris, Cyrille Y. Botté
Published in PLoS pathogens (01.03.2022)
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Published in PLoS pathogens (01.03.2022)
Journal Article
Toxoplasma acyl-CoA synthetase TgACS3 is crucial to channel host fatty acids in lipid droplets and for parasite propagation
Dass, Sheena, Shunmugam, Serena, Charital, Sarah, Duley, Samuel, Arnold, Christophe-Sébastien, Katris, Nicholas J., Cavaillès, Pierre, Cesbron-Delauw, Marie-France, Yamaryo-Botté, Yoshiki, Botté, Cyrille Y.
Published in Journal of lipid research (01.10.2024)
Published in Journal of lipid research (01.10.2024)
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Journal Article
The acyl-CoA synthetase Tg ACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions
Charital, Sarah, Shunmugam, Serena, Dass, Sheena, Alazzi, Anna Maria, Arnold, Christophe-Sébastien, Katris, Nicholas J, Duley, Samuel, Quansah, Nyamekye A, Pierrel, Fabien, Govin, Jérôme, Yamaryo-Botté, Yoshiki, Botté, Cyrille Y
Published in mBio (10.04.2024)
Published in mBio (10.04.2024)
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Journal Article
Rapid kinetics of lipid second messengers controlled by a cGMP signalling network coordinates apical complex functions in Toxoplasma tachyzoites
Katris, Nicholas J, Yamaryo-Botte, Yoshiki, Janouskovec, Jan, Shunmugam, Serena, Christophe-Sebastien Arnold, Yang, Annie Sp, Vardakis, Alexandros, Stewart, Rebecca, Sauerwein, Robert, Mcfadden, Geoff, Tonkin, Christopher J, Marie-France Cesbron-Delauw, Botte, Cyrille Y
Published in bioRxiv (20.06.2020)
Published in bioRxiv (20.06.2020)
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Paper
Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites
Kutub Ashraf, Tajeri, Shahin, Christophe-Sébastien Arnold, Amanzougaghene, Nadia, Jean-François Franetich, Vantaux, Amélie, Soulard, Valérie, Bordessoulles, Mallaury, Cazals, Guillaume, Bousema, Teun, Geert-Jan Van Gemert, Roger Le Grand, Dereuddre-Bosquet, Nathalie, Barale, Jean-Christophe, Witkowski, Benoit, Snounou, Georges, Duval, Romain, Botté, Cyrille, Mazier, Dominique
Published in bioRxiv (11.08.2021)
Published in bioRxiv (11.08.2021)
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Paper