Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
Stafford, William C, Peng, Xiaoxiao, Olofsson, Maria Hägg, Zhang, Xiaonan, Luci, Diane K, Lu, Li, Cheng, Qing, Trésaugues, Lionel, Dexheimer, Thomas S, Coussens, Nathan P, Augsten, Martin, Ahlzén, Hanna-Stina Martinsson, Orwar, Owe, Östman, Arne, Stone-Elander, Sharon, Maloney, David J, Jadhav, Ajit, Simeonov, Anton, Linder, Stig, Arnér, Elias S J
Published in Science translational medicine (14.02.2018)
Published in Science translational medicine (14.02.2018)
Get more information
Journal Article
Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically
Felber, Jan G., Poczka, Lena, Scholzen, Karoline C., Zeisel, Lukas, Maier, Martin S., Busker, Sander, Theisen, Ulrike, Brandstädter, Christina, Becker, Katja, Arnér, Elias S. J., Thorn-Seshold, Julia, Thorn-Seshold, Oliver
Published in Nature communications (01.04.2022)
Published in Nature communications (01.04.2022)
Get full text
Journal Article
Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target
Kuntz, Angela N, Davioud-Charvet, Elisabeth, Sayed, Ahmed A, Califf, Lindsay L, Dessolin, Jean, Arnér, Elias S J, Williams, David L
Published in PLoS medicine (01.06.2007)
Published in PLoS medicine (01.06.2007)
Get full text
Journal Article
TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy
McLoughlin, Michael R., Orlicky, David J., Prigge, Justin R., Krishna, Pushya, Talago, Emily A., Cavigli, Ian R., Eriksson, Sofi, Miller, Colin G., Kundert, Jean A., Sayin, Volkan I., Sabol, Rachel A., Heinemann, Joshua, Brandenberger, Luke O., Iverson, Sonya V., Bothner, Brian, Papagiannakopoulos, Thales, Shearn, Colin T., Arnér, Elias S. J., Schmidt, Edward E.
Published in Proceedings of the National Academy of Sciences - PNAS (04.06.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (04.06.2019)
Get full text
Journal Article
System-wide identification and prioritization of enzyme substrates by thermal analysis
Saei, Amir Ata, Beusch, Christian M., Sabatier, Pierre, Wells, Juan Astorga, Gharibi, Hassan, Meng, Zhaowei, Chernobrovkin, Alexey, Rodin, Sergey, Näreoja, Katja, Thorsell, Ann-Gerd, Karlberg, Tobias, Cheng, Qing, Lundström, Susanna L., Gaetani, Massimiliano, Végvári, Ákos, Arnér, Elias S. J., Schüler, Herwig, Zubarev, Roman A.
Published in Nature communications (26.02.2021)
Published in Nature communications (26.02.2021)
Get full text
Journal Article
Development of therapies for rare genetic disorders of GPX4: roadmap and opportunities
Cheff, Dorian M, Muotri, Alysson R, Stockwell, Brent R, Schmidt, Edward E, Ran, Qitao, Kartha, Reena V, Johnson, Simon C, Mittal, Plavi, Arnér, Elias S. J, Wigby, Kristen M, Hall, Matthew D, Ramesh, Sanath Kumar
Published in Orphanet journal of rare diseases (23.10.2021)
Published in Orphanet journal of rare diseases (23.10.2021)
Get full text
Journal Article
Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation
James, Jaime, Chen, Yifei, Hernandez, Clara M, Forster, Florian, Dagnell, Markus, Cheng, Qing, Saei, Amir A, Gharibi, Hassan, Lahore, Gonzalo Fernandez, Åstrand, Annika, Malhotra, Rajneesh, Malissen, Bernard, Zubarev, Roman A, Arnér, Elias S J, Holmdahl, Rikard
Published in eLife (19.05.2022)
Published in eLife (19.05.2022)
Get full text
Journal Article
Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry
Silvestri, Ilaria, Lyu, Haining, Fata, Francesca, Boumis, Giovanna, Miele, Adriana E, Ardini, Matteo, Ippoliti, Rodolfo, Bellelli, Andrea, Jadhav, Ajit, Lea, Wendy A, Simeonov, Anton, Cheng, Qing, Arnér, Elias S. J, Thatcher, Gregory R. J, Petukhov, Pavel A, Williams, David L, Angelucci, Francesco
Published in ACS chemical biology (17.08.2018)
Published in ACS chemical biology (17.08.2018)
Get full text
Journal Article
Structure Mechanism Insights and the Role of Nitric Oxide Donation Guide the Development of Oxadiazole-2-Oxides as Therapeutic Agents against Schistosomiasis
Rai, Ganesha, Sayed, Ahmed A, Lea, Wendy A, Luecke, Hans F, Chakrapani, Harinath, Prast-Nielsen, Stefanie, Jadhav, Ajit, Leister, William, Shen, Min, Inglese, James, Austin, Christopher P, Keefer, Larry, Arnér, Elias S. J, Simeonov, Anton, Maloney, David J, Williams, David L, Thomas, Craig J
Published in Journal of medicinal chemistry (22.10.2009)
Published in Journal of medicinal chemistry (22.10.2009)
Get full text
Journal Article
Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells
van Gisbergen, Marike W, Cebula, Marcus, Zhang, Jie, Ottosson-Wadlund, Astrid, Dubois, Ludwig, Lambin, Philippe, Tew, Kenneth D, Townsend, Danyelle M, Haenen, Guido R. M. M, Drittij-Reijnders, Marie-José, Saneyoshi, Hisao, Araki, Mika, Shishido, Yuko, Ito, Yoshihiro, Arnér, Elias S. J, Abe, Hiroshi, Morgenstern, Ralf, Johansson, Katarina
Published in Molecular pharmaceutics (06.06.2016)
Published in Molecular pharmaceutics (06.06.2016)
Get full text
Journal Article
Biochemical discrimination between selenium and sulfur 1: a single residue provides selenium specificity to human selenocysteine lyase
Collins, Ruairi, Johansson, Ann-Louise, Karlberg, Tobias, Markova, Natalia, van den Berg, Susanne, Olesen, Kenneth, Hammarström, Martin, Flores, Alex, Schüler, Herwig, Schiavone, Lovisa Holmberg, Brzezinski, Peter, Arnér, Elias S J, Högbom, Martin
Published in PloS one (25.01.2012)
Published in PloS one (25.01.2012)
Get full text
Journal Article
Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts
Cheng, Qing, Lu, Li, Grafström, Jonas, Olofsson, Maria Hägg, Thorell, Jan-Olov, Samén, Erik, Johansson, Katarina, Ahlzén, Hanna-Stina, Stone-Elander, Sharon, Linder, Stig, Arnér, Elias S J
Published in PloS one (01.08.2012)
Published in PloS one (01.08.2012)
Get full text
Journal Article
Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications
Lei, Xin Gen, Zhu, Jian-Hong, Cheng, Wen-Hsing, Bao, Yongping, Ho, Ye-Shih, Reddi, Amit R, Holmgren, Arne, Arnér, Elias S J
Published in Physiological reviews (01.01.2016)
Published in Physiological reviews (01.01.2016)
Get full text
Journal Article
Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase
Pader, Irina, Sengupta, Rajib, Cebula, Marcus, Xu, Jianqiang, Lundberg, Jon O, Holmgren, Arne, Johansson, Katarina, Arnér, Elias S J
Published in Proceedings of the National Academy of Sciences - PNAS (13.05.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (13.05.2014)
Get full text
Journal Article
Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase
Prigge, Justin R., Coppo, Lucia, Martin, Sebastin S., Ogata, Fernando, Miller, Colin G., Bruschwein, Michael D., Orlicky, David J., Shearn, Colin T., Kundert, Jean A., Lytchier, Julia, Herr, Alix E., Mattsson, Åse, Taylor, Matthew P., Gustafsson, Tomas N., Arnér, Elias S.J., Holmgren, Arne, Schmidt, Edward E.
Published in Cell reports (Cambridge) (27.06.2017)
Published in Cell reports (Cambridge) (27.06.2017)
Get full text
Journal Article
Direct Observation of Methylmercury and Auranofin Binding to Selenocysteine in Thioredoxin Reductase
Pickering, Ingrid J, Cheng, Qing, Rengifo, Emérita Mendoza, Nehzati, Susan, Dolgova, Natalia V, Kroll, Thomas, Sokaras, Dimosthenis, George, Graham N, Arnér, Elias S. J
Published in Inorganic chemistry (02.03.2020)
Published in Inorganic chemistry (02.03.2020)
Get full text
Journal Article
Structure and Mechanism of Mammalian Thioredoxin Reductase: The Active Site Is a Redox-Active Selenolthiol/Selenenylsulfide Formed from the Conserved Cysteine-Selenocysteine Sequence
Zhong, Liangwei, Elias S. J. Arner, Holmgren, Arne
Published in Proceedings of the National Academy of Sciences - PNAS (23.05.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (23.05.2000)
Get full text
Journal Article
Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif
Felber, Jan G, Zeisel, Lukas, Poczka, Lena, Scholzen, Karoline, Busker, Sander, Maier, Martin S, Theisen, Ulrike, Brandstädter, Christina, Becker, Katja, Arnér, Elias S. J, Thorn-Seshold, Julia, Thorn-Seshold, Oliver
Published in Journal of the American Chemical Society (16.06.2021)
Published in Journal of the American Chemical Society (16.06.2021)
Get full text
Journal Article
Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells
Anestål, Karin, Prast-Nielsen, Stefanie, Cenas, Narimantas, Arnér, Elias S J
Published in PloS one (02.04.2008)
Published in PloS one (02.04.2008)
Get full text
Journal Article
Redox active motifs in selenoproteins
Li, Fei, Lutz, Patricia B., Pepelyayeva, Yuliya, Arnér, Elias S. J., Bayse, Craig A., Rozovsky, Sharon
Published in Proceedings of the National Academy of Sciences - PNAS (13.05.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (13.05.2014)
Get full text
Journal Article