Maraviroc (UK-427,857), a Potent, Orally Bioavailable, and Selective Small-Molecule Inhibitor of Chemokine Receptor CCR5 with Broad-Spectrum Anti-Human Immunodeficiency Virus Type 1 Activity
DORR, Patrick, WESTBY, Mike, WEBSTER, Rob, ARMOUR, Duncan, PRICE, David, STAMMEN, Blanda, WOOD, Anthony, PERROS, Manos, DOBBS, Susan, GRIFFIN, Paul, IRVINE, Becky, MACARTNEY, Malcolm, MORI, Julie, RICKETT, Graham, SMITH-BURCHNELL, Caroline, NAPIER, Carolyn
Published in Antimicrobial Agents and Chemotherapy (01.11.2005)
Published in Antimicrobial Agents and Chemotherapy (01.11.2005)
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Journal Article
Overcoming hERG affinity in the discovery of maraviroc; a CCR5 antagonist for the treatment of HIV
Price, David A, Armour, Duncan, de Groot, Marcel, Leishman, Derek, Napier, Carolyn, Perros, Manos, Stammen, Blanda L, Wood, Anthony
Published in Current topics in medicinal chemistry (01.09.2008)
Published in Current topics in medicinal chemistry (01.09.2008)
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Enantioselective Synthesis of 3,6-Dihydro-1H-pyridin-2-ones: Unexpected Regioselectivity in the Palladium-Catalyzed Decarboxylative Carbonylation of 5-Vinyloxazolidin-2-ones
Knight, Julian G, Ainge, Simon W, Harm, Andrew M, Harwood, Simon J, Maughan, Haydn I, Armour, Duncan R, Hollinshead, David M, Jaxa-Chamiec, Albert A
Published in Journal of the American Chemical Society (29.03.2000)
Published in Journal of the American Chemical Society (29.03.2000)
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Journal Article
The Discovery of Tropane-derived CCR5 Receptor Antagonists
Armour, Duncan R., De Groot, Marcel J., Price, David A., Stammen, Blanda L. C., Wood, Anthony, Perros, Manos, Burt, Catherine
Published in Chemical biology & drug design (01.04.2006)
Published in Chemical biology & drug design (01.04.2006)
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Journal Article
Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity. 1. Optimization of the Agonist “Trigger”
Aquino, Christopher J, Armour, Duncan R, Berman, Judd M, Birkemo, Larry S, Carr, Robin A. E, Croom, Dallas K, Dezube, Milana, Dougherty, Robert W, Ervin, Gregory N, Grizzle, Mary K, Head, Julie E, Hirst, Gavin C, James, Michael K, Johnson, Michael F, Miller, Laurence J, Queen, Kennedy L, Rimele, Thomas J, Smith, David N, Sugg, Elizabeth E
Published in Journal of medicinal chemistry (19.01.1996)
Published in Journal of medicinal chemistry (19.01.1996)
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Discovery of an Orally Bioavailable NK1 Receptor Antagonist, (2S,3S)-(2-Methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with Potent Antiemetic Activity
Ward, Peter, Armour, Duncan R, Bays, David E, Evans, Brian, Giblin, Gerard M. P, Heron, Nicola, Hubbard, Tania, Liang, Kai, Middlemiss, David
Published in Journal of medicinal chemistry (01.12.1995)
Published in Journal of medicinal chemistry (01.12.1995)
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Journal Article
Overcoming HERG affinity in the discovery of the CCR5 antagonist maraviroc
Price, David A., Armour, Duncan, de Groot, Marcel, Leishman, Derek, Napier, Carolyn, Perros, Manos, Stammen, Blanda L., Wood, Anthony
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Journal Article
Synthesis and applications of tert-alkoxysiloxane linkers in solid-phase chemistry
Meloni, Marco M., White, Peter D., Armour, Duncan, Brown, Richard C.D.
Published in Tetrahedron (08.01.2007)
Published in Tetrahedron (08.01.2007)
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Novel silyl linkers for solid-phase synthesis
Meloni, Marco M., Brown, R.C.D., White, Peter D., Armour, Duncan
Published in Tetrahedron letters (19.08.2002)
Published in Tetrahedron letters (19.08.2002)
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Journal Article
Enantioselective Synthesis of 3,6-Dihydro-1 H -pyridin-2-ones: Unexpected Regioselectivity in the Palladium-Catalyzed Decarboxylative Carbonylation of 5-Vinyloxazolidin-2-ones
Knight, Julian G., Ainge, Simon W., Harm, Andrew M., Harwood, Simon J., Maughan, Haydn I., Armour, Duncan R., Hollinshead, David M., Jaxa-Chamiec, Albert A.
Published in Journal of the American Chemical Society (01.03.2000)
Published in Journal of the American Chemical Society (01.03.2000)
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Journal Article
AZABICYCLOALKANES AS CCR5 MODULATORS
Price, David Anthony, Wood, Anthony, Edwards, Martin Paul, Armour, Duncan Robert, Perros, Manoussos, Stammen, Blanda Luzia Christa
Year of Publication 26.01.2018
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Year of Publication 26.01.2018
Patent
AZABICYCLOALKANES AS CCR5 MODULATORS
Price, David Anthony, Wood, Anthony, Edwards, Martin Paul, Armour, Duncan Robert, Perros, Manoussos, Stammen, Blanda Luzia Christa
Year of Publication 03.11.2017
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Year of Publication 03.11.2017
Patent
AZABICYCLOALKANES AS CCR5 MODULATORS
WOOD, Anthony, PERROS, Manoussos, STAMMEN, Blanda, Luzia, Christa, ARMOUR, Duncan, Robert, PRICE, David, Anthony, EDWARDS, Martin, Paul
Year of Publication 10.10.2011
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Year of Publication 10.10.2011
Patent
AZABICYCLOALKANES AS CCR5 MODULATORS
WOOD ANTHONY, PERROS MANOUSSOS, PRICE DAVID ANTHONY, EDWARDS MARTIN PAUL, ARMOUR DUNCAN ROBERT, STAMMEN BLANDA LUZIA C
Year of Publication 31.08.2011
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Year of Publication 31.08.2011
Patent
Azabicycloalkan som CCR5-modulatorer
EDWARDS, MARTIN PAUL, PRICE, DAVID ANTHONY, PERROS, MANOUSSOS, ARMOUR, DUNCAN ROBERT, STAMMEN, BLANDA LUZIA C, WOOD, ANTHONY
Year of Publication 27.06.2011
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Year of Publication 27.06.2011
Patent