Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor
Zhang, Penglie, Huang, Wenrong, Wang, Lingyan, Bao, Liang, Jia, Zhaozhong J., Bauer, Shawn M., Goldman, Erick A., Probst, Gary D., Song, Yonghong, Su, Ting, Fan, Jingmei, Wu, Yanhong, Li, Wenhao, Woolfrey, John, Sinha, Uma, Wong, Paul W., Edwards, Susan T., Arfsten, Ann E., Clizbe, Lane A., Kanter, James, Pandey, Anjali, Park, Gary, Hutchaleelaha, Athiwat, Lambing, Joseph L., Hollenbach, Stanley J., Scarborough, Robert M., Zhu, Bing-Yan
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 3: Design, synthesis and sar of orally bioavailable benzamidine-P4 inhibitors
JIA, Zhaozhong J, YANHONG WU, HOLLENNBACH, Stanley J, LAMBING, Joseph L, SCARBOROUGH, Robert M, ZHU, Bing-Yan, WENRONG HUANG, PENGLIE ZHANG, YONGHONG SONG, WOOLFREY, John, SINHA, Uma, ARFSTEN, Ann E, EDWARDS, Susan T, HUTCHALEELAHA, Athiwat
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
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Journal Article
1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 2: A survey of P4 motifs
JIA, Zhaozhong J, YANHONG WU, HUTCHALEELAHA, Athiwat, SCARBOROUGH, Robert M, ZHU, Bing-Yan, WENRONG HUANG, PENGLIE ZHANG, CLIZBE, Lane A, GOLDMAN, Erick A, SINHA, Uma, ARFSTEN, Ann E, EDWARDS, Susan T, ALPHONSO, Merlyn
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
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N, N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors
JIA, Zhaozhong J, TING SU, WENRONG HUANG, WOOLFREY, John, SINHA, Uma, ARFSTEN, Ann E, HUTCHALEELAHA, Athiwat, HOLLENBACH, Stanley J, LAMBING, Joseph L, SCARBOROUGH, Robert M, ZHU, Bing-Yan, ZUCKETT, Jingmei F, YANHONG WU, GOLDMAN, Erick A, WENHAO LI, PENGLIE ZHANG, CLIZBE, Lane A, YONGHONG SONG, BAUER, Shawn M
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
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Inhibition of Purified Factor Xa Amidolytic Activity May Not Be Predictive of Inhibition of In Vivo Thrombosis: Implications for Identification of Therapeutically Active Inhibitors
Sinha, Uma, Lin, Pei Hua, Edwards, Susan T, Wong, Paul W, Zhu, Bingyan, Scarborough, Robert M, Su, Ting, Jia, Zhaozhong J, Song, Yonghong, Zhang, Penglie, Clizbe, Lane, Park, Gary, Reed, Andrea, Hollenbach, Stanley J, Malinowski, John, Arfsten, Ann E
Published in Arteriosclerosis, thrombosis, and vascular biology (01.06.2003)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.06.2003)
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1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors
Jia, Zhaozhong J., Wu, Yanhong, Huang, Wenrong, Zhang, Penglie, Song, Yonghong, Woolfrey, John, Sinha, Uma, Arfsten, Ann E., Edwards, Susan T., Hutchaleelaha, Athiwat, Hollennbach, Stanley J., Lambing, Joseph L., Scarborough, Robert M., Zhu, Bing-Yan
Published in Bioorganic & medicinal chemistry letters (01.03.2004)
Published in Bioorganic & medicinal chemistry letters (01.03.2004)
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Non-Peptide RGD Surrogates Which Mimic a Gly-Asp β-Turn: Potent Antagonists of Platelet Glycoprotein IIb−IIIa
Fisher, Matthew J, Gunn, Bruce, Harms, Cathy S, Kline, Allen D, Mullaney, Jeffrey T, Nunes, Anne, Scarborough, Robert M, Arfsten, Ann E, Skelton, Marshall A, Um, Suzane L, Utterback, Barbara G, Jakubowski, Joseph A
Published in Journal of medicinal chemistry (20.06.1997)
Published in Journal of medicinal chemistry (20.06.1997)
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Fibrinogen Receptor (GPIIb-IIIa) Antagonists Derived from 5,6-Bicyclic Templates. Amidinoindoles, Amidinoindazoles, and Amidinobenzofurans Containing the N-α-Sulfonamide Carboxylic Acid Function as Potent Platelet Aggregation Inhibitors
Su, Ting, Naughton, Mary Ann H, Smyth, Mark S, Rose, Jack W, Arfsten, Ann E, McCowan, Jefferson R, Jakubowski, Joseph A, Wyss, Virginia L, Ruterbories, Kenneth J, Sall, Daniel J, Scarborough, Robert M
Published in Journal of medicinal chemistry (19.12.1997)
Published in Journal of medicinal chemistry (19.12.1997)
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Journal Article
Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido )-5-metho xybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor
Zhang, Penglie, Huang, Wenrong, Wang, Lingyan, Bao, Liang, Jia, Zhaozhong J, Bauer, Shawn M, Goldman, Erick A, Probst, Gary D, Song, Yonghong, Su, Ting, Fan, Jingmei, Wu, Yanhong, Li, Wenhao, Woolfrey, John, Sinha, Uma, Wong, Paul W, Edwards, Susan T, Arfsten, Ann E, Clizbe, Lane A, Kanter, James, Pandey, Anjali, Park, Gary, Hutchaleelaha, Athiwat, Lambing, Joseph L, Hollenbach, Stanley J, Scarborough, Robert M, Zhu, Bing-Yan
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
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Journal Article
1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs
Jia, Zhaozhong J., Wu, Yanhong, Huang, Wenrong, Zhang, Penglie, Clizbe, Lane A., Goldman, Erick A., Sinha, Uma, Arfsten, Ann E., Edwards, Susan T., Alphonso, Merlyn, Hutchaleelaha, Athiwat, Scarborough, Robert M., Zhu, Bing-Yan
Published in Bioorganic & medicinal chemistry letters (01.03.2004)
Published in Bioorganic & medicinal chemistry letters (01.03.2004)
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Journal Article
Use of Conformationally Restricted Benzamidines as Arginine Surrogates in the Design of Platelet GPIIb-IIIa Receptor Antagonists
Sall, Daniel J, Arfsten, Ann E, Bastian, Jolie A, Denney, Michael L, Harms, Cathy S, McCowan, Jefferson R, Morin, John M, Rose, Jack W, Scarborough, Robert M, Smyth, Mark S, Um, Suzane L, Utterback, Barbara G, Vasileff, Robert T, Wikel, James H, Wyss, Virginia L, Jakubowski, Joseph A
Published in Journal of medicinal chemistry (29.08.1997)
Published in Journal of medicinal chemistry (29.08.1997)
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Platelet glycoprotein IIb–IIIa receptor (GPIIb–IIIa) antagonists derived from amidinoindoles
Sall, Daniel J., Arfsten, Ann E., Berry, Dennis R., Denney, Michael L., Harms, Cathy S., McCowan, Jefferson R., Ray, Judith K., Scarborough, Robert M., Um, Suzane L., Utterback, Barbara G., Jakubowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (09.01.1996)
Published in Bioorganic & medicinal chemistry letters (09.01.1996)
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Characterization of Human Prorenin Expressed in Mammalian Cells from Cloned cDNA
Fritz, Lawrence C., Arfsten, Ann E., Dzau, Victor J., Atlas, Steven A., Baxter, John D., Fiddes, John C., Shine, John, Cofer, Claire L., Kushner, Peter, Ponte, Phyllis A.
Published in Proceedings of the National Academy of Sciences - PNAS (01.06.1986)
Published in Proceedings of the National Academy of Sciences - PNAS (01.06.1986)
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Isolation and characterization of a promoter mutant in the str ribosomal protein operon in E. coli
Post, Leonard E., Arfsten, Ann E., Nomura, Masayasu, Jaskunas, S.Richard
Published in Cell (01.09.1978)
Published in Cell (01.09.1978)
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MEMBRANE-DERIVED ANTIFLEA VACCINES
ROBYN E BOREHAM, MILES K YAMANAKE, BEVERLY DALE, LYNNOR B STEVENSON, ANN E ARFSTEN, JOAN P OPDEBEECK, ANDREW W HEATH
Year of Publication 17.03.1992
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Year of Publication 17.03.1992
Patent
MEMBRANE-DERIVED ANTIFLEA VACCINES
ARFSTEN, ANN, E, DALE, BEVERLY, HEATH, ANDREW, W, OPDEBEECK, JOAN, P, STEVENSON, LYNNOR, B, BOREHAM, ROBYN, E, YAMANAKE, MILES, K
Year of Publication 05.03.1992
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Year of Publication 05.03.1992
Patent