Oral cedazuridine/decitabine for MDS and CMML: a phase 2 pharmacokinetic/pharmacodynamic randomized crossover study
Garcia-Manero, Guillermo, Griffiths, Elizabeth A., Steensma, David P., Roboz, Gail J., Wells, Richard, McCloskey, James, Odenike, Olatoyosi, DeZern, Amy E., Yee, Karen, Busque, Lambert, O'Connell, Casey, Michaelis, Laura C., Brandwein, Joseph, Kantarjian, Hagop, Oganesian, Aram, Azab, Mohammad, Savona, Michael R.
Published in Blood (06.08.2020)
Published in Blood (06.08.2020)
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Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study
Issa, Jean-Pierre J, Prof, Roboz, Gail, Prof, Rizzieri, David, Prof, Jabbour, Elias, MD, Stock, Wendy, Prof, O'Connell, Casey, MD, Yee, Karen, MD, Tibes, Raoul, MD, Griffiths, Elizabeth A, MD, Walsh, Katherine, MD, Daver, Naval, MD, Chung, Woonbok, PhD, Naim, Sue, BS, Taverna, Pietro, PhD, Oganesian, Aram, PhD, Hao, Yong, MD, Lowder, James N, MD, Azab, Mohammad, MD, Kantarjian, Hagop, Prof
Published in The lancet oncology (01.09.2015)
Published in The lancet oncology (01.09.2015)
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A Phase I Clinical Trial of Guadecitabine and Carboplatin in Platinum-Resistant, Recurrent Ovarian Cancer: Clinical, Pharmacokinetic, and Pharmacodynamic Analyses
Matei, Daniela, Ghamande, Sharad, Roman, Lynda, Alvarez Secord, Angeles, Nemunaitis, John, Markham, Merry Jennifer, Nephew, Kenneth P, Jueliger, Simone, Oganesian, Aram, Naim, Sue, Su, Xiang Yao, Keer, Harold, Azab, Mohammad, Fleming, Gini F
Published in Clinical cancer research (15.05.2018)
Published in Clinical cancer research (15.05.2018)
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An oral fixed-dose combination of decitabine and cedazuridine in myelodysplastic syndromes: a multicentre, open-label, dose-escalation, phase 1 study
Savona, Michael R, Odenike, Olatoyosi, Amrein, Philip C, Steensma, David P, DeZern, Amy E, Michaelis, Laura C, Faderl, Stefan, Harb, Wael, Kantarjian, Hagop, Lowder, James, Oganesian, Aram, Azab, Mohammad, Garcia-Manero, Guillermo
Published in The Lancet. Haematology (01.04.2019)
Published in The Lancet. Haematology (01.04.2019)
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Oral Azacitidine and Cedazuridine Approximate Parenteral Azacitidine Efficacy in Murine Model
Ramsey, Haley E., Oganesian, Aram, Gorska, Agnieszka E., Fuller, Londa, Arrate, Maria, Boyd, Kelli, Keer, Harold, Azab, Mohammad, Savona, Michael R.
Published in Targeted oncology (01.04.2020)
Published in Targeted oncology (01.04.2020)
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The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease
Riddell, David R., Zhou, Hua, Comery, Thomas A., Kouranova, Evguenia, Lo, C. Frederick, Warwick, Helen K., Ring, Robert H., Kirksey, Yolanda, Aschmies, Suzan, Xu, Jane, Kubek, Katie, Hirst, Warren D., Gonzales, Catherine, Chen, Yi, Murphy, Erin, Leonard, Sarah, Vasylyev, Dmytro, Oganesian, Aram, Martone, Robert L., Pangalos, Menelas N., Reinhart, Peter H., Jacobsen, J. Steve
Published in Molecular and cellular neuroscience (01.04.2007)
Published in Molecular and cellular neuroscience (01.04.2007)
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Mass balance and metabolite profiling of 14C-guadecitabine in patients with advanced cancer
Roosendaal, Jeroen, Rosing, Hilde, Lucas, Luc, Gebretensae, Abadi, Huitema, Alwin D. R., van Dongen, Marloes G., Beijnen, Jos H., Oganesian, Aram
Published in Investigational new drugs (01.08.2020)
Published in Investigational new drugs (01.08.2020)
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Journal Article
Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade
Jacobsen, J. Steven, Comery, Thomas A, Martone, Robert L, Elokdah, Hassan, Crandall, David L, Oganesian, Aram, Aschmies, Suzan, Kirksey, Yolanda, Gonzales, Cathleen, Xu, Jane, Zhou, Hua, Atchison, Kevin, Wagner, Erik, Zaleska, Margaret M, Das, Indranil, Arias, Robert L, Bard, Jonathan, Riddell, David, Gardell, Stephen J, Abou-Gharbia, Magid, Robichaud, Albert, Magolda, Ronald, Vlasuk, George P, Bjornsson, Thorir, Reinhart, Peter H, Pangalos, Menelas N
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
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Characterization of HKI-272 Covalent Binding to Human Serum Albumin
JIANYAO WANG, LI-CHAN, Xiao Xian, CHANDRASEKARAN, Appavu, OGANESIAN, Aram, SCATINA, Joann, MUTLIB, Abdul, TALAAT, Rasmy, ATHERTON, Jim, LIN DENG, ESPINA, Robert, LINNING YU, HORWATT, Peter, ROSS, Steven, LOCKHEAD, Susan, AHMAD, Syed
Published in Drug metabolism and disposition (01.07.2010)
Published in Drug metabolism and disposition (01.07.2010)
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P735: EFFICACY AND SAFETY OF ORAL DECITABINE/CEDAZURIDINE (ASTX727) IN THE CMML SUBPOPULATION FROM PHASE 2 AND ASCERTAIN PHASE 3 STUDIES
Robert Savona, Michael, K Mccloskey, James, A. Griffiths, Elizabeth, Yee, Karen, M. Zeidan, Amer, Al‐Kali, Aref, Joachim Deeg, H., A. Patel, Prapti, Sabloff, Mitchell, Keating, Mary‐Margaret, Y Zhu, Nancy, Gabrail, Nashat, Fazal, Salman, J. Maly, Joseph, Odenike, Olatoyosi, Kantarjian, Hagop, Dezern, Amy, L Oconnell, Casey, Roboz, Gail, Busque, Lambert, Buckstein, Rena, Amin, Harshad, K Randhawa, Jasleen, Leber, Brian, Dao, Kim‐Hien, Chan, Winny, Oganesian, Aram, Sano, Yuri, Mirakhur, Beloo, Keer, Harold, Garcia‐Manero, Guillermo
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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P719: RANDOMIZED PHASE 1-2 STUDY TO ASSESS SAFETY AND EFFICACY OF LOW-DOSE (LD) ORAL DECITABINE/CEDAZURIDINE (ASTX727) IN LOWER-RISK MYELODYSPLASTIC SYNDROMES (LR-MDS) PATIENTS: INTERIM SAFETY ANALYSIS
Garcia-Manero, Guillermo, Bachishvili, Kimo, A. Griffiths, Elizabeth, M. Zeidan, Amer, Traer, Elie, Saini, Lalit, Amin, Harshad, Mohan, Sanjay, Lübbert, Michael, Maness-Harris, Lori, M Foran, James, Selleslag, Dominik, Xicoy Cirici, Blanca, Aaron Pollyea, Daniel, Sallman, David, Al-Kali, Aref, Berdeja, Jesus, Kathrin Al-Ali, Haifa, Y Zhu, Nancy, Font Lopez, Patricia, Sanz Santillana, Guillermo, Santini, Valeria, A. Yimer, Habte, D Cripe, Larry, Priego, Victor, Odenike, Olatoyosi, Heyrman, Bert, Valcarcel, David, Vachhani, Pankit, Sano, Yuri, Mirakhur, Beloo, Oganesian, Aram, Keer, Harold, Yacoub, Abdulraheem
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Potency of dietary indole-3-carbinol as a promoter of aflatoxin B1-initiated hepatocarcinogenesis: results from a 9000 animal tumor study
Oganesian, Aram, Hendricks, Jerry D., Pereira, Cliff B., Orner, Gayle A., Baileyand, George S., Williams, David E.
Published in Carcinogenesis (New York) (01.03.1999)
Published in Carcinogenesis (New York) (01.03.1999)
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Journal Article
Identification of a Novel Route of Extraction of Sirolimus in Human Small Intestine: Roles of Metabolism and Secretion
Paine, Mary F, Leung, Louis Y, Lim, H K, Liao, Kecheng, Oganesian, Aram, Zhang, Mei-Yi, Thummel, Kenneth E, Watkins, Paul B
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
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A commentary on the use of pharmacoenhancers in the pharmaceutical industry and the implication for DMPK drug discovery strategies
Martins, Vanessa, Fazal, Lynsey, Oganesian, Aram, Shah, Alpesh, Stow, Jessie, Walton, Hugh, Wilsher, Nicola
Published in Xenobiotica (03.08.2022)
Published in Xenobiotica (03.08.2022)
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Guadecitabine Plus Ipilimumab in Unresectable Melanoma: The NIBIT-M4 Clinical Trial
Di Giacomo, Anna Maria, Covre, Alessia, Finotello, Francesca, Rieder, Dietmar, Danielli, Riccardo, Sigalotti, Luca, Giannarelli, Diana, Petitprez, Florent, Lacroix, Laetitia, Valente, Monica, Cutaia, Ornella, Fazio, Carolina, Amato, Giovanni, Lazzeri, Andrea, Monterisi, Santa, Miracco, Clelia, Coral, Sandra, Anichini, Andrea, Bock, Christoph, Nemc, Amelie, Oganesian, Aram, Lowder, James, Azab, Mohammad, Fridman, Wolf H, Sautès-Fridman, Catherine, Trajanoski, Zlatko, Maio, Michele
Published in Clinical cancer research (15.12.2019)
Published in Clinical cancer research (15.12.2019)
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Development of Oral Azacitidine with Cedazuridine for Myelodysplastic Syndrome (MDS) and Myeloproliferative Neoplasms (MPN) Including CMML (Chronic Myelomonocytic Leukemia) By Targeting Pharmacokinetic AUC Equivalence Vs Subcutaneous Azacitidine
Garcia-Manero, Guillermo, McCloskey, James, Scott, Bart L., Griffiths, Elizabeth A., Kiner-Strachan, Bonnie, Roboz, Gail J., Meyer, Janelle, Chan, Winny, Mirakhur, Beloo, Sano, Yuri, Oganesian, Aram, Keer, Harold N., Savona, Michael R.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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A Randomized Phase II Trial of Epigenetic Priming with Guadecitabine and Carboplatin in Platinum-resistant, Recurrent Ovarian Cancer
Oza, Amit M, Matulonis, Ursula A, Alvarez Secord, Angeles, Nemunaitis, John, Roman, Lynda D, Blagden, Sarah P, Banerjee, Susana, McGuire, William P, Ghamande, Sharad, Birrer, Michael J, Fleming, Gini F, Markham, Merry Jennifer, Hirte, Hal W, Provencher, Diane M, Basu, Bristi, Kristeleit, Rebecca, Armstrong, Deborah K, Schwartz, Benjamin, Braly, Patricia, Hall, Geoff D, Nephew, Kenneth P, Jueliger, Simone, Oganesian, Aram, Naim, Sue, Hao, Yong, Keer, Harold, Azab, Mohammad, Matei, Daniela
Published in Clinical cancer research (01.03.2020)
Published in Clinical cancer research (01.03.2020)
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A Phase I Trial of a Guadecitabine (SGI-110) and Irinotecan in Metastatic Colorectal Cancer Patients Previously Exposed to Irinotecan
Lee, Valerie, Wang, Judy, Zahurak, Marianna, Gootjes, Elske, Verheul, Henk M, Parkinson, Rose, Kerner, Zachary, Sharma, Anup, Rosner, Gary, De Jesus-Acosta, Ana, Laheru, Daniel, Le, Dung T, Oganesian, Aram, Lilly, Ellen, Brown, Thomas, Jones, Peter, Baylin, Stephen, Ahuja, Nita, Azad, Nilofer
Published in Clinical cancer research (15.12.2018)
Published in Clinical cancer research (15.12.2018)
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Journal Article
ASTX727-03: Phase 1 Study Evaluating Oral Decitabine/Cedazuridine (ASTX727) Low-Dose (LD) in Lower-Risk Myelodysplastic Syndromes (LR-MDS) Patients
Garcia-Manero, Guillermo, Bachiashvili, Kimo, Amin, Harshad, Traer, Elie, Pollyea, Daniel A., Sallman, David A., Al-Kali, Aref, Cripe, Larry D., Berdeja, Jesus G, Griffiths, Elizabeth A., Mohan, Sanjay R, Sano, Yuri, Oganesian, Aram, Keer, Harold N., Yacoub, Abdulraheem
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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