Ratiometric Pulsed Alkylation/Mass Spectrometry of the Cysteine Pairs in Individual Zinc Fingers of MRE-Binding Transcription Factor-1 (MTF-1) as a Probe of Zinc Chelate Stability
Apuy, Julius L, Chen, Xiaohua, Russell, David H, Baldwin, Thomas O, Giedroc, David P
Published in Biochemistry (Easton) (18.12.2001)
Published in Biochemistry (Easton) (18.12.2001)
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Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E
Rowbottom, Martin W, Faraoni, Raffaella, Chao, Qi, Campbell, Brian T, Lai, Andiliy G, Setti, Eduardo, Ezawa, Maiko, Sprankle, Kelly G, Abraham, Sunny, Tran, Lan, Struss, Brian, Gibney, Michael, Armstrong, Robert C, Gunawardane, Ruwanthi N, Nepomuceno, Ronald R, Valenta, Ianina, Hua, Helen, Gardner, Michael F, Cramer, Merryl D, Gitnick, Dana, Insko, Darren E, Apuy, Julius L, Jones-Bolin, Susan, Ghose, Arup K, Herbertz, Torsten, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce, Williams, Michael, Bhagwat, Shripad, James, Joyce, Holladay, Mark W
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
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Journal Article
CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity
James, Joyce, Ruggeri, Bruce, Armstrong, Robert C, Rowbottom, Martin W, Jones-Bolin, Susan, Gunawardane, Ruwanthi N, Dobrzanski, Pawel, Gardner, Michael F, Zhao, Hugh, Cramer, Merryl D, Hunter, Kathryn, Nepomuceno, Ronald R, Cheng, Mangeng, Gitnick, Dana, Yazdanian, Mehran, Insko, Darren E, Ator, Mark A, Apuy, Julius L, Faraoni, Raffaella, Dorsey, Bruce D, Williams, Michael, Bhagwat, Shripad S, Holladay, Mark W
Published in Molecular cancer therapeutics (01.04.2012)
Published in Molecular cancer therapeutics (01.04.2012)
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Discovery of Highly Potent and Selective Pan-Aurora Kinase Inhibitors with Enhanced in Vivo Antitumor Therapeutic Index
Liu, Gang, Abraham, Sunny, Tran, Lan, Vickers, Troy D, Xu, Shimin, Hadd, Michael J, Quiambao, Sheena, Holladay, Mark W, Hua, Helen, Ford Pulido, Julia M, Gunawardane, Ruwanthi N, Davis, Mindy I, Eichelberger, Shawn R, Apuy, Julius L, Gitnick, Dana, Gardner, Michael F, James, Joyce, Breider, Mike A, Belli, Barbara, Armstrong, Robert C, Treiber, Daniel K
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
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Journal Article
Ratiometric Pulsed Alkylation Mass Spectrometry as a Probe of Thiolate Reactivity in Different Metalloderivatives of Staphylococcus aureus pI258 CadC
Apuy, Julius L, Busenlehner, Laura S, Russell, David H, Giedroc, David P
Published in Biochemistry (Easton) (06.04.2004)
Published in Biochemistry (Easton) (06.04.2004)
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Journal Article
Clinical Pharmacokinetics and FLT3 Phosphorylation of AC220, a Highly Potent and Selective Inhibitor of FLT3
James, Joyce, Pratz, Keith, Stine, Adam, Apuy, Julius L, Insko, Darren E, Armstrong, Robert C, Zarrinkar, Patrick P, Small, Donald, Wierenga, Wendell, Levis, Mark J.
Published in Blood (16.11.2008)
Published in Blood (16.11.2008)
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Journal Article
Pulsed-Alkylation Mass Spectrometry for the Study of Protein Folding and Dynamics: Development and Application to the Study of a Folding/Unfolding Intermediate of Bacterial Luciferase
Apuy, Julius L, Park, Zee-Yong, Swartz, Paul D, Dangott, Lawrence J, Russell, David H, Baldwin, Thomas O
Published in Biochemistry (Easton) (18.12.2001)
Published in Biochemistry (Easton) (18.12.2001)
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Journal Article
CEP-32496: A Novel Orally Active BRAFV600E Inhibitor with Selective Cellular and In Vivo Antitumor Activity
James, Joyce, Ruggeri, Bruce, Armstrong, Robert C., Rowbottom, Martin W., Jones-Bolin, Susan, Gunawardane, Ruwanthi N., Dobrzanski, Pawel, Gardner, Michael F., Zhao, Hugh, Cramer, Merryl D., Hunter, Kathryn, Nepomuceno, Ronald R., Cheng, Mangeng, Gitnick, Dana, Yazdanian, Mehran, Insko, Darren E., Ator, Mark A., Apuy, Julius L., Faraoni, Raffaella, Dorsey, Bruce D., Williams, Michael, Bhagwat, Shripad S., Holladay, Mark W.
Published in Molecular cancer therapeutics (01.04.2012)
Published in Molecular cancer therapeutics (01.04.2012)
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Journal Article
Application of 1D and 2D 1H-NMR in the structural elucidation of a N-glucuronidated metabolite and oxidized metabolites generated in microsomal incubation
Apuy, Julius L, Bai, April, Paisner, David, Hegde, Sayee G, Moghaddam, Mehran F
Published in Drug metabolism letters (2012)
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Published in Drug metabolism letters (2012)
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