Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
Rogers, Corey, Erkes, Dan A., Nardone, Alexandria, Aplin, Andrew E., Fernandes-Alnemri, Teresa, Alnemri, Emad S.
Published in Nature communications (11.04.2019)
Published in Nature communications (11.04.2019)
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Journal Article
Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis
Erkes, Dan A, Cai, Weijia, Sanchez, Ileine M, Purwin, Timothy J, Rogers, Corey, Field, Conroy O, Berger, Adam C, Hartsough, Edward J, Rodeck, Ulrich, Alnemri, Emad S, Aplin, Andrew E
Published in Cancer discovery (01.02.2020)
Published in Cancer discovery (01.02.2020)
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Journal Article
Roles of the BAP1 Tumor Suppressor in Cell Metabolism
Han, Anna, Purwin, Timothy J, Aplin, Andrew E
Published in Cancer research (Chicago, Ill.) (01.06.2021)
Published in Cancer research (Chicago, Ill.) (01.06.2021)
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Journal Article
RAS-mediated tumor stress adaptation and the targeting opportunities it presents
Redding, Alexandra, Aplin, Andrew E, Grabocka, Elda
Published in Disease models & mechanisms (01.02.2022)
Published in Disease models & mechanisms (01.02.2022)
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Journal Article
Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway
Li, Xiang, Wang, Shaomin, Mu, Wei, Barry, Jennifer, Han, Anna, Carpenter, Richard L, Jiang, Bing-Hua, Peiper, Stephen C, Mahoney, Mỹ G, Aplin, Andrew E, Ren, Hong, He, Jun
Published in Journal of experimental & clinical cancer research (27.01.2022)
Published in Journal of experimental & clinical cancer research (27.01.2022)
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Journal Article
Raptinal Induces Gasdermin E-Dependent Pyroptosis in Naïve and Therapy-Resistant Melanoma
Vernon, Megane, Wilski, Nicole A, Kotas, Daniel, Cai, Weijia, Pomante, Danielle, Tiago, Manoela, Alnemri, Emad S, Aplin, Andrew E
Published in Molecular cancer research (02.12.2022)
Published in Molecular cancer research (02.12.2022)
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Journal Article
A Genome-Wide Screen Identifies PDPK1 as a Target to Enhance the Efficacy of MEK1/2 Inhibitors in NRAS Mutant Melanoma
Cai, Weijia, Nguyen, Mai Q, Wilski, Nicole A, Purwin, Timothy J, Vernon, Mégane, Tiago, Manoela, Aplin, Andrew E
Published in Cancer research (Chicago, Ill.) (18.07.2022)
Published in Cancer research (Chicago, Ill.) (18.07.2022)
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Journal Article
Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma
Capparelli, Claudia, Purwin, Timothy J., Glasheen, McKenna, Caksa, Signe, Tiago, Manoela, Wilski, Nicole, Pomante, Danielle, Rosenbaum, Sheera, Nguyen, Mai Q., Cai, Weijia, Franco-Barraza, Janusz, Zheng, Richard, Kumar, Gaurav, Chervoneva, Inna, Shimada, Ayako, Rebecca, Vito W., Snook, Adam E., Hookim, Kim, Xu, Xiaowei, Cukierman, Edna, Herlyn, Meenhard, Aplin, Andrew E.
Published in Nature communications (16.03.2022)
Published in Nature communications (16.03.2022)
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Journal Article
Lysosomal lipid peroxidation regulates tumor immunity
Bhardwaj, Monika, Lee, Jennifer J, Versace, Amanda M, Harper, Sandra L, Goldman, Aaron R, Crissey, Mary Ann S, Jain, Vaibhav, Singh, Mahendra Pal, Vernon, Megane, Aplin, Andrew E, Lee, Seokwoo, Morita, Masao, Winkler, Jeffrey D, Liu, Qin, Speicher, David W, Amaravadi, Ravi K
Published in The Journal of clinical investigation (17.04.2023)
Published in The Journal of clinical investigation (17.04.2023)
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Journal Article
BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association
Vido, Michael J., Le, Kaitlyn, Hartsough, Edward J., Aplin, Andrew E.
Published in Cell reports (Cambridge) (06.11.2018)
Published in Cell reports (Cambridge) (06.11.2018)
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Journal Article
ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma
Han, Shujun, Ren, Yibo, He, Wangxiao, Liu, Huadong, Zhi, Zhe, Zhu, Xinliang, Yang, Tielin, Rong, Yu, Ma, Bohan, Purwin, Timothy J., Ouyang, Zhenlin, Li, Caixia, Wang, Xun, Wang, Xueqiang, Yang, Huizi, Zheng, Yan, Aplin, Andrew E., Liu, Jiankang, Shao, Yongping
Published in Nature communications (02.01.2018)
Published in Nature communications (02.01.2018)
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Journal Article
FOXD3 Regulates VISTA Expression in Melanoma
Rosenbaum, Sheera R., Knecht, Meghan, Mollaee, Mehri, Zhong, Zhijiu, Erkes, Dan A., McCue, Peter A., Chervoneva, Inna, Berger, Adam C., Lo, Jennifer A., Fisher, David E., Gershenwald, Jeffrey E., Davies, Michael A., Purwin, Timothy J., Aplin, Andrew E.
Published in Cell reports (Cambridge) (14.01.2020)
Published in Cell reports (Cambridge) (14.01.2020)
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Journal Article
RAC1 P29S regulates PD-L1 expression in melanoma
Vu, Ha Linh, Rosenbaum, Sheera, Purwin, Timothy J., Davies, Michael A., Aplin, Andrew E.
Published in Pigment cell and melanoma research (01.09.2015)
Published in Pigment cell and melanoma research (01.09.2015)
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Journal Article
Meeting Report From the 2023 Cure Ocular Melanoma (CURE OM) Global Science Meeting, Philadelphia, PA, November 2023
Seedor, Rino S, Aplin, Andrew E, Bertolotto, Corine, Carvajal, Richard D, Deacon, Nigel, Doble, Katie, Hamid, Omid, Haq, Rizwan, Kadosh, Miriam, Khan, Shaheer, Kraska, Jacqueline, Lutzky, Jose, McKean, Meredith, Montazeri, Kamaneh, Moser, Justin, Onken, Michael, Orloff, Marlana, Sacco, Joseph J, Smalley, Keiran, Selig, Sara M
Published in Pigment cell and melanoma research (09.10.2024)
Published in Pigment cell and melanoma research (09.10.2024)
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Journal Article
Co‐targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor‐resistant melanoma
Echevarría‐Vargas, Ileabett M, Reyes‐Uribe, Patricia I, Guterres, Adam N, Yin, Xiangfan, Kossenkov, Andrew V, Liu, Qin, Zhang, Gao, Krepler, Clemens, Cheng, Chaoran, Wei, Zhi, Somasundaram, Rajasekharan, Karakousis, Giorgos, Xu, Wei, Morrissette, Jennifer JD, Lu, Yiling, Mills, Gordon B, Sullivan, Ryan J, Benchun, Miao, Frederick, Dennie T, Boland, Genevieve, Flaherty, Keith T, Weeraratna, Ashani T, Herlyn, Meenhard, Amaravadi, Ravi, Schuchter, Lynn M, Burd, Christin E, Aplin, Andrew E, Xu, Xiaowei, Villanueva, Jessie
Published in EMBO molecular medicine (01.05.2018)
Published in EMBO molecular medicine (01.05.2018)
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