Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell
Bagdany, Miklos, Veit, Guido, Fukuda, Ryosuke, Avramescu, Radu G, Okiyoneda, Tsukasa, Baaklini, Imad, Singh, Jay, Sovak, Guy, Xu, Haijin, Apaja, Pirjo M, Sattin, Sara, Beitel, Lenore K, Roldan, Ariel, Colombo, Giorgio, Balch, William, Young, Jason C, Lukacs, Gergely L
Published in Nature communications (30.08.2017)
Published in Nature communications (30.08.2017)
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Journal Article
Protein quality control at the plasma membrane
Okiyoneda, Tsukasa, Apaja, Pirjo M, Lukacs, Gergely L
Published in Current opinion in cell biology (01.08.2011)
Published in Current opinion in cell biology (01.08.2011)
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Journal Article
Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration
Kharitidi, Dmitri, Apaja, Pirjo M., Manteghi, Sanaz, Suzuki, Kei, Malitskaya, Elena, Roldan, Ariel, Gingras, Marie-Claude, Takagi, Junichi, Lukacs, Gergely L., Pause, Arnim
Published in Cell reports (Cambridge) (20.10.2015)
Published in Cell reports (Cambridge) (20.10.2015)
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Journal Article
Control of membrane protein homeostasis by a chaperone-like glial cell adhesion molecule at multiple subcellular locations
Xu, Haijin, Isenmann, Sandra, López-Hernández, Tania, Estévez, Raúl, Lukacs, Gergely L, Apaja, Pirjo M
Published in Scientific reports (16.09.2021)
Published in Scientific reports (16.09.2021)
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Journal Article
Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect
Veit, Guido, Oliver, Kathryn, Apaja, Pirjo M, Perdomo, Doranda, Bidaud-Meynard, Aurélien, Lin, Sheng-Ting, Guo, Jingyu, Icyuz, Mert, Sorscher, Eric J, Hartman, IV, John L, Lukacs, Gergely L
Published in PLoS biology (01.05.2016)
Published in PLoS biology (01.05.2016)
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Journal Article
Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice
Rashidieh, Behnam, Bain, Amanda Louise, Tria, Simon Manuel, Sharma, Sowmya, Stewart, Cameron Allan, Simmons, Jacinta Ley, Apaja, Pirjo M, Duijf, Pascal H G, Finnie, John, Khanna, Kum Kum
Published in Experimental hematology & oncology (09.01.2023)
Published in Experimental hematology & oncology (09.01.2023)
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Journal Article
Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes
Kazan, Jalal M., Desrochers, Guillaume, Martin, Claire E., Jeong, Hyeonju, Kharitidi, Dmitri, Apaja, Pirjo M., Roldan, Ariel, St. Denis, Nicole, Gingras, Anne-Claude, Lukacs, Gergely L., Pause, Arnim
Published in iScience (19.11.2021)
Published in iScience (19.11.2021)
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Journal Article
Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression
Veit, Guido, Avramescu, Radu G, Perdomo, Doranda, Phuan, Puay-Wah, Bagdany, Miklos, Apaja, Pirjo M, Borot, Florence, Szollosi, Daniel, Wu, Yu-Sheng, Finkbeiner, Walter E, Hegedus, Tamas, Verkman, Alan S, Lukacs, Gergely L
Published in Science translational medicine (23.07.2014)
Published in Science translational medicine (23.07.2014)
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Journal Article
Identification and Structural Characterization of the Neuronal Luteinizing Hormone Receptor Associated with Sensory Systems
Apaja, Pirjo M., Harju, Kirsi T., Aatsinki, Jyrki T., Petäjä-Repo, Ulla E., Rajaniemi, Hannu J.
Published in The Journal of biological chemistry (16.01.2004)
Published in The Journal of biological chemistry (16.01.2004)
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Journal Article
Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase
Okiyoneda, Tsukasa, Veit, Guido, Sakai, Ryohei, Aki, Misaki, Fujihara, Takeshi, Higashi, Momoko, Susuki-Miyata, Seiko, Miyata, Masanori, Fukuda, Norihito, Yoshida, Akihiko, Xu, Haijin, Apaja, Pirjo M., Lukacs, Gergely L.
Published in Developmental cell (26.03.2018)
Published in Developmental cell (26.03.2018)
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Journal Article
Ubr1-induced selective endophagy/autophagy protects against the endosomal and Ca2+-induced proteostasis disease stress
Wang, Ben B., Xu, Haijin, Isenmann, Sandra, Huang, Cheng, Elorza-Vidal, Xabier, Rychkov, Grigori Y., Estévez, Raúl, Schittenhelm, Ralf B., Lukacs, Gergely L., Apaja, Pirjo M.
Published in Cellular and molecular life sciences : CMLS (01.03.2022)
Published in Cellular and molecular life sciences : CMLS (01.03.2022)
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Journal Article
A novel fluorescent probe reveals starvation controls the commitment of amyloid precursor protein to the lysosome
Hein, Leanne K., Apaja, Pirjo M., Hattersley, Kathryn, Grose, Randall H., Xie, Jianling, Proud, Christopher G., Sargeant, Timothy J.
Published in Biochimica et biophysica acta. Molecular cell research (01.10.2017)
Published in Biochimica et biophysica acta. Molecular cell research (01.10.2017)
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Journal Article
Leukoencephalopathy‐causing CLCN2 mutations are associated with impaired Cl− channel function and trafficking
Gaitán‐Peñas, Héctor, Apaja, Pirjo M, Arnedo, Tanit, Castellanos, Aida, Elorza‐Vidal, Xabier, Soto, David, Gasull, Xavier, Lukacs, Gergely L, Estévez, Raúl
Published in The Journal of physiology (15.11.2017)
Published in The Journal of physiology (15.11.2017)
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Journal Article
Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane
Apaja, Pirjo M, Foo, Brian, Okiyoneda, Tsukasa, Valinsky, William C, Barriere, Herve, Atanasiu, Roxana, Ficker, Eckhard, Lukacs, Gergely L, Shrier, Alvin
Published in Molecular biology of the cell (15.12.2013)
Published in Molecular biology of the cell (15.12.2013)
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Journal Article
Insights into MLC pathogenesis: GlialCAM is an MLC1 chaperone required for proper activation of volume-regulated anion currents
Capdevila-Nortes, Xavier, López-Hernández, Tania, Apaja, Pirjo M, López de Heredia, Miguel, Sirisi, Sònia, Callejo, Gerard, Arnedo, Tanit, Nunes, Virginia, Lukacs, Gergely L, Gasull, Xavier, Estévez, Raúl
Published in Human molecular genetics (01.11.2013)
Published in Human molecular genetics (01.11.2013)
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Journal Article
Degradation mechanism of a Golgi-retained distal renal tubular acidosis mutant of the kidney anion exchanger 1 in renal cells
Chu, Carmen Y, King, Jennifer, Berrini, Mattia, Rumley, Alina C, Apaja, Pirjo M, Lukacs, Gergely L, Alexander, R Todd, Cordat, Emmanuelle
Published in American Journal of Physiology: Cell Physiology (01.08.2014)
Published in American Journal of Physiology: Cell Physiology (01.08.2014)
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Journal Article