Phase 1 Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-type TP53
Saleh, Mansoor N, Patel, Manish R, Bauer, Todd M, Goel, Sanjay, Falchook, Gerald S, Shapiro, Geoffrey I, Chung, Ki Y, Infante, Jeffrey R, Conry, Robert M, Rabinowits, Guilherme, Hong, David S, Wang, Judy S, Steidl, Ulrich, Naik, Gurudatta, Guerlavais, Vincent, Vukovic, Vojislav, Annis, D Allen, Aivado, Manuel, Meric-Bernstam, Funda
Published in Clinical cancer research (01.10.2021)
Published in Clinical cancer research (01.10.2021)
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Pharmacologic Activation of p53 Triggers Viral Mimicry Response Thereby Abolishing Tumor Immune Evasion and Promoting Antitumor Immunity
Zhou, Xiaolei, Singh, Madhurendra, Sanz Santos, Gema, Guerlavais, Vincent, Carvajal, Luis A, Aivado, Manuel, Zhan, Yue, Oliveira, Mariana M S, Westerberg, Lisa S, Annis, D Allen, Johnsen, John Inge, Selivanova, Galina
Published in Cancer discovery (01.12.2021)
Published in Cancer discovery (01.12.2021)
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Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
Chang, Yong S, Graves, Bradford, Guerlavais, Vincent, Tovar, Christian, Packman, Kathryn, To, Kwong-Him, Olson, Karen A, Kesavan, Kamala, Gangurde, Pranoti, Mukherjee, Aditi, Baker, Theresa, Darlak, Krzysztof, Elkin, Carl, Filipovic, Zoran, Qureshi, Farooq Z, Cai, Hongliang, Berry, Pamela, Feyfant, Eric, Shi, Xiangguo E, Horstick, James, Annis, D Allen, Manning, Anthony M, Fotouhi, Nader, Nash, Huw, Vassilev, Lyubomir T, Sawyer, Tomi K
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2013)
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Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia
Carvajal, Luis A, Neriah, Daniela Ben, Senecal, Adrien, Benard, Lumie, Thiruthuvanathan, Victor, Yatsenko, Tatyana, Narayanagari, Swathi-Rao, Wheat, Justin C, Todorova, Tihomira I, Mitchell, Kelly, Kenworthy, Charles, Guerlavais, Vincent, Annis, D Allen, Bartholdy, Boris, Will, Britta, Anampa, Jesus D, Mantzaris, Ioannis, Aivado, Manuel, Singer, Robert H, Coleman, Robert A, Verma, Amit, Steidl, Ulrich
Published in Science translational medicine (11.04.2018)
Published in Science translational medicine (11.04.2018)
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Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α‑Helical Peptide in Clinical Development
Guerlavais, Vincent, Sawyer, Tomi K., Carvajal, Luis, Chang, Yong S., Graves, Bradford, Ren, Jian-Guo, Sutton, David, Olson, Karen A., Packman, Kathryn, Darlak, Krzysztof, Elkin, Carl, Feyfant, Eric, Kesavan, Kamala, Gangurde, Pranoti, Vassilev, Lyubomir T., Nash, Huw M., Vukovic, Vojislav, Aivado, Manuel, Annis, D. Allen
Published in Journal of medicinal chemistry (27.07.2023)
Published in Journal of medicinal chemistry (27.07.2023)
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Journal Article
MDM4 inhibition: a novel therapeutic strategy to reactivate p53 in hepatoblastoma
Woodfield, Sarah E., Shi, Yan, Patel, Roma H., Chen, Zhenghu, Shah, Aayushi P., Srivastava, Rohit K., Whitlock, Richard S., Ibarra, Aryana M., Larson, Samuel R., Sarabia, Stephen F., Badachhape, Andrew, Starosolski, Zbigniew, Ghaghada, Ketan B., Sumazin, Pavel, Annis, D. Allen, López-Terrada, Dolores, Vasudevan, Sanjeev A.
Published in Scientific reports (03.02.2021)
Published in Scientific reports (03.02.2021)
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Exploring new targets and chemical space with affinity selection-mass spectrometry
Prudent, Renaud, Annis, D. Allen, Dandliker, Peter J., Ortholand, Jean-Yves, Roche, Didier
Published in Nature reviews. Chemistry (01.01.2021)
Published in Nature reviews. Chemistry (01.01.2021)
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Author Correction: MDM4 inhibition: a novel therapeutic strategy to reactivate p53 in hepatoblastoma
Woodfield, Sarah E., Shi, Yan, Patel, Roma H., Chen, Zhenghu, Shah, Aayushi P., Srivastava, Rohit K., Whitlock, Richard S., Ibarra, Aryana M., Larson, Samuel R., Sarabia, Stephen F., Badachhape, Andrew, Starosolski, Zbigniew, Ghaghada, Ketan B., Sumazin, Pavel, Annis, D. Allen, López-Terrada, Dolores, Vasudevan, Sanjeev A.
Published in Scientific reports (01.10.2021)
Published in Scientific reports (01.10.2021)
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Hydrogen Exchange-Mass Spectrometry Measures Stapled Peptide Conformational Dynamics and Predicts Pharmacokinetic Properties
Shi, Xiangguo (Eric), Wales, Thomas E, Elkin, Carl, Kawahata, Noriyuki, Engen, John R, Annis, D. Allen
Published in Analytical chemistry (Washington) (03.12.2013)
Published in Analytical chemistry (Washington) (03.12.2013)
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Correction: Phase I Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-type TP53
Saleh, Mansoor N, Patel, Manish R, Bauer, Todd M, Goel, Sanjay, Falchook, Gerald S, Shapiro, Geoffrey I, Chung, Ki Y, Infante, Jeffrey R, Conry, Robert M, Rabinowits, Guilherme, Hong, David S, Wang, Judy S, Steidl, Ulrich, Walensky, Loren D, Naik, Gurudatta, Guerlavais, Vincent, Vukovic, Vojislav, Annis, D Allen, Aivado, Manuel, Meric-Bernstam, Funda
Published in Clinical cancer research (15.01.2022)
Published in Clinical cancer research (15.01.2022)
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Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase
Deng, Yongqi, Shipps, Gerald W, Cooper, Alan, English, Jessie M, Annis, D. Allen, Carr, Donna, Nan, Yang, Wang, Tong, Zhu, Hugh Y, Chuang, Cheng-Chi, Dayananth, Priya, Hruza, Alan W, Xiao, Li, Jin, Weihong, Kirschmeier, Paul, Windsor, William T, Samatar, Ahmed A
Published in Journal of medicinal chemistry (13.11.2014)
Published in Journal of medicinal chemistry (13.11.2014)
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A General Technique To Rank Protein−Ligand Binding Affinities and Determine Allosteric versus Direct Binding Site Competition in Compound Mixtures
Annis, D. Allen, Nazef, Naim, Chuang, Cheng-Chi, Scott, Margaret Porter, Nash, Huw M
Published in Journal of the American Chemical Society (01.12.2004)
Published in Journal of the American Chemical Society (01.12.2004)
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Novel Benzimidazole Inhibitors Bind to a Unique Site in the Kinesin Spindle Protein Motor Domain
Sheth, Payal R, Shipps, Gerald W, Seghezzi, Wolfgang, Smith, Catherine K, Chuang, Cheng-Chi, Sanden, David, Basso, Andrea D, Vilenchik, Lev, Gray, Kimberly, Annis, D. Allen, Nickbarg, Elliott, Ma, Yao, Lahue, Brian, Herbst, Ronald, Le, Hung V
Published in Biochemistry (Easton) (28.09.2010)
Published in Biochemistry (Easton) (28.09.2010)
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Identification of a Small Molecule Nonpeptide Active Site β-Secretase Inhibitor That Displays a Nontraditional Binding Mode for Aspartyl Proteases
Coburn, Craig A, Stachel, Shawn J, Li, Yue-Ming, Rush, Diane M, Steele, Thomas G, Chen-Dodson, Elizabeth, Holloway, M. Katharine, Xu, Min, Huang, Qian, Lai, Ming-Tain, DiMuzio, Jillian, Crouthamel, Ming-Chih, Shi, Xiao-Ping, Sardana, Vinod, Chen, Zhongguo, Munshi, Sanjeev, Kuo, Lawrence, Makara, Gergely M, Annis, D. Allen, Tadikonda, Praveen K, Nash, Huw M, Vacca, Joseph P, Wang, Tong
Published in Journal of medicinal chemistry (02.12.2004)
Published in Journal of medicinal chemistry (02.12.2004)
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Journal Article
Method for Quantitative Protein−Ligand Affinity Measurements in Compound Mixtures
Annis, D. Allen, Shipps, Gerald W, Deng, Yongqi, Popovici-Müller, Janeta, Siddiqui, M. Arshad, Curran, Patrick J, Gowen, Matthew, Windsor, William T
Published in Analytical chemistry (Washington) (15.06.2007)
Published in Analytical chemistry (Washington) (15.06.2007)
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Inhibitors of the lipid phosphatase SHIP2 discovered by high-throughput affinity selection-mass spectrometry screening of combinatorial libraries
Annis, D Allen, Cheng, Cliff C, Chuang, Cheng-Chi, McCarter, John D, Nash, Huw M, Nazef, Naim, Rowe, Todd, Kurzeja, Robert J M, Shipps, Jr, Gerald W
Published in Combinatorial chemistry & high throughput screening (01.09.2009)
Published in Combinatorial chemistry & high throughput screening (01.09.2009)
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