Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor
Caravella, Justin A, Lin, Jian, Diebold, R. Bruce, Campbell, Ann-Marie, Ericsson, Anna, Gustafson, Gary, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R, Katz, Marie, Kershaw, Mark, Yao, Lili, Toms, Angela V, Barr, Kenneth J, Dinsmore, Christopher J, Walker, Duncan, Ashwell, Susan, Lu, Wei
Published in Journal of medicinal chemistry (27.02.2020)
Published in Journal of medicinal chemistry (27.02.2020)
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In vitro SAR of (5-(2 H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase
Lowe, Derek B., Magnuson, Steven, Qi, Ning, Campbell, Ann-Marie, Cook, James, Hong, Zhenqiu, Wang, Ming, Rodriguez, Mareli, Achebe, Furahi, Kluender, Harold, Wong, Wai C., Bullock, William H., Salhanick, Arthur I., Witman-Jones, Terri, Bowling, Mary E., Keiper, Christine, Clairmont, Kevin B.
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors
Follows, Bruce, Fessler, Shawn, Baumeister, Timm, Campbell, Ann-Marie, Zablocki, Mary Margaret, Li, Hongbin, Gotur, Deepali, Wang, Zhongguo, Zheng, Xiaozhang, Molz, Lisa, Nguyen, Cokey, Herbertz, Torsten, Wang, Liann, Bair, Kenneth
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate
Wood, Jill, Bagi, Cedo M., Akuche, Christiana, Bacchiocchi, Antonietta, Baryza, Jeremy, Blue, Marie-Luise, Brennan, Catherine, Campbell, Ann-Marie, Choi, Soongyu, Cook, James H., Conrad, Patricia, Dixon, Brian R., Ehrlich, Paul P., Gane, Todd, Gunn, David, Joe, Ted, Johnson, Jeffrey S., Jordan, Jerold, Kramss, Richard, Liu, Peiying, Levy, Joan, Lowe, Derek B., McAlexander, Ian, Natero, Reina, Redman, Anikó M., Scott, William J., Town, Christopher, Wang, Ming, Wang, Yamin, Zhang, Zhonghua
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
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Journal Article
4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 2. SAR
Gunn, David, Akuche, Christiana, Baryza, Jeremy, Blue, Marie-Louise, Brennan, Catherine, Campbell, Ann-Marie, Choi, Soongyu, Cook, James, Conrad, Patricia, Dixon, Brian, Dumas, Jacques, Ehrlich, Paul, Gane, Todd, Joe, Ted, Johnson, Jeffrey, Jordan, Jerold, Kramss, Richard, Liu, Peying, Levy, Joan, Lowe, Derek, McAlexander, Ian, Natero, Reina, Redman, Anikó M., Scott, William, Seng, Thomas, Sibley, Robert, Wang, Ming, Wang, Yamin, Wood, Jill, Zhang, Zhonghua
Published in Bioorganic & medicinal chemistry letters (15.06.2005)
Published in Bioorganic & medicinal chemistry letters (15.06.2005)
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COMPUESTOS DERIVADOS DE 2,3-DIHIDROIMIDAZOL[1,2-C]QUINAZOLINA; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHOS COMPUESTOS; Y SU USO PARA TRATAR ENFERMEDADES Y TRASTORNOS HIPERPROLIFERATIVOS ASOCIADOS A LA ANGIOGENESIS, TALES COMO INFLAMACION, ENFERME
MARTIN HENTEMANN; JILL WOOD; WILLIAM SCOTT; ANN-MARIE CAMPBELL; ANN-MARIE BULLION; R. BRUCE ROWLEY;ANIKO REDMAN; MARTIN
Year of Publication 04.07.2008
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Year of Publication 04.07.2008
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Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors
Lin, Jian, Lu, Wei, Caravella, Justin A, Campbell, Ann Marie, Diebold, R. Bruce, Ericsson, Anna, Fritzen, Edward, Gustafson, Gary R, Lancia, David R, Shelekhin, Tatiana, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R, Katz, Marie, Diep, Hien, Kershaw, Mark, Yao, Lili, Kauffman, Goss, Hubbs, Stephen E, Luke, George P, Toms, Angela V, Wang, Liann, Bair, Kenneth W, Barr, Kenneth J, Dinsmore, Christopher, Walker, Duncan, Ashwell, Susan
Published in Journal of medicinal chemistry (25.07.2019)
Published in Journal of medicinal chemistry (25.07.2019)
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PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
Caravella, Justin Andrew, Gustafson, Gary, Lancia, JR., David R, Lu, Wei, Ashwell, Susan, Campbell, Ann-Marie, Lin, Jian, Ericsson, Anna, Wang, Zhongguo, Diebold, R. Bruce
Year of Publication 09.05.2024
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Year of Publication 09.05.2024
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PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
LU, WEI, CARAVELLA, JUSTIN ANDREW, ERICSSON, ANNA, CAMPBELL, ANN-MARIE, LIN, JIAN, GUSTAFSON, GARY, WANG, ZHONGGUO, ASHWELL, SUSAN, LANCIA, DAVID R, DIEBOLD, R. BRUCE
Year of Publication 12.03.2024
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Year of Publication 12.03.2024
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PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
LIN, Jian, CARAVELLA, Justin Andrew, DIEBOLD, R. Bruce, ERICSSON, Anna, LU, Wei, WANG, Zhongguo, GUSTAFSON, Gary, ASHWELL, Susan, LANCIA, David R. Jr, CAMPBELL, Ann-Marie
Year of Publication 10.01.2024
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Year of Publication 10.01.2024
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Pyridin-2(1h)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
Caravella, Justin Andrew, Gustafson, Gary, Lu, Wei, Ashwell, Susan, Campbell, Ann-Marie, Lin, Jian, Ericsson, Anna, Lancia, Jr, Wang, Zhongguo, Diebold, R. Bruce
Year of Publication 22.12.2023
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Year of Publication 22.12.2023
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PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
LIN, Jian, CAMPBELL, Ann-marie, CARAVELLA, Justin Andrew, DIEBOLD, R. Bruce, ERICSSON, Anna, LU, Wei, WANG, Zhongguo, GUSTAFSON, Gary, ASHWELL, Susan, LANCIA, David R. Jr
Year of Publication 28.11.2023
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Year of Publication 28.11.2023
Patent
4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate
Wood, Jill, Bagi, Cedo M, Akuche, Christiana, Bacchiocchi, Antonietta, Baryza, Jeremy, Blue, Marie-Luise, Brennan, Catherine, Campbell, Ann-Marie, Choi, Soongyu, Cook, James H, Conrad, Patricia, Dixon, Brian R, Ehrlich, Paul P, Gane, Todd, Gunn, David, Joe, Ted, Johnson, Jeffrey S, Jordan, Jerold, Kramss, Richard, Liu, Peiying, Levy, Joan, Lowe, Derek B, McAlexander, Ian, Natero, Reina, Redman, Anikó M, Scott, William J, Town, Christopher, Wang, Ming, Wang, Yamin, Zhang, Zhonghua
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
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Published in Bioorganic & medicinal chemistry letters (15.09.2006)
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Pyridin-2(1h)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
Caravella, Justin Andrew, Gustafson, Gary, Lu, Wei, Ashwell, Susan, Campbell, Ann-Marie, Lin, Jian, Ericsson, Anna, Lancia Jr., David R, Wang, Zhongguo, Diebold, R. Bruce
Year of Publication 19.10.2023
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Year of Publication 19.10.2023
Patent
PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
LIN, Jian, CARAVELLA, Justin Andrew, DIEBOLD, R. Bruce, ERICSSON, Anna, LU, Wei, WANG, Zhongguo, GUSTAFSON, Gary, ASHWELL, Susan, LANCIA, David R. Jr, CAMPBELL, Ann-Marie
Year of Publication 11.10.2023
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Year of Publication 11.10.2023
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