soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)
Raucci, Angela, Cugusi, Simona, Antonelli, Antonella, Barabino, Silvia M, Monti, Lucilla, Bierhaus, Angelika, Reiss, Karina, Saftig, Paul, Bianchi, Marco E
Published in The FASEB journal (01.10.2008)
Published in The FASEB journal (01.10.2008)
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critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
Yang, Huan, Hreggvidsdottir, Hulda S, Palmblad, Karin, Wang, Haichao, Ochani, Mahendar, Li, Jianhua, Lu, Ben, Chavan, Sangeeta, Rosas-Ballina, Mauricio, Al-Abed, Yousef, Akira, Shizuo, Bierhaus, Angelika, Erlandsson-Harris, Helena, Andersson, Ulf, Tracey, Kevin J
Published in Proceedings of the National Academy of Sciences - PNAS (29.06.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (29.06.2010)
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The HMGB1 Receptor RAGE Mediates Ischemic Brain Damage
Muhammad, Sajjad, Barakat, Waleed, Stoyanov, Stoyan, Murikinati, Sasidhar, Yang, Huan, Tracey, Kevin J, Bendszus, Martin, Rossetti, Grazisa, Nawroth, Peter P, Bierhaus, Angelika, Schwaninger, Markus
Published in The Journal of neuroscience (12.11.2008)
Published in The Journal of neuroscience (12.11.2008)
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Methylglyoxal evokes pain by stimulating TRPA1
Andersson, David A, Gentry, Clive, Light, Emily, Vastani, Nisha, Vallortigara, Julie, Bierhaus, Angelika, Fleming, Thomas, Bevan, Stuart
Published in PloS one (22.10.2013)
Published in PloS one (22.10.2013)
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RAGE-Induced Cytosolic ROS Promote Mitochondrial Superoxide Generation in Diabetes
COUGHLAN, Melinda T, THORBURN, David R, BROWNLEE, Michael, BIERHAUS, Angelika, COOPER, Mark E, FORBES, Josephine M, PENFOLD, Sally A, LASKOWSKI, Adrienne, HARCOURT, Brooke E, SOURRIS, Karly C, TAN, Adeline L. Y, FUKAMI, Kei, THALLAS-BONKE, Vicki, NAWROTH, Peter P
Published in Journal of the American Society of Nephrology (01.04.2009)
Published in Journal of the American Society of Nephrology (01.04.2009)
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Receptor for Advanced Glycation End Products Is Subjected to Protein Ectodomain Shedding by Metalloproteinases
Zhang, Ling, Bukulin, Monika, Kojro, Elzbieta, Roth, Annette, Metz, Verena V., Fahrenholz, Falk, Nawroth, Peter P., Bierhaus, Angelika, Postina, Rolf
Published in The Journal of biological chemistry (19.12.2008)
Published in The Journal of biological chemistry (19.12.2008)
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Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
Coyle, Anthony J, Tian, Jane, Avalos, Ana Maria, Mao, Su-Yau, Chen, Bo, Senthil, Kannaki, Wu, Herren, Parroche, Peggy, Drabic, Stacey, Golenbock, Douglas, Sirois, Cherilyn, Hua, Jing, An, Ling Ling, Audoly, Laurent, La Rosa, Greg, Bierhaus, Angelika, Naworth, Peter, Marshak-Rothstein, Ann, Crow, Mary K, Fitzgerald, Katherine A, Latz, Eicke, Kiener, Peter A
Published in Nature Immunology (01.05.2007)
Published in Nature Immunology (01.05.2007)
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RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
Turovskaya, Olga, Foell, Dirk, Sinha, Pratima, Vogl, Thomas, Newlin, Robbin, Nayak, Jonamani, Nguyen, Mien, Olsson, Anna, Nawroth, Peter P., Bierhaus, Angelika, Varki, Nissi, Kronenberg, Mitchell, Freeze, Hudson H., Srikrishna, Geetha
Published in Carcinogenesis (New York) (01.10.2008)
Published in Carcinogenesis (New York) (01.10.2008)
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Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice
McVicar, Carmel M., Ward, Micheal, Colhoun, Liza M., Guduric-Fuchs, Jasenka, Bierhaus, Angelika, Fleming, Thomas, Schlotterer, Andreas, Kolibabka, Matthias, Hammes, Hans-Peter, Chen, Mei, Stitt, Alan W.
Published in Diabetologia (01.05.2015)
Published in Diabetologia (01.05.2015)
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High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart
ANDRASSY, Martin, VOLZ, Hans C, BEA, Florian, HARDT, Stefan E, HUMPERT, Per M, BIANCHI, Marco E, MAIRBÄURL, Heimo, NAWROTH, Peter P, REMPPIS, Andrew, KATUS, Hugo A, BIERHAUS, Angelika, IGWE, John C, FUNKE, Benjamin, EICHBERGER, Sebastian N, KAYA, Ziya, BUSS, Sebastian, AUTSCHBACH, Frank, PLEGER, Sven T, LUKIC, Ivan K
Published in Circulation (New York, N.Y.) (24.06.2008)
Published in Circulation (New York, N.Y.) (24.06.2008)
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RAGE signaling sustains inflammation and promotes tumor development
Gebhardt, Christoffer, Riehl, Astrid, Durchdewald, Moritz, Németh, Julia, Fürstenberger, Gerhard, Müller-Decker, Karin, Enk, Alexander, Arnold, Bernd, Bierhaus, Angelika, Nawroth, Peter P, Hess, Jochen, Angel, Peter
Published in The Journal of experimental medicine (18.02.2008)
Published in The Journal of experimental medicine (18.02.2008)
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Journal Article
Understanding RAGE, the receptor for advanced glycation end products
BIERHAUS, Angelika, HUMPERT, Per M, MORCOS, Michael, WENDT, Thoralf, CHAVAKIS, Triantafyllos, ARNOLD, Bernd, STERN, David M, NAWROTH, Peter P
Published in Journal of molecular medicine (Berlin, Germany) (01.11.2005)
Published in Journal of molecular medicine (Berlin, Germany) (01.11.2005)
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C. elegans as Model for the Study of High Glucose– Mediated Life Span Reduction
SCHLOTTERER, Andreas, KUKUDOV, Georgi, SAYED, Ahmed, FLEMING, Thomas, HUMPERT, Per, SCHWENGER, Vedat, ZEIER, Martin, HAMANN, Andreas, STERN, David, BROWNLEE, Michael, BIERHAUS, Angelika, NAWROTH, Peter, BOZORGMEHR, Farastuk, MORCOS, Michael, HUTTER, Harald, XUELIANG DU, OIKONOMOU, Dimitrios, IBRAHIM, Youssef, PFISTERER, Friederike, RABBANI, Naila, THORNALLEY, Paul
Published in Diabetes (New York, N.Y.) (01.11.2009)
Published in Diabetes (New York, N.Y.) (01.11.2009)
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Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation‐associated liver carcinogenesis in mice
Pusterla, Tobias, Nèmeth, Julia, Stein, Ilan, Wiechert, Lars, Knigin, David, Marhenke, Silke, Longerich, Thomas, Kumar, Varun, Arnold, Bernd, Vogel, Arndt, Bierhaus, Angelika, Pikarsky, Eli, Hess, Jochen, Angel, Peter
Published in Hepatology (Baltimore, Md.) (01.07.2013)
Published in Hepatology (Baltimore, Md.) (01.07.2013)
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Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes
SORO-PAAVONEN, Aino, WATSON, Anna M. D, THOMAS, Merlin, FORBES, Josephine M, NAWROTH, Peter P, BIERHAUS, Angelika, COOPER, Mark E, JANDELEIT-DAHM, Karin A, JIAZE LI, PAAVONEN, Karri, KOITKA, Audrey, CALKIN, Anna C, BARIT, David, COUGHLAN, Melinda T, DREW, Brian G, LANCASTER, Graeme I
Published in Diabetes (New York, N.Y.) (01.09.2008)
Published in Diabetes (New York, N.Y.) (01.09.2008)
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Journal Article
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
Isermann, Berend, Nawroth, Peter P, Bierhaus, Angelika, Herzog, Stefanie, Corat, Marcus A F, Weiler, Hartmut, Grinnell, Brian W, Kashif, Muhammed, Blautzik, Janusch, Berg, David T, Madhusudhan, Thati, Esmon, Charles T, Vinnikov, Ilya A, Blessing, Erwin, Oh, Jun, Zeier, Martin, Gerlitz, Bruce, Chavakis, Triantafyllos
Published in Nature medicine (01.11.2007)
Published in Nature medicine (01.11.2007)
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RAGE (receptor for advanced glycation end products): a central player in the inflammatory response
Chavakis, Triantafyllos, Bierhaus, Angelika, Nawroth, Peter P.
Published in Microbes and infection (01.11.2004)
Published in Microbes and infection (01.11.2004)
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