A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit
De Muylder, Geraldine, Ang, Kenny K H, Chen, Steven, Arkin, Michelle R, Engel, Juan C, McKerrow, James H
Published in PLoS neglected tropical diseases (01.07.2011)
Published in PLoS neglected tropical diseases (01.07.2011)
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Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation
Mendiola, Andrew S, Ryu, Jae Kyu, Bardehle, Sophia, Meyer-Franke, Anke, Ang, Kenny Kean-Hooi, Wilson, Chris, Baeten, Kim M, Hanspers, Kristina, Merlini, Mario, Thomas, Sean, Petersen, Mark A, Williams, Alexander, Thomas, Reuben, Rafalski, Victoria A, Meza-Acevedo, Rosa, Tognatta, Reshmi, Yan, Zhaoqi, Pfaff, Samuel J, Machado, Michael R, Bedard, Catherine, Rios Coronado, Pamela E, Jiang, Xiqian, Wang, Jin, Pleiss, Michael A, Green, Ari J, Zamvil, Scott S, Pico, Alexander R, Bruneau, Benoit G, Arkin, Michelle R, Akassoglou, Katerina
Published in Nature immunology (01.05.2020)
Published in Nature immunology (01.05.2020)
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Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi, the Agent of Chagas' Disease
Engel, Juan C, Ang, Kenny K H, Chen, Steven, Arkin, Michelle R, McKerrow, James H, Doyle, Patricia S
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
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Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch
Gallagher, Ciara M, Garri, Carolina, Cain, Erica L, Ang, Kenny Kean-Hooi, Wilson, Christopher G, Chen, Steven, Hearn, Brian R, Jaishankar, Priyadarshini, Aranda-Diaz, Andres, Arkin, Michelle R, Renslo, Adam R, Walter, Peter
Published in eLife (20.07.2016)
Published in eLife (20.07.2016)
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Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration
Ryu, Jae Kyu, Rafalski, Victoria A, Meyer-Franke, Anke, Adams, Ryan A, Poda, Suresh B, Rios Coronado, Pamela E, Pedersen, Lars Østergaard, Menon, Veena, Baeten, Kim M, Sikorski, Shoana L, Bedard, Catherine, Hanspers, Kristina, Bardehle, Sophia, Mendiola, Andrew S, Davalos, Dimitrios, Machado, Michael R, Chan, Justin P, Plastira, Ioanna, Petersen, Mark A, Pfaff, Samuel J, Ang, Kenny K, Hallenbeck, Kenneth K, Syme, Catriona, Hakozaki, Hiroyuki, Ellisman, Mark H, Swanson, Raymond A, Zamvil, Scott S, Arkin, Michelle R, Zorn, Stevin H, Pico, Alexander R, Mucke, Lennart, Freedman, Stephen B, Stavenhagen, Jeffrey B, Nelson, Robert B, Akassoglou, Katerina
Published in Nature immunology (01.11.2018)
Published in Nature immunology (01.11.2018)
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Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51
Gunatilleke, Shamila S, Calvet, Claudia M, Johnston, Jonathan B, Chen, Chiung-Kuang, Erenburg, Grigori, Gut, Jiri, Engel, Juan C, Ang, Kenny K H, Mulvaney, Joseph, Chen, Steven, Arkin, Michelle R, McKerrow, James H, Podust, Larissa M
Published in PLoS neglected tropical diseases (01.07.2012)
Published in PLoS neglected tropical diseases (01.07.2012)
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Pharmacological brake-release of mRNA translation enhances cognitive memory
Sidrauski, Carmela, Acosta-Alvear, Diego, Khoutorsky, Arkady, Vedantham, Punitha, Hearn, Brian R, Li, Han, Gamache, Karine, Gallagher, Ciara M, Ang, Kenny K-H, Wilson, Chris, Okreglak, Voytek, Ashkenazi, Avi, Hann, Byron, Nader, Karim, Arkin, Michelle R, Renslo, Adam R, Sonenberg, Nahum, Walter, Peter
Published in eLife (28.05.2013)
Published in eLife (28.05.2013)
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Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening
Sanchez, Mateo I, de Vries, Laura E, Lehmann, Christine, Lee, Jeong T, Ang, Kenny K, Wilson, Christopher, Chen, Steven, Arkin, Michelle R, Bogyo, Matthew, Deu, Edgar
Published in PloS one (18.12.2019)
Published in PloS one (18.12.2019)
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Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases
Bryant, Clifford, Kerr, Iain D., Debnath, Moumita, Ang, Kenny K.H., Ratnam, Joseline, Ferreira, Rafaela S., Jaishankar, Priyadarshini, Zhao, DongMei, Arkin, Michelle R., McKerrow, James H., Brinen, Linda S., Renslo, Adam R.
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
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Venetoclax and dinaciclib elicit synergistic preclinical efficacy against hypodiploid acute lymphoblastic leukemia
Pariury, Holly, Fandel, Joshua, Bachl, Stefanie, Ang, Kenny K, Markossian, Sarine, Wilson, Chris G, Braun, Benjamin S, Popescu, Bogdan, Wohlfeil, Margo, Beckman, Kyle, Xirenayi, Simayijiang, Roy, Ritu P, Olshen, Adam B, Smith, Catherine, Arkin, Michelle R, Loh, Mignon L, Diaz-Flores, Ernesto
Published in Haematologica (Roma) (01.05.2023)
Published in Haematologica (Roma) (01.05.2023)
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Mining a cathepsin inhibitor library for new antiparasitic drug leads
Ang, Kenny K H, Ratnam, Joseline, Gut, Jiri, Legac, Jennifer, Hansell, Elizabeth, Mackey, Zachary B, Skrzypczynska, Katarzyna M, Debnath, Anjan, Engel, Juan C, Rosenthal, Philip J, McKerrow, James H, Arkin, Michelle R, Renslo, Adam R
Published in PLoS neglected tropical diseases (01.05.2011)
Published in PLoS neglected tropical diseases (01.05.2011)
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Small-Molecule Screening for Genetic Diseases
Markossian, Sarine, Ang, Kenny K, Wilson, Christopher G, Arkin, Michelle R
Published in Annual review of genomics and human genetics (31.08.2018)
Published in Annual review of genomics and human genetics (31.08.2018)
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Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit
Chen, Chiung-Kuang, Doyle, Patricia S, Yermalitskaya, Liudmila V, Mackey, Zachary B, Ang, Kenny K H, McKerrow, James H, Podust, Larissa M
Published in PLoS neglected tropical diseases (2009)
Published in PLoS neglected tropical diseases (2009)
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An image-based assay for high throughput screening of Giardia lamblia
Gut, Jiri, Ang, Kenny K.H., Legac, Jennifer, Arkin, Michelle R., Rosenthal, Philip J., McKerrow, James H.
Published in Journal of microbiological methods (01.03.2011)
Published in Journal of microbiological methods (01.03.2011)
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Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB
Mott, Bryan T, Ferreira, Rafaela S, Simeonov, Anton, Jadhav, Ajit, Ang, Kenny Kean-Hooi, Leister, William, Shen, Min, Silveira, Julia T, Doyle, Patricia S, Arkin, Michelle R, McKerrow, James H, Inglese, James, Austin, Christopher P, Thomas, Craig J, Shoichet, Brian K, Maloney, David J
Published in Journal of medicinal chemistry (14.01.2010)
Published in Journal of medicinal chemistry (14.01.2010)
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Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans ' Lifespan
Zhang, Peichuan, Zhai, Yuying, Cregg, James, Ang, Kenny Kean-Hooi, Arkin, Michelle, Kenyon, Cynthia
Published in G3 : genes - genomes - genetics (01.02.2020)
Published in G3 : genes - genomes - genetics (01.02.2020)
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Natural Product Libraries to Accelerate the High-Throughput Discovery of Therapeutic Leads
Johnson, Tyler A, Sohn, Johann, Inman, Wayne D, Estee, Samarkand A, Loveridge, Steven T, Vervoort, Helene C, Tenney, Karen, Liu, Junke, Ang, Kenny Kean-Hooi, Ratnam, Joseline, Bray, Walter M, Gassner, Nadine C, Shen, Young Y, Lokey, R. Scott, McKerrow, James H, Boundy-Mills, Kyria, Nukanto, Arif, Kanti, Atit, Julistiono, Heddy, Kardono, Leonardus B. S, Bjeldanes, Leonard F, Crews, Phillip
Published in Journal of natural products (Washington, D.C.) (27.12.2011)
Published in Journal of natural products (Washington, D.C.) (27.12.2011)
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A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver
Suzawa, Miyuki, Miranda, Diego A, Ramos, Karmela A, Ang, Kenny K-H, Faivre, Emily J, Wilson, Christopher G, Caboni, Laura, Arkin, Michelle R, Kim, Yeong-Sang, Fletterick, Robert J, Diaz, Aaron, Schneekloth, John S, Ingraham, Holly A
Published in eLife (11.12.2015)
Published in eLife (11.12.2015)
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Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation
Mendiola, Andrew S, Ryu, Jae Kyu, Bardehle, Sophia, Meyer-Franke, Anke, Ang, Kenny Kean-Hooi, Wilson, Chris, Baeten, Kim M, Hanspers, Kristina, Merlini, Mario, Thomas, Sean, Petersen, Mark A, Williams, Alexander, Thomas, Reuben, Rafalski, Victoria A, Meza-Acevedo, Rosa, Tognatta, Reshmi, Yan, Zhaoqi, Pfaff, Samuel J, Machado, Michael R, Bedard, Catherine, Coronado, Pamela E Rios, Jiang, Xiqian, Wang, Jin, Pleiss, Michael A, Green, Ari J, Zamvil, Scott S, Pico, Alexander R, Bruneau, Benoit G, Arkin, Michelle R, Akassoglou, Katerina
Published in Nature immunology (01.09.2020)
Published in Nature immunology (01.09.2020)
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