Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis
Ashraf, Sadaf, Bouhana, Karyn S, Pheneger, Jed, Andrews, Steven W, Walsh, David A
Published in Arthritis research & therapy (04.05.2016)
Published in Arthritis research & therapy (04.05.2016)
Get full text
Journal Article
Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)
Seiwert, Scott D, Andrews, Steven W, Jiang, Yutong, Serebryany, Vladimir, Tan, Hua, Kossen, Karl, Rajagopalan, P T Ravi, Misialek, Shawn, Stevens, Sarah K, Stoycheva, Antitsa, Hong, Jin, Lim, Sharlene R, Qin, Xiaoli, Rieger, Robert, Condroski, Kevin R, Zhang, Hailong, Do, Mary Geck, Lemieux, Christine, Hingorani, Gary P, Hartley, Dylan P, Josey, John A, Pan, Lin, Beigelman, Leonid, Blatt, Lawrence M
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
Get full text
Journal Article
Inhibition and Binding Kinetics of the Hepatitis C Virus NS3 Protease Inhibitor ITMN-191 Reveals Tight Binding and Slow Dissociative Behavior
Rajagopalan, Ravi, Misialek, Shawn, Stevens, Sarah K, Myszka, David G, Brandhuber, Barbara J, Ballard, Joshua A, Andrews, Steven W, Seiwert, Scott D, Kossen, Karl
Published in Biochemistry (Easton) (24.03.2009)
Published in Biochemistry (Easton) (24.03.2009)
Get full text
Journal Article
Discovery of (1S,2R,3R)-2,3-Dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: Novel and Highly Selective Aggrecanase Inhibitors
Shiozaki, Makoto, Maeda, Katsuya, Miura, Tomoya, Kotoku, Masayuki, Yamasaki, Takayuki, Matsuda, Isamu, Aoki, Kenta, Yasue, Katsutaka, Imai, Hiroto, Ubukata, Minoru, Suma, Akira, Yokota, Masahiro, Hotta, Takahiro, Tanaka, Masahiro, Hase, Yasunori, Haas, Julia, Fryer, Andrew M, Laird, Ellen R, Littmann, Nicole M, Andrews, Steven W, Josey, John A, Mimura, Takayuki, Shinozaki, Yuichi, Yoshiuchi, Hiromi, Inaba, Takashi
Published in Journal of medicinal chemistry (28.04.2011)
Published in Journal of medicinal chemistry (28.04.2011)
Get full text
Journal Article
Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer
Vaishnavi, Aria, Capelletti, Marzia, Le, Anh T, Kako, Severine, Butaney, Mohit, Ercan, Dalia, Mahale, Sakshi, Davies, Kurtis D, Aisner, Dara L, Pilling, Amanda B, Berge, Eamon M, Kim, Jhingook, Sasaki, Hidefumi, Park, Seung-il, Kryukov, Gregory, Garraway, Levi A, Hammerman, Peter S, Haas, Julia, Andrews, Steven W, Lipson, Doron, Stephens, Philip J, Miller, Vince A, Varella-Garcia, Marileila, Jänne, Pasi A, Doebele, Robert C
Published in Nature medicine (01.11.2013)
Published in Nature medicine (01.11.2013)
Get full text
Journal Article
Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors
SHIOZAKI, Makoto, MAEDA, Katsuya, MIMURA, Takayuki, SHINOZAKI, Yuichi, YOSHIUCHI, Hiromi, INABA, Takashi, MIURA, Tomoya, OGOSHI, Yosuke, HAAS, Julia, FRYER, Andrew M, LAIRD, Ellen R, LITTMANN, Nicole M, ANDREWS, Steven W, JOSEY, John A
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Get full text
Journal Article
Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease
Jiang, Yutong, Andrews, Steven W., Condroski, Kevin R., Buckman, Brad, Serebryany, Vlad, Wenglowsky, Steve, Kennedy, April L., Madduru, Machender R., Wang, Bin, Lyon, Michael, Doherty, George A., Woodard, Benjamin T., Lemieux, Christine, Do, Mary Geck, Zhang, Hailong, Ballard, Joshua, Vigers, Guy, Brandhuber, Barbra J., Stengel, Peter, Josey, John A., Beigelman, Leonid, Blatt, Lawrence, Seiwert, Scott D.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
Get full text
Journal Article
Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers
Ghilardi, Joseph R, Freeman, Katie T, Jimenez-Andrade, Juan M, Mantyh, William G, Bloom, Aaron P, Bouhana, Karyn S, Trollinger, David, Winkler, James, Lee, Patrice, Andrews, Steven W, Kuskowski, Michael A, Mantyh, Patrick W
Published in Bone (New York, N.Y.) (01.02.2011)
Published in Bone (New York, N.Y.) (01.02.2011)
Get full text
Journal Article
Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors
Shiozaki, Makoto, Imai, Hiroto, Maeda, Katsuya, Miura, Tomoya, Yasue, Katsutaka, Suma, Akira, Yokota, Masahiro, Ogoshi, Yosuke, Haas, Julia, Fryer, Andrew M., Laird, Ellen R., Littmann, Nicole M., Andrews, Steven W., Josey, John A., Mimura, Takayuki, Shinozaki, Yuichi, Yoshiuchi, Hiromi, Inaba, Takashi
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
Get full text
Journal Article
RET 키나제를 억제하는데 유용한 화합물
ANDREWS STEVEN W, MCKENNEY MEGAN L, KOLAKOWSKI GABRIELLE R, ANDERSON ERIN D, CONDROSKI KEVIN R, KUMAR MANOJ, MCFADDIN ELIZABETH A, IRVIN THOMAS C, MUNCHHOF MICHAEL J, WELCH MICHAEL B
Year of Publication 09.01.2023
Get full text
Year of Publication 09.01.2023
Patent
RET 키나제 억제제로서의 피라졸 유도체
ANDREWS STEVEN W, MCKENNEY MEGAN L, PINTO MARTA, CONDROSKI KEVIN R, MCFADDIN ELIZABETH A, KOLAKOWSKI GABRIELLE R. A, IRVIN THOMAS C, MCLEAN JOHNATHAN ALEXANDER, ANDERSON ERIN D, KUMAR MANOJ, PILKINGTON MIKSA MICHAEL ALEXANDER, BOLDRON CHRISTOPHER PIERRE ALBERT JEAN, MOURET TIPHAINE, MUNCHHOF MICHAEL J, PANCALDI THOMAS PIERRE DINO
Year of Publication 07.07.2023
Get full text
Year of Publication 07.07.2023
Patent
TrkA 1-3S4R-4-3--1-2--3--3-4--3-2--5--1--1H--5-1-3S4R-4-3-FLUOROPHENYL-1-2-METHOXYETHYLPYRROLIDIN-3-YL-3-4-METHYL-3-2-METHYLPYRIMIDIN-5-YL-1-PHENYL-1H-PYRAZOL-5-YLUREA AS A TRKA KINASE INHIBITOR
ALLEN SHELLEY, ANDREWS STEVEN W, CRANE ZACKARY, BAER BRIAN, WATSON DANIEL JOHN, LIU WEIDONG
Year of Publication 11.07.2019
Get full text
Year of Publication 11.07.2019
Patent
S)-N-(5-((R)-2--피라졸로[1,5-A]피리미딘-3-일)-3-히드록시피롤리딘-1-카르복사미드의 제조 방법
JIANG YUTONG, ANDREWS STEVEN W, REYNOLDS MARK, EARY CHARLES TODD, HACHE BRUNO, JUENGST DERRICK, HAAS JULIA, SPENCER STACEY
Year of Publication 12.04.2019
Get full text
Year of Publication 12.04.2019
Patent
RET 키나아제 억제제로서 치환된 피라졸로[1,5-A]피리딘 화합물
GOLOS ADAM, JIANG YUTONG, ANDREWS STEVEN W, KOLAKOWSKI GABRIELLE R, HAAS JULIA, CHICARELLI MARK J, BLAKE JAMES F
Year of Publication 23.04.2018
Get full text
Year of Publication 23.04.2018
Patent