Studies leading to the identification of ZD1839 (Iressa) : An orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer
BARKER, Andrew J, GIBSON, Keith H, HENTHORN, Lianne, RICHARDS, Laura, GRUNDY, Walter, GODFREY, Andrew A, BARLOW, Jeffrey J, HEALY, Mark P, WOODBURN, James R, ASHTON, Susan E, CURRY, Brenda J, SCARLETT, Lynn
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
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Journal Article
The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing
Jones, Clifford D., Andrews, David M., Barker, Andrew J., Blades, Kevin, Daunt, Paula, East, Simon, Geh, Catherine, Graham, Mark A., Johnson, Keith M., Loddick, Sarah A., McFarland, Heather M., McGregor, Alexandra, Moss, Louise, Rudge, David A., Simpson, Peter B., Swain, Michael L., Tam, Kin Y., Tucker, Julie A., Walker, Mike
Published in Bioorganic & medicinal chemistry (15.12.2008)
Published in Bioorganic & medicinal chemistry (15.12.2008)
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Journal Article
ZD1839 (Iressa): An orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy
WAKELING, Alan E, GUY, Simon P, WOODBURN, Jim R, ASHTON, Susan E, CURRY, Brenda J, BARKER, Andrew J, GIBSON, Keith H
Published in Cancer research (Chicago, Ill.) (15.10.2002)
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Published in Cancer research (Chicago, Ill.) (15.10.2002)
Journal Article
Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors
Jones, Clifford D., Andrews, David M., Barker, Andrew J., Blades, Kevin, Byth, Kate F., Finlay, M. Raymond V., Geh, Catherine, Green, Clive P., Johannsen, Marie, Walker, Mike, Weir, Hazel M.
Published in Bioorganic & medicinal chemistry (15.12.2008)
Published in Bioorganic & medicinal chemistry (15.12.2008)
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Journal Article
Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode
Finlay, M. Raymond V., Acton, David G., Andrews, David M., Barker, Andrew J., Dennis, Michael, Fisher, Eric, Graham, Mark A., Green, Clive P., Heaton, David W., Karoutchi, Galith, Loddick, Sarah A., Morgentin, Rémy, Roberts, Andrew, Tucker, Julie A., Weir, Hazel M.
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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Journal Article
Numerical study of fluid flow of deforming fractured rocks using dual permeability model
Zhang, Xing, Sanderson, David J., Barker, Andrew J.
Published in Geophysical journal international (01.11.2002)
Published in Geophysical journal international (01.11.2002)
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Journal Article
Controlled drying to enhance properties of technical ceramics
Misra, Rajnish, Barker, Andrew J., East, James
Published in Chemical engineering journal (1996) (28.02.2002)
Published in Chemical engineering journal (1996) (28.02.2002)
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Journal Article
Conference Proceeding
respiration rate of composting pig manure
Cronje, A.L, Turner, C, Williams, A.G, Barker, A.J, Guy, S
Published in Compost science & utilization (01.03.2004)
Published in Compost science & utilization (01.03.2004)
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Journal Article
Key to rock-forming minerals in thin-section
Barker, Andrew J
Published in A Key for Identification of Rock-Forming Minerals in Thin Section (2014)
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Published in A Key for Identification of Rock-Forming Minerals in Thin Section (2014)
Book Chapter
Quinazoline Antifolate Thymidylate Synthase Inhibitors: Replacement of Glutamic Acid in the C2-Methyl Series
Marsham, Peter R, Jackman, Ann L, Barker, Andrew J, Boyle, F. Thomas, Pegg, Stephen J, Wardleworth, J. Michael, Kimbell, Rosemary, O'Connor, Brigid M, Calvert, A. Hilary, Hughes, Leslie R
Published in Journal of medicinal chemistry (01.03.1995)
Published in Journal of medicinal chemistry (01.03.1995)
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Journal Article
Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents
Warner, Peter, Barker, Andrew J, Jackman, Ann L, Burrows, Kenneth D, Roberts, Neal, Bishop, Joel A. M, O'Connor, Brigid M, Hughes, Leslie R
Published in Journal of medicinal chemistry (01.07.1992)
Published in Journal of medicinal chemistry (01.07.1992)
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Journal Article
Synthesis of substituted aromatic compounds by Diels-Alder reactions of alkoxycyclobutenes produced via photocycloadditions between vinyl ethers and 1,3-dione enol esters
BARKER, A. J, BEGLEY, M. J, BIRCH, A. M, PATTENDEN, G
Published in J. Chem. Soc., Perkin Trans. 1 (1983)
Published in J. Chem. Soc., Perkin Trans. 1 (1983)
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Journal Article
A new synthetic approach to the bicyclo[3.2.1]octane ring system, based on intramolecular photocycloaddition involving cyclopentane-1,3-dione enol esters
BARKER, A. J, BEGLEY, M. J, MELLOR, M, OTIENO, D. A, PATTENDEN, G
Published in Journal of the Chemical Society, Perkin Transactions 1 (1983)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1983)
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Journal Article
Section 6: 0 Cleavage traces, colourless
Barker, Andrew J
Published in A Key for Identification of Rock-Forming Minerals in Thin Section (2014)
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Published in A Key for Identification of Rock-Forming Minerals in Thin Section (2014)
Book Chapter
Section 8: Opaque minerals
Barker, Andrew J
Published in A Key for Identification of Rock-Forming Minerals in Thin Section (2014)
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Published in A Key for Identification of Rock-Forming Minerals in Thin Section (2014)
Book Chapter