Homology Modeling, de Novo Design of Ligands, and Molecular Docking Identify Potential Inhibitors of Leishmania donovani 24-Sterol Methyltransferase
Sakyi, Patrick O., Broni, Emmanuel, Amewu, Richard K., Miller, Whelton A., Wilson, Michael D., Kwofie, Samuel Kojo
Published in Frontiers in cellular and infection microbiology (02.06.2022)
Published in Frontiers in cellular and infection microbiology (02.06.2022)
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Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins
O'Neill, Paul M, Amewu, Richard K, Nixon, Gemma L, Bousejra ElGarah, Fatima, Mungthin, Mathirut, Chadwick, James, Shone, Alison E, Vivas, Livia, Lander, Hollie, Barton, Victoria, Muangnoicharoen, Sant, Bray, Patrick G, Davies, Jill, Park, B. Kevin, Wittlin, Sergio, Brun, Reto, Preschel, Michael, Zhang, Kesheng, Ward, Stephen A
Published in Angewandte Chemie (International ed.) (02.08.2010)
Published in Angewandte Chemie (International ed.) (02.08.2010)
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Antischistosomal, antionchocercal and antitrypanosomal potentials of some Ghanaian traditional medicines and their constituents
Twumasi, Emmanuella Bema, Akazue, Pearl Ihuoma, Kyeremeh, Kwaku, Gwira, Theresa Manful, Keiser, Jennifer, Cho-Ngwa, Fidelis, Flint, Adrian, Anibea, Barbara, Bonsu, Emmanuel Yeboah, Amewu, Richard K, Amoah, Linda Eva, Appiah-Opong, Regina, Osei-Safo, Dorcas
Published in PLoS neglected tropical diseases (01.12.2020)
Published in PLoS neglected tropical diseases (01.12.2020)
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Journal Article
Inhibiting Leishmania donovani Sterol Methyltransferase to Identify Lead Compounds Using Molecular Modelling
Sakyi, Patrick O, Kwofie, Samuel K, Tuekpe, Julius K, Gwira, Theresa M, Broni, Emmanuel, Miller, 3rd, Whelton A, Wilson, Michael D, Amewu, Richard K
Published in Pharmaceuticals (Basel, Switzerland) (21.02.2023)
Published in Pharmaceuticals (Basel, Switzerland) (21.02.2023)
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Targeting the Ubiquinol-Reduction (Qi) Site of the Mitochondrial Cytochrome bc1 Complex for the Development of Next Generation Quinolone Antimalarials
Amporndanai, Kangsa, Pinthong, Nattapon, O’Neill, Paul M., Hong, W. David, Amewu, Richard K., Pidathala, Chandrakala, Berry, Neil G., Leung, Suet C., Ward, Stephen A., Biagini, Giancarlo A., Hasnain, S. Samar, Antonyuk, Svetlana V.
Published in Biology (Basel, Switzerland) (25.07.2022)
Published in Biology (Basel, Switzerland) (25.07.2022)
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Correction: Antischistosomal, antionchocercal and antitrypanosomal potentials of some Ghanaian traditional medicines and their constituents
Twumasi, Emmanuella Bema, Akazue, Pearl Ihuoma, Kyeremeh, Kwaku, Gwira, Theresa Manful, Keiser, Jennifer, Cho-Ngwa, Fidelis, Flint, Adrian, Anibea, Barbara, Bonsu, Emmanuel Yeboah, Amewu, Richard K, Amoah, Linda Eva, Appiah-Opong, Regina, Osei-Safo, Dorcas
Published in PLoS neglected tropical diseases (04.01.2023)
Published in PLoS neglected tropical diseases (04.01.2023)
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A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
O'Neill, Paul M, Amewu, Richard K, Charman, Susan A, Sabbani, Sunil, Gnädig, Nina F, Straimer, Judith, Fidock, David A, Shore, Emma R, Roberts, Natalie L, Wong, Michael H-L, Hong, W David, Pidathala, Chandrakala, Riley, Chris, Murphy, Ben, Aljayyoussi, Ghaith, Gamo, Francisco Javier, Sanz, Laura, Rodrigues, Janneth, Cortes, Carolina Gonzalez, Herreros, Esperanza, Angulo-Barturén, Iñigo, Jiménez-Díaz, María Belén, Bazaga, Santiago Ferrer, Martínez-Martínez, María Santos, Campo, Brice, Sharma, Raman, Ryan, Eileen, Shackleford, David M, Campbell, Simon, Smith, Dennis A, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Palmer, Michael J, Copple, Ian M, Mercer, Amy E, Ruecker, Andrea, Delves, Michael J, Sinden, Robert E, Siegl, Peter, Davies, Jill, Rochford, Rosemary, Kocken, Clemens H M, Zeeman, Anne-Marie, Nixon, Gemma L, Biagini, Giancarlo A, Ward, Stephen A
Published in Nature communications (24.05.2017)
Published in Nature communications (24.05.2017)
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Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria
Biagini, Giancarlo A, Fisher, Nicholas, Shone, Alison E, Mubaraki, Murad A, Srivastava, Abhishek, Hill, Alisdair, Antoine, Thomas, Warman, Ashley J, Davies, Jill, Pidathala, Chandrakala, Amewu, Richard K, Leung, Suet C, Sharma, Raman, Gibbons, Peter, Hong, David W, Pacorel, Bénédicte, Lawrenson, Alexandre S, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Stocks, Paul A, Nixon, Gemma L, Chadwick, James, Hemingway, Janet, Delves, Michael J, Sinden, Robert E, Zeeman, Anne-Marie, Kocken, Clemens H. M, Berry, Neil G, O’Neill, Paul M, Ward, Stephen A
Published in Proceedings of the National Academy of Sciences - PNAS (22.05.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (22.05.2012)
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Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials
O' Neill, Paul M., Sabbani, Sunil, Nixon, Gemma L., Schnaderbeck, Matthew, Roberts, Natalie L., Shore, Emma R., Riley, Christopher, Murphy, Ben, McGillan, Paul, Ward, Stephen A., Davies, Jill, Amewu, Richard K.
Published in Tetrahedron (06.10.2016)
Published in Tetrahedron (06.10.2016)
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Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria
O' Neill, Paul M., Stocks, Paul A., Sabbani, Sunil, Roberts, Natalie L., Amewu, Richard K., Shore, Emma R., Aljayyoussi, Ghaith, Angulo-Barturén, Iñigo, Belén, María, Jiménez-Díaz, Bazaga, Santiago Ferrer, Martínez, María Santos, Campo, Brice, Sharma, Raman, Charman, Susan A., Ryan, Eileen, Chen, Gong, Shackleford, David M., Davies, Jill, Nixon, Gemma L., Biagini, Giancarlo A., Ward, Stephen A.
Published in Bioorganic & medicinal chemistry (15.07.2018)
Published in Bioorganic & medicinal chemistry (15.07.2018)
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Journal Article
Targeting Leishmania donovani sterol methyltransferase for leads using pharmacophore modeling and computational molecular mechanics studies
Sakyi, Patrick O., Broni, Emmanuel, Amewu, Richard K., Miller, Whelton A., Wilson, Michael D., Kwofie, Samuel K.
Published in Informatics in medicine unlocked (2023)
Published in Informatics in medicine unlocked (2023)
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Comparison of the Reactivity of Antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the Presence of Ferrous Iron Salts, Heme, and Ferrous Iron Salts/Phosphatidylcholine
Bousejra-El Garah, Fatima, Wong, Michael He-Long, Amewu, Richard K, Muangnoicharoen, Sant, Maggs, James L, Stigliani, Jean-Luc, Park, B. Kevin, Chadwick, James, Ward, Stephen A, O’Neill, Paul M
Published in Journal of medicinal chemistry (13.10.2011)
Published in Journal of medicinal chemistry (13.10.2011)
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The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade
Sakyi, Patrick O., Amewu, Richard K., Devine, Robert N. O. A., Ismaila, Emahi, Miller, Whelton A., Kwofie, Samuel K.
Published in Natural products and bioprospecting (01.10.2021)
Published in Natural products and bioprospecting (01.10.2021)
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Journal Article
Unravelling the myth surrounding sterol biosynthesis as plausible target for drug design against leishmaniasis
Sakyi, Patrick O., Amewu, Richard K., Devine, Robert N. O. A., Bienibuor, Alfred K., Miller, Whelton A., Kwofie, Samuel K.
Published in Journal of parasitic diseases (01.12.2021)
Published in Journal of parasitic diseases (01.12.2021)
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Journal Article
An Endoperoxide-Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites
Oliveira, Rudi, Newton, Ana S., Guedes, Rita C., Miranda, Daniela, Amewu, Richard K., Srivastava, Abhishek, Gut, Jiri, Rosenthal, Philip J., O'Neill, Paul M., Ward, Stephen A., Lopes, Francisca, Moreira, Rui
Published in ChemMedChem (01.09.2013)
Published in ChemMedChem (01.09.2013)
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Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers
Amewu, Richard K., Chadwick, James, Hussain, Afthab, Panda, Somnath, Rinki, Rinki, Janneh, Omar, Ward, Stephen A., Miguel, Candel, Burrell-Saward, Hollie, Vivas, Livia, O’Neill, Paul M.
Published in Bioorganic & medicinal chemistry (01.12.2013)
Published in Bioorganic & medicinal chemistry (01.12.2013)
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