Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls
Ghatak, Swagata, Dolatabadi, Nima, Trudler, Dorit, Zhang, XiaoTong, Wu, Yin, Mohata, Madhav, Ambasudhan, Rajesh, Talantova, Maria, Lipton, Stuart A
Published in eLife (29.11.2019)
Published in eLife (29.11.2019)
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NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models
Ghatak, Swagata, Dolatabadi, Nima, Gao, Richard, Wu, Yin, Scott, Henry, Trudler, Dorit, Sultan, Abdullah, Ambasudhan, Rajesh, Nakamura, Tomohiro, Masliah, Eliezer, Talantova, Maria, Voytek, Bradley, Lipton, Stuart A.
Published in Molecular psychiatry (01.10.2021)
Published in Molecular psychiatry (01.10.2021)
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Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds
Zhu, Saiyong, Li, Wenlin, Zhou, Hongyan, Wei, Wanguo, Ambasudhan, Rajesh, Lin, Tongxiang, Kim, Janghwan, Zhang, Kang, Ding, Sheng
Published in Cell stem cell (03.12.2010)
Published in Cell stem cell (03.12.2010)
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Direct Reprogramming of Adult Human Fibroblasts to Functional Neurons under Defined Conditions
Ambasudhan, Rajesh, Talantova, Maria, Coleman, Ronald, Yuan, Xu, Zhu, Saiyong, Lipton, Stuart A., Ding, Sheng
Published in Cell stem cell (05.08.2011)
Published in Cell stem cell (05.08.2011)
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Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein
Ryan, Tammy, Bamm, Vladimir V., Stykel, Morgan G., Coackley, Carla L., Humphries, Kayla M., Jamieson-Williams, Rhiannon, Ambasudhan, Rajesh, Mosser, Dick D., Lipton, Stuart A., Harauz, George, Ryan, Scott D.
Published in Nature communications (26.02.2018)
Published in Nature communications (26.02.2018)
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Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors
Li, Wenlin, Sun, Woong, Zhang, Yu, Wei, Wanguo, Ambasudhan, Rajesh, Xia, Peng, Talantova, Maria, Lin, Tongxiang, Kim, Janghwan, Wang, Xiaolei, Kim, Woon Ryoung, Lipton, Stuart A, Zhang, Kang, Ding, Sheng
Published in Proceedings of the National Academy of Sciences - PNAS (17.05.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (17.05.2011)
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Aberrant protein S -nitrosylation contributes to the pathophysiology of neurodegenerative diseases
Nakamura, Tomohiro, Prikhodko, Olga A, Pirie, Elaine, Nagar, Saumya, Akhtar, Mohd Waseem, Oh, Chang-Ki, McKercher, Scott R, Ambasudhan, Rajesh, Okamoto, Shu-ichi, Lipton, Stuart A
Published in Neurobiology of disease (01.12.2015)
Published in Neurobiology of disease (01.12.2015)
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A chemical platform for improved induction of human iPSCs
Ding, Sheng, Lin, Tongxiang, Ambasudhan, Rajesh, Yuan, Xu, Li, Wenlin, Hilcove, Simon, Abujarour, Ramzey, Lin, Xiangyi, Hahm, Heung Sik, Hao, Ergeng, Hayek, Alberto
Published in Nature methods (01.11.2009)
Published in Nature methods (01.11.2009)
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Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
Talantova, Maria, Sanz-Blasco, Sara, Zhang, Xiaofei, Xia, Peng, Akhtar, Mohd Waseem, Okamoto, Shu-ichi, Dziewczapolski, Gustavo, Nakamura, Tomohiro, Cao, Gang, Pratt, Alexander E, Kang, Yeon-Joo, Tu, Shichun, Molokanova, Elena, McKercher, Scott R, Hires, Samuel Andrew, Sason, Hagit, Stouffer, David G, Buczynski, Matthew W, Solomon, James P, Michael, Sarah, Powers, Evan T, Kelly, Jeffery W, Roberts, Amanda, Tong, Gary, Fang-Newmeyer, Traci, Parker, James, Holland, Emily A, Zhang, Dongxian, Nakanishi, Nobuki, Chen, H-S Vincent, Wolosker, Herman, Wang, Yuqiang, Parsons, Loren H, Ambasudhan, Rajesh, Masliah, Eliezer, Heinemann, Stephen F, Piña-Crespo, Juan C, Lipton, Stuart A
Published in Proceedings of the National Academy of Sciences - PNAS (02.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (02.07.2013)
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Hydrogen Sulfide—Mechanisms of Toxicity and Development of an Antidote
Jiang, Jingjing, Chan, Adriano, Ali, Sameh, Saha, Arindam, Haushalter, Kristofer J., Lam, Wai-Ling Macrina, Glasheen, Megan, Parker, James, Brenner, Matthew, Mahon, Sari B., Patel, Hemal H., Ambasudhan, Rajesh, Lipton, Stuart A., Pilz, Renate B., Boss, Gerry R.
Published in Scientific reports (15.02.2016)
Published in Scientific reports (15.02.2016)
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Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
Akhtar, Mohd Waseem, Sanz-Blasco, Sara, Dolatabadi, Nima, Parker, James, Chon, Kevin, Lee, Michelle S., Soussou, Walid, McKercher, Scott R., Ambasudhan, Rajesh, Nakamura, Tomohiro, Lipton, Stuart A.
Published in Nature communications (08.01.2016)
Published in Nature communications (08.01.2016)
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S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models
Oh, Chang-Ki, Sultan, Abdullah, Platzer, Joseph, Dolatabadi, Nima, Soldner, Frank, McClatchy, Daniel B., Diedrich, Jolene K., Yates, John R., Ambasudhan, Rajesh, Nakamura, Tomohiro, Jaenisch, Rudolf, Lipton, Stuart A.
Published in Cell reports (Cambridge) (21.11.2017)
Published in Cell reports (Cambridge) (21.11.2017)
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Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease
Mann, Aman P., Scodeller, Pablo, Hussain, Sazid, Braun, Gary B., Mölder, Tarmo, Toome, Kadri, Ambasudhan, Rajesh, Teesalu, Tambet, Lipton, Stuart A., Ruoslahti, Erkki
Published in Nature communications (10.11.2017)
Published in Nature communications (10.11.2017)
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NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism
Tu, Shichun, Akhtar, Mohd Waseem, Escorihuela, Rosa Maria, Amador-Arjona, Alejandro, Swarup, Vivek, Parker, James, Zaremba, Jeffrey D., Holland, Timothy, Bansal, Neha, Holohan, Daniel R., Lopez, Kevin, Ryan, Scott D., Chan, Shing Fai, Yan, Li, Zhang, Xiaofei, Huang, Xiayu, Sultan, Abdullah, McKercher, Scott R., Ambasudhan, Rajesh, Xu, Huaxi, Wang, Yuqiang, Geschwind, Daniel H., Roberts, Amanda J., Terskikh, Alexey V., Rissman, Robert A., Masliah, Eliezer, Lipton, Stuart A., Nakanishi, Nobuki
Published in Nature communications (14.11.2017)
Published in Nature communications (14.11.2017)
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Publisher Correction: Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease
Mann, Aman P., Scodeller, Pablo, Hussain, Sazid, Braun, Gary B., Mölder, Tarmo, Toome, Kadri, Ambasudhan, Rajesh, Teesalu, Tambet, Lipton, Stuart A., Ruoslahti, Erkki
Published in Nature communications (09.03.2018)
Published in Nature communications (09.03.2018)
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High-frequency hippocampal oscillations activated by optogenetic stimulation of transplanted human ESC-derived neurons
Piña-Crespo, Juan C, Talantova, Maria, Cho, Eun-Gyung, Soussou, Walid, Dolatabadi, Nima, Ryan, Scott D, Ambasudhan, Rajesh, McKercher, Scott, Deisseroth, Karl, Lipton, Stuart A
Published in The Journal of neuroscience (07.11.2012)
Published in The Journal of neuroscience (07.11.2012)
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Direct Reprogramming of Human Fibroblasts into Induced Neural Progenitor Cells Using Suicide Gene Embodied Episomal Vectors for Rapid Selection of Exogenous DNA-Free Cells
Lee, Minhyung, Kim, Janghwan, Ambasudhan, Rajesh
Published in Methods in molecular biology (Clifton, N.J.) (2021)
Published in Methods in molecular biology (Clifton, N.J.) (2021)
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Direct lineage reprogramming to neural cells
Kim, Janghwan, Ambasudhan, Rajesh, Ding, Sheng
Published in Current opinion in neurobiology (01.10.2012)
Published in Current opinion in neurobiology (01.10.2012)
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Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia
Trudler, Dorit, Nazor, Kristopher L., Eisele, Yvonne S., Grabauskas, Titas, Dolatabadi, Nima, Parker, James, Sultan, Abdullah, Zhong, Zhenyu, Goodwin, Marshall S., Levites, Yona, Golde, Todd E., Kelly, Jeffery W., Sierks, Michael R., Schork, Nicholas J., Karin, Michael, Ambasudhan, Rajesh, Lipton, Stuart A.
Published in Proceedings of the National Academy of Sciences - PNAS (13.04.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (13.04.2021)
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