A major role for ferroptosis in Mycobacterium tuberculosis -induced cell death and tissue necrosis
Amaral, Eduardo P, Costa, Diego L, Namasivayam, Sivaranjani, Riteau, Nicolas, Kamenyeva, Olena, Mittereder, Lara, Mayer-Barber, Katrin D, Andrade, Bruno B, Sher, Alan
Published in The Journal of experimental medicine (04.03.2019)
Published in The Journal of experimental medicine (04.03.2019)
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Journal Article
Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk
Mayer-Barber, Katrin D., Andrade, Bruno B., Oland, Sandra D., Amaral, Eduardo P., Barber, Daniel L., Gonzales, Jacqueline, Derrick, Steven C., Shi, Ruiru, Kumar, Nathella Pavan, Wei, Wang, Yuan, Xing, Zhang, Guolong, Cai, Ying, Babu, Subash, Catalfamo, Marta, Salazar, Andres M., Via, Laura E., Barry III, Clifton E., Sher, Alan
Published in Nature (London) (03.07.2014)
Published in Nature (London) (03.07.2014)
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Journal Article
Mycobacterium tuberculosis strains of the modern sublineage of the Beijing family are more likely to display increased virulence than strains of the ancient sublineage
Ribeiro, Simone C M, Gomes, Lia Lima, Amaral, Eduardo P, Andrade, Marcelle R M, Almeida, Fabricio M, Rezende, Andreza L, Lanes, Verônica R, Carvalho, Eulógio C Q, Suffys, Philip N, Mokrousov, Igor, Lasunskaia, Elena B
Published in Journal of clinical microbiology (01.07.2014)
Published in Journal of clinical microbiology (01.07.2014)
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Journal Article
Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages
Amaral, Eduardo P, Riteau, Nicolas, Moayeri, Mahtab, Maier, Nolan, Mayer-Barber, Katrin D, Pereira, Rosana M, Lage, Silvia L, Kubler, Andre, Bishai, William R, D'Império-Lima, Maria R, Sher, Alan, Andrade, Bruno B
Published in Frontiers in immunology (21.06.2018)
Published in Frontiers in immunology (21.06.2018)
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Journal Article
Bacterial-induced or passively administered interferon gamma conditions the lung for early control of SARS-CoV-2
Hilligan, Kerry L., Namasivayam, Sivaranjani, Clancy, Chad S., Baker, Paul J., Old, Samuel I., Peluf, Victoria, Amaral, Eduardo P., Oland, Sandra D., O’Mard, Danielle, Laux, Julie, Cohen, Melanie, Garza, Nicole L., Lafont, Bernard A. P., Johnson, Reed F., Feng, Carl G., Jankovic, Dragana, Lamiable, Olivier, Mayer-Barber, Katrin D., Sher, Alan
Published in Nature communications (12.12.2023)
Published in Nature communications (12.12.2023)
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Journal Article
N-acetyl-cysteine exhibits potent anti-mycobacterial activity in addition to its known anti-oxidative functions
Amaral, Eduardo P, Conceição, Elisabete L, Costa, Diego L, Rocha, Michael S, Marinho, Jamocyr M, Cordeiro-Santos, Marcelo, D'Império-Lima, Maria Regina, Barbosa, Theolis, Sher, Alan, Andrade, Bruno B
Published in BMC microbiology (28.10.2016)
Published in BMC microbiology (28.10.2016)
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Journal Article
The role of ESAT-6 in tuberculosis immunopathology
Passos, Beatriz B S, Araújo-Pereira, Mariana, Vinhaes, Caian L, Amaral, Eduardo P, Andrade, Bruno B
Published in Frontiers in immunology (03.04.2024)
Published in Frontiers in immunology (03.04.2024)
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Journal Article
Mycobacterium tuberculosis Induces Irg1 in Murine Macrophages by a Pathway Involving Both TLR-2 and STING/IFNAR Signaling and Requiring Bacterial Phagocytosis
Bomfim, Caio C B, Fisher, Logan, Amaral, Eduardo P, Mittereder, Lara, McCann, Katelyn, Correa, André A S, Namasivayam, Sivaranjani, Swamydas, Muthulekha, Moayeri, Mahtab, Weiss, Jonathan M, Chari, Raj, McVicar, Daniel W, Costa, Diego L, D'Império Lima, Maria R, Sher, Alan
Published in Frontiers in cellular and infection microbiology (02.05.2022)
Published in Frontiers in cellular and infection microbiology (02.05.2022)
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Journal Article
Co-infection of mice with SARS-CoV-2 and Mycobacterium tuberculosis limits early viral replication but does not affect mycobacterial loads
Baker, Paul J, Amaral, Eduardo P, Castro, Ehydel, Bohrer, Andrea C, Torres-Juárez, Flor, Jordan, Cassandra M, Nelson, Christine E, Barber, Daniel L, Johnson, Reed F, Hilligan, Kerry L, Mayer-Barber, Katrin D
Published in Frontiers in immunology (01.09.2023)
Published in Frontiers in immunology (01.09.2023)
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Journal Article
Safety and efficacy of N-acetylcysteine in hospitalized patients with HIV-associated tuberculosis: An open-label, randomized, phase II trial (RIPENACTB Study)
Safe, Izabella Picinin, Lacerda, Marcus Vinícius Guimarães, Printes, Vitoria Silva, Praia Marins, Adriana Ferreira, Rebelo Rabelo, Amanda Lia, Costa, Amanda Araújo, Tavares, Michel Araújo, Jesus, Jaquelane Silva, Souza, Alexandra Brito, Beraldi-Magalhães, Francisco, Neves, Cynthia Pessoa, Monteiro, Wuelton Marcelo, Sampaio, Vanderson Souza, Amaral, Eduardo P, Gomes, Renata Spener, Andrade, Bruno B, Cordeiro-Santos, Marcelo, Goletti, Delia
Published in PloS one (26.06.2020)
Published in PloS one (26.06.2020)
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Journal Article
Pulmonary infection with hypervirulent Mycobacteria reveals a crucial role for the P2X7 receptor in aggressive forms of tuberculosis
Amaral, Eduardo P, Ribeiro, Simone C M, Lanes, Verônica R, Almeida, Fabrício M, de Andrade, Marcelle R M, Bomfim, Caio Cesar Barbosa, Salles, Erika M, Bortoluci, Karina R, Coutinho-Silva, Robson, Hirata, Mario H, Alvarez, José M, Lasunskaia, Elena B, D'Império-Lima, Maria Regina
Published in PLoS pathogens (01.07.2014)
Published in PLoS pathogens (01.07.2014)
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Journal Article
Adjunct N-Acetylcysteine Treatment in Hospitalized Patients With HIV-Associated Tuberculosis Dampens the Oxidative Stress in Peripheral Blood: Results From the RIPENACTB Study Trial
Safe, Izabella P, Amaral, Eduardo P, Araújo-Pereira, Mariana, Lacerda, Marcus V G, Printes, Vitoria S, Souza, Alexandra B, Beraldi-Magalhães, Francisco, Monteiro, Wuelton M, Sampaio, Vanderson S, Barreto-Duarte, Beatriz, Andrade, Alice M S, Spener-Gomes, Renata, Costa, Allyson Guimarães, Cordeiro-Santos, Marcelo, Andrade, Bruno B
Published in Frontiers in immunology (04.02.2021)
Published in Frontiers in immunology (04.02.2021)
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Journal Article
Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes
Rockwood, Neesha, Costa, Diego L, Amaral, Eduardo P, Du Bruyn, Elsa, Kubler, Andre, Gil-Santana, Leonardo, Fukutani, Kiyoshi F, Scanga, Charles A, Flynn, JoAnne L, Jackson, Sharon H, Wilkinson, Katalin A, Bishai, William R, Sher, Alan, Wilkinson, Robert J, Andrade, Bruno B
Published in Frontiers in immunology (12.05.2017)
Published in Frontiers in immunology (12.05.2017)
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Journal Article
Hypervirulent Mycobacterium tuberculosis strain triggers necrotic lung pathology associated with enhanced recruitment of neutrophils in resistant C57BL/6 mice
Almeida, Fabrício M, Ventura, Thatiana L B, Amaral, Eduardo P, Ribeiro, Simone C M, Calixto, Sanderson D, Manhães, Marcelle R, Rezende, Andreza L, Souza, Giliane S, de Carvalho, Igor S, Silva, Elisangela C, Silva, Juliana Azevedo da, Carvalho, Eulógio C Q, Kritski, Afranio L, Lasunskaia, Elena B
Published in PloS one (17.03.2017)
Published in PloS one (17.03.2017)
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Journal Article
Host-directed therapies in pulmonary tuberculosis: Updates on anti-inflammatory drugs
Cubillos-Angulo, Juan M, Nogueira, Betânia M F, Arriaga, María B, Barreto-Duarte, Beatriz, Araújo-Pereira, Mariana, Fernandes, Catarina D, Vinhaes, Caian L, Villalva-Serra, Klauss, Nunes, Vanessa M, Miguez-Pinto, João P, Amaral, Eduardo P, Andrade, Bruno B
Published in Frontiers in medicine (23.09.2022)
Published in Frontiers in medicine (23.09.2022)
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Journal Article
Enhancement of CD4+ T Cell Function as a Strategy for Improving Antibiotic Therapy Efficacy in Tuberculosis: Does It Work?
Costa, Diego L., Amaral, Eduardo P., Namasivayam, Sivaranjani, Mittereder, Lara R., Andrade, Bruno B., Sher, Alan
Published in Frontiers in cellular and infection microbiology (21.06.2021)
Published in Frontiers in cellular and infection microbiology (21.06.2021)
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Journal Article
Combining Host Genetics and Functional Analysis to Depict Inflammasome Contribution in Tuberculosis Susceptibility and Outcome in Endemic Areas
Souza De Lima, Dhêmerson, Bomfim, Caio C B, Leal, Vinícius N C, Reis, Edione C, Soares, Jaíne L S, Fernandes, Fernanda P, Amaral, Eduardo P, Loures, Flavio V, Ogusku, Mauricio M, Lima, Maria R D'Imperio, Sadahiro, Aya, Pontillo, Alessandra
Published in Frontiers in immunology (21.10.2020)
Published in Frontiers in immunology (21.10.2020)
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Journal Article
Cytosolic flagellin-induced lysosomal pathway regulates inflammasome-dependent and -independent macrophage responses
Lage, Silvia L, Buzzo, Carina L, Amaral, Eduardo P, Matteucci, Kely C, Massis, Liliana M, Icimoto, Marcelo Y, Carmona, Adriana Karaoglanovic, D'Império Lima, Maria R, Rodrigues, Mauricio M, Ferreira, Luis C S, Amarante-Mendes, Gustavo P, Bortoluci, Karina R
Published in Proceedings of the National Academy of Sciences - PNAS (27.08.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (27.08.2013)
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