Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5
Clement-Lacroix, P., Little, C.B., Smith, M.M., Cottereaux, C., Merciris, D., Meurisse, S., Mollat, P., Touitou, R., Brebion, F., Gosmini, R., De Ceuninck, F., Botez, I., Lepescheux, L., van der Aar, E., Christophe, T., Vandervoort, N., Blanqué, R., Comas, D., Deprez, P., Amantini, D.
Published in Osteoarthritis and cartilage (01.02.2022)
Published in Osteoarthritis and cartilage (01.02.2022)
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Journal Article
OP0258 Efficacy of the highly selective adamts-5 inhibitor glpg1972 in the rat meniscectomy model
Lepescheux, L., Clement-Lacroix, P., Merciris, D., Meurisse, S., Borgonovi, M., Cottereaux, C., Mollat, P., Brebion, F., Gosmini, R., De Ceuninck, F., Botez, I., van der Aar, E., Christophe, T., Vandervoort, N., Blanqué, R., Comas, D., Deprez, P., Amantini, D.
Published in Annals of the rheumatic diseases (01.06.2018)
Published in Annals of the rheumatic diseases (01.06.2018)
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Journal Article
GLPG1972: a potent, selective, orally available adamts-5 inhibitor for the treatment of OA
Clement-Lacroix, P, Little, C, Meurisse, S, Blanqué, R, Mollat, P, Brebion, F, Gosmini, R, De Ceuninck, F, Botez, I, Lepescheux, L, van der Aar, E, Christophe, T, Vandervoort, N, Cottereaux, C, Comas, D, Deprez, P, Amantini, D
Published in Osteoarthritis and cartilage (01.04.2017)
Published in Osteoarthritis and cartilage (01.04.2017)
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Journal Article
New cartilage quality evaluation using bio-indentation: effect of a tool dmoad compound active in the rat MNX model
Lavet, C, Clement-Lacroix, P, Merciris, D, Meurisse, S, Lepescheux, L, Gaillard, V, Pastoureau, P, Deprez, P, Amantini, D, Ammann, P
Published in Osteoarthritis and cartilage (01.04.2016)
Published in Osteoarthritis and cartilage (01.04.2016)
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Journal Article
Efficient O-Trimethylsilylation of Alcohols and Phenols with Trimethylsilyl Azide Catalyzed by Tetrabutylammonium Bromide under Neat Conditions
Amantini, David, Fringuelli, Francesco, Pizzo, Ferdinando, Vaccaro, Luigi
Published in Journal of organic chemistry (05.10.2001)
Published in Journal of organic chemistry (05.10.2001)
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Journal Article
Water, a clean, inexpensive, and re-usable reaction medium. One-pot synthesis of (E)-2-aryl-1-cyano-1-nitroethenes
Amantini, D., Fringuelli, F., Piermatti, O., Pizzo, F., Vaccaro, L.
Published in Green chemistry : an international journal and green chemistry resource : GC (2001)
Published in Green chemistry : an international journal and green chemistry resource : GC (2001)
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Journal Article
Bromolysis and Iodolysis of α,β-Epoxycarboxylic Acids in Water Catalyzed by Indium Halides
Amantini, David, Fringuelli, Francesco, Pizzo, Ferdinando, Vaccaro, Luigi
Published in Journal of organic chemistry (29.06.2001)
Published in Journal of organic chemistry (29.06.2001)
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Journal Article
SELECTED METHODS FOR THE REDUCTION OF THE AZIDO GROUP
Amantini, D., Fringuelli, F., Pizza, F., Vaccaro, L.
Published in Organic preparations and procedures international (01.04.2002)
Published in Organic preparations and procedures international (01.04.2002)
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Journal Article
TBAF-Catalyzed synthesis of 5-substituted IH-tetrazoles under solventless conditions
Amantini, D, Beleggia, R, Fringuelli, F, Pizzo, F, Vaccaro, L
Published in Journal of organic chemistry (16.04.2004)
Published in Journal of organic chemistry (16.04.2004)
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Journal Article
POS0442 GLPG4399: SELECTIVE SIK3 INHIBITION AS A NOVEL MODE OF ACTION FOR THE TREATMENT OF INFLAMMATORY ARTHRITIC DISEASES (PRECLINICAL)
Lavazais, S., Pereira-Fernandes, A., Delachaume, C., Jagerschmidt, C., Drennan, M., Merciris, D., Peixoto, C., Borgonovi, M., Desroy, N., Amantini, D., De Vos, S., Nys, K.
Published in Annals of the rheumatic diseases (01.06.2022)
Published in Annals of the rheumatic diseases (01.06.2022)
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Journal Article
AB0144 PHARMACOLOGICAL CHARACTERIZATION OF GLPG3667, A SELECTIVE TYK2 INHIBITOR, SUPPORTS DEVELOPMENT IN DERMATOMYOSITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS
Aggarwal, R, Morand, E F, Blanque, R, Shoji, K, Jans, M, Marsais, F, Furio, L, Colli, M, Lavazais, S, Cottereaux, C, David, C, Houvenaghel, N, Parent, I, Lagoutte, E, Van de Water, A, Perret, L, Alves, S, Amantini, D, Van der Plas, S, Galien, R
Published in Annals of the rheumatic diseases (01.06.2023)
Published in Annals of the rheumatic diseases (01.06.2023)
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Journal Article
ADAMTS-5 inhibitor GLPG1972, a potential new treatment in osteoarthritis, shows favorable safety, pharmacokinetics and pharmacodynamics in healthy subjects
van der Aar, E.M., Desrivot, J., Fagard, L., Amantini, D., Larsson, S., Struglics, A., Lohmander, S., Vanhoutte, F., Dupont, S.
Published in Osteoarthritis and cartilage (01.04.2018)
Published in Osteoarthritis and cartilage (01.04.2018)
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Journal Article
Synthesis of 4-Aryl-1H-1,2,3-triazoles through TBAF-Catalyzed [3 + 2] Cycloaddition of 2-Aryl-1-nitroethenes with TMSN3 under Solvent-Free Conditions
Amantini, David, Fringuelli, Francesco, Piermatti, Oriana, Pizzo, Ferdinando, Zunino, Ennio, Vaccaro, Luigi
Published in Journal of organic chemistry (05.08.2005)
Published in Journal of organic chemistry (05.08.2005)
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Blepharo-Cheilo-Dontic (BCD) syndrome: report on four new patients
Guion-Almeida, M L, Rodini, E S, Kokitsu-Nakata, N M, Bologna-Amantini, D
Published in American journal of medical genetics (05.03.1998)
Published in American journal of medical genetics (05.03.1998)
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Journal Article
ADAMTS-5 inhibition with the potent and highly selective inhibitor GLPG1972 results in strong disease-modifying OA drug effects in the rat meniscectomy model
Clement-Lacroix, P., Meurisse, S., Lepescheux, L., Merciris, D., Borgonovi, M., Cottereaux, C., Mollat, P., Brebion, F., Gosmini, R., De Ceuninck, F., Botez, I., Christophe, T., van der Aar, E.E., Vandervoort, N., Blanqué, R., Comas, D., Deprez, P., Amantini, D.
Published in Osteoarthritis and cartilage (01.04.2018)
Published in Osteoarthritis and cartilage (01.04.2018)
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Journal Article
OP0180 Pharmacological characterization of the ADAMTS-5 inhibitor GLPG1972: an oral anti-catabolic agent for the treatment of osteoarthritis
Clement-Lacroix, P, Little, C, Blanqué, R, Meurisse, S, Mollat, P, Brebion, F, Gosmini, R, Ceuninck, F De, Botez, I, Lepescheux, L, Aar, E van der, Christophe, T, Vandervoort, N, Cottereaux, C, Comas, D, Deprez, P, Amantini, D
Published in Annals of the rheumatic diseases (01.06.2017)
Published in Annals of the rheumatic diseases (01.06.2017)
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Journal Article
3-Nitrocoumarins as Dienophiles in the Diels−Alder Reaction in Water. An Approach to the Synthesis of Nitrotetrahydrobenzo[c]chromenones and Dihydrodibenzo[b,d]furans
Amantini, David, Fringuelli, Francesco, Piermatti, Oriana, Pizzo, Ferdinando, Vaccaro, Luigi
Published in Journal of organic chemistry (28.11.2003)
Published in Journal of organic chemistry (28.11.2003)
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Journal Article
Nucleophilic ring opening of 1,2-epoxides in aqueous medium
Amantini, David, Fringuelli, Francesco, Piermatti, Oriana, Tortoioli, Simone, Vaccaro, Luigi
Published in ARKIVOC (08.03.2003)
Published in ARKIVOC (08.03.2003)
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