Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Hamaguchi, Hisao, Amano, Yasushi, Moritomo, Ayako, Shirakami, Shohei, Nakajima, Yutaka, Nakai, Kazuo, Nomura, Naoko, Ito, Misato, Higashi, Yasuyuki, Inoue, Takayuki
Published in Bioorganic & medicinal chemistry (01.10.2018)
Published in Bioorganic & medicinal chemistry (01.10.2018)
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Journal Article
Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors
Chino, Ayaka, Seo, Ryushi, Amano, Yasushi, Namatame, Ichiji, Hamaguchi, Wataru, Honbou, Kazuya, Mihara, Takuma, Yamazaki, Mayako, Tomishima, Masaki, Masuda, Naoyuki
Published in Chemical & pharmaceutical bulletin (2018)
Published in Chemical & pharmaceutical bulletin (2018)
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Journal Article
In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease
Yoshino, Ryunosuke, Yasuo, Nobuaki, Hagiwara, Yohsuke, Ishida, Takashi, Inaoka, Daniel Ken, Amano, Yasushi, Tateishi, Yukihiro, Ohno, Kazuki, Namatame, Ichiji, Niimi, Tatsuya, Orita, Masaya, Kita, Kiyoshi, Akiyama, Yutaka, Sekijima, Masakazu
Published in Scientific reports (27.07.2017)
Published in Scientific reports (27.07.2017)
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Journal Article
Addressing phototoxicity observed in a novel series of biaryl derivatives: Discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436
Hamaguchi, Wataru, Masuda, Naoyuki, Miyamoto, Satoshi, Kikuchi, Shigetoshi, Narazaki, Fumie, Shiina, Yasuhiro, Seo, Ryushi, Amano, Yasushi, Mihara, Takuma, Moriguchi, Hiroyuki, Hattori, Kouji
Published in Bioorganic & medicinal chemistry (01.07.2015)
Published in Bioorganic & medicinal chemistry (01.07.2015)
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Journal Article
Unique “delta lock” structure of telmisartan is involved in its strongest binding affinity to angiotensin II type 1 receptor
Ohno, Kazuki, Amano, Yasushi, Kakuta, Hirotoshi, Niimi, Tatsuya, Takakura, Shoji, Orita, Masaya, Miyata, Keiji, Sakashita, Hitoshi, Takeuchi, Makoto, Komuro, Issei, Higaki, Jitsuo, Horiuchi, Masatsugu, Kim-Mitsuyama, Shokei, Mori, Yutaka, Morishita, Ryuichi, Yamagishi, Sho-ichi
Published in Biochemical and biophysical research communications (07.01.2011)
Published in Biochemical and biophysical research communications (07.01.2011)
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Journal Article
Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity
Imaizumi, Tomoyoshi, Akaiwa, Michinori, Abe, Tomoaki, Nigawara, Takahiro, Koike, Takanori, Satake, Yoshiki, Watanabe, Kazushi, Kaneko, Osamu, Amano, Yasushi, Mori, Kenichi, Yamanaka, Yosuke, Nagashima, Takeyuki, Shimazaki, Masashi, Kuramoto, Kazuyuki
Published in Bioorganic & medicinal chemistry (01.10.2022)
Published in Bioorganic & medicinal chemistry (01.10.2022)
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Journal Article
Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl} prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors
Imaizumi, Tomoyoshi, Shimada, Itsuro, Satake, Yoshiki, Yamaki, Susumu, Koike, Takanori, Nigawara, Takahiro, Kaneko, Osamu, Amano, Yasushi, Mori, Kenichi, Yamanaka, Yosuke, Nakayama, Ayako, Nishizono, Yoshihiro, Shimazaki, Masashi, Nagashima, Takeyuki, Kuramoto, Kazuyuki
Published in Bioorganic & medicinal chemistry (15.01.2024)
Published in Bioorganic & medicinal chemistry (15.01.2024)
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Journal Article
Structures of complexes of type 5 17β-hydroxysteroid dehydrogenase with structurally diverse inhibitors: insights into the conformational changes upon inhibitor binding
Amano, Yasushi, Yamaguchi, Tomohiko, Niimi, Tatsuya, Sakashita, Hitoshi
Published in Acta crystallographica. Section D, Biological crystallography. (01.04.2015)
Published in Acta crystallographica. Section D, Biological crystallography. (01.04.2015)
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Journal Article
ELECTRIC POWER SYSTEM
HAKUTA YUSUKE, JINBO TOMOHIKO, TOMURA SHUJI, AMANO YASUSHI, KAWAMURA YOSHIMI
Year of Publication 22.09.2023
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Year of Publication 22.09.2023
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