One-step synthesis of imidazoles from Asmic (anisylsulfanylmethyl isocyanide)
Mueller, Louis G, Chao, Allen, AlWedi, Embarek, Fleming, Fraser F
Published in Beilstein journal of organic chemistry (24.06.2021)
Published in Beilstein journal of organic chemistry (24.06.2021)
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Journal Article
Dearomatization of aromatic asmic isocyanides to complex cyclohexadienes
Altundas, Bilal, Alwedi, Embarek, Song, Zhihui, Gogoi, Achyut Ranjan, Dykstra, Ryan, Gutierrez, Osvaldo, Fleming, Fraser F.
Published in Nature communications (28.10.2022)
Published in Nature communications (28.10.2022)
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Journal Article
Polar-Radical Cyclization Cascades with Magnesiated Nitriles
Bolgunas, Stephen, Paleo, Ehecatl, Alwedi, Embarek, Wei, Yunjing, Keller, Taylor M., Fleming, Fraser F.
Published in Organic letters (19.05.2023)
Published in Organic letters (19.05.2023)
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Journal Article
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 6Development of a Nucleophilic Aromatic Substitution in Water
Le, Diane N., Wright, Timothy J., Alwedi, Embarek, Hartmanshenn, Clara, Li, Hong, McMullen, Jonathan P., DiRocco, Daniel A.
Published in Organic process research & development (16.02.2024)
Published in Organic process research & development (16.02.2024)
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Journal Article
Oxazole Synthesis by Sequential Asmic-Ester Condensations and Sulfanyl–Lithium Exchange–Trapping
Mueller, Louis G, Chao, Allen, Alwedi, Embarek, Natrajan, Maanasa, Fleming, Fraser F
Published in Organic letters (19.02.2021)
Published in Organic letters (19.02.2021)
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Journal Article
Manufacturing Process Development for Belzutifan, Part 5: A Streamlined Fluorination–Dynamic Kinetic Resolution Process
Wang, Tao, Phillips, Eric M, Dalby, Stephen M, Sirota, Eric, Axnanda, Stephanus, Shultz, C. Scott, Patel, Pratiq, Waldman, Jacob H, Alwedi, Embarek, Wang, Xiao, Zawatzky, Kerstin, Chow, Matthew, Padivitage, Nilusha, Weisel, Mark, Whittington, Michael, Duan, Jianjun, Lu, Taotao
Published in Organic process research & development (18.03.2022)
Published in Organic process research & development (18.03.2022)
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Journal Article
Chain Extension of Boronic Esters with Lithiooxiranes Generated by Sulfoxide-Metal Exchange - Stereocontrolled Access to 2 degrees/2 degrees, 2 degrees/3 degrees, and 3 degrees/3 degrees Vicinal Diols and Related Compounds
Alwedi, Embarek, Zakharov, Lev N., Blakemore, Paul R.
Published in European journal of organic chemistry (01.10.2014)
Published in European journal of organic chemistry (01.10.2014)
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Journal Article
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 5Chemoenzymatic Diastereoselective Fluorination/DKR
McCann, Scott D., Dubina, Sean H., Kosjek, Birgit, Alwedi, Embarek, Behre, Taylor, Burgess, Samantha A., Dal Poggetto, Guilherme, DiRocco, Daniel A., Hartmanshenn, Clara, McMullen, Jonathan P., Padivitage, Nilusha, Sun, Alexandra C.
Published in Organic process research & development (16.02.2024)
Published in Organic process research & development (16.02.2024)
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Journal Article
Development of a derivatization RP-HPLC method for determination of sulfuryl chloride in chlorosulfonic acid for gefapixant citrate manufacture
Huang, Chunli, Song, Siqing, Liu, Wenjun, Parganiha, Priya, Zhuang, Ping, Lohani, Sachin, Alwedi, Embarek, Ren, Hong, Bishara, Daniel, Chang, Hsieh Yao D.
Published in Journal of pharmaceutical and biomedical analysis (05.06.2022)
Published in Journal of pharmaceutical and biomedical analysis (05.06.2022)
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Journal Article
Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan
Cheung‐Lee, Wai Ling, Kolev, Joshua N., McIntosh, John A., Gil, Agnieszka A., Pan, Weilan, Xiao, Li, Velásquez, Juan E., Gangam, Rekha, Winston, Matthew S., Li, Shasha, Abe, Kotoe, Alwedi, Embarek, Dance, Zachary E. X., Fan, Haiyang, Hiraga, Kaori, Kim, Jungchul, Kosjek, Birgit, Le, Diane N., Marzijarani, Nastaran Salehi, Mattern, Keith, McMullen, Jonathan P., Narsimhan, Karthik, Vikram, Ajit, Wang, Wei, Yan, Jia‐Xuan, Yang, Rong‐Sheng, Zhang, Victoria, Zhong, Wendy, DiRocco, Daniel A., Morris, William J., Murphy, Grant S., Maloney, Kevin M.
Published in Angewandte Chemie International Edition (22.03.2024)
Published in Angewandte Chemie International Edition (22.03.2024)
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Journal Article
Front Cover: Asmic Isocyanide‐Nitrile Isomerization‐Alkylations (Eur. J. Org. Chem. 29/2019)
Alwedi, Embarek, Lujan‐Montelongo, J. Armando, Cortés‐Mejía, Rodrigo, del Campo, Jorge M., Altundas, Bilal, Fleming, Fraser F.
Published in European journal of organic chemistry (07.08.2019)
Published in European journal of organic chemistry (07.08.2019)
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Journal Article
Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation–Lithiation as a Batch–Flow Process
Otte, Douglas A. L., Larson, Reed T., Alwedi, Embarek, Armiger, Travis, Chen, Yonggang, Chung, Cheol K., Corry, James, Desmond, Richard, Fier, Patrick S., Franklin, Robert D., Guetschow, Erik D., Hall, Jackson R., Halsey, Holst M., Hartmanshenn, Clara, Jellett, Lisa, Kuhl, Nadine, Lévesque, François, McMullen, Jonathan P., Patel, Pratiq A., Paulines, Mellie June, Ren, Hong, Rodrigues, Vailankanni L., Ruccolo, Serge, Tan, Lushi, Thaisrivongs, David A., Xiao, Kai-Jiong
Published in Organic process research & development (17.05.2024)
Published in Organic process research & development (17.05.2024)
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Journal Article
Chain Extension of Boronic Esters with Lithiooxiranes Generated by Sulfoxide-Metal Exchange - Stereocontrolled Access to 2°/2°, 2°/3°, and 3°/3° Vicinal Diols and Related Compounds
Alwedi, Embarek, Zakharov, Lev N., Blakemore, Paul R.
Published in European journal of organic chemistry (01.10.2014)
Published in European journal of organic chemistry (01.10.2014)
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Journal Article
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 5: Completion of the API Free Base via a Direct Chlorosulfonylation Process
Di Maso, Michael J, Ren, Hong, Zhang, Si-Wei, Liu, Wenjun, Desmond, Richard, Alwedi, Embarek, Narsimhan, Karthik, Kalinin, Alexei, Larpent, Patrick, Lee, Alfred Y, Ren, Sumei, Maloney, Kevin M
Published in Organic process research & development (20.11.2020)
Published in Organic process research & development (20.11.2020)
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Journal Article
Asmic: An Exceptional Building Block for Isocyanide Alkylations
Alwedi, Embarek, Lujan-Montelongo, J. Armando, Pitta, Bhaskar R, Chao, Allen, Cortés-Mejía, Rodrigo, del Campo, Jorge M, Fleming, Fraser F
Published in Organic letters (21.09.2018)
Published in Organic letters (21.09.2018)
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Journal Article
Asmic Isocyanide‐Nitrile Isomerization‐Alkylations
Alwedi, Embarek, Lujan‐Montelongo, J. Armando, Cortés‐Mejía, Rodrigo, del Campo, Jorge M., Altundas, Bilal, Fleming, Fraser F.
Published in European journal of organic chemistry (07.08.2019)
Published in European journal of organic chemistry (07.08.2019)
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Journal Article
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview
Ren, Hong, Maloney, Kevin M, Basu, Kallol, Di Maso, Michael J, Humphrey, Guy R, Peng, Feng, Desmond, Richard, Otte, Douglas A. L, Alwedi, Embarek, Liu, Wenjun, Zhang, Si-Wei, Song, Siqing, Arvary, Rebecca A, Zompa, Michael A, Lehnherr, Dan, Martin, Gary E, Chang, Hsieh Yao D, Mohan, Anne E, Guzman, Francisco J, Jellett, Lisa, Lee, Alfred Y, Spencer, Glenn, Fisher, Elizabeth S, Naber, John R, Gao, Hong, Lohani, Sachin, Ruck, Rebecca T, Campeau, Louis-Charles
Published in Organic process research & development (20.11.2020)
Published in Organic process research & development (20.11.2020)
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Journal Article
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 6: Development of an Improved Commercial Salt Formation Process
Maloney, Kevin M, Zhang, Si-Wei, Mohan, Anne E, Lee, Alfred Y, Larpent, Patrick, Ren, Hong, Humphrey, Guy R, Desmond, Richard, DiBenedetto, Michael, Liu, Wenjun, Lee, Ivan H, Sirota, Eric, Di Maso, Michael J, Alwedi, Embarek, Song, Siqing, Chang, Hsieh Yao D
Published in Organic process research & development (20.11.2020)
Published in Organic process research & development (20.11.2020)
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Journal Article
Development and Demonstration of a Co-feed Process to Address Form and Physical Attribute Control of the Gefapixant (MK-7264) Citrate Active Pharmaceutical Ingredient
Mohan, Anne E, DiBenedetto, Michael, Alwedi, Embarek, Ang, Yee Swan, Asi Sihombing, Muhammad Sofian Bin, Chang, Hsieh Yao D, Cote, Aaron, Desmond, Richard, Diaz-Santana, Anthony, Khong, Eric, Lee, Ivan H, Liu, Wenjun, Maloney, Kevin M, Mattern, Keith, Pridgen, Christopher, Ren, Hong, Sirk, Kevin, Sirota, Eric, Spencer, Glenn, Tao, Beata, Whittington, Michael, Yang, Cuixian, Zhang, Si-Wei
Published in Organic process research & development (19.03.2021)
Published in Organic process research & development (19.03.2021)
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