Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion
Singh, Mandeep S, Balmer, Jasmin, Barnard, Alun R, Aslam, Sher A, Moralli, Daniela, Green, Catherine M, Barnea-Cramer, Alona, Duncan, Isabel, MacLaren, Robert E
Published in Nature communications (30.11.2016)
Published in Nature communications (30.11.2016)
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Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial
MacLaren, Robert E, Prof, Groppe, Markus, PhD, Barnard, Alun R, PhD, Cottriall, Charles L, PhD, Tolmachova, Tanya, PhD, Seymour, Len, Prof, Clark, K Reed, PhD, During, Matthew J, Prof, Cremers, Frans P M, Prof, Black, Graeme C M, Prof, Lotery, Andrew J, Prof, Downes, Susan M, FRCOphth, Webster, Andrew R, Prof, Seabra, Miguel C, Prof
Published in The Lancet (British edition) (29.03.2014)
Published in The Lancet (British edition) (29.03.2014)
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Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization
Charbel Issa, Peter, Alun R. Barnard, Philipp Herrmann, Ilyas Washington, Robert E. MacLaren
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2015)
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Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia
Xue, Kanmin, Jolly, Jasleen K, Barnard, Alun R, Rudenko, Anna, Salvetti, Anna P, Patrício, Maria I, Edwards, Thomas L, Groppe, Markus, Orlans, Harry O, Tolmachova, Tanya, Black, Graeme C, Webster, Andrew R, Lotery, Andrew J, Holder, Graham E, Downes, Susan M, Seabra, Miguel C, MacLaren, Robert E
Published in Nature medicine (01.10.2018)
Published in Nature medicine (01.10.2018)
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Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation
Singh, Mandeep S., Issa, Peter Charbel, Butler, Rachel, Martin, Chris, Lipinski, Daniel M., Sekaran, Sumathi, Barnard, Alun R., MacLaren, Robert E.
Published in Proceedings of the National Academy of Sciences - PNAS (15.01.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (15.01.2013)
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Visual Acuity after Retinal Gene Therapy for Choroideremia
Edwards, Thomas L, Jolly, Jasleen K, Groppe, Markus, Barnard, Alun R, Cottriall, Charles L, Tolmachova, Tanya, Black, Graeme C, Webster, Andrew R, Lotery, Andrew J, Holder, Graham E, Xue, Kanmin, Downes, Susan M, Simunovic, Matthew P, Seabra, Miguel C, MacLaren, Robert E
Published in The New England journal of medicine (19.05.2016)
Published in The New England journal of medicine (19.05.2016)
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Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice
Barnea-Cramer, Alona O, Wang, Wei, Lu, Shi-Jiang, Singh, Mandeep S, Luo, Chenmei, Huo, Hongguang, McClements, Michelle E, Barnard, Alun R, MacLaren, Robert E, Lanza, Robert
Published in Scientific reports (13.07.2016)
Published in Scientific reports (13.07.2016)
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Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy
De Silva, Samantha R., Barnard, Alun R., Hughes, Steven, Tam, Shu K. E., Martin, Chris, Singh, Mandeep S., Barnea-Cramer, Alona O., McClements, Michelle E., During, Matthew J., Peirson, Stuart N., Hankins, Mark W., MacLaren, Robert E.
Published in Proceedings of the National Academy of Sciences - PNAS (17.10.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (17.10.2017)
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Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision
Altimus, Cara M, Zhao, Haiqing, Badea, Tudor C, Yau, King-Wai, Ecker, Jennifer L, Barnard, Alun R, Lall, Gurprit S, Hankins, Mark W, Berson, David M, Haq, Shafiqul, Lucas, Robert J, Güler, Ali D, Hattar, Samer, Liao, Hsi-Wen, Cahill, Hugh
Published in Nature (01.05.2008)
Published in Nature (01.05.2008)
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Journal Article
Immunomodulatory Effects of Hydroxychloroquine and Chloroquine in Viral Infections and Their Potential Application in Retinal Gene Therapy
Chandler, Laurel C, Yusuf, Imran H, McClements, Michelle E, Barnard, Alun R, MacLaren, Robert E, Xue, Kanmin
Published in International journal of molecular sciences (14.07.2020)
Published in International journal of molecular sciences (14.07.2020)
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Journal Article
Repair of Retinal Degeneration following Ex Vivo Minicircle DNA Gene Therapy and Transplantation of Corrected Photoreceptor Progenitors
Barnea-Cramer, Alona O., Singh, Mandeep, Fischer, Dominik, De Silva, Samantha, McClements, Michelle E., Barnard, Alun R., MacLaren, Robert E.
Published in Molecular therapy (04.03.2020)
Published in Molecular therapy (04.03.2020)
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The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification
Cross, Sally H, Mckie, Lisa, Hurd, Toby W, Riley, Sam, Wills, Jimi, Barnard, Alun R, Young, Fiona, MacLaren, Robert E, Jackson, Ian J
Published in PLoS genetics (01.04.2020)
Published in PLoS genetics (01.04.2020)
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Filtration of Short-Wavelength Light Provides Therapeutic Benefit in Retinitis Pigmentosa Caused by a Common Rhodopsin Mutation
Orlans, Harry O, Merrill, Jonathon, Barnard, Alun R, Charbel Issa, Peter, Peirson, Stuart N, MacLaren, Robert E
Published in Investigative ophthalmology & visual science (27.06.2019)
Published in Investigative ophthalmology & visual science (27.06.2019)
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After-Hours Mutant Reveals a Role for Fbxl3 in Determining Mammalian Circadian Period
Godinho, Sofia I.H, Maywood, Elizabeth S, Shaw, Linda, Tucci, Valter, Barnard, Alun R, Busino, Luca, Pagano, Michele, Kendall, Rachel, Quwailid, Mohamed M, Romero, M. Rosario, O'Neill, John, Chesham, Johanna E, Brooker, Debra, Lalanne, Zuzanna, Hastings, Michael H, Nolan, Patrick M
Published in Science (American Association for the Advancement of Science) (11.05.2007)
Published in Science (American Association for the Advancement of Science) (11.05.2007)
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Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo
Tolmachova, Tanya, Tolmachov, Oleg E., Barnard, Alun R., de Silva, Samantha R., Lipinski, Daniel M., Walker, Nathan J., MacLaren, Robert E., Seabra, Miguel C.
Published in Journal of molecular medicine (Berlin, Germany) (01.07.2013)
Published in Journal of molecular medicine (Berlin, Germany) (01.07.2013)
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