An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation
Muik, Alexander, Altintas, Isil, Gieseke, Friederike, Schoedel, Kristina B, Burm, Saskia M, Toker, Aras, Salcedo, Theodora W., Verzijl, Dennis, Eisel, David, Grunwitz, Christian, Kranz, Lena M, Vormehr, Mathias, Satijn, David P.E., Diken, Mustafa, Kreiter, Sebastian, Sasser, Kate, Ahmadi, Tahamtan, Türeci, Özlem, Breij, Esther C.W., Jure-Kunkel, Maria, Sahin, Ugur
Published in Oncoimmunology (2022)
Published in Oncoimmunology (2022)
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Journal Article
DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity
Muik, Alexander, Adams III, Homer C, Gieseke, Friederike, Altintas, Isil, Schoedel, Kristina B, Blum, Jordan M, Sänger, Bianca, Burm, Saskia M, Stanganello, Eliana, Verzijl, Dennis, Spires, Vanessa M, Vascotto, Fulvia, Toker, Aras, Quinkhardt, Juliane, Fereshteh, Mark, Diken, Mustafa, Satijn, David P E, Kreiter, Sebastian, Ahmadi, Tahamtan, Breij, Esther C W, Türeci, Özlem, Sasser, Kate, Sahin, Ugur, Jure-Kunkel, Maria
Published in Journal for immunotherapy of cancer (01.06.2022)
Published in Journal for immunotherapy of cancer (01.06.2022)
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Journal Article
813 Combination of HexaBody-CD27 with PD-(L)1 blockade potentiates single-agent activity leading to enhanced human T-cell effector functions in vitro
Imle, Andrea, Altintas, Isil, Nuermberger, Kristina, Blum, Jordan, Krause, Anna-Lena, Toker, Aras, Daszkiewicz, Lidia, Muik, Alexander, Gieseke, Friederike, Ahmadi, Tahamtan, Fellermeier-Kopf, Sina, Kemper, Kristel, Tuereci, Oezlem, Breij, Esther, Sahin, Ugur
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
561 DuoBody®-PD-L1×4–1BB (GEN1046) induces superior immune-cell activation, cytokine production and cytotoxicity by combining PD-L1 blockade with conditional 4–1BB co-stimulation
Muik, Alexander, Altintas, Isil, Kosoff, Rachelle, Gieseke, Friederike, Schödel, Kristina, Salcedo, Theodora, Burm, Saskia, Toker, Aras, Kranz, Lena, Vormehr, Mathias, Eisel, David, Fereshteh, Mark, Türeci, Özlem, Breij, Esther, Ahmadi, Tahamtan, Sahin, Ugur, Jure-Kunkel, Maria
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
TNF AGONISTIC TNF RECEPTOR BINDING AGENTS
ALTINTAS ISIL, GIESEKE FRIEDERIKE, PARREN PAUL, SAHIN UGUR, SATIJN DAVID
Year of Publication 05.03.2024
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Year of Publication 05.03.2024
Patent
Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors
Muik, Alexander, Garralda, Elena, Altintas, Isil, Gieseke, Friederike, Geva, Ravit, Ben-Ami, Eytan, Maurice-Dror, Corinne, Calvo, Emiliano, LoRusso, Patricia M, Alonso, Guzman, Rodriguez-Ruiz, Maria E, Schoedel, Kristina B, Blum, Jordan M, Sänger, Bianca, Salcedo, Theodora W, Burm, Saskia M, Stanganello, Eliana, Verzijl, Dennis, Vascotto, Fulvia, Sette, Angelica, Quinkhardt, Juliane, Plantinga, Theo S, Toker, Aras, van den Brink, Edward N, Fereshteh, Mark, Diken, Mustafa, Satijn, David, Kreiter, Sebastian, Breij, Esther C W, Bajaj, Gaurav, Lagkadinou, Eleni, Sasser, Kate, Türeci, Özlem, Forssmann, Ulf, Ahmadi, Tahamtan, Şahin, Uğur, Jure-Kunkel, Maria, Melero, Ignacio
Published in Cancer discovery (02.05.2022)
Published in Cancer discovery (02.05.2022)
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Journal Article
Epcoritamab SC Monotherapy Leads to Deep and Durable Responses in Patients with Relapsed or Refractory Follicular Lymphoma: First Data Disclosure from the Epcore NHL-1 Follicular Lymphoma Dose-Expansion Cohort
Linton, Kim, Jurczak, Wojciech, Lugtenburg, Pieternella, Gyan, Emmanuel, Sureda Balari, Anna Maria, Christensen, Jacob Haaber, Hess, Brian, Tilly, Hervé, Cordoba, Raul, Lewis, David, Okada, Craig, Hutchings, Martin, Clausen, Michael Roost, Vitolo, Umberto, Cochrane, Tara, Leppa, Sirpa, Chamuleau, Martine E.D., Conlon, Rebekah, Favaro, Elena, Gernhardt, Diana, Altintas, Isil, Liu, Yan, Thieblemont, Catherine
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Abstract 1846: DuoBody-CD40×4-1BB (GEN1042) induces dendritic-cell maturation and enhances T-cell activation and effector functions in vitro by conditional CD40 and 4-1BB agonist activity
Muik, Alexander, Kosoff, Rachelle, Gieseke, Friederike, Altintas, Isil, Schödel, Kristina, Burm, Saskia, Stanganello, Eliana, Vascotto, Fulvia, Toker, Aras, Adams, Homer, Breij, Esther, Diken, Mustafa, Ahmadi, Tahamtan, Sasser, Kate, Türeci, Özlem, Fereshteh, Mark, Sahin, Ugur, Jure-Kunkel, Maria
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells
Altintas, Isil, Heukers, Raimond, van der Meel, Roy, Lacombe, Marie, Amidi, Maryam, van Bergen en Henegouwen, Paul M.P., Hennink, Wim E., Schiffelers, Raymond M., Kok, Robbert J.
Published in Journal of controlled release (28.01.2013)
Published in Journal of controlled release (28.01.2013)
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Journal Article
CD40 CD137 MULTISPECIFIC ANTIBODIES AGAINST CD40 AND CD137
ALTINTAS ISIL, GIESEKE FRIEDERIKE, RADEMAKER RIK, PARREN PAUL, SAHIN UGUR, SATIJN DAVID
Year of Publication 06.02.2024
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Year of Publication 06.02.2024
Patent
Targeting hepatocyte growth factor receptor (Met) positive tumor cells using internalizing nanobody-decorated albumin nanoparticles
Heukers, Raimond, Altintas, Isil, Raghoenath, Smiriti, De Zan, Erica, Pepermans, Richard, Roovers, Rob C, Haselberg, Rob, Hennink, Wim E, Schiffelers, Raymond M, Kok, Robbert J, van Bergen en Henegouwen, Paul M.P
Published in Biomaterials (01.01.2014)
Published in Biomaterials (01.01.2014)
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Journal Article
Targeting epidermal growth factor receptor in tumors: From conventional monoclonal antibodies via heavy chain-only antibodies to nanobodies
Altintas, Isil, Kok, Robbert Jan, Schiffelers, Raymond M.
Published in European journal of pharmaceutical sciences (12.03.2012)
Published in European journal of pharmaceutical sciences (12.03.2012)
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Journal Article
Conference Proceeding
Glucocorticoid-Loaded Core-Cross-Linked Polymeric Micelles with Tailorable Release Kinetics for Targeted Therapy of Rheumatoid Arthritis
Crielaard, Bart J., Rijcken, Cristianne J. F., Quan, Lingdong, van der Wal, Steffen, Altintas, Isil, van der Pot, Martin, Kruijtzer, John A. W., Liskamp, Rob M. J., Schiffelers, Raymond M., van Nostrum, Cornelus F., Hennink, Wim E., Wang, Dong, Lammers, Twan, Storm, Gert
Published in Angewandte Chemie (International ed.) (16.07.2012)
Published in Angewandte Chemie (International ed.) (16.07.2012)
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Journal Article
TNF AGONISTIC TNF RECEPTOR BINDING AGENTS
ALTINTAS ISIL, GIESEKE FRIEDERIKE, PARREN PAUL, SAHIN UGUR, SATIJN DAVID
Year of Publication 15.04.2021
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Year of Publication 15.04.2021
Patent
Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment
van der Meel, Roy, Oliveira, Sabrina, Altintas, Isil, Haselberg, Rob, van der Veeken, Joris, Roovers, Rob C., van Bergen en Henegouwen, Paul M.P., Storm, Gert, Hennink, Wim E., Schiffelers, Raymond M., Kok, Robbert J.
Published in Journal of controlled release (30.04.2012)
Published in Journal of controlled release (30.04.2012)
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Journal Article
요법에 사용하기 위한 항체
FORSSMANN ULF, MUIK ALEXANDER, ALTINTAS ISIL, SASSER KATE, SAHIN UGUR, JURE KUNKEL MARIA N, GUPTA MANISH
Year of Publication 11.10.2022
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Year of Publication 11.10.2022
Patent
CD3 CD20 Bispecific Antibodies against CD3 and CD20
BREIJ ESTHER, SCHUURMAN JANINE, ALTINTAS ISIL, VAN DEN BRINK EDWARD, ENGELBERTS PATRICK, VERPLOEGEN SANDRA, RADEMAKER RIK, RADERSMA RIEMKE VAN DIJKHUIZEN, PARREN PAUL, SATIJN DAVID
Year of Publication 13.05.2024
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Year of Publication 13.05.2024
Patent
항체 제제
ALTINTAS ISIL, MUIK ALEXANDER, GIESEKE FRIEDERIKKE, RADEMAKER RIK, PARREN PAUL, SAHIN UGUR, SATIJN DAVID
Year of Publication 15.10.2021
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Year of Publication 15.10.2021
Patent
CD27과 결합할 수 있는 항체, 그의 변이체 및 그의 용도
BREIJ ESTHER C W, MUIK ALEXANDER, SCHODEL KRISTINA, DE GOEJE PAULINE LINDA, GIESEKE FRIEDERIKKE, BEURSKENS FRANK, IOAN ANDREEA, SAHIN UGUR, SCHUURMAN JANINE, ALTINTAS ISIL, DE JONG ROB, BORROS PETER, SATIJN DAVID
Year of Publication 19.04.2024
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Year of Publication 19.04.2024
Patent
CD3-Bispecific Antibody Therapy Turns Solid Tumors into Inflammatory Sites but Does Not Install Protective Memory
Benonisson, Hreinn, Altıntaş, Işıl, Sluijter, Marjolein, Verploegen, Sandra, Labrijn, Aran F, Schuurhuis, Danita H, Houtkamp, Mischa A, Verbeek, J Sjef, Schuurman, Janine, van Hall, Thorbald
Published in Molecular cancer therapeutics (01.02.2019)
Published in Molecular cancer therapeutics (01.02.2019)
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