The CRISPR/Cas9 system efficiently reverts the tumorigenic ability of BCR/ABL in vitro and in a xenograft model of chronic myeloid leukemia
García-Tuñón, Ignacio, Hernández-Sánchez, María, Ordoñez, José Luis, Alonso-Pérez, Veronica, Álamo-Quijada, Miguel, Benito, Rocio, Guerrero, Carmen, Hernández-Rivas, Jesús María, Sánchez-Martín, Manuel
Published in Oncotarget (18.04.2017)
Published in Oncotarget (18.04.2017)
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Suppression of metastatic organ colonization and antiangiogenic activity of the orally bioavailable lipid raft-targeted alkylphospholipid edelfosine
Alonso-Pérez, Verónica, Hernández, Vanessa, Calzado, Marco A., Vicente-Blázquez, Alba, Gajate, Consuelo, Soler-Torronteras, Rafael, DeCicco-Skinner, Kathleen, Sierra, Angels, Mollinedo, Faustino
Published in Biomedicine & pharmacotherapy (01.02.2024)
Published in Biomedicine & pharmacotherapy (01.02.2024)
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Developmental interplay between transcriptional alterations and a targetable cytokine signaling dependency in pediatric ETO2::GLIS2 leukemia
Alonso-Pérez, Verónica, Galant, Klaudia, Boudia, Fabien, Robert, Elie, Aid, Zakia, Renou, Laurent, Barroca, Vilma, Devanand, Saryiami, Babin, Loélia, Rouiller-Fabre, Virginie, Moison, Delphine, Busso, Didier, Piton, Guillaume, Metereau, Christophe, Abermil, Nassera, Ballerini, Paola, Hirsch, Pierre, Haddad, Rima, Martinovic, Jelena, Petit, Arnaud, Lapillonne, Hélène, Brunet, Erika, Mercher, Thomas, Pflumio, Françoise
Published in Molecular cancer (20.09.2024)
Published in Molecular cancer (20.09.2024)
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CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition
Quijada-Álamo, Miguel, Hernández-Sánchez, María, Alonso-Pérez, Verónica, Rodríguez-Vicente, Ana E., García-Tuñón, Ignacio, Martín-Izquierdo, Marta, Hernández-Sánchez, Jesús María, Herrero, Ana B., Bastida, José María, San Segundo, Laura, Gruber, Michaela, García, Juan Luis, Yin, Shanye, ten Hacken, Elisa, Benito, Rocío, Ordóñez, José Luis, Wu, Catherine J., Hernández-Rivas, Jesús María
Published in Leukemia (01.06.2020)
Published in Leukemia (01.06.2020)
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Journal Article
Splice donor site sgRNAs enhance CRISPR/Cas9-mediated knockout efficiency
García-Tuñón, Ignacio, Alonso-Pérez, Verónica, Vuelta, Elena, Pérez-Ramos, Sandra, Herrero, María, Méndez, Lucía, Hernández-Sánchez, Jesús María, Martín-Izquierdo, Marta, Saldaña, Raquel, Sevilla, Julián, Sánchez-Guijo, Fermín, Hernández-Rivas, Jesús María, Sánchez-Martín, Manuel
Published in PloS one (09.05.2019)
Published in PloS one (09.05.2019)
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Biological significance of monoallelic and biallelic BIRC3 loss in del(11q) chronic lymphocytic leukemia progression
Quijada-Álamo, Miguel, Hernández-Sánchez, María, Rodríguez-Vicente, Ana-Eugenia, Pérez-Carretero, Claudia, Rodríguez-Sánchez, Alberto, Martín-Izquierdo, Marta, Alonso-Pérez, Verónica, García-Tuñón, Ignacio, Bastida, José María, Vidal-Manceñido, María Jesús, Galende, Josefina, Aguilar, Carlos, Queizán, José Antonio, González-Gascón y Marín, Isabel, Hernández-Rivas, José-Ángel, Benito, Rocío, Ordóñez, José Luis, Hernández-Rivas, Jesús-María
Published in Blood cancer journal (New York) (09.07.2021)
Published in Blood cancer journal (New York) (09.07.2021)
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Journal Article
ETV6 / RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia
Montaño, Adrián, Ordoñez, Jose Luis, Alonso-Pérez, Verónica, Hernández-Sánchez, Jesús, Santos, Sandra, González, Teresa, Benito, Rocío, García-Tuñón, Ignacio, Hernández-Rivas, Jesús María
Published in Cells (Basel, Switzerland) (15.01.2020)
Published in Cells (Basel, Switzerland) (15.01.2020)
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Journal Article
CRISPR-Cas9 Technology as a Tool to Target Gene Drivers in Cancer: Proof of Concept and New Opportunities to Treat Chronic Myeloid Leukemia
Vuelta, Elena, Ordoñez, José Luis, Alonso-Pérez, Verónica, Méndez, Lucía, Hernández-Carabias, Patricia, Saldaña, Raquel, Sevilla, Julián, Sebastián, Elena, Muntión, Sandra, Sánchez-Guijo, Fermín, Hernández-Rivas, Jesús María, García-Tuñón, Ignacio, Sánchez-Martín, Manuel
Published in CRISPR journal (01.08.2021)
Published in CRISPR journal (01.08.2021)
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Journal Article
Splice donor site sgRNAs enhance CRISPR/Cas9-mediated knockout efficiency
Garcia-Tunon, Ignacio, Alonso-Perez, Veronica, Vuelta, Elena, Perez- Ramos, Sandra, Herrero, Maria, Mendez, Lucia, Hernandez-Sanchez, Jesus Maria, Martin-Izquierdo, Marta, Saldana, Raquel, Sevilla, Julian, Sanchez-Guijo, Fermin, Hernandez-Rivas, Jesus Maria, Sanchez-Martin, Manuel Adolfo
Published in bioRxiv (29.01.2019)
Published in bioRxiv (29.01.2019)
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Biological Impact of Monoallelic and Biallelic BIRC3 Loss in Del(11q) Chronic Lymphocytic Leukemia Progression
Quijada Álamo, Miguel, Hernandez-Sanchez, Maria, Rodriguez, Ana E., Pérez Carretero, Claudia, Martín Izquierdo, Marta, Alonso Pérez, Verónica, García-Tuñón, Ignacio, Bastida, Jose Maria, Vidal, Maria Jesus, Galende DEL Canto, Josefina, Aguilar, Carlos, Queizán, José Antonio, González-Gascón Y Marín, Isabel, Hernandez, Jose-Angel, Benito, Rocio, Ordóñez, José Luis, Hernández-Rivas, Jesus Maria
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
CRISPR/Cas9-Generated Models Uncover Therapeutic Vulnerabilities of Del(11q) Chronic Lymphocytic Leukemia Cells to Dual BCR and PARP Inhibition
Quijada Álamo, Miguel, Hernández-Sánchez, María, Ordóñez, José Luis, Alonso Pérez, Verónica, Rodriguez, Ana E., García-Tuñón, Ignacio, Herrero, Ana B, San-Segundo, Laura, Gruber, Michaela, García, Juan Luis, Benito, Rocio, Wu, Catherine J., Hernández-Rivas, Jesús-María
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Etv6/Runx1 Fusion Gene Abrogation Decreases The Oncogenic Potencial Of Tumour Cells In A Preclinical Model Of Acute Lymphoblastic Leukaemia
Montaño, Adrián, Ordoñez, Jose Luis, Alonso-Pérez, Verónica, Hernández-Sánchez, Jesús, González, Teresa, Benito, Rocío, García-Tuñón, Ignacio, Hernández-Rivas, Jesús María
Published in bioRxiv (18.10.2019)
Published in bioRxiv (18.10.2019)
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Paper
CRISPR/Cas9 technology abolishes the BCR/ABL1 oncogene in chronic myeloid leukemia and restores normal hematopoiesis
Vuelta, Elena, Ordoñez, José Luis, Alonso-Pérez, Verónica, Méndez, Lucía, Hernández-Carabias, Patricia, Saldaña, Raquel, Sevilla, Julián, Sebastian, Elena, Muntión, Sandra, Sánchez-Guijo, Fermín, Hernadez-Rivas, Jesús María, García-Tuñón, Ignacio, Sánchez-Martín, Manuel
Published in bioRxiv (04.09.2020)
Published in bioRxiv (04.09.2020)
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