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Structural insight into allosteric modulation of protease-activated receptor 2
Cheng, Robert K. Y., Fiez-Vandal, Cédric, Schlenker, Oliver, Edman, Karl, Aggeler, Birte, Brown, Dean G., Brown, Giles A., Cooke, Robert M., Dumelin, Christoph E., Doré, Andrew S., Geschwindner, Stefan, Grebner, Christoph, Hermansson, Nils-Olov, Jazayeri, Ali, Johansson, Patrik, Leong, Louis, Prihandoko, Rudi, Rappas, Mathieu, Soutter, Holly, Snijder, Arjan, Sundström, Linda, Tehan, Benjamin, Thornton, Peter, Troast, Dawn, Wiggin, Giselle, Zhukov, Andrei, Marshall, Fiona H., Dekker, Niek
Published in Nature (London) (04.05.2017)
Published in Nature (London) (04.05.2017)
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Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
Baltgalvis, Kristen A., Lamb, Kelsey N., Symons, Kent T., Wu, Chu-Chiao, Hoffman, Melissa A., Snead, Aaron N., Song, Xiaodan, Glaza, Thomas, Kikuchi, Shota, Green, Jason C., Rogness, Donald C., Lam, Betty, Rodriguez-Aguirre, Maria E., Woody, David R., Eissler, Christie L., Rodiles, Socorro, Negron, Seth M., Bernard, Steffen M., Tran, Eileen, Pollock, Jonathan, Tabatabaei, Ali, Contreras, Victor, Williams, Heather N., Pastuszka, Martha K., Sigler, John J., Pettazzoni, Piergiorgio, Rudolph, Markus G., Classen, Moritz, Brugger, Doris, Claiborne, Christopher, Plancher, Jean-Marc, Cuartas, Isabel, Seoane, Joan, Burgess, Laurence E., Abraham, Robert T., Weinstein, David S., Simon, Gabriel M., Patricelli, Matthew P., Kinsella, Todd M.
Published in Nature (London) (09.05.2024)
Published in Nature (London) (09.05.2024)
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Development of Allosteric Hydrazide-Containing Class I Histone Deacetylase Inhibitors for Use in Acute Myeloid Leukemia
McClure, Jesse J, Zhang, Cheng, Inks, Elizabeth S, Peterson, Yuri K, Li, Jiaying, Chou, C. James
Published in Journal of medicinal chemistry (10.11.2016)
Published in Journal of medicinal chemistry (10.11.2016)
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Protection from Amyloid β Peptide–Induced Memory, Biochemical, and Morphological Deficits by a Phosphodiesterase-4D Allosteric Inhibitor
Cui, Su-Ying, Yang, Ming-Xin, Zhang, Yong-He, Zheng, Victor, Zhang, Han-Ting, Gurney, Mark E., Xu, Ying, O’Donnell, James M.
Published in The Journal of pharmacology and experimental therapeutics (01.11.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2019)
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TAT-tagging of VIP exerts positive allosteric modulation of the PAC1 receptor and enhances VIP neuroprotective effect in the MPTP mouse model of Parkinson's disease
Yu, Rongjie, Li, Junfeng, Lin, Zhuochao, Ouyang, Zehua, Huang, Xiaoling, Reglodi, Dora, Vaudry, David
Published in Biochimica et biophysica acta. General subjects (01.08.2020)
Published in Biochimica et biophysica acta. General subjects (01.08.2020)
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Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M 4 PAM VU0467154
Gould, Robert W, Grannan, Michael D, Gunter, Barak W, Ball, Jacob, Bubser, Michael, Bridges, Thomas M, Wess, Jurgen, Wood, Michael W, Brandon, Nicholas J, Duggan, Mark E, Niswender, Colleen M, Lindsley, Craig W, Conn, P Jeffrey, Jones, Carrie K
Published in Neuropharmacology (01.01.2018)
Published in Neuropharmacology (01.01.2018)
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First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288
Gee, Kelvin W, Olincy, Ann, Kanner, Richard, Johnson, Lynn, Hogenkamp, Derk, Harris, Josette, Tran, Minhtam, Edmonds, Stephen A, Sauer, William, Yoshimura, Ryan, Johnstone, Timothy, Freedman, Robert
Published in Journal of psychopharmacology (Oxford) (01.04.2017)
Published in Journal of psychopharmacology (Oxford) (01.04.2017)
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Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury
Titus, David J., Johnstone, Timothy, Johnson, Nathan H., London, Sidney H., Chapalamadugu, Meghana, Hogenkamp, Derk, Gee, Kelvin W., Atkins, Coleen M.
Published in PloS one (01.10.2019)
Published in PloS one (01.10.2019)
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Safety, Tolerability, and Pharmacokinetics of Mevidalen (LY3154207), a Centrally Acting Dopamine D1 Receptor‐Positive Allosteric Modulator (D1PAM), in Healthy Subjects
Wilbraham, Darren, Biglan, Kevin M., Svensson, Kjell A., Tsai, Max, Kielbasa, William
Published in Clinical pharmacology in drug development (01.04.2021)
Published in Clinical pharmacology in drug development (01.04.2021)
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Pharmacokinetic and pharmacodynamic characterisation of JNJ-40411813, a positive allosteric modulator of mGluR2, in two randomised, double-blind phase-I studies
Salih, Hiba, Anghelescu, Ion, Kezic, Iva, Sinha, Vikash, Hoeben, Eef, Van Nueten, Luc, De Smedt, Heidi, De Boer, Peter
Published in Journal of psychopharmacology (Oxford) (01.04.2015)
Published in Journal of psychopharmacology (Oxford) (01.04.2015)
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GABA A Receptor Subtypes and the Abuse‐Related Effects of Ethanol in Rhesus Monkeys: Experiments with Selective Positive Allosteric Modulators
Berro, Lais F., Rüedi‐Bettschen, Daniela, Cook, Jemma E., Golani, Lalit K., Li, Guanguan, Jahan, Rajwana, Rashid, Farjana, Cook, James M., Rowlett, James K., Platt, Donna M.
Published in Alcoholism, clinical and experimental research (01.05.2019)
Published in Alcoholism, clinical and experimental research (01.05.2019)
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Allosteric MAPKAPK2 inhibitors improve plaque stability in advanced atherosclerosis
Ozcan, Lale, Kasikara, Canan, Yurdagul, Arif, Kuriakose, George, Hubbard, Brian, Serrano-Wu, Michael H., Tabas, Ira
Published in PloS one (13.05.2021)
Published in PloS one (13.05.2021)
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Results and evaluation of a first‐in‐human study of RG7342, an mGlu5 positive allosteric modulator, utilizing Bayesian adaptive methods
Sturm, Stefan, Delporte, Marie‐Laure, Hadi, Salah, Schobel, Scott, Lindemann, Lothar, Weikert, Robert, Jaeschke, Georg, Derks, Michael, Palermo, Giuseppe
Published in British journal of clinical pharmacology (01.03.2018)
Published in British journal of clinical pharmacology (01.03.2018)
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Inhibition of human mevalonate kinase by allosteric inhibitors of farnesyl pyrophosphate synthase
Salari, Saman, Lee, Hiu‐Fung, Tsantrizos, Youla S., Park, Jaeok
Published in FEBS open bio (01.08.2024)
Published in FEBS open bio (01.08.2024)
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Kinetic characterization and molecular docking of novel allosteric inhibitors of aminoglycoside phosphotransferases
Leban, Nadia, Kaplan, Elise, Chaloin, Laurent, Godreuil, Sylvain, Lionne, Corinne
Published in Biochimica et biophysica acta. General subjects (01.01.2017)
Published in Biochimica et biophysica acta. General subjects (01.01.2017)
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Positive allosteric mGluR 2 modulation with BINA alleviates dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset
Kang, Woojin, Frouni, Imane, Bédard, Dominique, Kwan, Cynthia, Hamadjida, Adjia, Nuara, Stephen G, Gourdon, Jim C, Huot, Philippe
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.11.2024)
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.11.2024)
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Randomised clinical trial: effects of monotherapy with ADX10059, a mGluR5 inhibitor, on symptoms and reflux events in patients with gastro‐oesophageal reflux disease
Zerbib, F., Bruley des Varannes, S., Roman, S., Tutuian, R., Galmiche, J.‐P., Mion, F., Tack, J., Malfertheiner, P., Keywood, C.
Published in Alimentary pharmacology & therapeutics (01.04.2011)
Published in Alimentary pharmacology & therapeutics (01.04.2011)
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