Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren’s syndrome
Nayar, Saba, Campos, Joana, Smith, Charlotte G, Iannizzotto, Valentina, Gardner, David H, Colafrancesco, Serena, Pipi, Elena, Kollert, Florian, Hunter, Kelly J, Brewer, Charlotte, Buckley, Christopher Dominic, Bowman, Simon J, Priori, Roberta, Valesini, Guido, Juarez, Maria, Fahy, William A, Fisher, Benjamin A, Payne, Andrew, Allen, Rodger A, Barone, Francesca
Published in Annals of the rheumatic diseases (01.02.2019)
Published in Annals of the rheumatic diseases (01.02.2019)
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Journal Article
Seletalisib: Characterization of a Novel, Potent, and Selective Inhibitor of PI3K δ
Allen, Rodger A, Brookings, Daniel C, Powell, Mark J, Delgado, Jean, Shuttleworth, Lindsay K, Merriman, Mark, Fahy, Ian J, Tewari, Roohi, Silva, John P, Healy, Louise J, Davies, Gareth C G, Twomey, Breda, Cutler, Rona M, Kotian, Apoorva, Crosby, Andrea, McCluskey, Gillian, Watt, Gillian F, Payne, Andrew
Published in The Journal of pharmacology and experimental therapeutics (01.06.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2017)
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Enhanced anti-tumour activity of the combination of the novel MEK inhibitor WX-554 and the novel PI3K inhibitor WX-037
Haagensen, Emma J., Thomas, Huw D., Schmalix, Wolfgang A., Payne, Andrew C., Kevorkian, Lara, Allen, Rodger A., Bevan, Paul, Maxwell, Ross J., Newell, David R.
Published in Cancer chemotherapy and pharmacology (01.12.2016)
Published in Cancer chemotherapy and pharmacology (01.12.2016)
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Small Molecule Receptor Agonists and Antagonists of CCR3 Provide Insight into Mechanisms of Chemokine Receptor Activation
Wise, Emma L., Duchesnes, Cécile, da Fonseca, Paula C.A., Allen, Rodger A., Williams, Timothy J., Pease, James E.
Published in The Journal of biological chemistry (21.09.2007)
Published in The Journal of biological chemistry (21.09.2007)
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Journal Article
Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting
Meier, Christoph, Brookings, Daniel C., Ceska, Thomas A., Doyle, Carl, Gong, Haiping, McMillan, David, Saville, Giles P., Mushtaq, Adeel, Knight, David, Reich, Stefanie, Pearl, Laurence H., Powell, Keith A., Savva, Renos, Allen, Rodger A.
Published in Journal of structural biology (01.02.2012)
Published in Journal of structural biology (01.02.2012)
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Journal Article
Fused thiophene derivatives as MEK inhibitors
Laing, Victoria E., Brookings, Daniel C., Carbery, Rachel J., Simorte, Jose Gascon, Hutchings, Martin C., Langham, Barry J., Lowe, Martin A., Allen, Rodger A., Fetterman, Joanne R., Turner, James, Meier, Christoph, Kennedy, Jeff, Merriman, Mark
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging
Yadav, Rahul B, Burgos, Pierre, Parker, Anthony W, Iadevaia, Valentina, Proud, Christopher G, Allen, Rodger A, O'Connell, James P, Jeshtadi, Ananya, Stubbs, Christopher D, Botchway, Stanley W
Published in BMC cell biology (12.01.2013)
Published in BMC cell biology (12.01.2013)
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A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor Potentiates the Activity of the Conventional Chemotherapeutic Agents Paclitaxel and Doxorubicin in Tumor Xenograft Models
Stuart Emanuel, Robert H. Gruninger, Angel Fuentes-Pesquera, Peter J. Connolly, Jennifer A. Seamon, Susan Hazel, Rose Tominovich, Beth Hollister, Cheryl Napier, Michael R. D'Andrea, Michael Reuman, Gilles Bignan, Robert Tuman, Dana Johnson, David Moffatt, Mark Batchelor, Anne Foley, James O'Connell, Rodger Allen, Martin Perry, Linda Jolliffe, Steven A. Middleton
Published in Molecular pharmacology (01.09.2004)
Published in Molecular pharmacology (01.09.2004)
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Expression of PI3K Signaling Associated with T Cells in Psoriasis Is Inhibited by Seletalisib, a PI3Kδ Inhibitor, and Is Required for Functional Activity
Yager, Nicole, Haddadeen, Ciara, Powell, Mark, Payne, Andrew, Allen, Rodger, Healy, Eugene
Published in Journal of investigative dermatology (01.06.2018)
Published in Journal of investigative dermatology (01.06.2018)
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Journal Article
PDE 4 inhibitors: the use of molecular cloning in the design and development of novel drugs
Hughes, Bernadette, Owens, Ray, Perry, Martin, Warrellow, Graham, Allen, Rodger
Published in Drug discovery today (01.03.1997)
Published in Drug discovery today (01.03.1997)
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First-in-human studies of seletalisib, an orally bioavailable small-molecule PI3Kδ inhibitor for the treatment of immune and inflammatory diseases
Helmer, Eric, Watling, Mark, Jones, Emma, Tytgat, Dominique, Jones, Mark, Allen, Rodger, Payne, Andrew, Koch, Annelize, Healy, Eugene
Published in European journal of clinical pharmacology (01.05.2017)
Published in European journal of clinical pharmacology (01.05.2017)
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Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo
Reuberson, James, Horsley, Helen, Franklin, Richard J, Ford, Daniel, Neuss, Judi, Brookings, Daniel, Huang, Qiuya, Vanderhoydonck, Bart, Gao, Ling-Jie, Jang, Mi-Yeon, Herdewijn, Piet, Ghawalkar, Anant, Fallah-Arani, Farnaz, Khan, Adnan R, Henshall, Jamie, Jairaj, Mark, Malcolm, Sarah, Ward, Eleanor, Shuttleworth, Lindsay, Lin, Yuan, Li, Shengqiao, Louat, Thierry, Waer, Mark, Herman, Jean, Payne, Andrew, Ceska, Tom, Doyle, Carl, Pitt, Will, Calmiano, Mark, Augustin, Martin, Steinbacher, Stefan, Lammens, Alfred, Allen, Rodger
Published in Journal of medicinal chemistry (09.08.2018)
Published in Journal of medicinal chemistry (09.08.2018)
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Priming of polymorphonuclear granulocytes by lipopolysaccharides and its complexes with lipopolysaccharide binding protein and high density lipoprotein
Vosbeck, Klaus, Tobias, Peter, Mueller, Heinz, Allen, Rodger A., Arfors, Karl‐E., Ulevitch, Richard J., Sklar, Larry A.
Published in Journal of leukocyte biology (01.02.1990)
Published in Journal of leukocyte biology (01.02.1990)
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Journal Article
First-in-human studies of seletalisib, an orally bioavailable small-molecule PI3K[delta] inhibitor for the treatment of immune and inflammatory diseases
Helmer, Eric, Watling, Mark, Jones, Emma, Tytgat, Dominique, Jones, Mark, Allen, Rodger, Payne, Andrew, Koch, Annelize, Healy, Eugene
Published in European journal of clinical pharmacology (01.05.2017)
Published in European journal of clinical pharmacology (01.05.2017)
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A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours
Jamieson, David, Griffin, Melanie J, Sludden, Julieann, Drew, Yvette, Cresti, Nicola, Swales, Karen, Merriman, Mark, Allen, Rodger, Bevan, Paul, Buerkle, Markus, Mala, Carola, Coyle, Vicky, Rodgers, Lisa, Dean, Emma, Greystoke, Alastair, Banerji, Udai, Wilson, Richard H, Evans, T.R. Jeffery, Anthoney, Alan, Ranson, Malcolm, Boddy, Alan V, Plummer, Ruth
Published in European journal of cancer (1990) (01.11.2016)
Published in European journal of cancer (1990) (01.11.2016)
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