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Published in Cancer cell (17.04.2012)
Published in Cancer cell (17.04.2012)
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DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
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Reversible Inhibitors of LSD1 as Therapeutic Agents in Acute Myeloid Leukemia: Clinical Significance and Progress to Date
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Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia
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Published in Cell reports (Cambridge) (27.03.2018)
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ERK5 is a critical mediator of inflammation-driven cancer
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Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2
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Published in Biochemical journal (01.07.2016)
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Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides
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Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone
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Published in Journal of medicinal chemistry (13.08.2009)
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Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells
Atkin, Jane, Halova, Lenka, Ferguson, Jennifer, Hitchin, James R, Lichawska-Cieslar, Agata, Jordan, Allan M, Pines, Jonathon, Wellbrock, Claudia, Petersen, Janni
Published in Journal of cell science (15.03.2014)
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Toxoflavins and Deazaflavins as the First Reported Selective Small Molecule Inhibitors of Tyrosyl-DNA Phosphodiesterase II
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Antagonists of the human adenosine A2A receptor. Part 3 Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines
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Published in Bioorganic & medicinal chemistry letters (01.05.2008)
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Published in Nature cancer (01.10.2021)
Published in Nature cancer (01.10.2021)
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First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib
James, Dominic I, Smith, Kate M, Jordan, Allan M, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, Jones, Stuart, Kelly, Paul, McGonagle, Alison E, Small, Helen, Stowell, Alexandra I. J, Tucker, Julie, Waddell, Ian D, Waszkowycz, Bohdan, Ogilvie, Donald J
Published in ACS chemical biology (18.11.2016)
Published in ACS chemical biology (18.11.2016)
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The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
Harris, William J., Huang, Xu, Lynch, James T., Hitchin, James R., Li, Yaoyong, Ciceri, Filippo, Blaser, Julian G., Greystoke, Brigit F., Jordan, Allan M., Ogilvie, Donald J., Somervaille, Tim C.P.
Published in Cancer cell (12.06.2012)
Published in Cancer cell (12.06.2012)
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Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer
Jain, Aditi, Agostini, Lebaron C, McCarthy, Grace A, Chand, Saswati N, Ramirez, AnnJosette, Nevler, Avinoam, Cozzitorto, Joseph, Schultz, Christopher W, Lowder, Cinthya Yabar, Smith, Kate M, Waddell, Ian D, Raitses-Gurevich, Maria, Stossel, Chani, Gorman, Yulia Glick, Atias, Dikla, Yeo, Charles J, Winter, Jordan M, Olive, Kenneth P, Golan, Talia, Pishvaian, Michael J, Ogilvie, Donald, James, Dominic I, Jordan, Allan M, Brody, Jonathan R
Published in Cancer research (Chicago, Ill.) (01.09.2019)
Published in Cancer research (Chicago, Ill.) (01.09.2019)
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Rethinking ‘academic’ drug discovery: the Manchester Institute perspective
Jordan, Allan M., Waddell, Ian D., Ogilvie, Donald J.
Published in Drug discovery today (01.05.2015)
Published in Drug discovery today (01.05.2015)
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Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase
Newton, Rebecca, Waszkowycz, Bohdan, Seewooruthun, Chitra, Burschowsky, Daniel, Richards, Mark, Hitchin, Samantha, Begum, Habiba, Watson, Amanda, French, Eleanor, Hamilton, Niall, Jones, Stuart, Lin, Li-Ying, Waddell, Ian, Echalier, Aude, Bayliss, Richard, Jordan, Allan M, Ogilvie, Donald
Published in ACS medicinal chemistry letters (09.04.2020)
Published in ACS medicinal chemistry letters (09.04.2020)
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