The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase
Alhammad, Yousef M O, Kashipathy, Maithri M, Roy, Anuradha, Gagné, Jean-Philippe, McDonald, Peter, Gao, Philip, Nonfoux, Louis, Battaile, Kevin P, Johnson, David K, Holmstrom, Erik D, Poirier, Guy G, Lovell, Scott, Fehr, Anthony R
Published in Journal of virology (13.01.2021)
Published in Journal of virology (13.01.2021)
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Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity
Heer, Collin D., Sanderson, Daniel J., Voth, Lynden S., Alhammad, Yousef M.O., Schmidt, Mark S., Trammell, Samuel A.J., Perlman, Stanley, Cohen, Michael S., Fehr, Anthony R., Brenner, Charles
Published in The Journal of biological chemistry (25.12.2020)
Published in The Journal of biological chemistry (25.12.2020)
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High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV‑2 Mac1 Macrodomain
Dasovich, Morgan, Zhuo, Junlin, Goodman, Jack A., Thomas, Ajit, McPherson, Robert Lyle, Jayabalan, Aravinth Kumar, Busa, Veronica F., Cheng, Shang-Jung, Murphy, Brennan A., Redinger, Karli R., Alhammad, Yousef M. O., Fehr, Anthony R., Tsukamoto, Takashi, Slusher, Barbara S., Bosch, Jürgen, Wei, Huijun, Leung, Anthony K. L.
Published in ACS chemical biology (21.01.2022)
Published in ACS chemical biology (21.01.2022)
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Pharmacological inhibition of ENT1 enhances the impact of specific dietary fats on energy metabolism gene expression
Pain, Erwann, Snowden, Stuart, Oddy, Joseph, Shinhmar, Sonia, Alhammad, Yousef M A, King, Jason S, Müller-Taubenberger, Annette, Williams, Robin S B
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2024)
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Journal Article
Longitudinal Sequence and Functional Evolution within Glycoprotein E2 in Hepatitis C Virus Genotype 3a Infection
Alhammad, Yousef M O, Maharajh, Sanvir, Butcher, Rebecca, Eden, John-Sebastian, White, Peter A, Poumbourios, Pantelis, Drummer, Heidi E
Published in PloS one (13.05.2015)
Published in PloS one (13.05.2015)
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SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice
Alhammad, Yousef M, Parthasarathy, Srivatsan, Ghimire, Roshan, Kerr, Catherine M, O'Connor, Joseph J, Pfannenstiel, Jessica J, Chanda, Debarati, Miller, Caden A, Baumlin, Nathalie, Salathe, Matthias, Unckless, Robert L, Zuñiga, Sonia, Enjuanes, Luis, More, Sunil, Channappanavar, Rudragouda, Fehr, Anthony R
Published in Proceedings of the National Academy of Sciences - PNAS (29.08.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (29.08.2023)
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Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication
Kerr, Catherine M, Pfannenstiel, Jessica J, Alhammad, Yousef M, O'Connor, Joseph J, Ghimire, Roshan, Shrestha, Rakshya, Khattabi, Reem, Saenjamsai, Pradtahna, Parthasarathy, Srivatsan, McDonald, Peter R, Gao, Philip, Johnson, David K, More, Sunil, Roy, Anuradha, Channappanavar, Rudragouda, Fehr, Anthony R
Published in Journal of virology (10.10.2024)
Published in Journal of virology (10.10.2024)
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Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening
Roy, Anu, Alhammad, Yousef M., McDonald, Peter, Johnson, David K., Zhuo, Junlin, Wazir, Sarah, Ferraris, Dana, Lehtiö, Lari, Leung, Anthony K.L., Fehr, Anthony R.
Published in Antiviral research (01.07.2022)
Published in Antiviral research (01.07.2022)
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Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain
Sherrill, Lavinia M., Joya, Elva E., Walker, AnnMarie, Roy, Anuradha, Alhammad, Yousef M., Atobatele, Moriama, Wazir, Sarah, Abbas, George, Keane, Patrick, Zhuo, Junlin, Leung, Anthony K.L., Johnson, David K., Lehtiö, Lari, Fehr, Anthony R., Ferraris, Dana
Published in Bioorganic & medicinal chemistry (01.08.2022)
Published in Bioorganic & medicinal chemistry (01.08.2022)
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Circulation of Influenza A(H5N8) Virus, Saudi Arabia
Al-Ghadeer, Hussain, Chu, Daniel K W, Rihan, Ehab M A, Abd-Allah, Ehab A, Gu, Haogao, Chin, Alex W H, Qasim, Ibrahim A, Aldoweriej, Ali, Alharbi, Sanad S, Al-Aqil, Marshad A, Al-Sahaf, Ali, Abdel Rahman, Salah S, Aljassem, Ali H, Abdul-Al, Ali, Aljasir, Mohammed R, Alhammad, Yousef M O, Kasem, Samy, Peiris, Malik, Zaki, Ahmed Z S A, Poon, Leo L M
Published in Emerging infectious diseases (01.10.2018)
Published in Emerging infectious diseases (01.10.2018)
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Journal Article
Full-Length Genome of the Equine Influenza A Virus Subtype H3N8 from 2019 Outbreak in Saudi Arabia
Alaql, Fanan A., Alhafufi, Ali N., Kasem, Samy, Alhammad, Yousef M. O., Albaqshi, Hassan, Alyousaf, Ameen, Alsubaie, Faisal M., Alghamdi, Ahmed N., Abdel-Moneim, Ahmed S., Alharbi, Sulaiman A.
Published in Animals (Basel) (10.10.2022)
Published in Animals (Basel) (10.10.2022)
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Journal Article
The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase
Alhammad, Yousef M O, Kashipathy, Maithri M, Roy, Anuradha, Gagné, Jean-Philippe, McDonald, Peter, Gao, Philip, Nonfoux, Louis, Battaile, Kevin P, Johnson, David K, Holmstrom, Erik D, Poirier, Guy G, Lovell, Scott, Fehr, Anthony R
Published in bioRxiv (28.10.2020)
Published in bioRxiv (28.10.2020)
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Paper
Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity
Heer, Collin D, Sanderson, Daniel J, Voth, Lynden S, Alhammad, Yousef M O, Schmidt, Mark S, Trammell, Samuel A J, Perlman, Stanley, Cohen, Michael S, Fehr, Anthony R, Brenner, Charles
Published in bioRxiv (06.10.2020)
Published in bioRxiv (06.10.2020)
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Paper
Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening
Roy, Anu, Alhammad, Yousef M, McDonald, Peter, Johnson, David K, Zhuo, Junlin, Wazir, Sarah, Ferraris, Dana, Lehtiö, Lari, Leung, Anthony K L, Fehr, Anthony R
Published in bioRxiv (02.03.2022)
Published in bioRxiv (02.03.2022)
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Journal Article
Paper
Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV2 nsp3 Macrodomain
Sherrill, Lavinia M, Joya, Elva E, Walker, AnnMarie, Roy, Anuradha, Alhammad, Yousef M, Atobatele, Moriama, Wazir, Sarah, Abbas, George, Keane, Patrick, Zhuo, Junlin, Leung, Anthony K L, Johnson, David K, Lehtiö, Lari, Fehr, Anthony R, Ferraris, Dana
Published in bioRxiv : the preprint server for biology (28.02.2022)
Published in bioRxiv : the preprint server for biology (28.02.2022)
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Escape of Hepatitis C Virus from Epitope I Neutralization Increases Sensitivity of Other Neutralization Epitopes
Gu, Jun, Hardy, Joshua, Boo, Irene, Vietheer, Patricia, McCaffrey, Kathleen, Alhammad, Yousef, Chopra, Abha, Gaudieri, Silvana, Poumbourios, Pantelis, Coulibaly, Fasséli, Drummer, Heidi E
Published in Journal of virology (01.05.2018)
Published in Journal of virology (01.05.2018)
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Journal Article
Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region
Alhammad, Yousef, Gu, Jun, Boo, Irene, Harrison, David, McCaffrey, Kathleen, Vietheer, Patricia T, Edwards, Stirling, Quinn, Charles, Coulibaly, Fásseli, Poumbourios, Pantelis, Drummer, Heidi E
Published in Journal of virology (01.12.2015)
Published in Journal of virology (01.12.2015)
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Journal Article
Circulation of Influenza A
Ghadeer, Hussain Al, Chu, Daniel K.W, Rihan, Ehab A, Abd-Allah, Ehab M, Gu, Haogao, Chin, Alex W.H, Qasim, Ibrahim A, Aldoweriej, Ali, Alharbi, Sanad S, Aqil, Marshad A. Al, Sahaf, Ali Al, Rahman, Salah S. Abdel, Aljassem, Ali H, Abdul-Al, Ali, Aljasir, Mohammed R, Alhammad, Yousef M.O, Kasem, Samy, Peiris, Malik, Zaki, Ahmed Z.S.A, Poon, Leo L.M
Published in Emerging infectious diseases (01.10.2018)
Published in Emerging infectious diseases (01.10.2018)
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Journal Article
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity
Heer, Collin D, Sanderson, Daniel J, Voth, Lynden S, Alhammad, Yousef M O, Schmidt, Mark S, Trammell, Samuel A J, Perlman, Stanley, Cohen, Michael S, Fehr, Anthony R, Brenner, Charles
Published in The Journal of biological chemistry (25.12.2020)
Get full text
Published in The Journal of biological chemistry (25.12.2020)
Journal Article