The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells
Muñoz-Guardiola, Pau, Casas, Josefina, Megías-Roda, Elisabet, Solé, Sònia, Perez-Montoyo, Héctor, Yeste-Velasco, Marc, Erazo, Tatiana, Diéguez-Martínez, Nora, Espinosa-Gil, Sergio, Muñoz-Pinedo, Cristina, Yoldi, Guillermo, Abad, Jose L, Segura, Miguel F, Moran, Teresa, Romeo, Margarita, Bosch-Barrera, Joaquim, Oaknin, Ana, Alfón, Jose, Domènech, Carles, Fabriàs, Gemma, Velasco, Guillermo, Lizcano, Jose M
Published in Autophagy (03.06.2021)
Published in Autophagy (03.06.2021)
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Journal Article
A first-in-human phase I/Ib dose-escalation clinical trial of the autophagy inducer ABTL0812 in patients with advanced solid tumours
Vidal, Laura, Victoria, Ivan, Gaba, Lydia, Martín, Marta Gil, Brunet, Mercè, Colom, Helena, Cortal, Marc, Gómez-Ferrería, Mariana, Yeste-Velasco, Marc, Perez, Antonio, Rodon, Jordi, Sohal, Davendra P.S., Lizcano, José Miguel, Domènech, Carles, Alfón, José, Gascón, Pere
Published in European journal of cancer (1990) (01.03.2021)
Published in European journal of cancer (1990) (01.03.2021)
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Journal Article
ENDOLUNG trial. A phase 1/2 study of the Akt/mTOR inhibitor and autophagy inducer Ibrilatazar (ABTL0812) in combination with paclitaxel/carboplatin in patients with advanced/recurrent endometrial cancer
Leary, Alexandra, Estévez-García, Purificación, Sabatier, Renaud, Ray-Coquard, Isabelle, Romeo, Margarita, Barretina-Ginesta, Pilar, Gil-Martin, Marta, Garralda, Elena, Bosch-Barrera, Joaquim, Morán, Teresa, Martin-Martorell, Paloma, Nadal, Ernest, Gascón, Pere, Rodon, Jordi, Lizcano, Jose M, Muñoz-Guardiola, Pau, Fierro-Durán, Gemma, Pedrós-Gámez, Oriol, Pérez-Montoyo, Héctor, Yeste-Velasco, Marc, Cortal, Marc, Pérez-Campos, Antonio, Alfon, Jose, Domenech, Carles, Pérez-Fidalgo, Alejandro, Oaknin, Ana
Published in BMC cancer (22.07.2024)
Published in BMC cancer (22.07.2024)
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Journal Article
Correction: ENDOLUNG trial. A phase 1/2 study of the Akt/mTOR inhibitor and autophagy inducer Ibrilatazar (ABTL0812) in combination with paclitaxel/carboplatin in patients with advanced/recurrent endometrial cancer
Leary, Alexandra, Estévez-García, Purificación, Sabatier, Renaud, Ray-Coquard, Isabelle, Romeo, Margarita, Barretina-Ginesta, Pilar, Gil-Martin, Marta, Garralda, Elena, Bosch-Barrera, Joaquim, Morán, Teresa, Martin-Martorell, Paloma, Nadal, Ernest, Gascón, Pere, Rodon, Jordi, Lizcano, Jose M, Muéoz-Guardiola, Pau, Fierro-Durán, Gemma, Pedrós-Gámez, Oriol, Pérez-Montoyo, Héctor, Yeste-Velasco, Marc, Cortal, Marc, Pérez-Campos, Antonio, Alfon, Jose, Domenech, Carles, Pérez-Fidalgo, Alejandro, Oaknin, Ana
Published in BMC cancer (29.07.2024)
Published in BMC cancer (29.07.2024)
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Journal Article
Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models
Mancini, Andrea, Colapietro, Alessandro, Cristiano, Loredana, Rossetti, Alessandra, Mattei, Vincenzo, Gravina, Giovanni Luca, Perez-Montoyo, Héctor, Yeste-Velasco, Marc, Alfon, Jose, Domenech, Carles, Festuccia, Claudio
Published in Frontiers in oncology (02.11.2022)
Published in Frontiers in oncology (02.11.2022)
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Journal Article
The antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosis
París-Coderch, Laia, Soriano, Aroa, Jiménez, Carlos, Erazo, Tatiana, Muñoz-Guardiola, Pau, Masanas, Marc, Antonelli, Roberta, Boloix, Ariadna, Alfón, José, Pérez-Montoyo, Héctor, Yeste-Velasco, Marc, Domènech, Carles, Roma, Josep, Sánchez de Toledo, Josep, Moreno, Lucas, Lizcano, José M., Gallego, Soledad, Segura, Miguel F.
Published in Cell death & disease (17.09.2020)
Published in Cell death & disease (17.09.2020)
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Journal Article
ABTL0812 enhances antitumor effect of paclitaxel and reverts chemoresistance in triple‐negative breast cancer models
Polonio‐Alcalá, Emma, Solé‐Sánchez, Sònia, Muñoz‐Guardiola, Pau, Megías‐Roda, Elisabet, Perez‐Montoyo, Héctor, Yeste‐Velasco, Marc, Alfón, Jose, Lizcano, Jose Miguel, Domènech, Carles, Ruiz‐Martínez, Santiago, Puig, Teresa
Published in Cancer communications (London, England) (01.06.2022)
Published in Cancer communications (London, England) (01.06.2022)
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Journal Article
Therapeutic potential of the new TRIB3-mediated cell autophagy anticancer drug ABTL0812 in endometrial cancer
Felip, Isidre, Moiola, Cristian Pablo, Megino-Luque, Cristina, Lopez-Gil, Carlos, Cabrera, Silvia, Solé-Sánchez, Sonia, Muñoz-Guardiola, Pau, Megias-Roda, Elisabet, Pérez-Montoyo, Héctor, Alfon, José, Yeste-Velasco, Marc, Santacana, María, Dolcet, Xavier, Reques, Armando, Oaknin, Ana, Rodríguez-Freixinos, Victor, Lizcano, José Miguel, Domènech, Carles, Gil-Moreno, Antonio, Matias-Guiu, Xavier, Colas, Eva, Eritja, Nuria
Published in Gynecologic oncology (01.05.2019)
Published in Gynecologic oncology (01.05.2019)
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Abstract 1805: ABTL0812, a Phase 2 clinical stage pro-autophagy anticancer drug exhibits immunomodulatory effects that modify tumor microenvironment in pancreatic cancer models
Yoldi, Guillermo, Munoz-Guardiola, Pau, Megias, Elisabet, Perez-Montoyo, Hector, Yeste-Velasco, Marc, Alfon, Jose, Domenech, Carles, Lizcano, Jose Miguel
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Phase 2 clinical trial of the proautophagic drug ABTL0812 combined with paclitaxel and carboplatin in first-line patients with advanced squamous non-small cell lung carcinoma
Bosch-Barrera, Joaquim, Moran, Teresa, Estévez-García, Purificación, Martín-Martorell, Paloma, Sabatier, Renaud, Nadal, Ernest, Lizcano, Jose M., Pedrós-Gámez, Oriol, Pérez-Montoyo, Héctor, Yeste-Velasco, Marc, Domenech, Carles, Alfon, Jose Alberto
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Journal Article
Correction: ENDOLUNG trial. A phase 1/2 study of the Akt/mTOR inhibitor and autophagy inducer Ibrilatazar (ABTL0812) in combination with paclitaxel/carboplatin in patients with advanced/recurrent endometrial cancer : Alexandra Leary
Leary, Alexandra, Estévez-García, Purificación, Sabatier, Renaud, Ray-Coquard, Isabelle, Romeo, Margarita, Barretina-Ginesta, Pilar, Gil-Martin, Marta, Garralda, Elena, Bosch-Barrera, Joaquim, Morán, Teresa, Martin-Martorell, Paloma, Nadal, Ernest, Gascón, Pere, Rodon, Jordi, Lizcano, Jose M, Muñoz-Guardiola, Pau, Fierro-Durán, Gemma, Pedrós-Gámez, Oriol, Pérez-Montoyo, Héctor, Yeste-Velasco, Marc, Cortal, Marc, Pérez-Campos, Antonio, Alfon, Jose, Domenech, Carles, Pérez-Fidalgo, Alejandro, Oaknin, Ana
Published in BMC cancer (29.07.2024)
Published in BMC cancer (29.07.2024)
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Journal Article
The novel proautophagy anticancer drug ABTL0812 potentiates chemotherapy in adenocarcinoma and squamous nonsmall cell lung cancer
López‐Plana, Anna, Fernández‐Nogueira, Patricia, Muñoz‐Guardiola, Pau, Solé‐Sánchez, Sònia, Megías‐Roda, Elisabet, Pérez‐Montoyo, Héctor, Jauregui, Patricia, Yeste‐Velasco, Marc, Gómez‐Ferreria, Mariana, Erazo, Tatiana, Ametller, Elisabet, Recalde‐Percaz, Leire, Moragas‐Garcia, Núria, Noguera‐Castells, Aleix, Mancino, Mario, Morán, Teresa, Nadal, Ernest, Alfón, José, Domènech, Carles, Gascon, Pere, Lizcano, Jose M., Fuster, Gemma, Bragado, Paloma
Published in International journal of cancer (15.08.2020)
Published in International journal of cancer (15.08.2020)
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Journal Article
Abstract 1234: The anticancer drug ABTL0812 induces cancer cell death by impairing Akt/mTORC1 axis and inducing ER stress-mediated cytotoxic autophagy
Muñoz-Guardiola, Pau, Casas, Josefina, Megías-Roda, Elisabet, Perez-Montoyo, Hector, Solé-Sánchez, Sonia, Yeste-Velasco, Marc, Erazo, Tatiana, Diéguez-Martínez, Nora, Espinosa-Gil, Sergio, Yoldi, Guillermo, Muñoz-Pinedo, Cristina, Segura, Miguel F., Alfon, Jose, Fabriàs, Gemma, Velasco, Guillermo, Domenech, Carles, Lizcano, Jose M.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Phase 1 of ABTL0812, a proautophagic drug, in combination with paclitaxel and carboplatin at first-line in advanced endometrial cancer and squamous cell lung carcinoma
Farinas-Madrid, Lorena, Estévez-García, Purificación, Perez-Fidalgo, Jose Alejandro, Bosch-Barrera, Joaquim, Moran, Teresa, Nadal, Ernest, Rodriguez Freixinos, Victor, Calvo, Elisa, Falcon, Alejandro, Martín-Martorell, Paloma, Huerta Alvaro, Marisol, Barretina-Ginesta, Maria Pilar, Romeo, Margarita, Gil-Martin, Marta, Garralda, Elena, Rodon, Jordi, Lizcano, Jose M., Domenech, Carles, Alfon, Jose Alberto, Oaknin, Ana
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Journal Article
The first-in-class anti-cancer agent ABTL0812 is effective in preclinical models of human endometrial cancer
Colàs, Eva Colàs, Eritja, Nuria, Muñoz-Guardiola, Pau, Sole-Sanchez, Sonia, Moiola, Cristian, Felip, Isidre, Gil-Moreno, Antonio, Perez-Montoyo, Hector, Alfon, Jose Alberto, Domenech, Carles, Lizcano, Jose M, Matias-Guiu, Xavier
Published in Journal of clinical oncology (20.05.2017)
Published in Journal of clinical oncology (20.05.2017)
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Abstract 672: ABTL0812, a new antitumor drug that inhibits the axis Akt/mTOR through a novel mechanism of action
Erazo, Tatiana, Gomez-Ferreria, Mariana, Alfon, Jose, Lorente, Mar, Salazar, Maria, Lopez, Anna, Cortal, Marc, Munoz-Guardiola, Pau, Gascon, Pedro, Velasco, Guillermo, Domenech, Carles, Lizcano, Jose M.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Effect of ABTL0812, a safe dual inhibitor of mTORC1/C2 and dihydrofolate reductase, on gemcitabine and docetaxel cytotoxicity in pancreatic and lung cancer cells
Alfon, Jose, Espadaler, Jordi, Garcia, Jose A, Domenech, Carles, Lizcano, Jose M
Published in Journal of clinical oncology (20.05.2013)
Published in Journal of clinical oncology (20.05.2013)
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Abstract LB-C18: First-in-Human Clinical Trial of ABTL0812, a Compound that Inhibits PI3K/Akt/mTOR Pathway by Upregulating TRIB3, in Patients with Advanced Solid Tumors
Vidal, Laura, Gaba, Lydia, Victoria, Ivan, Gil-Martin, Marta, Laquente, Berta, Cortal, Marc, Brunet, Merce, Paredes, Pilar, Gomez-Ferreria, Mariana, Alfon, Jose, Domenech, Carles, Gascon, Pedro
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Dose-escalation of the first-in human phase I/Ib study of ABTL0812, a novel antitumor drug inhibiting the Akt/mTOR pathway in patients with advanced solid tumors
Vidal Boixader, Laura, Gaba, Lydia, Victoria, Iván, Brunet, Merce, Paredes, Pilar, Buxo, Elvira, Vilella, Teresa, Riu, Gisela, Cortal, Marc, Gomez-Ferreria, Mariana, Alfon, Jose, Domenech, Carles, Gascon, Pedro
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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