Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release
Alexandrou, Aristos J, Brown, Adam R, Chapman, Mark L, Estacion, Mark, Turner, Jamie, Mis, Malgorzata A, Wilbrey, Anna, Payne, Elizabeth C, Gutteridge, Alex, Cox, Peter J, Doyle, Rachel, Printzenhoff, David, Lin, Zhixin, Marron, Brian E, West, Christopher, Swain, Nigel A, Storer, R Ian, Stupple, Paul A, Castle, Neil A, Hounshell, James A, Rivara, Mirko, Randall, Andrew, Dib-Hajj, Sulayman D, Krafte, Douglas, Waxman, Stephen G, Patel, Manoj K, Butt, Richard P, Stevens, Edward B
Published in PloS one (06.04.2016)
Published in PloS one (06.04.2016)
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A novel selective and orally bioavailable Nav1.8 channel blocker, PF‐01247324, attenuates nociception and sensory neuron excitability
Payne, Claire Elizabeth, Brown, Adam R, Theile, Jonathon W, Loucif, Alexandre J C, Alexandrou, Aristos J, Fuller, Mathew D, Mahoney, John H, Antonio, Brett M, Gerlach, Aaron C, Printzenhoff, David M, Prime, Rebecca L, Stockbridge, Gillian, Kirkup, Anthony J, Bannon, Anthony W, England, Steve, Chapman, Mark L, Bagal, Sharan, Roeloffs, Rosemarie, Anand, Uma, Anand, Praveen, Bungay, Peter J, Kemp, Mark, Butt, Richard P, Stevens, Edward B
Published in British journal of pharmacology (01.05.2015)
Published in British journal of pharmacology (01.05.2015)
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An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes
Cho, Lily T.-Y., Alexandrou, Aristos J., Torella, Rubben, Knafels, John, Hobbs, Jake, Taylor, Toni, Loucif, Alex, Konopacka, Agnieszka, Bell, Sigourney, Stevens, Edward B., Pandit, Jay, Horst, Reto, Withka, Jane M., Pryde, David C., Liu, Shenping, Young, Gareth T.
Published in Structure (London) (03.04.2018)
Published in Structure (London) (03.04.2018)
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Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes
Storer, R. Ian, Pike, Andy, Swain, Nigel A., Alexandrou, Aristos J., Bechle, Bruce M., Blakemore, David C., Brown, Alan D., Castle, Neil A., Corbett, Matthew S., Flanagan, Neil J., Fengas, David, Johnson, M. Scott, Jones, Lyn H., Marron, Brian E., Payne, C. Elizabeth, Printzenhoff, David, Rawson, David J., Rose, Colin R., Ryckmans, Thomas, Sun, Jianmin, Theile, Jonathan W., Torella, Rubben, Tseng, Elaine, Warmus, Joseph S.
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
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Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia
Cao, Lishuang, McDonnell, Aoibhinn, Nitzsche, Anja, Alexandrou, Aristos, Saintot, Pierre-Philippe, Loucif, Alexandre J C, Brown, Adam R, Young, Gareth, Mis, Malgorzata, Randall, Andrew, Waxman, Stephen G, Stanley, Philip, Kirby, Simon, Tarabar, Sanela, Gutteridge, Alex, Butt, Richard, McKernan, Ruth M, Whiting, Paul, Ali, Zahid, Bilsland, James, Stevens, Edward B
Published in Science translational medicine (20.04.2016)
Published in Science translational medicine (20.04.2016)
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Highly potent and selective Na(V)1.7 inhibitors for use as intravenous agents and chemical probes
Storer, R. Ian, Pike, Andy, Swain, Nigel A., Alexandrou, Aristos J., Bechle, Bruce M., Blakemore, David C., Brown, Alan D., Castle, Neil A., Corbett, Matthew S., Flanagan, Neil J., Fengas, David, Johnson, M. Scott, Jones, Lyn H., Marron, Brian E., Payne, C. Elizabeth, Printzenhoff, David, Rawson, David J., Rose, Colin R., Ryckmans, Thomas, Sun, Jianmin, Theile, Jonathan W., Torella, Rubben, Tseng, Elaine, Warmus, Joseph S.
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
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Journal Article
A novel selective and orally bioavailable Na sub(v)1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability
Payne, Claire Elizabeth, Brown, Adam R, Theile, Jonathon W, Loucif, Alexandre J C, Alexandrou, Aristos J, Fuller, Mathew D, Mahoney, John H, Antonio, Brett M, Gerlach, Aaron C, Printzenhoff, David M, Prime, Rebecca L, Stockbridge, Gillian, Kirkup, Anthony J, Bannon, Anthony W, England, Steve, Chapman, Mark L, Bagal, Sharan, Roeloffs, Rosemarie, Anand, Uma, Anand, Praveen, Bungay, Peter J, Kemp, Mark, Butt, Richard P, Stevens, Edward B
Published in British journal of pharmacology (01.05.2015)
Published in British journal of pharmacology (01.05.2015)
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Journal Article
A novel selective and orally bioavailable N a v 1.8 channel blocker, PF ‐01247324, attenuates nociception and sensory neuron excitability
Payne, Claire Elizabeth, Brown, Adam R, Theile, Jonathon W, Loucif, Alexandre J C, Alexandrou, Aristos J, Fuller, Mathew D, Mahoney, John H, Antonio, Brett M, Gerlach, Aaron C, Printzenhoff, David M, Prime, Rebecca L, Stockbridge, Gillian, Kirkup, Anthony J, Bannon, Anthony W, England, Steve, Chapman, Mark L, Bagal, Sharan, Roeloffs, Rosemarie, Anand, Uma, Anand, Praveen, Bungay, Peter J, Kemp, Mark, Butt, Richard P, Stevens, Edward B
Published in British journal of pharmacology (01.05.2015)
Published in British journal of pharmacology (01.05.2015)
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Journal Article
Highly potent and selective Na V 1.7 inhibitors for use as intravenous agents and chemical probes
Storer, R Ian, Pike, Andy, Swain, Nigel A, Alexandrou, Aristos J, Bechle, Bruce M, Blakemore, David C, Brown, Alan D, Castle, Neil A, Corbett, Matthew S, Flanagan, Neil J, Fengas, David, Johnson, M Scott, Jones, Lyn H, Marron, Brian E, Payne, C Elizabeth, Printzenhoff, David, Rawson, David J, Rose, Colin R, Ryckmans, Thomas, Sun, Jianmin, Theile, Jonathan W, Torella, Rubben, Tseng, Elaine, Warmus, Joseph S
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
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Published in Bioorganic & medicinal chemistry letters (01.11.2017)
Journal Article
A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability
Payne, Claire Elizabeth, Brown, Adam R, Theile, Jonathon W, Loucif, Alexandre J C, Alexandrou, Aristos J, Fuller, Mathew D, Mahoney, John H, Antonio, Brett M, Gerlach, Aaron C, Printzenhoff, David M, Prime, Rebecca L, Stockbridge, Gillian, Kirkup, Anthony J, Bannon, Anthony W, England, Steve, Chapman, Mark L, Bagal, Sharan, Roeloffs, Rosemarie, Anand, Uma, Anand, Praveen, Bungay, Peter J, Kemp, Mark, Butt, Richard P, Stevens, Edward B
Published in British journal of pharmacology (01.05.2015)
Published in British journal of pharmacology (01.05.2015)
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Journal Article