Discovery of α,γ-Diketo Acids as Potent Selective and Reversible Inhibitors of Hepatitis C Virus NS5b RNA-Dependent RNA Polymerase
Summa, Vincenzo, Petrocchi, Alessia, Pace, Paola, Matassa, Victor G, De Francesco, Raffaele, Altamura, Sergio, Tomei, Licia, Koch, Uwe, Neuner, Philippe
Published in Journal of medicinal chemistry (01.01.2004)
Published in Journal of medicinal chemistry (01.01.2004)
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From dihydroxypyrimidine carboxylic acids to carboxamide HIV-1 integrase inhibitors: SAR around the amide moiety
Petrocchi, Alessia, Koch, Uwe, Matassa, Victor G., Pacini, Barbara, Stillmock, Kara A., Summa, Vincenzo
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
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Discovery of pyrrolidine-based β-secretase inhibitors: Lead advancement through conformational design for maintenance of ligand binding efficiency
Stachel, Shawn J., Steele, Thomas G., Petrocchi, Alessia, Haugabook, Sharie J., McGaughey, Georgia, Katharine Holloway, M., Allison, Timothy, Munshi, Sanjeev, Zuck, Paul, Colussi, Dennis, Tugasheva, Katherine, Wolfe, Abigail, Graham, Samuel L., Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Abstract 3528: The SMARCA2/4 catalytic activity, but not the bromodomain, is a drug target in SWI/SNF mutant cancers
Vangamudi, Bhavatarini, Paul, Thomas, Shah, Parantu K., Alimova, Maria K., Nottebaum, Lisa, Shi, Xi, Zhan, Yanai, Leo, Elisabetta, Mahadeshwar, Harshad S., Protopopov, Alexei, Futreal, Andrew, Tieu, Trang N., Peoples, Mike, Petrocchi, Alessia, Marszalek, Joseph R., Toniatti, Carlo, Heffernan, Timothy P., Verhelle, Dominique, Draetta, Giulio, Owen, Dafydd, Jones, Philip, Palmer, Wylie, Sharma, Shikhar, Andersen, Jannik N.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Dihydroxypyrimidine-4-carboxamides as Novel Potent and Selective HIV Integrase Inhibitors
Pace, Paola, Di Francesco, M. Emilia, Gardelli, Cristina, Harper, Steven, Muraglia, Ester, Nizi, Emanuela, Orvieto, Federica, Petrocchi, Alessia, Poma, Marco, Rowley, Michael, Scarpelli, Rita, Laufer, Ralph, Gonzalez Paz, Odalys, Monteagudo, Edith, Bonelli, Fabio, Hazuda, Daria, Stillmock, Kara A, Summa, Vincenzo
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
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HCV NS5b RNA-Dependent RNA Polymerase Inhibitors: From α,γ-Diketoacids to 4,5-Dihydroxypyrimidine- or 3-Methyl-5- hydroxypyrimidinonecarboxylic Acids. Design and Synthesis
Summa, Vincenzo, Petrocchi, Alessia, Matassa, Victor G, Taliani, Marina, Laufer, Ralph, De Francesco, Raffaele, Altamura, Sergio, Pace, Paola
Published in Journal of medicinal chemistry (21.10.2004)
Published in Journal of medicinal chemistry (21.10.2004)
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Abstract 949: Identification of OXPHOS inhibitors which selectively kill tumors with specific metabolic vulnerabilities
Marszalek, Joseph R., Bandi, Madhavi, Bardenhagen, Jennifer, Bristow, Christopher, Carroll, Christopher, Chang, Edward, Feng, Ninping, Czako, Barbara, Gay, Jason, Do, Mary Geck, Greer, Jennifer, Johnson, Ryan M., Konopleva, Marina, Kang, Zhijun, Liu, Gang, Lofton, Timothy, McAfoos, Timothy, Protopopova, Marina, Petrocchi, Alessia, Muller, Florian, Theroff, Jay, Wu, Yuanqing, Chin, Lynda, Draetta, Giulio, Jones, Philip, Toniatti, Carlo, Francesco, Emilia Di
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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A series of novel, potent, and selective histone deacetylase inhibitors
Jones, Philip, Altamura, Sergio, Chakravarty, Prasun K., Cecchetti, Ottavia, Francesco, Raffaele De, Gallinari, Paola, Ingenito, Raffaele, Meinke, Peter T., Petrocchi, Alessia, Rowley, Michael, Scarpelli, Rita, Serafini, Sergio, Steinkühler, Christian
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
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Inhibitors of the Hepatitis C Virus NS3 Protease with Basic Amine Functionality at the P3-Amino Acid N-Terminus: Discovery and Optimization of a New Series of P2−P4 Macrocycles
Harper, Steven, Ferrara, Marco, Crescenzi, Benedetta, Pompei, Marco, Palumbi, Maria Cecilia, DiMuzio, Jillian M, Donghi, Monica, Fiore, Fabrizio, Koch, Uwe, Liverton, Nigel J, Pesci, Silvia, Petrocchi, Alessia, Rowley, Michael, Summa, Vincenzo, Gardelli, Cristina
Published in Journal of medicinal chemistry (13.08.2009)
Published in Journal of medicinal chemistry (13.08.2009)
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Journal Article
Discovery of pyrrolidine-based I2-secretase inhibitors: Lead advancement through conformational design for maintenance of ligand binding efficiency
Stachel, Shawn J, Steele, Thomas G, Petrocchi, Alessia, Haugabook, Sharie J, McGaughey, Georgia, Holloway, MKatharine, Allison, Timothy, Munshi, Sanjeev, Zuck, Paul, Colussi, Dennis, Tugasheva, Katherine, Wolfe, Abigail, Graham, Samuel L, Vacca, Joseph P
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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AZOLE DERIVATIVES AS SHP2 INHIBITORS
DI FABIO, Romano, ROSSETTI, Ilaria, MONTALBETTI, Christian, PETROCCHI, Alessia, CIAMMAICHELLA, Alina
Year of Publication 04.04.2024
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Year of Publication 04.04.2024
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AZOLE DERIVATIVES AS SHP2 INHIBITORS
DI FABIO, Romano, ROSSETTI, Ilaria, MONTALBETTI, Christian, PETROCCHI, Alessia, CIAMMAICHELLA, Alina
Year of Publication 03.04.2024
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Year of Publication 03.04.2024
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(S)-1-(5-((PYRIDIN-3-YL)THIO)PYRAZIN-2-YL)-4'H,6'H-SPIRO[PIPERIDINE-4,5'-PYRROLO [1,2-B]PYRAZOL]-4'-AMINE DERIVATIVES AND SIMILAR COMPOUNDS AS SHP2 INHIBITORS FOR THE TREATMENT OF E.G. CANCER
RANDAZZO, Pietro, GRILLO, Alessandro, DI FABIO, Romano, ROSSETTI, Ilaria, MONTALBETTI, Christian, PETROCCHI, Alessia, CIAMMAICHELLA, Alina
Year of Publication 18.07.2024
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Year of Publication 18.07.2024
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(S)-1-(5-((PYRIDIN-3-YL)THIO)PYRAZIN-2-YL)-4'H,6'H-SPIRO[PIPERIDINE-4,5'-PYRROLO [1,2-B]PYRAZOL]-4'-AMINE DERIVATIVES AND SIMILAR COMPOUNDS AS SHP2 INHIBITORS FOR THE TREATMENT OF E.G. CANCER
RANDAZZO, Pietro, GRILLO, Alessandro, DI FABIO, Romano, ROSSETTI, Ilaria, MONTALBETTI, Christian, PETROCCHI, Alessia, CIAMMAICHELLA, Alina
Year of Publication 07.02.2024
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Year of Publication 07.02.2024
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(S)-1-(5-((PYRIDIN-3-YL)THIO)PYRAZIN-2-YL)-4'H,6'H-SPIRO[PIPERIDINE-4,5'-PYRROLO [1,2-B]PYRAZOL]-4'-AMINE DERIVATIVES AND SIMILAR COMPOUNDS AS SHP2 INHIBITORS FOR THE TREATMENT OF E.G. CANCER
RANDAZZO, Pietro, GRILLO, Alessandro, DI FABIO, Romano, ROSSETTI, Ilaria, MONTALBETTI, Christian, PETROCCHI, Alessia, CIAMMAICHELLA, Alina
Year of Publication 16.11.2023
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Year of Publication 16.11.2023
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(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
CIAMMAICHELLA Alina, GRILLO Alessandro, MONTALBETTI Christian, ROSSETTI Ilaria, PETROCCHI Alessia, DI FABIO Romano, RANDAZZO Pietro
Year of Publication 01.11.2023
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Year of Publication 01.11.2023
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(S)-1-(5-((PYRIDIN-3-YL)THIO)PYRAZIN-2-YL)-4'H,6'H-SPIRO[PIPERIDINE-4,5'-PYRROLO[1,2-B]PYRAZOL]-4'-AMINE DERIVATIVES AND SIMILAR COMPOUNDS AS SHP2 INHIBITORS FOR THE TREATMENT OF E.G. CANCER
RANDAZZO, Pietro, GRILLO, Alessandro, DI FABIO, Romano, MONTALBETTI, Christian, PETROCCHI, Alessia
Year of Publication 05.10.2022
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Year of Publication 05.10.2022
Patent
AZABICYCLIC SHP2 INHIBITORS
RELITTI, Nicola, SFERRAZZA, Alessio, GRILLO, Alessandro, DI FABIO, Romano, FEZZARDI, Paola, ROSSETTI, Ilaria, MONTALBETTI, Christian, FERRIGNO, Federica, TORRENTE, Esther, PETROCCHI, Alessia, CIAMMAICHELLA, Alina, FERRANTE, Luca
Year of Publication 04.04.2024
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Year of Publication 04.04.2024
Patent
AZABICYCLIC SHP2 INHIBITORS
RELITTI, Nicola, SFERRAZZA, Alessio, GRILLO, Alessandro, DI FABIO, Romano, FEZZARDI, Paola, ROSSETTI, Ilaria, MONTALBETTI, Christian, FERRIGNO, Federica, TORRENTE, Esther, PETROCCHI, Alessia, CIAMMAICHELLA, Alina, FERRANTE, Luca
Year of Publication 13.12.2023
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Year of Publication 13.12.2023
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(S)-1-(5-((PYRIDIN-3-YL)THIO)PYRAZIN-2-YL)-4'H,6'H-SPIRO[PIPERIDINE-4,5'-PYRROLO [1,2-B]PYRAZOL]-4'-AMINE DERIVATIVES AND SIMILAR COMPOUNDS AS SHP2 INHIBITORS FOR THE TREATMENT OF E.G. CANCER
RANDAZZO, Pietro, GRILLO, Alessandro, DI FABIO, Romano, ROSSETTI, Ilaria, MONTALBETTI, Christian, PETROCCHI, Alessia, CIAMMAICHELLA, Alina
Year of Publication 06.10.2022
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Year of Publication 06.10.2022
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