Identification of Novel HSP90α/β Isoform Selective Inhibitors Using Structure-Based Drug Design. Demonstration of Potential Utility in Treating CNS Disorders such as Huntington’s Disease
Ernst, Justin T, Neubert, Timothy, Liu, Michael, Sperry, Samuel, Zuccola, Harmon, Turnbull, Amy, Fleck, Beth, Kargo, William, Woody, Lisa, Chiang, Peggy, Tran, Dao, Chen, Weichao, Snyder, Phillip, Alcacio, Timothy, Nezami, Azin, Reynolds, James, Alvi, Khisal, Goulet, Lance, Stamos, Dean
Published in Journal of medicinal chemistry (24.04.2014)
Published in Journal of medicinal chemistry (24.04.2014)
Get full text
Journal Article
낭포성 섬유증 막횡단 전도 조절자의 조절제, 제약 조성물, 치료 방법, 및 상기 조절제의 제조 방법
HADIDA RUAH SARA SABINA, BUSCH BRETT BRADLEY, MCCARTNEY JASON, JOSHI PRAMOD VIRUPAX, HUGHES ROBERT M, BAEK MINSON, PARASELLI PRASUNA, PIERRE FABRICE JEAN DENIS, KHATUYA HARIPADA, UY JOHNNY, KESHAVARZ SHOKRI ALI, GROOTENHUIS PETER, VAN GOOR FREDRICK, KRENITSKY PAUL JOHN, MCAULEY AOKI RACHEL, FRIEMAN BRYAN A, TERMIN ANDREAS P, SIESEL DAVID ANDREW, ZHOU JINGLAN, ANDERSON COREY, MELILLO VITO, CLEVELAND THOMAS, ALCACIO TIMOTHY, ABELA ALEXANDER RUSSELL, ZHANG BEILI, MILLER MARK THOMAS
Year of Publication 17.06.2019
Get full text
Year of Publication 17.06.2019
Patent
낭포성 섬유증 막관통 전도성 조절인자의 조절제, 약제학적 조성물, 치료 방법, 및 상기 조절제를 제조하는 방법
HADIDA RUAH SARA SABINA, YOUNG TOMOTHY JOHN, MCCARTNEY JASON, JOSHI PRAMOD VIRUPAX, SHI YI, HUGHES ROBERT M, BAEK MINSON, FERRIS LORI ANN, GULEVICH ANTON, PARASELLI PRASUNA, PIERRE FABRICE JEAN DENIS, KHATUYA HARIPADA, UY JOHNNY, KESHAVARZ SHOKRI ALI, HSIA CLARA KUANG JU, GROSS RAYMOND STANLEY, KRENITSKY PAUL JOHN, ANGELL PAUL TIMOTHY, SIESEL DAVID ANDREW, TERMIN ANDREAS P, ZHOU JINGLAN, GROOTENHUIS PETER DIEDERIK JAN, STAVROPOULOS KATHY, ANDERSON COREY, CLEVELAND THOMAS, ALCACIO TIMOTHY, ABELA ALEXANDER RUSSELL, SHRESTHA MUNA, KANG PING, VAN GOOR FREDRICK F, MILLER MARK THOMAS, CLEMENS JEREMY J
Year of Publication 02.09.2019
Get full text
Year of Publication 02.09.2019
Patent
MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
HADIDA RUAH, SARA SABINA, JOSHI, PRAMOD VIRUPAX, ALCACIO, TIMOTHY, KHATUYA, HARIPADA, MCAULEY-AOKI, RACHEL, ZHOU, JINGLAN, MCCARTNEY, JASON, SIESEL, DAVID ANDREW, HUGHES, ROBERT M, PARASELLI, PRASUNA, CLEVELAND, THOMAS, TERMIN, ANDREAS P, PIERRE, FABRICE JEAN DENIS, FRIEMAN, BRYAN A, KESHAVARZ-SHOKRI, ALI, ABELA, ALEXANDER RUSSELL, BAEK, MINSON, ANDERSON, COREY, KRENITSKY, PAUL JOHN, BUSCH, BRETT BRADLEY, ZHANG, BEILI, MELILLO, VITO, GROOTENHUIS, PETER, VAN GOOR, FREDRICK, UY, JOHNNY, MILLER, MARK THOMAS
Year of Publication 05.03.2024
Get full text
Year of Publication 05.03.2024
Patent
MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
GROSS, Raymond, Stanley, ABELA, Alexander, Russell, MCCARTNEY, Jason, CLEVELAND, Thomas, KANG, Ping, KESHAVARZ-SHOKRI, Ali, JOSHI, Pramod, Virupax, STAVROPOULOS, Kathy, ALCACIO, Timothy, KHATUYA, KHATUYA, Haripada, TERMIN, Andreas, P, BAEK, Minson, SHI, Yi, SHRESTHA, Muna, FERRIS,, Lori, Ann, GROOTENHUIS, Peter Diederik, Jan, HSIA, Clara, Kuang-Ju, KRENITSKY, Paul, John, ANGELL, Paul, Timothy, MILLER, Mark, Thomas, ANDERSON, Corey, PARASELLI, Prasuna, YOUNG, Tomothy, John, ZHOU,, Jinglan, GULEVICH, Anton, VAN GOOR, Fredrik, F, UY, Johnny, CLEMENS, Jeremy, J, HADIDA RUAH, Sara, Sabina, PIERRE, Fa brice Jean, Denis, SIESEL, David, Andrew, HUGHES, Robert, M
Year of Publication 25.06.2024
Get full text
Year of Publication 25.06.2024
Patent
Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
Hsia, Clara, Mccartney, Jason, Ferris, Lori, Cleveland, Thomas, Young, Timothy, Uy, Johnny, Gulevich, Anton, Termin, Andreas P, Abela, Alexander Russell, Krenitsky, Paul John, Alcacio, Timothy, Pierre, Fabrice Jean Denis, Stavropoulos, Kathy, Grootenhuis, Peter Diederik, Shi, Yi, Khatuya, Haripada, Hughes, Robert M, Gross, Raymond, Hadida Ruah, Sara Sabina, Angell, Paul, Clemens, Jeremy, Kang, Ping, Siesel, David Andrew, Baek, Minson, Joshi, Pramod Virupax, Paraselli, Prasuna, Zhou, Jinglan, Van Goor, Fredrick, Miller, Mark Thomas, Shrestha, Muna, Anderson, Corey, Keshavarz-Shokri, Ali
Year of Publication 24.11.2023
Get full text
Year of Publication 24.11.2023
Patent
MODULATOR OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
Gross, Raymond Stanley, Ferris, Lori Ann, Hsia, Clara Kuang-Ju, Clemens, Jeremy J, Cleveland, Thomas, Uy, Johnny, Termin, Andreas P, Abela, Alexander Russell, Krenitsky, Paul John, Alcacio, Timothy, Gulevich, Anton V, Van Goor, Fredrick F, Pierre, Fabrice Jean Denis, Stavropoulos, Kathy, Shi, Yi, Angell, Paul Timothy, Khatuya, Haripada, Hughes, Robert M, Hadida Ruah, Sara Sabina, McCartney, Jason, Kang, Ping, Siesel, David Andrew, Baek, Minson, Grootenhuis, Peter Diederik Jan, Joshi, Pramod Virupax, Paraselli, Prasuna, Young, Timothy John, Zhou, Jinglan, Miller, Mark Thomas, Shrestha, Muna, Anderson, Corey, Keshavarz-Shokri, Ali
Year of Publication 09.11.2023
Get full text
Year of Publication 09.11.2023
Patent
Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
Mccartney, Jason, Cleveland, Thomas, Uy, Johnny, Mcauley-Aoki, Rachel, Termin, Andreas P, Abela, Alexander Russell, Krenitsky, Paul John, Alcacio, Timothy, Zhang, Beili, Pierre, Fabrice Jean Denis, Khatuya, Haripada, Hughes, Robert M, Hadida Ruah, Sara Sabina, Frieman, Bryan A, Busch, Brett Bradley, Siesel, David Andrew, Baek, Minson, Joshi, Pramod Virupax, Paraselli, Prasuna, Van Goor, Fredrick, Zhou, Jinglan, Miller, Mark Thomas, Melillo, Vito, Anderson, Corey, Grootenhuis, Peter, Keshavarz-Shokri, Ali
Year of Publication 28.04.2023
Get full text
Year of Publication 28.04.2023
Patent
MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
Cleveland, Thomas, Uy, Johnny, McAuley-Aoki, Rachel, Termin, Andreas P, Abela, Alexander Russell, Krenitsky, Paul John, Alcacio, Timothy, Zhang, Beili, Pierre, Fabrice Jean Denis, Khatuya, Haripada, Hughes, Robert M, Hadida Ruah, Sara Sabina, McCartney, Jason, Frieman, Bryan A, Busch, Brett Bradley, Baek, Minson, Joshi, Pramod Virupax, Paraselli, Prasuna, Van Goor, Fredrick, Zhou, Jinglan, Miller, Mark Thomas, Melillo, Vito, Anderson, Corey, Grootenhuis, Peter, Keshavarz-Shokri, Ali
Year of Publication 29.09.2022
Get full text
Year of Publication 29.09.2022
Patent
MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
KHATUYA, Haripada, HADIDA RUAH, Sara Sabina, YOUNG, Timothy John, FERRIS, Lori Ann, MCCARTNEY, Jason, CLEVELAND, Thomas, KANG, Ping, KESHAVARZ-SHOKRI, Ali, GROSS, Raymond Stanley, STAVROPOULOS, Kathy, ALCACIO, Timothy, HUGHES, Robert M, PIERRE, Fabrice Jean Denis, KRENITSKY, Paul John, ANGELL, Paul Timothy, GROOTENHUIS, Peter Diederik Jan, BAEK, Minson, SHI, Yi, SHRESTHA, Muna, CLEMENS, Jeremy J, ZHOU, Jinglan, ANDERSON, Corey, PARASELLI, Prasuna, MILLER, Mark Thomas, SIESEL, David Andrew, VAN GOOR, Fredrick F, HSIA, Clara Kuang-Ju, GULEVICH, Anton, TERMIN, Andreas P, UY, Johnny, ABELA, Alexander Russell, JOSHI, Pramond Virupax
Year of Publication 13.07.2023
Get full text
Year of Publication 13.07.2023
Patent
MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
ANDREAS P TERMIN, VITO MELILLO, FREDRICK VAN GOOR, FABRICE JEAN DENIS PIERRE, BRETT BRADLEY BUSCH, PRASUNA PARASELLI, ALI KESHAVARZ-SHOKRI, THOMAS CLEVELAND, ALEXANDER RUSSELL ABELA, JOHNNY UY, TIMOTHY ALCACIO, PRAMOD VIRUPAX JOSHI, PAUL JOHN KRENITSKY, PETER GROOTENHUIS, ROBERT M HUGHES, SARA SABINA HADIDA RUAH, JASON MCCARTNEY, MINSON BAEK, RACHEL MCAULEY-AOKI, DAVID ANDREW SIESEL, JINGLAN ZHOU, MARK THOMAS MILLER, BEILI ZHANG, BRYAN A FRIEMAN, HARIPADA KHATUYA, COREY ANDERSON
Year of Publication 30.11.2022
Get full text
Year of Publication 30.11.2022
Patent
MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
KHATUYA, Haripada, HADIDA RUAH, Sara Sabina, YOUNG, Timothy John, FERRIS, Lori Ann, MCCARTNEY, Jason, CLEVELAND, Thomas, KANG, Ping, KESHAVARZ-SHOKRI, Ali, GROSS, Raymond Stanley, STAVROPOULOS, Kathy, ALCACIO, Timothy, HUGHES, Robert M, PIERRE, Fabrice Jean Denis, KRENITSKY, Paul John, ANGELL, Paul Timothy, GROOTENHUIS, Peter Diederik Jan, BAEK, Minson, SHI, Yi, SHRESTHA, Muna, CLEMENS, Jeremy J, ZHOU, Jinglan, ANDERSON, Corey, PARASELLI, Prasuna, MILLER, Mark Thomas, SIESEL, David Andrew, VAN GOOR, Fredrick F, HSIA, Clara Kuang-Ju, GULEVICH, Anton, TERMIN, Andreas P, UY, Johnny, ABELA, Alexander Russell, JOSHI, Pramond Virupax
Year of Publication 06.04.2023
Get full text
Year of Publication 06.04.2023
Patent
MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
KHATUYA, Haripada, MCCARTNEY, Jason, TERMIN, Andreas, MILLER, Mark, CLEVELAND, Thomas, ABELA, Alexander, KESHAVARZ-SHOKRI, Ali, MCAULEY-AOKI, Rachel, ALCACIO, Timothy, HADIDA RUAH, Sara, KRENITSKY, Paul, PIERRE, Fabrice, BAEK, Minson, BUSCH, Brett, ZHOU, Jinglan, VAN GOOR, Fredrick, ANDERSON, Corey, PARASELLI, Prasuna, FRIEMAN, Bryan, SIESEL, David, GROOTENHUIS, Peter, HUGHES, Robert, JOSHI, Pramod, UY, Johnny, MELILLO, Vito, ZHANG, Beili
Year of Publication 28.03.2022
Get full text
Year of Publication 28.03.2022
Patent
MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
PING KANG, ANTON GULEVICH, ANDREAS P TERMIN, PAUL TIMOTHY ANGELL, PRASUNA PARASELLI, FABRICE JEAN DENIS PIERRE, THOMAS CLEVELAND, ALI KESHAVARZ-SHOKRI, ALEXANDER RUSSELL ABELA, JOHNNY UY, RAYMOND STANLEY GROSS, FREDRICK F VAN GOOR, TIMOTHY ALCACIO, PRAMOD VIRUPAX JOSHI, PAUL JOHN KRENITSKY, MUNA SHRESTHA, LORI ANN FERRIS, JEREMY J CLEMENS, ROBERT M HUGHES, SARA SABINA HADIDA RUAH, JASON MCCARTNEY, MINSON BAEK, DAVID ANDREW SIESEL, JINGLAN ZHOU, MARK THOMAS MILLER, PETER DIEDERIK JAN GROOTENHUIS, CLARA KUANG-JU HSIA, HARIPADA KHATUYA, TOMOTHY JOHN YOUNG, COREY ANDERSON, YI SHI, KATHY STAVROPOULOS
Year of Publication 21.12.2022
Get full text
Year of Publication 21.12.2022
Patent
Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
Cleveland, Thomas, Uy, Johnny, McAuley-Aoki, Rachel, Termin, Andreas P, Abela, Alexander Russell, Krenitsky, Paul John, Alcacio, Timothy, Zhang, Beili, Pierre, Fabrice Jean Denis, Khatuya, Haripada, Hughes, Robert M, Hadida Ruah, Sara Sabina, McCartney, Jason, Frieman, Bryan A, Busch, Brett Bradley, Baek, Minson, Joshi, Pramod Virupax, Paraselli, Prasuna, Van Goor, Fredrick, Zhou, Jinglan, Miller, Mark Thomas, Melillo, Vito, Anderson, Corey, Grootenhuis, Peter, Keshavarz-Shokri, Ali
Year of Publication 30.11.2021
Get full text
Year of Publication 30.11.2021
Patent
MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
KHATUYA, Haripada, MCCARTNEY, Jason, TERMIN, Andreas, MILLER, Mark, CLEVELAND, Thomas, ABELA, Alexander, KESHAVARZ-SHOKRI, Ali, MCAULEY-AOKI, Rachel, ALCACIO, Timothy, HADIDA RUAH, Sara, KRENITSKY, Paul, PIERRE, Fabrice, BAEK, Minson, BUSCH, Brett, ZHOU, Jinglan, VAN GOOR, Fredrick, ANDERSON, Corey, PARASELLI, Prasuna, FRIEMAN, Bryan, SIESEL, David, GROOTENHUIS, Peter, HUGHES, Robert, JOSHI, Pramod, UY, Johnny, MELILLO, Vito, ZHANG, Beili
Year of Publication 25.11.2021
Get full text
Year of Publication 25.11.2021
Patent
Modulator of the cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
Gross, Raymond Stanley, Ferris, Lori Ann, Hsia, Clara Kuang-Ju, Clemens, Jeremy J, Cleveland, Thomas, Uy, Johnny, Termin, Andreas P, Abela, Alexander Russell, Krenitsky, Paul John, Alcacio, Timothy, Gulevich, Anton V, Van Goor, Fredrick F, Pierre, Fabrice Jean Denis, Stavropoulos, Kathy, Shi, Yi, Angell, Paul Timothy, Khatuya, Haripada, Hughes, Robert M, Hadida Ruah, Sara Sabina, McCartney, Jason, Kang, Ping, Siesel, David Andrew, Baek, Minson, Grootenhuis, Peter Diederik Jan, Joshi, Pramod Virupax, Paraselli, Prasuna, Young, Timothy John, Zhou, Jinglan, Miller, Mark Thomas, Shrestha, Muna, Anderson, Corey, Keshavarz-Shokri, Ali
Year of Publication 27.09.2022
Get full text
Year of Publication 27.09.2022
Patent
MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
Cleveland, Thomas, Uy, Johnny, McAuley-Aoki, Rachel, Termin, Andreas P, Abela, Alexander Russell, Krenitsky, Paul John, Alcacio, Timothy, Zhang, Beili, Pierre, Fabrice Jean Denis, Khatuya, Haripada, Hughes, Robert M, McCartney, Jason, Frieman, Bryan A, Busch, Brett Bradley, Siesel, David Andrew, Baek, Minson, Hadida Ruah, Sara, Sabina, Joshi, Pramod Virupax, Paraselli, Prasuna, Van Goor, Fredrick, Zhou, Jinglan, Miller, Mark Thomas, Melillo, Vito, Anderson, Corey, Grootenhuis, Peter, Keshavarz-Shokri, Ali
Year of Publication 04.03.2022
Get full text
Year of Publication 04.03.2022
Patent
MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
BAEK Minson, VAN GOOR Fredrick, KHATUYA Haripada, MCCARTNEY Jason, HADIDA RUAH Sara Sabina, JOSHI Pramod Virupax, UY Johnny, ALCACIO Timothy, KRENITSKY Paul John, MELILLO Vito, ANDERSON Corey, FRIEMAN Bryan A, GROOTENHUIS Peter, CLEVELAND Thomas, HUGHES Robert M, ZHANG Beili, BUSCH Brett Bradley, TERMIN Andreas P, ABELA Alexander Russell, PARASELLI Prasuna, KESHAVARZ-SHOKRI Ali, MCAULEY-AOKI Rachel, PIERRE Fabrice Jean Denis, MILLER Mark Thomas, SIESEL David Andrew, ZHOU Jinglan
Year of Publication 31.01.2022
Get full text
Year of Publication 31.01.2022
Patent
MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
HADIDA RUAH, SARA SABINA, JOSHI, PRAMOD VIRUPAX, ALCACIO, TIMOTHY, KHATUYA, HARIPADA, MCAULEY-AOKI, RACHEL, ZHOU, JINGLAN, MCCARTNEY, JASON, SIESEL, DAVID ANDREW, HUGHES, ROBERT M, PARASELLI, PRASUNA, CLEVELAND, THOMAS, TERMIN, ANDREAS P, PIERRE, FABRICE JEAN DENIS, FRIEMAN, BRYAN A, KESHAVARZ-SHOKRI, ALI, ABELA, ALEXANDER RUSSELL, BAEK, MINSON, ANDERSON, COREY, KRENITSKY, PAUL JOHN, BUSCH, BRETT BRADLEY, ZHANG, BEILI, MELILLO, VITO, GROOTENHUIS, PETER, VAN GOOR, FREDRICK, UY, JOHNNY, MILLER, MARK THOMAS
Year of Publication 31.01.2022
Get full text
Year of Publication 31.01.2022
Patent