Mevinolin: A Highly Potent Competitive Inhibitor of Hydroxymethylglutaryl-Coenzyme A Reductase and a Cholesterol-Lowering Agent
Alberts, A. W., Chen, J., Kuron, G., Hunt, V., Huff, J., Hoffman, C., Rothrock, J., Lopez, M., Joshua, H., Harris, E., Patchett, A., Monaghan, R., Currie, S., Stapley, E., Albers-Schonberg, G., Hensens, O., Hirshfield, J., Hoogsteen, K., Liesch, J., Springer, J.
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.1980)
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.1980)
Get full text
Journal Article
Inhibition of 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis by β-lactone inhibitors and binding of these inhibitors to the enzyme
GREENSPAN, M. D, BULL, H. G, YUDKOVITZ, J. B, HANF, D. P, ALBERTS, A. W
Published in Biochemical journal (01.02.1993)
Published in Biochemical journal (01.02.1993)
Get full text
Journal Article
On the etiology of subcapsular lenticular opacities produced in dogs receiving HMG-CoA reductase inhibitors
Gerson, R.J., MacDonald, J.S., Alberts, A.W., Chen, J., Yudkovitz, J.B., Greenspan, M.D., Rubin, L.F., Bokelman, D.L.
Published in Experimental eye research (1990)
Published in Experimental eye research (1990)
Get full text
Journal Article
Biochemical and pharmacological characterization of L-659,989: an extremely potent, selective and competitive receptor antagonist of platelet-activating factor
SAN-BAO HWANG, MY-HANH LAM, ALBERTS, A. W, BUGIANESI, R. L, CHABALA, J. C, PONPIPOM, M. M
Published in The Journal of pharmacology and experimental therapeutics (01.08.1988)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.08.1988)
Journal Article
Hydroxymethylglutaryl-coenzyme A Reductase-Containing Hepatocytes are Distributed Periportally in Normal and Mevinolin-Treated Rat Livers
Singer, Irwin I., Kawka, Douglas W., Kazazis, Diana M., Alberts, Alfred W., Chen, Julie S., Huff, Jesse W., Ness, Gene C.
Published in Proceedings of the National Academy of Sciences - PNAS (01.09.1984)
Published in Proceedings of the National Academy of Sciences - PNAS (01.09.1984)
Get full text
Journal Article
Inhibition of Hydroxymethylglutaryl-Coenzyme A Synthase by L-659,699
Greenspan, Michael D., Yudkovitz, Joel B., Lo, Chia-Yee L., Chen, Julie S., Alberts, Alfred W., Hunt, Vincent M., Chang, Michael N., Yang, Shu Shu, Thompson, Kathryn L., Chiang, Yuan-Ching P., Chabala, John C., Monaghan, Richard L., Schwartz, Robert L.
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.1987)
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.1987)
Get full text
Journal Article
Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3-hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester
Girotra, N. N, Biftu, T, Ponpipom, M. M, Acton, J. J, Alberts, A. W, Bach, T. N, Ball, R. G, Bugianesi, R. L, Chabala, J. C
Published in Journal of medicinal chemistry (01.09.1992)
Published in Journal of medicinal chemistry (01.09.1992)
Get full text
Journal Article
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 3. 7-(3,5-Disubstituted-[1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives
Stokker, G. E, Alberts, A. W, Anderson, P. S, Cragoe, E. J, Deana, A. A, Gilfillan, J. L, Hirshfield, J, Holtz, W. J, Hoffman, W. F
Published in Journal of medicinal chemistry (01.02.1986)
Published in Journal of medicinal chemistry (01.02.1986)
Get full text
Journal Article
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 8. Side chain ether analogs of lovastatin
Lee, Ta Jyh, Holtz, W. J, Smith, R. L, Alberts, A. W, Gilfillan, J. L
Published in Journal of medicinal chemistry (01.08.1991)
Published in Journal of medicinal chemistry (01.08.1991)
Get full text
Journal Article
Metabolism of lovastatin by rat and human liver microsomes in vitro
Greenspan, M D, Yudkovitz, J B, Alberts, A W, Argenbright, L S, Arison, B H, Smith, J L
Published in Drug metabolism and disposition (01.09.1988)
Get more information
Published in Drug metabolism and disposition (01.09.1988)
Journal Article
Plasma mevalonate as a measure of cholesterol synthesis in man
Parker, T S, McNamara, D J, Brown, C D, Kolb, R, Ahrens, Jr, E H, Alberts, A W, Tobert, J, Chen, J, De Schepper, P J
Published in The Journal of clinical investigation (01.09.1984)
Published in The Journal of clinical investigation (01.09.1984)
Get full text
Journal Article
Brain and optic system pathology in hypocholesterolemic dogs treated with a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase
Berry, PH, MacDonald, JS, Alberts, AW, Molon-Noblot, S, Chen, JS, Lo, CY, Greenspan, MD, Allen, H, Durand-Cavagna, G, Jensen, R
Published in The American journal of pathology (01.09.1988)
Get full text
Published in The American journal of pathology (01.09.1988)
Journal Article
(±)-Trans-2-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist
Ponpipom, Mitree M., Hwang, San-Bao, Doebber, Thomas W., Acton, John J., Alberts, Alfred W., Biftu, Tesfaye, Brooker, David R., Bugianesi, Robert L., Chabala, John C., Gamble, Nancy L., Graham, Donald W., Lam, My-Hanh, Wu, Margaret S.
Published in Biochemical and biophysical research communications (15.02.1988)
Published in Biochemical and biophysical research communications (15.02.1988)
Get full text
Journal Article
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 2. Structural modification of 7-(substituted aryl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives
Hoffman, William F, Alberts, A. W, Cragoe, E. J, Deana, A. A, Evans, B. E, Gilfillan, J. L, Gould, N. P, Huff, J. W, Novello, F. C
Published in Journal of medicinal chemistry (01.02.1986)
Published in Journal of medicinal chemistry (01.02.1986)
Get full text
Journal Article
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 5. 6-(Fluoren-9-yl)- and 6-(fluoren-9-ylidene)-3,5-dihydroxyhexanoic acids and their lactone derivatives
Stokker, G. E, Alberts, A. W, Gilfillan, J. L, Huff, J. W, Smith, R. L
Published in Journal of medicinal chemistry (01.05.1986)
Published in Journal of medicinal chemistry (01.05.1986)
Get full text
Journal Article