Locked nucleic acid: modality, diversity, and drug discovery
Hagedorn, Peter H., Persson, Robert, Funder, Erik D., Albæk, Nanna, Diemer, Sanna L., Hansen, Dennis J., Møller, Marianne R., Papargyri, Natalia, Christiansen, Helle, Hansen, Bo R., Hansen, Henrik F., Jensen, Mads A., Koch, Troels
Published in Drug discovery today (01.01.2018)
Published in Drug discovery today (01.01.2018)
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Journal Article
Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death
Schmidt, Steffen, Gallego, Sandra F., Zelnik, Iris Daphne, Kovalchuk, Sergey, Albæk, Nanna, Sprenger, Richard R., Øverup, Charlotte, Pewzner-Jung, Yael, Futerman, Anthony H., Lindholm, Marie W., Jensen, Ole N., Ejsing, Christer S.
Published in Molecular therapy (06.04.2022)
Published in Molecular therapy (06.04.2022)
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Journal Article
Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo
Javanbakht, Hassan, Mueller, Henrik, Walther, Johanna, Zhou, Xue, Lopez, Anaïs, Pattupara, Thushara, Blaising, Julie, Pedersen, Lykke, Albæk, Nanna, Jackerott, Malene, Shi, Tianlai, Ploix, Corinne, Driessen, Wouter, Persson, Robert, Ravn, Jacob, Young, John A.T., Ottosen, Søren
Published in Molecular therapy. Nucleic acids (01.06.2018)
Published in Molecular therapy. Nucleic acids (01.06.2018)
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Journal Article
LNA (locked nucleic acid) and analogs as triplex-forming oligonucleotides
Højland, Torben, Kumar, Surender, Babu, B Ravindra, Umemoto, Tadashi, Albaek, Nanna, Sharma, Pawan K, Nielsen, Poul, Wengel, Jesper
Published in Organic & biomolecular chemistry (01.01.2007)
Published in Organic & biomolecular chemistry (01.01.2007)
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Journal Article
Refining LNA safety profile by controlling phosphorothioate stereochemistry
Funder, Erik Daa, Albæk, Nanna, Moisan, Annie, Sewing, Sabine, Koch, Troels
Published in PloS one (12.06.2020)
Published in PloS one (12.06.2020)
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Journal Article
In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3' and 5' thiophosphate linkages
Duschmalé, Jörg, Hansen, Henrik Frydenlund, Duschmalé, Martina, Koller, Erich, Albaek, Nanna, Møller, Marianne Ravn, Jensen, Klaus, Koch, Troels, Wengel, Jesper, Bleicher, Konrad
Published in Nucleic acids research (10.01.2020)
Published in Nucleic acids research (10.01.2020)
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Journal Article
Determining a Synthetic Approach to Pierisformaside C
Chow, Sharon, Kreß, Christoph, Albæk, Nanna, Jessen, Carsten, Williams, Craig M
Published in Organic letters (07.10.2011)
Published in Organic letters (07.10.2011)
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Journal Article
Synthesis of a bicyclic double-headed nucleoside
Kumar, Surender, Steffansen, Signe Inglev, Albæk, Nanna, Nielsen, Poul
Published in Tetrahedron (21.01.2014)
Published in Tetrahedron (21.01.2014)
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Journal Article
Synthesis of Functionalized Carbocyclic Locked Nucleic Acid Analogues by Ring-Closing Diene and Enyne Metathesis and Their Influence on Nucleic Acid Stability and Structure
Kumar, Surender, Hansen, Marianne H, Albæk, Nanna, Steffansen, Signe I, Petersen, Michael, Nielsen, Poul
Published in Journal of organic chemistry (04.09.2009)
Published in Journal of organic chemistry (04.09.2009)
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Journal Article
Bi- and Tricyclic Nucleoside Derivatives Restricted in S-Type Conformations and Obtained by RCM-Reactions
Albæk, Nanna, Ravn, Jacob, Freitag, Morten, Thomasen, Helena, Christensen, Nanna K., Petersen, Michael, Nielsen, Poul
Published in Nucleosides, nucleotides & nucleic acids (01.10.2003)
Published in Nucleosides, nucleotides & nucleic acids (01.10.2003)
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Journal Article
ANTISENSE OLIGOMERS TARGETING PCSK9
HEDTJÄRN, Maj, RAVN, Jacob, PETRI, Andreas, NIELSEN, Niels Fisker, ALBÆK, Nanna, LINDHOLM, Marie Wickstrom
Year of Publication 14.03.2024
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Year of Publication 14.03.2024
Patent
ANTISENSE OLIGOMERS AND CONJUGATES TARGETING PCSK9
PETRI, ANDREAS, LINDHOLM, MARIE, HEDTJARN, MAJ, RAVN, JACOB, ALBÆK, NANNA, NIELSEN, NIELS FISKER
Year of Publication 02.01.2024
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Year of Publication 02.01.2024
Patent
Antisense oligomers targeting PCSK9
Albæk, Nanna, Lindholm, Marie Wickstrom, Nielsen, Niels Fisker, Hedtjärn, Maj, Petri, Andreas, Ravn, Jacob
Year of Publication 29.08.2023
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Year of Publication 29.08.2023
Patent
Antisense oligomers and conjugates targeting pcsk9
Albæk, Nanna, Nielsen, Niels Fisker, Hedtjärn, Maj, Lindholm, Marie, Petri, Andreas, Ravn, Jacob
Year of Publication 25.02.2022
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Year of Publication 25.02.2022
Patent
ANTISENSE OLIGOMERS TARGETING PCSK9
HEDTJÄRN, Maj, RAVN, Jacob, PETRI, Andreas, NIELSEN, Niels Fisker, ALBÆK, Nanna, LINDHOLM, Marie Wickstrom
Year of Publication 27.01.2022
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Year of Publication 27.01.2022
Patent