Search Results - "Alan Stobie" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition

Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition

by Fish, Paul V., Deur, Christopher, Gan, Xinmin, Greene, Keri, Hoople, David, Mackenny, Malcolm, Para, Kimberly S., Reeves, Keith, Ryckmans, Thomas, Stiff, Cory, Stobie, Alan, Wakenhut, Florian, Whitlock, Gavin A.
Published in Bioorganic & medicinal chemistry (15.04.2008)

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Journal Article

Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability

Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability

by Johnson, Patrick S., Ryckmans, Thomas, Bryans, Justin, Beal, Dave M., Dack, Kevin N., Feeder, Neil, Harrison, Anthony, Lewis, Mark, Mason, Helen J., Mills, James, Newman, Julie, Pasquinet, Christelle, Rawson, Dave J., Roberts, Lee R., Russell, Rachel, Spark, Deborah, Stobie, Alan, Underwood, Toby J., Ward, Robin, Wheeler, Simon
Published in Bioorganic & medicinal chemistry letters (01.10.2011)

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Novel 2-imidazoles as potent, selective and CNS penetrant α1A adrenoceptor partial agonists

Novel 2-imidazoles as potent, selective and CNS penetrant α1A adrenoceptor partial agonists

by ROBERTS, Lee R, BRYANS, Justin, CONLON, Kelly, MCMURRAY, Gordon, STOBIE, Alan, WHITLOCK, Gavin A
Published in Bioorganic & medicinal chemistry letters (15.12.2008)

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Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity

Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity

by Whitlock, Gavin A., Fish, Paul V., Fray, M. Jonathan, Stobie, Alan, Wakenhut, Florian
Published in Bioorganic & medicinal chemistry (01.05.2008)

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[4-(Phenoxy)pyridin-3-yl]methylamines: A new class of selective noradrenaline reuptake inhibitors

[4-(Phenoxy)pyridin-3-yl]methylamines: A new class of selective noradrenaline reuptake inhibitors

by Fish, Paul V., Ryckmans, Thomas, Stobie, Alan, Wakenhut, Florian
Published in Bioorganic & medicinal chemistry (15.03.2008)

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Potent and selective α1A adrenoceptor partial agonists—Novel imidazole frameworks

Potent and selective α1A adrenoceptor partial agonists—Novel imidazole frameworks

by Whitlock, Gavin A., Brennan, Paul E., Roberts, Lee R., Stobie, Alan
Published in Bioorganic & medicinal chemistry letters (01.06.2009)

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Pharmacological Properties of 2-((R-5-Chloro-4-methoxymethylindan-1-yl)-1H-imidazole (PF-3774076), a Novel and Selective Î±1A-Adrenergic Partial Agonist, in in Vitro and in Vivo Models of Urethral Function

Pharmacological Properties of 2-((R-5-Chloro-4-methoxymethylindan-1-yl)-1H-imidazole (PF-3774076), a Novel and Selective Î±1A-Adrenergic Partial Agonist, in in Vitro and in Vivo Models of Urethral Function

by Kelly Conlon, Clare Christy, Simon Westbrook, Gavin Whitlock, Lee Roberts, Alan Stobie, Gordon McMurray
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)

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Pharmacological Properties of 2-(( R -5-Chloro-4-methoxymethylindan-1-yl)-1 H -imidazole (PF-3774076), a Novel and Selective α1 A -Adrenergic Partial Agonist, in in Vitro and in Vivo Models of Urethral Function

Pharmacological Properties of 2-(( R -5-Chloro-4-methoxymethylindan-1-yl)-1 H -imidazole (PF-3774076), a Novel and Selective α1 A -Adrenergic Partial Agonist, in in Vitro and in Vivo Models of Urethral Function

by Conlon, Kelly, Christy, Clare, Westbrook, Simon, Whitlock, Gavin, Roberts, Lee, Stobie, Alan, McMurray, Gordon
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)

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Design, synthesis and evaluation of N-[(3 S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template

Design, synthesis and evaluation of N-[(3 S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template

by Fish, Paul V., Wakenhut, Florian, Ryckmans, Thomas, Stobie, Alan
Published in Bioorganic & medicinal chemistry letters (15.08.2009)

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4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: Design, synthesis and structure–activity relationships

4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: Design, synthesis and structure–activity relationships

by Fish, Paul V., Andrews, Mark D., Jonathan Fray, M., Stobie, Alan, Wakenhut, Florian, Whitlock, Gavin A.
Published in Bioorganic & medicinal chemistry letters (15.05.2009)

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Potent and selective alpha 1A adrenoceptor partial agonists-Novel imidazole frameworks

Potent and selective alpha 1A adrenoceptor partial agonists-Novel imidazole frameworks

by Whitlock, Gavin A, Brennan, Paul E, Roberts, Lee R, Stobie, Alan
Published in Bioorganic & medicinal chemistry letters (01.06.2009)

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Novel 2-imidazoles as potent, selective and CNS penetrant alpha sub(1A) adrenoceptor partial agonists

Novel 2-imidazoles as potent, selective and CNS penetrant alpha sub(1A) adrenoceptor partial agonists

by Roberts, Lee R, Bryans, Justin, Conlon, Kelly, McMurray, Gordon, Stobie, Alan, Whitlock, Gavin A
Published in Bioorganic & medicinal chemistry (01.12.2008)

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Novel 2-imidazoles as potent and selective α1A adrenoceptor partial agonists

Novel 2-imidazoles as potent and selective α1A adrenoceptor partial agonists

by WHITLOCK, Gavin A, CONLON, Kelly, MCMURRAY, Gordon, ROBERTS, Lee R, STOBIE, Alan, THURLOW, Richard J
Published in Bioorganic & medicinal chemistry letters (01.05.2008)

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Novel 2-imidazoles as potent and selective alpha sub(1A) adrenoceptor partial agonists

Novel 2-imidazoles as potent and selective alpha sub(1A) adrenoceptor partial agonists

by Whitlock, Gavin A, Conlon, Kelly, McMurray, Gordon, Roberts, Lee R, Stobie, Alan, Thurlow, Richard J
Published in Bioorganic & medicinal chemistry (01.05.2008)

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Novel Selective Inhibitors of Neutral Endopeptidase for the Treatment of Female Sexual Arousal Disorder. Synthesis and Activity of Functionalized Glutaramides

Novel Selective Inhibitors of Neutral Endopeptidase for the Treatment of Female Sexual Arousal Disorder. Synthesis and Activity of Functionalized Glutaramides

by Pryde, David C, Maw, Graham N, Planken, Simon, Platts, Michelle Y, Sanderson, Vivienne, Corless, Martin, Stobie, Alan, Barber, Christopher G, Russell, Rachel, Foster, Laura, Barker, Laura, Wayman, Christopher, Van Der Graaf, Piet, Stacey, Peter, Morren, Debbie, Kohl, Christopher, Beaumont, Kevin, Coggon, Sara, Tute, Michael
Published in Journal of medicinal chemistry (13.07.2006)

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N-Benzyl- N-(tetrahydro-2 H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors

N-Benzyl- N-(tetrahydro-2 H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors

by Fish, Paul V., Fray, M. Jonathan, Stobie, Alan, Wakenhut, Florian, Whitlock, Gavin A.
Published in Bioorganic & medicinal chemistry letters (01.04.2007)

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N-[(3 S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetration

N-[(3 S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetration

by Wakenhut, Florian, Allan, Gill A., Fish, Paul V., Jonathan Fray, M., Harrison, Anthony C., McCoy, Rachel, Phillips, Stephen C., Stobie, Alan, Westbrook, Dominique, Westbrook, Simon L., Whitlock, Gavin A.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)

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N-Benzyl- N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors

N-Benzyl- N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors

by Wakenhut, Florian, Fish, Paul V., Fray, M. Jonathan, Gurrell, Ian, Mills, James E., Stobie, Alan, Whitlock, Gavin A.
Published in Bioorganic & medicinal chemistry (01.08.2008)

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Structure–activity relationships of N-substituted piperazine amine reuptake inhibitors

Structure–activity relationships of N-substituted piperazine amine reuptake inhibitors

by Jonathan Fray, M., Bish, Gerwyn, Fish, Paul V., Stobie, Alan, Wakenhut, Florian, Whitlock, Gavin A.
Published in Bioorganic & medicinal chemistry letters (15.08.2006)

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Journal Article

Novel 2-imidazoles as potent, selective and CNS penetrant α 1A adrenoceptor partial agonists

Novel 2-imidazoles as potent, selective and CNS penetrant α 1A adrenoceptor partial agonists

by Roberts, Lee R., Bryans, Justin, Conlon, Kelly, McMurray, Gordon, Stobie, Alan, Whitlock, Gavin A.
Published in Bioorganic & medicinal chemistry letters (2008)

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