Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition
Fish, Paul V., Deur, Christopher, Gan, Xinmin, Greene, Keri, Hoople, David, Mackenny, Malcolm, Para, Kimberly S., Reeves, Keith, Ryckmans, Thomas, Stiff, Cory, Stobie, Alan, Wakenhut, Florian, Whitlock, Gavin A.
Published in Bioorganic & medicinal chemistry (15.04.2008)
Published in Bioorganic & medicinal chemistry (15.04.2008)
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Journal Article
Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability
Johnson, Patrick S., Ryckmans, Thomas, Bryans, Justin, Beal, Dave M., Dack, Kevin N., Feeder, Neil, Harrison, Anthony, Lewis, Mark, Mason, Helen J., Mills, James, Newman, Julie, Pasquinet, Christelle, Rawson, Dave J., Roberts, Lee R., Russell, Rachel, Spark, Deborah, Stobie, Alan, Underwood, Toby J., Ward, Robin, Wheeler, Simon
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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Journal Article
Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity
Whitlock, Gavin A., Fish, Paul V., Fray, M. Jonathan, Stobie, Alan, Wakenhut, Florian
Published in Bioorganic & medicinal chemistry (01.05.2008)
Published in Bioorganic & medicinal chemistry (01.05.2008)
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Journal Article
[4-(Phenoxy)pyridin-3-yl]methylamines: A new class of selective noradrenaline reuptake inhibitors
Fish, Paul V., Ryckmans, Thomas, Stobie, Alan, Wakenhut, Florian
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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Journal Article
Potent and selective α1A adrenoceptor partial agonists—Novel imidazole frameworks
Whitlock, Gavin A., Brennan, Paul E., Roberts, Lee R., Stobie, Alan
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
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Journal Article
Pharmacological Properties of 2-((R-5-Chloro-4-methoxymethylindan-1-yl)-1H-imidazole (PF-3774076), a Novel and Selective α1A-Adrenergic Partial Agonist, in in Vitro and in Vivo Models of Urethral Function
Kelly Conlon, Clare Christy, Simon Westbrook, Gavin Whitlock, Lee Roberts, Alan Stobie, Gordon McMurray
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
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Journal Article
Pharmacological Properties of 2-(( R -5-Chloro-4-methoxymethylindan-1-yl)-1 H -imidazole (PF-3774076), a Novel and Selective α1 A -Adrenergic Partial Agonist, in in Vitro and in Vivo Models of Urethral Function
Conlon, Kelly, Christy, Clare, Westbrook, Simon, Whitlock, Gavin, Roberts, Lee, Stobie, Alan, McMurray, Gordon
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
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Journal Article
Design, synthesis and evaluation of N-[(3 S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template
Fish, Paul V., Wakenhut, Florian, Ryckmans, Thomas, Stobie, Alan
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Journal Article
4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: Design, synthesis and structure–activity relationships
Fish, Paul V., Andrews, Mark D., Jonathan Fray, M., Stobie, Alan, Wakenhut, Florian, Whitlock, Gavin A.
Published in Bioorganic & medicinal chemistry letters (15.05.2009)
Published in Bioorganic & medicinal chemistry letters (15.05.2009)
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Journal Article
Potent and selective alpha 1A adrenoceptor partial agonists-Novel imidazole frameworks
Whitlock, Gavin A, Brennan, Paul E, Roberts, Lee R, Stobie, Alan
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
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Journal Article
Novel Selective Inhibitors of Neutral Endopeptidase for the Treatment of Female Sexual Arousal Disorder. Synthesis and Activity of Functionalized Glutaramides
Pryde, David C, Maw, Graham N, Planken, Simon, Platts, Michelle Y, Sanderson, Vivienne, Corless, Martin, Stobie, Alan, Barber, Christopher G, Russell, Rachel, Foster, Laura, Barker, Laura, Wayman, Christopher, Van Der Graaf, Piet, Stacey, Peter, Morren, Debbie, Kohl, Christopher, Beaumont, Kevin, Coggon, Sara, Tute, Michael
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
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Journal Article
N-Benzyl- N-(tetrahydro-2 H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors
Fish, Paul V., Fray, M. Jonathan, Stobie, Alan, Wakenhut, Florian, Whitlock, Gavin A.
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
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Journal Article
N-[(3 S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetration
Wakenhut, Florian, Allan, Gill A., Fish, Paul V., Jonathan Fray, M., Harrison, Anthony C., McCoy, Rachel, Phillips, Stephen C., Stobie, Alan, Westbrook, Dominique, Westbrook, Simon L., Whitlock, Gavin A.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Journal Article
N-Benzyl- N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors
Wakenhut, Florian, Fish, Paul V., Fray, M. Jonathan, Gurrell, Ian, Mills, James E., Stobie, Alan, Whitlock, Gavin A.
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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Journal Article