Structural Basis for Inhibition of Protein-tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics
Ala, Paul J., Gonneville, Lucie, Hillman, Milton C., Becker-Pasha, Mary, Wei, Min, Reid, Brian G., Klabe, Ronald, Yue, Eddy W., Wayland, Brian, Douty, Brent, Polam, Padmaja, Wasserman, Zelda, Bower, Michael, Combs, Andrew P., Burn, Timothy C., Hollis, Gregory F., Wynn, Richard
Published in The Journal of biological chemistry (27.10.2006)
Published in The Journal of biological chemistry (27.10.2006)
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Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines
Douty, Brent, Wayland, Brian, Ala, Paul J., Bower, Michael J., Pruitt, James, Bostrom, Lori, Wei, Min, Klabe, Ronald, Gonneville, Lucie, Wynn, Richard, Burn, Timothy C., Liu, Phillip C.C., Combs, Andrew P., Yue, Eddy W.
Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
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Structural Insights into the Design of Nonpeptidic Isothiazolidinone-containing Inhibitors of Protein-tyrosine Phosphatase 1B
Ala, Paul J., Gonneville, Lucie, Hillman, Milton, Becker-Pasha, Mary, Yue, Eddy W., Douty, Brent, Wayland, Brian, Polam, Padmaja, Crawley, Matthew L., McLaughlin, Erin, Sparks, Richard B., Glass, Brian, Takvorian, Amy, Combs, Andrew P., Burn, Timothy C., Hollis, Gregory F., Wynn, Richard
Published in The Journal of biological chemistry (08.12.2006)
Published in The Journal of biological chemistry (08.12.2006)
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Potent Benzimidazole Sulfonamide Protein Tyrosine Phosphatase 1B Inhibitors Containing the Heterocyclic (S)-Isothiazolidinone Phosphotyrosine Mimetic
Combs, Andrew P, Zhu, Wenyu, Crawley, Matthew L, Glass, Brian, Polam, Padmaja, Sparks, Richard B, Modi, Dilip, Takvorian, Amy, McLaughlin, Erin, Yue, Eddy W, Wasserman, Zelda, Bower, Michael, Wei, Min, Rupar, Mark, Ala, Paul J, Reid, Brian M, Ellis, Dawn, Gonneville, Lucie, Emm, Thomas, Taylor, Nancy, Yeleswaram, Swamy, Li, Yanlong, Wynn, Richard, Burn, Timothy C, Hollis, Gregory, Liu, Phillip C. C, Metcalf, Brian
Published in Journal of medicinal chemistry (29.06.2006)
Published in Journal of medicinal chemistry (29.06.2006)
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Structure-Based Design and Discovery of Protein Tyrosine Phosphatase Inhibitors Incorporating Novel Isothiazolidinone Heterocyclic Phosphotyrosine Mimetics
Combs, Andrew P, Yue, Eddy W, Bower, Michael, Ala, Paul J, Wayland, Brian, Douty, Brent, Takvorian, Amy, Polam, Padmaja, Wasserman, Zelda, Zhu, Wenyu, Crawley, Matthew L, Pruitt, James, Sparks, Richard, Glass, Brian, Modi, Dilip, McLaughlin, Erin, Bostrom, Lori, Li, Mei, Galya, Laurine, Blom, Karl, Hillman, Milton, Gonneville, Lucie, Reid, Brian G, Wei, Min, Becker-Pasha, Mary, Klabe, Ronald, Huber, Reid, Li, Yanlong, Hollis, Gregory, Burn, Timothy C, Wynn, Richard, Liu, Phillip, Metcalf, Brian
Published in Journal of medicinal chemistry (20.10.2005)
Published in Journal of medicinal chemistry (20.10.2005)
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Benzothiazole benzimidazole ( S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors
Sparks, Richard B., Polam, Padmaja, Zhu, Wenyu, Crawley, Matthew L., Takvorian, Amy, McLaughlin, Erin, Wei, Min, Ala, Paul J., Gonneville, Lucie, Taylor, Nancy, Li, Yanlong, Wynn, Richard, Burn, Timothy C., Liu, Phillip C.C., Combs, Andrew P.
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
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Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: Synthesis and structure–activity relationships of a peptide scaffold
Yue, Eddy W., Wayland, Brian, Douty, Brent, Crawley, Matthew L., McLaughlin, Erin, Takvorian, Amy, Wasserman, Zelda, Bower, Michael J., Wei, Min, Li, Yanlong, Ala, Paul J., Gonneville, Lucie, Wynn, Richard, Burn, Timothy C., Liu, Phillip C.C., Combs, Andrew P.
Published in Bioorganic & medicinal chemistry (01.09.2006)
Published in Bioorganic & medicinal chemistry (01.09.2006)
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Journal Article
Molecular Basis of HIV-1 Protease Drug Resistance: Structural Analysis of Mutant Proteases Complexed with Cyclic Urea Inhibitors
Ala, Paul J, Huston, Edward E, Klabe, Ronald M, McCabe, Denise D, Duke, Jodie L, Rizzo, Christopher J, Korant, Bruce D, DeLoskey, Richard J, Lam, Patrick Y. S, Hodge, C. Nicholas, Chang, Chong-Hwan
Published in Biochemistry (Easton) (18.02.1997)
Published in Biochemistry (Easton) (18.02.1997)
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Counteracting HIV-1 Protease Drug Resistance: Structural Analysis of Mutant Proteases Complexed with XV638 and SD146, Cyclic Urea Amides with Broad Specificities
Ala, Paul J, Huston, Edward E, Klabe, Ronald M, Jadhav, Prabhakar K, Lam, Patrick Y. S, Chang, Chong-Hwan
Published in Biochemistry (Easton) (27.10.1998)
Published in Biochemistry (Easton) (27.10.1998)
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Molecular Recognition of Cyclic Urea HIV-1 Protease Inhibitors
Ala, Paul J., DeLoskey, Richard J., Huston, Edward E., Jadhav, Prabhakar K., Lam, Patrick Y.S., Eyermann, Charles J., Hodge, C. Nicholas, Schadt, Margaret C., Lewandowski, Frank A., Weber, Patricia C., McCabe, Denise D., Duke, Jodie L., Chang, Chong-Hwan
Published in The Journal of biological chemistry (15.05.1998)
Published in The Journal of biological chemistry (15.05.1998)
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Journal Article
Molecular Basis of HIV-1 Protease Drug Resistance: Structural Analysis of Mutant Proteases Complexed with Cyclic Urea Inhibitors
Ala, Paul J, Huston, Edward E, Klabe, Ronald M, McCabe, Denise D, Duke, Jodie L, Rizzo, Christopher J, Korant, Bruce D, DeLoskey, Richard J, Lam, Patrick Y. S, Hodge, C. Nicholas, Chang, Chong-Hwan
Published in Biochemistry (Easton) (27.05.1997)
Published in Biochemistry (Easton) (27.05.1997)
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PYRIDOPYRIMIDINE AND PYRIMIDINOPYRIMIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEROF AS ANTIBACTERIALS HAVING DHFR INHIBITOR ACTIVITY
PEROLA, EMANUELA, MAGEE, ANDREW S, WILL, PAUL M, MARCHESE, SALVATORE A, MOE, SCOTT T, ALA, PAUL J, NAVIA, MANUEL A, GAZZANIGA, JOHN V, CLEMENT, JACOB J, FAERMAN, CARLOS
Year of Publication 02.05.2007
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Year of Publication 02.05.2007
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FUSED PYRIMIDINE DHFR INHIBITORS AS ANTIBACTERIALS
PEROLA, EMANUELA, MAGEE, ANDREW S, WILL, PAUL M, MARCHESE, SALVATORE A, MOE, SCOTT T, ALA, PAUL J, NAVIA, MANUEL A, GAZZANIGA, JOHN V, CLEMENT, JACOB J, FAERMAN, CARLOS
Year of Publication 17.08.2006
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Year of Publication 17.08.2006
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STRUCTURE-BASED DRUG DESIGN METHODS FOR IDENTIFYING D-ALA-D-ALA LIGASE INHIBITORS AS ANTIBACTERIAL DRUGS
FAERMAN, CARLOS H, PEROLA, EMANUELE, MAGEE, ANDREW S, MOE, SCOTT T, CONNELLY, PATRICK R, ALA, PAUL J, NAVIA, MANUEL A, GRIFFITH, JAMES P, ALA, JANID A
Year of Publication 17.08.2006
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Year of Publication 17.08.2006
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HETEROCYCLIC COMPOUNDS AND USES THEREOF AS D-ALANYL-D-ALANINE LIGASE INHIBITORS
MARCHESE SALVATORE A, WILL PAUL, PEROLA EMANUELE, ALI JANID A, MAGEE ANDREW S, ALA PAUL J, CLEMENT JACOB J, MOE SCOTT T, GAZZANIGA JOHN V, FARADAY CHRISTOPHER, FAERMAN CARLOS H, NAVIA MANUEL A, CONNELLY PATRICK R
Year of Publication 17.04.2008
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Year of Publication 17.04.2008
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Heterocyclic compounds and uses thereof as D-alanyl-D-alanine ligase inhibitors
Ala, Paul J, Ali, Janid A, Clement, Jacob J, Connelly, Patrick R, Faerman, Carlos H, Faraday, Christopher, Gazzaniga, John V, Magee, Andrew S, Marchese, Salvatore A, Moe, Scott T, Navia, Manuel A, Perola, Emanuele, Will, Paul
Year of Publication 18.03.2008
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Year of Publication 18.03.2008
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Heterocyclic compounds and uses thereof as D-alanyl-D-alanine ligase inhibitors
MARCHESE SALVATORE A, WILL PAUL, ALI JANID A, MAGEE ANDREW S, PEROLA EMANUELE, ALA PAUL J, CLEMENT JACOB J, MOE SCOTT T, FARADAY CHRISTOPHER, GAZZANIGA JOHN V, FAERMAN CARLOS H, CONNELLY PATRICK R, NAVIA MANUEL A
Year of Publication 18.03.2008
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Year of Publication 18.03.2008
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STRUCTURE-BASED DRUG DESIGN METHODS FOR IDENTIFYING D-ALA-D-ALA LIGASE INHIBITORS AS ANTIBACTERIAL DRUGS
FAERMAN, CARLOS H, PEROLA, EMANUELE, MAGEE, ANDREW S, NAVIA, MANUEL, MOE, SCOTT T, CONNELLY, PATRICK R, ALA, PAUL J, GRIFFITH, JAMES P, ALI, JANID A
Year of Publication 29.05.2006
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Year of Publication 29.05.2006
Patent