Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941
Junttila, Teemu T., Akita, Robert W., Parsons, Kathryn, Fields, Carter, Lewis Phillips, Gail D., Friedman, Lori S., Sampath, Deepak, Sliwkowski, Mark X.
Published in Cancer cell (05.05.2009)
Published in Cancer cell (05.05.2009)
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Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody-Drug Conjugates
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Published in Cancer research (Chicago, Ill.) (15.12.2017)
Published in Cancer research (Chicago, Ill.) (15.12.2017)
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High cell-surface density of HER2 deforms cell membranes
Chung, Inhee, Reichelt, Mike, Shao, Lily, Akita, Robert W, Koeppen, Hartmut, Rangell, Linda, Schaefer, Gabriele, Mellman, Ira, Sliwkowski, Mark X
Published in Nature communications (07.09.2016)
Published in Nature communications (07.09.2016)
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Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
Agus, David B, Akita, Robert W, Fox, William D, Lewis, Gail D, Higgins, Brian, Pisacane, Paul I, Lofgren, Julie A, Tindell, Charles, Evans, Douglas P, Maiese, Krista, Scher, Howard I, Sliwkowski, Mark X
Published in Cancer cell (01.08.2002)
Published in Cancer cell (01.08.2002)
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Erlotinib directly inhibits HER2 kinase activation and downstream signaling events in intact cells lacking epidermal growth factor receptor expression
SCHAEFER, Gabriele, LIHUA SHAO, TOTPAL, Klara, AKITA, Robert W
Published in Cancer research (Chicago, Ill.) (01.02.2007)
Published in Cancer research (Chicago, Ill.) (01.02.2007)
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Biologic effects of heregulin/neu differentiation factor on normal and malignant human breast and ovarian epithelial cells
AGUILAR, Z, AKITA, R. W, FINN, R. S, RAMOS, B. L, PEGRAM, M. D, KABBINAVAR, F. F, PIETRAS, R. J, PISACANE, P, SLIWKOWSKI, M. X, SLAMON, D. J
Published in Oncogene (28.10.1999)
Published in Oncogene (28.10.1999)
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Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941
Junttila, Teemu T., Akita, Robert W., Parsons, Kathryn, Fields, Carter, Lewis Phillips, Gail D., Friedman, Lori S., Sampath, Deepak, Sliwkowski, Mark X.
Published in Cancer cell (2011)
Published in Cancer cell (2011)
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Identification of heregulin, a specific activator of p185erbB2
HOLMES, W. E, SLIWKOWSKI, M. X, SHEPARD, M. H, KUANG, W.-J, WOOD, W. I, GOEDDEL, D. V, VANDLEN, R. L, AKITA, R. W, HENZEL, W. J, LEE, J, PARK, J. W, YANSURA, D, ABADI, N, RAAB, H, LEWIS, G. D
Published in Science (American Association for the Advancement of Science) (22.05.1992)
Published in Science (American Association for the Advancement of Science) (22.05.1992)
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Identification of Heregulin, a Specific Activator of p185$^{erB2}
Holmes, William E., Sliwkowski, Mark X., Akita, Robert W., Henzel, William J., Lee, James, Park, John W., Yansura, Daniel, Abadi, Nasrin, Raab, Helga, Lewis, Gail D., Shepard, H. Michael, Kuang, Wun-Jing, Wood, William I., Goeddel, David V., Vandlen, Richard L.
Published in Science (American Association for the Advancement of Science) (22.05.1992)
Published in Science (American Association for the Advancement of Science) (22.05.1992)
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A potential role for activated HER-2 in prostate cancer
Agus, D B, Akita, R W, Fox, W D, Lofgren, J A, Higgins, B, Maiese, K, Scher, H I, Sliwkowski, M X
Published in Seminars in oncology (01.12.2000)
Published in Seminars in oncology (01.12.2000)
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An antigen immunologically related to the external domain of gp185 is shed from nude mouse tumors overexpressing the c-erbB-2 (HER-2/neu) oncogene
Langton, B C, Crenshaw, M C, Chao, L A, Stuart, S G, Akita, R W, Jackson, J E
Published in Cancer research (Chicago, Ill.) (15.05.1991)
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Published in Cancer research (Chicago, Ill.) (15.05.1991)
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Identification of Heregulin, a Specific Activator of p185 erbB2
Holmes, William E., Sliwkowski, Mark X., Akita, Robert W., Henzel, William J., Lee, James, Park, John W., Yansura, Daniel, Abadi, Nasrin, Raab, Helga, Lewis, Gail D., Shepard, H. Michael, Kuang, Wun-Jing, Wood, William l., Goeddel, David V., Vandlen, Richard L.
Published in Science (American Association for the Advancement of Science) (22.05.1992)
Published in Science (American Association for the Advancement of Science) (22.05.1992)
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