Spatial control of EGF receptor activation by reversible dimerization on living cells
Chung, Inhee, Akita, Robert, Vandlen, Richard, Toomre, Derek, Schlessinger, Joseph, Mellman, Ira
Published in Nature (London) (01.04.2010)
Published in Nature (London) (01.04.2010)
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Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941
Junttila, Teemu T., Akita, Robert W., Parsons, Kathryn, Fields, Carter, Lewis Phillips, Gail D., Friedman, Lori S., Sampath, Deepak, Sliwkowski, Mark X.
Published in Cancer cell (05.05.2009)
Published in Cancer cell (05.05.2009)
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Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody-Drug Conjugates
Caculitan, Niña G, Dela Cruz Chuh, Josefa, Ma, Yong, Zhang, Donglu, Kozak, Katherine R, Liu, Yichin, Pillow, Thomas H, Sadowsky, Jack, Cheung, Tommy K, Phung, Qui, Haley, Benjamin, Lee, Byoung-Chul, Akita, Robert W, Sliwkowski, Mark X, Polson, Andrew G
Published in Cancer research (Chicago, Ill.) (15.12.2017)
Published in Cancer research (Chicago, Ill.) (15.12.2017)
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High cell-surface density of HER2 deforms cell membranes
Chung, Inhee, Reichelt, Mike, Shao, Lily, Akita, Robert W., Koeppen, Hartmut, Rangell, Linda, Schaefer, Gabriele, Mellman, Ira, Sliwkowski, Mark X.
Published in Nature communications (07.09.2016)
Published in Nature communications (07.09.2016)
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Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
Agus, David B, Akita, Robert W, Fox, William D, Lewis, Gail D, Higgins, Brian, Pisacane, Paul I, Lofgren, Julie A, Tindell, Charles, Evans, Douglas P, Maiese, Krista, Scher, Howard I, Sliwkowski, Mark X
Published in Cancer cell (01.08.2002)
Published in Cancer cell (01.08.2002)
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Erlotinib directly inhibits HER2 kinase activation and downstream signaling events in intact cells lacking epidermal growth factor receptor expression
SCHAEFER, Gabriele, LIHUA SHAO, TOTPAL, Klara, AKITA, Robert W
Published in Cancer research (Chicago, Ill.) (01.02.2007)
Published in Cancer research (Chicago, Ill.) (01.02.2007)
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Neuregulin-3 (NRG3): A Novel Neural Tissue-Enriched Protein that Binds and Activates ErbB4
Zhang, Dongxiao, Sliwkowski, Mark X., Mark, Melanie, Frantz, Gretchen, Akita, Robert, Sun, Yang, Hillan, Kenneth, Crowley, Craig, Brush, Jennifer, Godowski, Paul J.
Published in Proceedings of the National Academy of Sciences - PNAS (02.09.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (02.09.1997)
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Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941
Junttila, Teemu T., Akita, Robert W., Parsons, Kathryn, Fields, Carter, Lewis Phillips, Gail D., Friedman, Lori S., Sampath, Deepak, Sliwkowski, Mark X.
Published in Cancer cell (2011)
Published in Cancer cell (2011)
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Biologic effects of heregulin/neu differentiation factor on normal and malignant human breast and ovarian epithelial cells
AGUILAR, Z, AKITA, R. W, FINN, R. S, RAMOS, B. L, PEGRAM, M. D, KABBINAVAR, F. F, PIETRAS, R. J, PISACANE, P, SLIWKOWSKI, M. X, SLAMON, D. J
Published in Oncogene (28.10.1999)
Published in Oncogene (28.10.1999)
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Identification of heregulin, a specific activator of p185erbB2
HOLMES, W. E, SLIWKOWSKI, M. X, SHEPARD, M. H, KUANG, W.-J, WOOD, W. I, GOEDDEL, D. V, VANDLEN, R. L, AKITA, R. W, HENZEL, W. J, LEE, J, PARK, J. W, YANSURA, D, ABADI, N, RAAB, H, LEWIS, G. D
Published in Science (American Association for the Advancement of Science) (22.05.1992)
Published in Science (American Association for the Advancement of Science) (22.05.1992)
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The Nature of Constitutive Activation of HER2 at the Single Molecule Level
Chung, Inhee, Akita, Robert, Shao, Lily, Schaefer, Gabriele, Sliwkowski, Mark, Mellman, Ira
Published in Biophysical journal (31.01.2012)
Published in Biophysical journal (31.01.2012)
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Identification of Heregulin, a Specific Activator of p185$^{erB2}
Holmes, William E., Sliwkowski, Mark X., Akita, Robert W., Henzel, William J., Lee, James, Park, John W., Yansura, Daniel, Abadi, Nasrin, Raab, Helga, Lewis, Gail D., Shepard, H. Michael, Kuang, Wun-Jing, Wood, William I., Goeddel, David V., Vandlen, Richard L.
Published in Science (American Association for the Advancement of Science) (22.05.1992)
Published in Science (American Association for the Advancement of Science) (22.05.1992)
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Her-2/neu expression in node-negative breast cancer: direct tissue quantitation by computerized image analysis and association of overexpression with increased risk of recurrent disease
Press, M F, Pike, M C, Chazin, V R, Hung, G, Udove, J A, Markowicz, M, Danyluk, J, Godolphin, W, Sliwkowski, M, Akita, R
Published in Cancer research (Chicago, Ill.) (15.10.1993)
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Published in Cancer research (Chicago, Ill.) (15.10.1993)
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The erbB3 gene product is a receptor for heregulin
K L Carraway, 3rd, M X Sliwkowski, R Akita, J V Platko, P M Guy, A Nuijens, A J Diamonti, R L Vandlen, L C Cantley, R A Cerione
Published in The Journal of biological chemistry (13.05.1994)
Published in The Journal of biological chemistry (13.05.1994)
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