An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
Schlepckow, Kai, Kleinberger, Gernot, Fukumori, Akio, Feederle, Regina, Lichtenthaler, Stefan F, Steiner, Harald, Haass, Christian
Published in EMBO molecular medicine (01.10.2017)
Published in EMBO molecular medicine (01.10.2017)
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Journal Article
Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
Steiner, Harald, Fukumori, Akio, Tagami, Shinji, Okochi, Masayasu
Published in Cell Stress (28.10.2018)
Published in Cell Stress (28.10.2018)
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Journal Article
Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis
Mentrup, Torben, Theodorou, Kosta, Cabrera-Cabrera, Florencia, Helbig, Andreas O, Happ, Kathrin, Gijbels, Marion, Gradtke, Ann-Christine, Rabe, Björn, Fukumori, Akio, Steiner, Harald, Tholey, Andreas, Fluhrer, Regina, Donners, Marjo, Schröder, Bernd
Published in The Journal of experimental medicine (01.04.2019)
Published in The Journal of experimental medicine (01.04.2019)
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Journal Article
Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation
Voss, Matthias, Künzel, Ulrike, Higel, Fabian, Kuhn, Peer-Hendrik, Colombo, Alessio, Fukumori, Akio, Haug-Kröper, Martina, Klier, Bärbel, Grammer, Gudula, Seidl, Andreas, Schröder, Bernd, Obst, Reinhard, Steiner, Harald, Lichtenthaler, Stefan F, Haass, Christian, Fluhrer, Regina
Published in The EMBO journal (17.12.2014)
Published in The EMBO journal (17.12.2014)
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Journal Article
Semagacestat Is a Pseudo-Inhibitor of γ-Secretase
Tagami, Shinji, Yanagida, Kanta, Kodama, Takashi S., Takami, Mako, Mizuta, Naoki, Oyama, Hiroshi, Nishitomi, Kouhei, Chiu, Yu-wen, Okamoto, Toru, Ikeuchi, Takeshi, Sakaguchi, Gaku, Kudo, Takashi, Matsuura, Yoshiharu, Fukumori, Akio, Takeda, Masatoshi, Ihara, Yasuo, Okochi, Masayasu
Published in Cell reports (Cambridge) (03.10.2017)
Published in Cell reports (Cambridge) (03.10.2017)
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Deletion of B-cell translocation gene 2 (BTG2) alters the responses of glial cells in white matter to chronic cerebral hypoperfusion
Suzuki, Kaoru, Shinohara, Mitsuru, Uno, Yoshihiro, Tashiro, Yoshitaka, Gheni, Ghupurjan, Yamamoto, Miho, Fukumori, Akio, Shindo, Akihiko, Mashimo, Tomoji, Tomimoto, Hidekazu, Sato, Naoyuki
Published in Journal of neuroinflammation (03.04.2021)
Published in Journal of neuroinflammation (03.04.2021)
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Journal Article
Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease
Kretner, Benedikt, Trambauer, Johannes, Fukumori, Akio, Mielke, Janina, Kuhn, Peer‐Hendrik, Kremmer, Elisabeth, Giese, Armin, Lichtenthaler, Stefan F, Haass, Christian, Arzberger, Thomas, Steiner, Harald
Published in EMBO molecular medicine (01.05.2016)
Published in EMBO molecular medicine (01.05.2016)
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Journal Article
APLP2 is predominantly cleaved by β‐secretase and γ‐secretase in the human brain
Yanagida, Kanta, Maruyama, Riki, Tagami, Shinji, Kudo, Takashi, Okochi, Masayasu, Fukumori, Akio
Published in Psychogeriatrics (01.03.2023)
Published in Psychogeriatrics (01.03.2023)
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Journal Article
Two Neuropsychiatric Cases Seropositive for Bornavirus Improved by Ribavirin
Matsunaga, Hidenori, Fukumori, Akio, Mori, Kohji, Honda, Tomoyuki, Uema, Takeshi, Tomonaga, Keizo
Published in Japanese Journal of Infectious Diseases (30.09.2018)
Published in Japanese Journal of Infectious Diseases (30.09.2018)
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Journal Article
Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases
Fleck, Daniel, Voss, Matthias, Brankatschk, Ben, Giudici, Camilla, Hampel, Heike, Schwenk, Benjamin, Edbauer, Dieter, Fukumori, Akio, Steiner, Harald, Kremmer, Elisabeth, Haug-Kröper, Martina, Rossner, Moritz J., Fluhrer, Regina, Willem, Michael, Haass, Christian
Published in The Journal of biological chemistry (01.01.2016)
Published in The Journal of biological chemistry (01.01.2016)
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Journal Article
The Yeast ER-Intramembrane Protease Ypf1 Refines Nutrient Sensing by Regulating Transporter Abundance
Avci, Dönem, Fuchs, Shai, Schrul, Bianca, Fukumori, Akio, Breker, Michal, Frumkin, Idan, Chen, Chia-yi, Biniossek, Martin L., Kremmer, Elisabeth, Schilling, Oliver, Steiner, Harald, Schuldiner, Maya, Lemberg, Marius K.
Published in Molecular cell (04.12.2014)
Published in Molecular cell (04.12.2014)
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Journal Article
Ribavirin Treatment for Severe Schizophrenia with Anti-Borna Disease Virus 1 Antibodies 30 Years after Onset
Matsunaga, Hidenori, Fukumori, Akio, Mori, Kohji, Morihara, Takashi, Sato, Shunsuke, Kitauchi, Kyoko, Yanagida, Kanta, Taguchi, Kazumi, Honda, Tomoyuki, Tomonaga, Keizo
Published in Case reports in psychiatry (2023)
Published in Case reports in psychiatry (2023)
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Journal Article
Data Science for QSAR for Protease activity
Ueda, Hideki, Fukumori, Akio, Koge, Daiki, Ono, Naoaki, Altaf-Ul-Amin, Md, Kanaya, Shigehiko
Published in Journal of Computer Aided Chemistry (2023)
Published in Journal of Computer Aided Chemistry (2023)
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Journal Article
Regulation of Notch Signaling by Dynamic Changes in the Precision of S3 Cleavage of Notch-1
Tagami, Shinji, Okochi, Masayasu, Yanagida, Kanta, Ikuta, Akiko, Fukumori, Akio, Matsumoto, Naohiko, Ishizuka-Katsura, Yoshiko, Nakayama, Taisuke, Itoh, Naohiro, Jiang, Jingwei, Nishitomi, Kouhei, Kamino, Kouzin, Morihara, Takashi, Hashimoto, Ryota, Tanaka, Toshihisa, Kudo, Takashi, Chiba, Shigeru, Takeda, Masatoshi
Published in Molecular and Cellular Biology (01.01.2008)
Published in Molecular and Cellular Biology (01.01.2008)
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Journal Article
Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM
Hachmeister, Matthias, Bobowski, Karolina D, Hogl, Sebastian, Dislich, Bastian, Fukumori, Akio, Eggert, Carola, Mack, Brigitte, Kremling, Heidi, Sarrach, Sannia, Coscia, Fabian, Zimmermann, Wolfgang, Steiner, Harald, Lichtenthaler, Stefan F, Gires, Olivier
Published in PloS one (29.08.2013)
Published in PloS one (29.08.2013)
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Journal Article
Upregulated expression of a subset of genes in APP;ob/ob mice: Evidence of an interaction between diabetes‐linked obesity and Alzheimer’s disease
Shinohara, Mitsuru, Kikuchi, Masataka, Onishi‐Takeya, Miyuki, Tashiro, Yoshitaka, Suzuki, Kaoru, Noda, Yasuhiro, Takeda, Shuko, Mukouzono, Masahiro, Nagano, Seiichi, Fukumori, Akio, Morishita, Ryuichi, Nakaya, Akihiro, Sato, Naoyuki
Published in FASEB bioAdvances (01.05.2021)
Published in FASEB bioAdvances (01.05.2021)
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Journal Article
Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs
Sato, Naoyuki, Okochi, Masayasu, Shinohara, Mitsuru, Thinakaran, Gopal, Takeda, Shuko, Fukumori, Akio, Shinohara-Noma, Motoko, Mori-Ueda, Mari, Hamada, Hizuki, Takeda, Masatoshi, Rakugi, Hiromi, Morishita, Ryuichi
Published in PloS one (12.11.2012)
Published in PloS one (12.11.2012)
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