The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells
Wang, Xin, Mazurkiewicz, Magdalena, Hillert, Ellin-Kristina, Olofsson, Maria Hägg, Pierrou, Stefan, Hillertz, Per, Gullbo, Joachim, Selvaraju, Karthik, Paulus, Aneel, Akhtar, Sharoon, Bossler, Felicitas, Khan, Asher Chanan, Linder, Stig, D’Arcy, Padraig
Published in Scientific reports (06.06.2016)
Published in Scientific reports (06.06.2016)
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Journal Article
Immunophenotyping of Waldenströms macroglobulinemia cell lines reveals distinct patterns of surface antigen expression: potential biological and therapeutic implications
Paulus, Aneel, Chitta, Kasyapa S, Wallace, Paul K, Advani, Pooja P, Akhtar, Sharoon, Kuranz-Blake, Maja, Ailawadhi, Sikander, Chanan-Khan, Asher A
Published in PloS one (08.04.2015)
Published in PloS one (08.04.2015)
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Journal Article
Developing a recombinant expression system for human serine protease PRSS23
Akhtar, Sharoon, Hockla, Alex, Coban, Matt, Radisky, Evette
Published in The FASEB journal (01.05.2022)
Published in The FASEB journal (01.05.2022)
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Journal Article
Abstract 1734 Investigating the catalytic activity of PRSS23 as a novel serine protease in ovarian cancer
Akhtar, Sharoon, Ilic, Stefan, Coban, Matt, Hockla, Alexandra, Gokara, Mahesh, Papo, Niv, Radisky, Evette
Published in The Journal of biological chemistry (01.03.2024)
Published in The Journal of biological chemistry (01.03.2024)
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Journal Article
Targeting CD38 Enhances the Antileukemic Activity of Ibrutinib in Chronic Lymphocytic Leukemia
Manna, Alak, Aulakh, Sonikpreet, Jani, Prachi, Ahmed, Salman, Akhtar, Sharoon, Coignet, Marie, Heckman, Michael, Meghji, Zahara, Bhatia, Kirtipal, Sharma, Aarushi, Sher, Taimur, Alegria, Victoria, Malavasi, Fabio, Chini, Eduardo N, Chanan-Khan, Asher, Ailawadhi, Sikander, Paulus, Aneel
Published in Clinical cancer research (01.07.2019)
Published in Clinical cancer research (01.07.2019)
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Journal Article
PSMB9 Mediates Resistance to Bortezomib in Multiple Myeloma
Paulus, Aneel, Akhtar, Sharoon, Caulfield, Thomas, Manna, Alak, Roy, Vivek, Ailawadhi, Sikander, Chanan-Khan, Asher A.
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Comparative Analysis on the Anti-Tumor Activity of Venetoclax and Obinutuzumab (VO) Versus Venetoclax and Rituximab (VR) in Primary CLL Cells, Ex Vivo
Iqbal, Madiha, Sharma, Aarushi, Manna, Alak, Akhtar, Sharoon, Sher, Taimur, Chanan-Khan, Asher A., Ailawadhi, Sikander, Paulus, Aneel
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Novel tumor-targeted liposomes comprised of an MDM2 antagonist plus proteasome inhibitor display anti-tumor activity in a xenograft model of bortezomib-resistant Waldenstrom macroglobulinemia
Madamsetty, Vijay Sagar, Paulus, Aneel, Akhtar, Sharoon, Manna, Alak, Rachamalla, Harikrishna Reddy, Banerjee, RajKumar, Mukhopadhyay, Debabrata, Chanan-Khan, Asher
Published in Leukemia & lymphoma (23.08.2020)
Published in Leukemia & lymphoma (23.08.2020)
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Journal Article
Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenstroom macroglobulinaemia tumour cells
Chitta, K, Paulus, A, Akhtar, S, Blake, MKK, Caulfield, TR, Novak, AJ, Ansell, SM, Advani, P, Ailawadhi, S, Sher, T
Published in British journal of haematology (01.05.2015)
Published in British journal of haematology (01.05.2015)
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Journal Article
Targeting CD38 with daratumumab is lethal to Waldenström macroglobulinaemia cells
Paulus, Aneel, Manna, Alak, Akhtar, Sharoon, Paulus, Shumail M., Sharma, Mayank, Coignet, Marie V., Jiang, Liuyan, Roy, Vivek, Witzig, Thomas E., Ansell, Stephen M., Allan, John, Furman, Richard, Aulakh, Sonikpreet, Manochakian, Rami, Ailawadhi, Sikander, Chanan‐Khan, Asher A., Sher, Taimur
Published in British journal of haematology (01.10.2018)
Published in British journal of haematology (01.10.2018)
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Journal Article
Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells
Chitta, Kasyapa, Paulus, Aneel, Akhtar, Sharoon, Blake, Maja Kristin K., Caulfield, Thomas R., Novak, Anne J., Ansell, Stephen M., Advani, Pooja, Ailawadhi, Sikander, Sher, Taimur, Linder, Stig, Chanan‐Khan, Asher
Published in British journal of haematology (01.05.2015)
Published in British journal of haematology (01.05.2015)
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Journal Article
Targeting Bcl-2 Enhances the Anti-Tumor Effects of Lenalidomide and Dexamethasone in in Vitro and In Vivo Models of Multiple Myeloma
Paulus, Aneel, Akhtar, Sharoon, Bashir, Yamima, Paulus, Shumail M., Menghani, Richa, Roy, Vivek, Ailawadhi, Sikander, Chanan-Khan, Asher A.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
Targeting CD38 with Daratumumab Suppresses B-Cell Receptor Signaling and Enhances the Activity of Ibrutinib in Waldenstrom Macroglobulinemia Cells
Paulus, Aneel, Manna, Alak, Akhtar, Sharoon, Sher, Taimur, Roy, Vivek, Coleman, Morton, Novak, Anne J, Ansell, Stephen M, Malavasi, Fabio, Ailawadhi, Sikander, Chanan-Khan, Asher A.
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Molecular architecture simulation and reverse engineering techniques to uncover clinically applicable novel therapeutic targets in B-lymphoma cells
Paulus, Aneel, Akhtar, Sharoon, Kumar, Ansu, Singh, Neeraj, Vali, Shireen, Abbasi, Taher, Ailawadhi, Sikander, Chanan-Khan, Asher
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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Journal Article
Drug Resistance Alters CD38 Expression and in Vitro Response to Daratumumab in Waldenstrom Macroglobulinemia Cells
Paulus, Aneel, Akhtar, Sharoon, Bashir, Yamima, Paulus, Shumail M., Yousaf, Hassan, Roy, Vivek, Ailawadhi, Sikander, Ansell, Stephen, Witzig, Thomas E., Chanan-Khan, Asher A.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
Daratumumab Decreases Treg-Mediated Immunosuppression and Potentiates CD8+ T-Cell-Induced Killing of Chronic Lymphocytic Leukemia (CLL) Cells Ex Vivo
Manna, Alak, Akhtar, Sharoon, Yi, Paul, Parikh, Sameer A., Ding, Wei, Leis, Jose F., Alegria, Victoria R., Sher, Taimur, Malavasi, Fabio, Ailawadhi, Sikander, Chanan-Khan, Asher A., Paulus, Aneel
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Daratumumab Mitigates B-Cell Receptor Signaling and Enhances Antitumor Activity of Ibrutinib in Chronic Lymphocytic Leukemia (CLL) Cells
Manna, Alak, Akhtar, Sharoon, Meghji, Zahara, Bhatia, Kirtipal, Yi, Paul, Parikh, Sameer A., Ding, Wei, Leis, Jose F., Sher, Taimur, Malavasi, Fabio, Alegria, Victoria R., Ailawadhi, Sikander, Chanan-Khan, Asher A., Paulus, Aneel
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
The Oral Proteasome Inhibitor Ixazomib, Alone and in Combination with Ibrutinib, Induces Lethality in Waldenstrom Macroglobulinemia Cells That Are Resistant to Ibrutinib
Paulus, Aneel, Manna, Alak, Akhtar, Sharoon, Singh, Neeraj Kumar, Kumar, Ansu, Basu, Kabya, Trivedi, Akshita, Majumdar, Debapriya, Abbasi, Taher, Vali, Shireen, Roy, Vivek, Martin, Peter, Coleman, Morton, Novak, Anne J, Ansell, Stephen M, Ailawadhi, Sikander, Chanan-Khan, Asher A.
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
AT‐101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia
Paulus, Aneel, Chitta, Kasyapa, Akhtar, Sharoon, Personett, David, Miller, Kena C., Thompson, Kevin J., Carr, Jennifer, Kumar, Shaji, Roy, Vivek, Ansell, Stephen M., Mikhael, Joseph R., Dispenzieri, Angela, Reeder, Craig B., Rivera, Candido E., Foran, James, Chanan‐Khan, Asher
Published in British journal of haematology (01.02.2014)
Published in British journal of haematology (01.02.2014)
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