Clinical implications of heterogeneity in PD-L1 immunohistochemical detection in hepatocellular carcinoma: the Blueprint-HCC study
Pinato, David J., Mauri, Francesco A., Spina, Paolo, Cain, Owen, Siddique, Abdul, Goldin, Robert, Victor, Stephane, Pizio, Corinna, Akarca, Ayse U., Boldorini, Renzo L., Mazzucchelli, Luca, Black, James R. M., Shetty, Shishir, Marafioti, Teresa, Sharma, Rohini
Published in British journal of cancer (01.05.2019)
Published in British journal of cancer (01.05.2019)
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Trans-arterial chemoembolization as a loco-regional inducer of immunogenic cell death in hepatocellular carcinoma: implications for immunotherapy
Pinato, David J., Murray, Sam M, Forner, Alejandro, Kaneko, Takahiro, Fessas, Petros, Toniutto, Pierluigi, Mínguez, Beatriz, Cacciato, Valentina, Avellini, Claudio, Diaz, Alba, Boyton, Rosemary J., Altmann, Daniel M., Goldin, Robert D, Akarca, Ayse U, Marafioti, Teresa, Mauri, Francesco A, Casagrande, Edoardo, Grillo, Federica, Giannini, Edoardo, Bhoori, Sherrie, Mazzaferro, Vincenzo
Published in Journal for immunotherapy of cancer (01.09.2021)
Published in Journal for immunotherapy of cancer (01.09.2021)
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Programmed Cell Death Ligand Expression Drives Immune Tolerogenesis across the Diverse Subtypes of Neuroendocrine Tumours
Pinato, David J, Vallipuram, Anu, Evans, Joanne S, Wong, Clement, Zhang, Hua, Brown, Matthew, Dina, Roberto E, Trivedi, Pritesh, Akarca, Ayse U, Marafioti, Teresa, Mauri, Francesco A, Sharma, Rohini
Published in Neuroendocrinology (01.05.2021)
Published in Neuroendocrinology (01.05.2021)
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ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies
Flynn, Michael J, Zammarchi, Francesca, Tyrer, Peter C, Akarca, Ayse U, Janghra, Narinder, Britten, Charles E, Havenith, Carin E G, Levy, Jean-Noel, Tiberghien, Arnaud, Masterson, Luke A, Barry, Conor, D'Hooge, Francois, Marafioti, Teresa, Parren, Paul W H I, Williams, David G, Howard, Philip W, van Berkel, Patrick H, Hartley, John A
Published in Molecular cancer therapeutics (01.11.2016)
Published in Molecular cancer therapeutics (01.11.2016)
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Journal Article
CD47 expression in acute myeloid leukemia varies according to genotype
Marra, Andrea, Akarca, Ayse U, Martino, Giovanni, Ramsay, Alan, Ascani, Stefano, Perriello, Vincenzo Maria, O'Nions, Jenny, Wilson, Andrew J, Gupta, Rajeev, Childerhouse, Anna, Proctor, Ian, Rodriguez-Justo, Manuel, Pomplun, Sabine, Martelli, Maria Paola, Lo Celso, Cristina, Falini, Brunangelo, Marafioti, Teresa
Published in Haematologica (Roma) (01.12.2023)
Published in Haematologica (Roma) (01.12.2023)
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Phenotyping of lymphoproliferative tumours generated in xenografts of non-small cell lung cancer
Pearce, David R, Akarca, Ayse U, De Maeyer, Roel P H, Kostina, Emily, Huebner, Ariana, Sivakumar, Monica, Karasaki, Takahiro, Shah, Kavina, Janes, Sam M, McGranahan, Nicholas, Reddy, Venkat, Akbar, Arne N, Moore, David A, Marafioti, Teresa, Swanton, Charles, Hynds, Robert E
Published in Frontiers in oncology (05.06.2023)
Published in Frontiers in oncology (05.06.2023)
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Journal Article
Microenvironmental immune cell alterations across the spectrum of nodular lymphocyte predominant Hodgkin lymphoma and T-cell/histiocyte-rich large B-cell lymphoma
Panayi, Christos, Akarca, Ayse U., Ramsay, Alan D., Shankar, Ananth G., Falini, Brunangelo, Piris, Miguel A., Linch, David, Marafioti, Teresa
Published in Frontiers in oncology (03.10.2023)
Published in Frontiers in oncology (03.10.2023)
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Journal Article
Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA
Kato, Itaru, Nishinaka, Yoko, Nakamura, Masahiro, Akarca, Ayse U., Niwa, Akira, Ozawa, Hiroki, Yoshida, Kenichi, Mori, Makiko, Wang, Dapeng, Morita, Makiko, Ueno, Hiroo, Shiozawa, Yusuke, Shiraishi, Yuichi, Miyano, Satoru, Gupta, Rajeev, Umeda, Katsutsugu, Watanabe, Kenichiro, Koh, Katsuyoshi, Adachi, Souichi, Heike, Toshio, Saito, Megumu K., Sanada, Masashi, Ogawa, Seishi, Marafioti, Teresa, Watanabe, Akira, Nakahata, Tatsutoshi, Enver, Tariq
Published in Blood (08.06.2017)
Published in Blood (08.06.2017)
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Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program
Granai, Massimo, Mundo, Lucia, Akarca, Ayse U, Siciliano, Maria Chiara, Rizvi, Hasan, Mancini, Virginia, Onyango, Noel, Nyagol, Joshua, Abinya, Nicholas Othieno, Maha, Ibrahim, Margielewska, Sandra, Wi, Wenbin, Bibas, Michele, Piccaluga, Pier Paolo, Quintanilla-Martinez, Leticia, Fend, Falko, Lazzi, Stefano, Leoncini, Lorenzo, Marafioti, Teresa
Published in Infectious agents and cancer (06.05.2020)
Published in Infectious agents and cancer (06.05.2020)
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Journal Article
Transcriptional analysis of multiple ovarian cancer cohorts reveals prognostic and immunomodulatory consequences of ERV expression
Natoli, Marina, Gallon, John, Lu, Haonan, Amgheib, Ala, Pinato, David J, Mauri, Francesco A, Marafioti, Teresa, Akarca, Ayse U, Ullmo, Ines, Ip, Jacey, Aboagye, Eric O, Brown, Robert, Karadimitris, Anastasios, Ghaem-Maghami, Sadaf
Published in Journal for immunotherapy of cancer (01.01.2021)
Published in Journal for immunotherapy of cancer (01.01.2021)
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Integrated phenotyping of the anti-cancer immune response in HIV-associated hepatocellular carcinoma
Pinato, David J., Kaneko, Takahiro, D’Alessio, Antonio, Forner, Alejandro, Fessas, Petros, Minguez, Beatriz, Giannini, Edoardo G., Grillo, Federica, Díaz, Alba, Mauri, Francesco A., Fulgenzi, Claudia A.M., Dalla Pria, Alessia, Goldin, Robert D., Pieri, Giulia, Toniutto, Pierluigi, Avellini, Claudio, Plaz Torres, Maria Corina, Akarca, Ayse U., Marafioti, Teresa, Bhoori, Sherrie, Miró, Jose María, Bower, Mark, Bräu, Norbert, Mazzaferro, Vincenzo
Published in JHEP reports (01.07.2023)
Published in JHEP reports (01.07.2023)
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Journal Article
Correction to: Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program
Granai, Massimo, Mundo, Lucia, Akarca, Ayse U, Siciliano, Maria Chiara, Rizvi, Hasan, Mancini, Virginia, Onyango, Noel, Nyagol, Joshua, Abinya, Nicholas Othieno, Maha, Ibrahim, Margielewska, Sandra, Wei, Wenbin, Bibas, Michele, Piccaluga, Pier Paolo, Quintanilla-Martinez, Leticia, Fend, Falko, Lazzi, Stefano, Leoncini, Lorenzo, Marafioti, Teresa
Published in Infectious agents and cancer (10.06.2020)
Published in Infectious agents and cancer (10.06.2020)
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Journal Article
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
McGranahan, Nicholas, Furness, Andrew J. S., Rosenthal, Rachel, Ramskov, Sofie, Lyngaa, Rikke, Saini, Sunil Kumar, Jamal-Hanjani, Mariam, Wilson, Gareth A., Birkbak, Nicolai J., Hiley, Crispin T., Watkins, Thomas B. K., Shafi, Seema, Murugaesu, Nirupa, Mitter, Richard, Akarca, Ayse U., Linares, Joseph, Marafioti, Teresa, Henry, Jake Y., Van Allen, Eliezer M., Miao, Diana, Schilling, Bastian, Schadendorf, Dirk, Garraway, Levi A., Makarov, Vladimir, Rizvi, Naiyer A., Snyder, Alexandra, Hellmann, Matthew D., Merghoub, Taha, Wolchok, Jedd D., Shukla, Sachet A., Wu, Catherine J., Peggs, Karl S., Chan, Timothy A., Hadrup, Sine R., Quezada, Sergio A., Swanton, Charles
Published in Science (American Association for the Advancement of Science) (25.03.2016)
Published in Science (American Association for the Advancement of Science) (25.03.2016)
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Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies
Maciocia, Paul M, Wawrzyniecka, Patrycja A, Philip, Brian, Ricciardelli, Ida, Akarca, Ayse U, Onuoha, Shimobi C, Legut, Mateusz, Cole, David K, Sewell, Andrew K, Gritti, Giuseppe, Somja, Joan, Piris, Miguel A, Peggs, Karl S, Linch, David C, Marafioti, Teresa, Pule, Martin A
Published in Nature medicine (01.12.2017)
Published in Nature medicine (01.12.2017)
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Journal Article
Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells
Śledzińska, Anna, Vila de Mucha, Maria, Bergerhoff, Katharina, Hotblack, Alastair, Demane, Dafne Franz, Ghorani, Ehsan, Akarca, Ayse U., Marzolini, Maria A.V., Solomon, Isabelle, Vargas, Frederick Arce, Pule, Martin, Ono, Masahiro, Seddon, Benedict, Kassiotis, George, Ariyan, Charlotte E., Korn, Thomas, Marafioti, Teresa, Lord, Graham M., Stauss, Hans, Jenner, Richard G., Peggs, Karl S., Quezada, Sergio A.
Published in Immunity (Cambridge, Mass.) (14.01.2020)
Published in Immunity (Cambridge, Mass.) (14.01.2020)
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Journal Article
Antitumor activity without on-target off-tumor toxicity of GD2-chimeric antigen receptor T cells in patients with neuroblastoma
Straathof, Karin, Flutter, Barry, Wallace, Rebecca, Jain, Neha, Loka, Thalia, Depani, Sarita, Wright, Gary, Thomas, Simon, Cheung, Gordon Weng-Kit, Gileadi, Talia, Stafford, Sian, Kokalaki, Evangelia, Barton, Jack, Marriott, Clare, Rampling, Dyanne, Ogunbiyi, Olumide, Akarca, Ayse U, Marafioti, Teresa, Inglott, Sarah, Gilmour, Kimberly, Al-Hajj, Muhammad, Day, William, McHugh, Kieran, Biassoni, Lorenzo, Sizer, Natalie, Barton, Claire, Edwards, David, Dragoni, Ilaria, Silvester, Julie, Dyer, Karen, Traub, Stephanie, Elson, Lily, Brook, Sue, Westwood, Nigel, Robson, Lesley, Bedi, Ami, Howe, Karen, Barry, Ailish, Duncan, Catriona, Barone, Giuseppe, Pule, Martin, Anderson, John
Published in Science translational medicine (25.11.2020)
Published in Science translational medicine (25.11.2020)
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Immune Surveillance in Clinical Regression of Preinvasive Squamous Cell Lung Cancer
Pennycuick, Adam, Teixeira, Vitor H, AbdulJabbar, Khalid, Raza, Shan E Ahmed, Lund, Tom, Akarca, Ayse U, Rosenthal, Rachel, Kalinke, Lukas, Chandrasekharan, Deepak P, Pipinikas, Christodoulos P, Lee-Six, Henry, Hynds, Robert E, Gowers, Kate H C, Henry, Jake Y, Millar, Fraser R, Hagos, Yeman B, Denais, Celine, Falzon, Mary, Moore, David A, Antoniou, Sophia, Durrenberger, Pascal F, Furness, Andrew J, Carroll, Bernadette, Marceaux, Claire, Asselin-Labat, Marie-Liesse, Larson, William, Betts, Courtney, Coussens, Lisa M, Thakrar, Ricky M, George, Jeremy, Swanton, Charles, Thirlwell, Christina, Campbell, Peter J, Marafioti, Teresa, Yuan, Yinyin, Quezada, Sergio A, McGranahan, Nicholas, Janes, Sam M
Published in Cancer discovery (01.10.2020)
Published in Cancer discovery (01.10.2020)
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CD25-T reg -depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity
Solomon, Isabelle, Amann, Maria, Goubier, Anne, Arce Vargas, Frederick, Zervas, Dimitrios, Qing, Chen, Henry, Jake Y, Ghorani, Ehsan, Akarca, Ayse U, Marafioti, Teresa, Śledzińska, Anna, Werner Sunderland, Mariana, Franz Demane, Dafne, Clancy, Joanne Ruth, Georgiou, Andrew, Salimu, Josephine, Merchiers, Pascal, Brown, Mark Adrian, Flury, Reto, Eckmann, Jan, Murgia, Claudio, Sam, Johannes, Jacobsen, Bjoern, Marrer-Berger, Estelle, Boetsch, Christophe, Belli, Sara, Leibrock, Lea, Benz, Joerg, Koll, Hans, Sutmuller, Roger, Peggs, Karl S, Quezada, Sergio A
Published in Nature cancer (01.12.2020)
Published in Nature cancer (01.12.2020)
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Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature
Ingelfinger, Florian, Krishnarajah, Sinduya, Kramer, Michael, Utz, Sebastian G., Galli, Edoardo, Lutz, Mirjam, Zwicky, Pascale, Akarca, Ayse U., Jurado, Nicole Puertas, Ulutekin, Can, Bamert, David, Widmer, Corinne C., Piccoli, Luca, Sallusto, Federica, Núñez, Nicolás G., Marafioti, Teresa, Schneiter, Didier, Opitz, Isabelle, Lanzavecchia, Antonio, Jung, Hans H., De Feo, Donatella, Mundt, Sarah, Schreiner, Bettina, Becher, Burkhard
Published in Acta neuropathologica (01.06.2021)
Published in Acta neuropathologica (01.06.2021)
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Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors
Vesely, Clare, Wong, Yien Ning Sophia, Childs, Alexa, Akarca, Ayse U, Dhami, Pawan, Vaikkinen, Heli, Conde, Lucia, Herrero, Javier, Ogunbiyi, Olagunju, Gander, Amir, Luong, Tu Vinh, Thirlwell, Chrissie, Caplin, Martyn, Toumpanakis, Christos, Peggs, Karl, Quezada, Sergio A, Marafioti, Teresa, Meyer, Tim
Published in Clinical cancer research (13.06.2022)
Published in Clinical cancer research (13.06.2022)
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