The role of apoptosis in acetaminophen hepatotoxicity
Jaeschke, Hartmut, Duan, Luqi, Akakpo, Jephte Y., Farhood, Anwar, Ramachandran, Anup
Published in Food and chemical toxicology (01.08.2018)
Published in Food and chemical toxicology (01.08.2018)
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Journal Article
Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls
Jaeschke, Hartmut, Adelusi, Olamide B., Akakpo, Jephte Y., Nguyen, Nga T., Sanchez-Guerrero, Giselle, Umbaugh, David S., Ding, Wen-Xing, Ramachandran, Anup
Published in Acta pharmaceutica Sinica. B (01.12.2021)
Published in Acta pharmaceutica Sinica. B (01.12.2021)
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Journal Article
Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice
Qian, Hui, Bai, Qingyun, Yang, Xiao, Akakpo, Jephte Y., Ji, Lili, Yang, Li, Rülicke, Thomas, Zatloukal, Kurt, Jaeschke, Hartmut, Ni, Hong-Min, Ding, Wen-Xing
Published in Acta pharmaceutica Sinica. B (01.12.2021)
Published in Acta pharmaceutica Sinica. B (01.12.2021)
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Journal Article
Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure
Jaeschke, Hartmut, Akakpo, Jephte Y, Umbaugh, David S, Ramachandran, Anup
Published in Toxicological sciences (01.04.2020)
Published in Toxicological sciences (01.04.2020)
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Journal Article
Fructose Protects Against Acetaminophen‐Induced Hepatotoxicity Mainly by Activating the Carbohydrate‐Response Element‐Binding Protein α–Fibroblast Growth Factor 21 Axis in Mice
Zhang, Deqiang, Wang, Sujuan, Ospina, Erin, Shabandri, Omar, Lank, Daniel, Akakpo, Jephte Y., Zhao, Zifeng, Yang, Meichan, Wu, Jun, Jaeschke, Hartmut, Saha, Pradip, Tong, Xin, Yin, Lei
Published in Hepatology communications (01.06.2021)
Published in Hepatology communications (01.06.2021)
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Journal Article
Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice
Sun, Hua, Ni, Hong-Min, McCracken, Jennifer M., Akakpo, Jephte Y, Fulte, Sam, McKeen, Tara, Jaeschke, Hartmut, Wang, Hua, Ding, Wen-Xing
Published in Liver research (01.06.2021)
Published in Liver research (01.06.2021)
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Journal Article
Novel strategies for the treatment of acetaminophen hepatotoxicity
Akakpo, Jephte Y, Ramachandran, Anup, Jaeschke, Hartmut
Published in Expert opinion on drug metabolism & toxicology (01.11.2020)
Published in Expert opinion on drug metabolism & toxicology (01.11.2020)
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Journal Article
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose
Akakpo, Jephte Y., Ramachandran, Anup, Curry, Steven C., Rumack, Barry H., Jaeschke, Hartmut
Published in Archives of toxicology (01.02.2022)
Published in Archives of toxicology (01.02.2022)
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Journal Article
Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice
Nguyen, Nga T., Du, Kuo, Akakpo, Jephte Y., Umbaugh, David S., Jaeschke, Hartmut, Ramachandran, Anup
Published in Toxicology letters (01.03.2021)
Published in Toxicology letters (01.03.2021)
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Journal Article
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice
Adelusi, Olamide B., Akakpo, Jephte Y., Eichenbaum, Gary, Sadaff, Ejaz, Ramachandran, Anup, Jaeschke, Hartmut
Published in Archives of toxicology (01.06.2024)
Published in Archives of toxicology (01.06.2024)
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Journal Article
Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human kidneys: Inhibition by 4-methylpyrazole but not N-acetylcysteine
Akakpo, Jephte Y, Ramachandran, Anup, Rumack, Barry H, Wallace, Darren P, Jaeschke, Hartmut
Published in Toxicology (Amsterdam) (01.12.2023)
Published in Toxicology (Amsterdam) (01.12.2023)
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Journal Article
High-Dose Acetaminophen with Concurrent CYP2E1 Inhibition Has Profound Anticancer Activity without Liver Toxicity
Bryan, Allyn, Pingali, Pavani, Faber, Anthony, Landry, Joseph, Akakpo, Jephte Y, Jaeschke, Hartmut, Li, Howard, Lee, Won Sok, May, Lauren, Patel, Bhaumik, Neuwelt, Alex
Published in The Journal of pharmacology and experimental therapeutics (01.01.2024)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2024)
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Journal Article
Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity
Duan, Luqi, Ramachandran, Anup, Akakpo, Jephte Y., Woolbright, Benjamin L., Zhang, Yuxia, Jaeschke, Hartmut
Published in Toxicology and applied pharmacology (15.01.2020)
Published in Toxicology and applied pharmacology (15.01.2020)
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Journal Article
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity
Ghallab, Ahmed, Hassan, Reham, Hofmann, Ute, Friebel, Adrian, Hobloss, Zaynab, Brackhagen, Lisa, Begher-Tibbe, Brigitte, Myllys, Maiju, Reinders, Joerg, Overbeck, Nina, Sezgin, Selahaddin, Zühlke, Sebastian, Seddek, Abdel-latif, Murad, Walaa, Brecklinghaus, Tim, Kappenberg, Franziska, Rahnenführer, Jörg, González, Daniela, Goldring, Christopher, Copple, Ian M., Marchan, Rosemarie, Longerich, Thomas, Vucur, Mihael, Luedde, Tom, Urban, Stephan, Canbay, Ali, Schreiter, Thomas, Trauner, Michael, Akakpo, Jephte Y., Olyaee, Mojtaba, Curry, Steven C., Sowa, Jan-Peter, Jaeschke, Hartmut, Hoehme, Stefan, Hengstler, Jan G.
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
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Journal Article
Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase
Akakpo, Jephte Y, Ramachandran, Anup, Duan, Luqi, Schaich, Matthew A, Jaeschke, Matthew W, Freudenthal, Bret D, Ding, Wen-Xing, Rumack, Barry H, Jaeschke, Hartmut
Published in Toxicological sciences (01.07.2019)
Published in Toxicological sciences (01.07.2019)
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Journal Article
Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole
Akakpo, Jephte Y., Jaeschke, Matthew W., Ramachandran, Anup, Curry, Steven C., Rumack, Barry H., Jaeschke, Hartmut
Published in Archives of toxicology (01.10.2021)
Published in Archives of toxicology (01.10.2021)
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