0053 SUVN-G3031: Safety, Tolerability and Pharmacokinetics of a Potent and Selective Histamine H3 Receptor Inverse Agonist - Single and Multiple Ascending Doses in Healthy Subjects
Nirogi, Ramakrishna, Shinde, Anil, Mudigonda, Koteshwara, Bhyrapuneni, Gopinadh, Muddana, Nageswara Rao, Palacharla, Raghava Chowdary, Ajjala, Devender Reddy, Goyal, Vinod Kumar, Ravula, Jyothsna, Jetta, Satish, Mohammed, Abdul Rasheed
Published in Sleep (New York, N.Y.) (13.04.2019)
Published in Sleep (New York, N.Y.) (13.04.2019)
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Journal Article
Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro – in vivo extrapolation of hepatic clearance
Palacharla, Raghava Choudary, Uthukam, Venkatesham, Manoharan, Arunkumar, Ponnamaneni, Ranjith Kumar, Padala, Nagasurya Prakash, Boggavarapu, Rajesh Kumar, Bhyrapuneni, Gopinadh, Ajjala, Devender Reddy, Nirogi, Ramakrishna
Published in European journal of pharmaceutical sciences (01.04.2017)
Published in European journal of pharmaceutical sciences (01.04.2017)
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Journal Article
LC–MS/MS method for the quantification of SUVN-G3031, a novel H3 receptor inverse agonist for narcolepsy treatment
Nirogi, Ramakrishna, Ajjala, Devender Reddy, Prakash Padala, Naga Surya, Kalaikadhiban, Ilayaraja, Rayapati, Lakshmi Prasanna, Chunduru, Prathyusha, Shinde, Anil
Published in Bioanalysis (01.04.2020)
Published in Bioanalysis (01.04.2020)
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Journal Article
LC–MS/MS method for quantification of 3,4-dihydroxyphenylglycol, a norepinephrine metabolite in plasma and brain regions
Padala, Naga Surya Prakash, Ajjala, Devender Reddy, Boggavarapu, Rajesh Kumar, Pantangi, Hanumanth Rao, Thentu, Jagadeesh Babu, Mohammed, Abdul Rasheed, Nirogi, Ramakrishna
Published in Bioanalysis (01.05.2019)
Published in Bioanalysis (01.05.2019)
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Journal Article
Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays
Nirogi, Ramakrishna, Palacharla, Raghava Choudary, Uthukam, Venkatesham, Manoharan, Arunkumar, Srikakolapu, Surya Rao, Kalaikadhiban, Ilayaraja, Boggavarapu, Rajesh Kumar, Ponnamaneni, Ranjith Kumar, Ajjala, Devender Reddy, Bhyrapuneni, Gopinadh
Published in Xenobiotica (01.02.2015)
Published in Xenobiotica (01.02.2015)
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Journal Article
Sensitive LC–MS/MS method for quantification of vitamin B 12 in rat serum: Application to pharmacokinetic study
Aleti, Raghupathi Reddy, Rayapati, Lakshmi Prasanna, Chunduru, Prathyusha, Palacharla, Raghava Choudary, Ajjala, Devender Reddy, Nirogi, Ramakrishna
Published in Drug metabolism and pharmacokinetics (01.01.2018)
Published in Drug metabolism and pharmacokinetics (01.01.2018)
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Journal Article
LC–MS/MS method for the simultaneous quantification of artemether, dihydroartemisinin and lumefantrine in rabbit plasma and its application to a PK study
Padala, Nagasurya Prakash, Boggavarapu, Rajesh Kumar, Kunduru, Praveen, Palacharla, Raghava Choudary, Ajjala, Devender Reddy, Nirogi, Ramakrishna
Published in Drug metabolism and pharmacokinetics (01.01.2018)
Published in Drug metabolism and pharmacokinetics (01.01.2018)
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Journal Article
Rat thalamic α4β2 neuronal nicotinic acetylcholine receptor occupancy assay using LC–MS/MS
Nirogi, Ramakrishna, Kandikere, Vishwottam, Bhyrapuneni, Gopinadh, Saralaya, Ramanatha, Muddana, Nageswararao, Ajjala, Devender Reddy
Published in Journal of pharmacological and toxicological methods (01.05.2012)
Published in Journal of pharmacological and toxicological methods (01.05.2012)
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Journal Article
Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes)
Palacharla, Veera Raghava Choudary, Chunduru, Prathyusha, Ajjala, Devender Reddy, Bhyrapuneni, Gopinadh, Nirogi, Ramakrishna, Li, Albert P
Published in Drug metabolism and disposition (01.10.2019)
Published in Drug metabolism and disposition (01.10.2019)
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Journal Article
Absorption, distribution, metabolism, excretion (ADME), drug-drug interaction potential and prediction of human pharmacokinetics of SUVN-G3031, a novel histamine 3 receptor (H3R) inverse agonist in clinical development for the treatment of narcolepsy
Nirogi, Ramakrishna, Bhyrapuneni, Gopinadh, Muddana, Nageswara Rao, Manoharan, Arunkumar, Shinde, Anil K, Mohammed, Abdul Rasheed, Padala, Nagasurya Prakash, Ajjala, Devender Reddy, Subramanian, Ramkumar, Palacharla, Veera Raghava Chowdary
Published in European journal of pharmaceutical sciences (01.09.2020)
Published in European journal of pharmaceutical sciences (01.09.2020)
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Journal Article
Development and validation of sensitive LC–MS/MS method for the quantification of SUVN-502 and its metabolite and its application for first in human pharmacokinetic study
Nirogi, Ramakrishna, Ajjala, Devender Reddy, Aleti, Raghupathi, Rayapati, Lakshmiprasanna, Pantangi, Hanumanth Rao, Boggavarapu, Rajesh Kumar, Padala, Naga Surya Prakash
Published in Journal of pharmaceutical and biomedical analysis (25.10.2017)
Published in Journal of pharmaceutical and biomedical analysis (25.10.2017)
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Journal Article
Methoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole
Palacharla, Raghava Choudary, Molgara, Parusharamulu, Panthangi, Hanumanth Rao, Boggavarapu, Rajesh Kumar, Manoharan, Arun Kumar, Ponnamaneni, Ranjith Kumar, Ajjala, Devender Reddy, Nirogi, Ramakrishna
Published in Xenobiotica (01.02.2019)
Published in Xenobiotica (01.02.2019)
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Journal Article
Simultaneous in-vivo receptor occupancy assays for serotonin 1A, 2A, and dopamine 2 receptors with the use of non-radiolabelled tracers: Proposed method in screening antipsychotics
Thentu, Jagadeesh Babu, Nirogi, Ramakrishna, Bhyrapuneni, Gopinadh, Ajjala, Devender Reddy, Aleti, Raghupathi Reddy, Palacharla, Raghava Choudary
Published in Journal of pharmacological and toxicological methods (01.05.2017)
Published in Journal of pharmacological and toxicological methods (01.05.2017)
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Journal Article
P2‐031: SAFETY, TOLERABILITY AND HUMAN PHARMACOKINETICS OF SUVN‐502, A POTENT AND PURE 5‐HT 6 RECEPTOR ANTAGONIST
Bhyrapuneni, Gopinadh, Goyal, Vinod Kumar, Pandey, Santosh Kumar, Muddana, Nageswara Rao, Chowdary Palacharla, Veera Raghava, Ajjala, Devender Reddy, Mudigonda, Koteshwara, Badange, Rajesh Kumar, Nirogi, Ramakrishna, Jasti, Venkat
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Journal Article
SAFETY, TOLERABILITY AND HUMAN PHARMACOKINETICS OF SUVN-502, A POTENT AND PURE 5-HT6 RECEPTOR ANTAGONIST
Bhyrapuneni, Gopinadh, Goyal, Vinod Kumar, Pandey, Santosh Kumar, Muddana, Nageswara Rao, Chowdary Palacharla, Veera Raghava, Ajjala, Devender Reddy, Mudigonda, Koteshwara, Badange, Rajesh Kumar, Nirogi, Ramakrishna, Jasti, Venkat
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Journal Article
P2‐031: SAFETY, TOLERABILITY AND HUMAN PHARMACOKINETICS OF SUVN‐502, A POTENT AND PURE 5‐HT6 RECEPTOR ANTAGONIST
Bhyrapuneni, Gopinadh, Goyal, Vinod Kumar, Pandey, Santosh Kumar, Muddana, Nageswara Rao, Chowdary Palacharla, Veera Raghava, Ajjala, Devender Reddy, Mudigonda, Koteshwara, Badange, Rajesh Kumar, Nirogi, Ramakrishna, Jasti, Venkat
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Journal Article
Sensitive LC–MS/MS method for quantification of vitamin B12 in rat serum: Application to pharmacokinetic study
Aleti, Raghupathi Reddy, Rayapati, Lakshmi Prasanna, Chunduru, Prathyusha, Palacharla, Raghava Choudary, Ajjala, Devender Reddy, Nirogi, Ramakrishna
Published in Drug metabolism and pharmacokinetics (01.01.2018)
Published in Drug metabolism and pharmacokinetics (01.01.2018)
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Journal Article
Approach to reduce the non-specific binding in microdialysis
Nirogi, Ramakrishna, Kandikere, Vishwottam, Bhyrapuneni, Gopinadh, Benade, Vijay, Saralaya, Ramanatha, Irappanavar, Shantaveer, Muddana, Nageswararao, Ajjala, Devender Reddy
Published in Journal of neuroscience methods (15.08.2012)
Published in Journal of neuroscience methods (15.08.2012)
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Journal Article
Dried blood spot analysis of an iron chelator – Deferasirox and its potential application to therapeutic drug monitoring
Nirogi, Ramakrishna, Ajjala, Devender Reddy, Kandikere, Vishwottam, Aleti, Raghupathi, Srikakolapu, SuryaRao, Vurimindi, Himabindu
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.10.2012)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.10.2012)
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Journal Article
Incurred sample reanalysis of fingolimod and fingolimod phosphate in blood: stability evaluation and application to a rat pharmacokinetic study
Nirogi, Ramakrishna, Padala, Nagasurya Prakash, Ajjala, Devender Reddy, Boggavarapu, Rajesh Kumar, Kunduru, Praveen
Published in Bioanalysis (01.04.2017)
Published in Bioanalysis (01.04.2017)
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