Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
Lama, Lodoe, Adura, Carolina, Xie, Wei, Tomita, Daisuke, Kamei, Taku, Kuryavyi, Vitaly, Gogakos, Tasos, Steinberg, Joshua I., Miller, Michael, Ramos-Espiritu, Lavoisier, Asano, Yasutomi, Hashizume, Shogo, Aida, Jumpei, Imaeda, Toshihiro, Okamoto, Rei, Jennings, Andy J., Michino, Mayako, Kuroita, Takanobu, Stamford, Andrew, Gao, Pu, Meinke, Peter, Glickman, J. Fraser, Patel, Dinshaw J., Tuschl, Thomas
Published in Nature communications (21.05.2019)
Published in Nature communications (21.05.2019)
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Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice
Vincent, Jessica, Adura, Carolina, Gao, Pu, Luz, Antonio, Lama, Lodoe, Asano, Yasutomi, Okamoto, Rei, Imaeda, Toshihiro, Aida, Jumpei, Rothamel, Katherine, Gogakos, Tasos, Steinberg, Joshua, Reasoner, Seth, Aso, Kazuyoshi, Tuschl, Thomas, Patel, Dinshaw J., Glickman, J. Fraser, Ascano, Manuel
Published in Nature communications (29.09.2017)
Published in Nature communications (29.09.2017)
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Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors
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Published in Journal of medicinal chemistry (25.10.2018)
Published in Journal of medicinal chemistry (25.10.2018)
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Design and Identification of a GPR40 Full Agonist (SCO-267) Possessing a 2‑Carbamoylphenyl Piperidine Moiety
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Published in Journal of medicinal chemistry (24.09.2020)
Published in Journal of medicinal chemistry (24.09.2020)
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Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice
Vincent, Jessica, Adura, Carolina, Gao, Pu, Luz, Antonio, Lama, Lodoe, Asano, Yasutomi, Okamoto, Rei, Imaeda, Toshihiro, Aida, Jumpei, Rothamel, Katherine, Gogakos, Tasos, Steinberg, Joshua, Reasoner, Seth, Aso, Kazuyoshi, Tuschl, Thomas, Patel, Dinshaw J., Glickman, J. Fraser, Ascano, Manuel
Published in Nature communications (23.11.2017)
Published in Nature communications (23.11.2017)
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Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2 H -benzo[ b ][1,4]oxazin-6-yl Moiety
Ikeda, Shuhei, Sugiyama, Hideyuki, Tokuhara, Hidekazu, Murakami, Masataka, Nakamura, Minoru, Oguro, Yuya, Aida, Jumpei, Morishita, Nao, Sogabe, Satoshi, Dougan, Douglas R., Gay, Sean C., Qin, Ling, Arimura, Naoto, Takahashi, Yasuko, Sasaki, Masako, Kamada, Yusuke, Aoyama, Kazunobu, Kimoto, Kouya, Kamata, Makoto
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2H‑benzo[b][1,4]oxazin-6-yl Moiety
Ikeda, Shuhei, Sugiyama, Hideyuki, Tokuhara, Hidekazu, Murakami, Masataka, Nakamura, Minoru, Oguro, Yuya, Aida, Jumpei, Morishita, Nao, Sogabe, Satoshi, Dougan, Douglas R., Gay, Sean C., Qin, Ling, Arimura, Naoto, Takahashi, Yasuko, Sasaki, Masako, Kamada, Yusuke, Aoyama, Kazunobu, Kimoto, Kouya, Kamata, Makoto
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS
Kabeche, Stephanie, Aida, Jumpei, Akther, Thamina, Ichikawa, Takashi, Ochida, Atsuko, Pulkoski-Gross, Michael J., Smith, Mark, Humphries, Paul S., Yeh, Ellen
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
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Design, Synthesis, and Evaluation of [18F]T-914 as a Novel Positron-Emission Tomography Tracer for Lysine-Specific Demethylase 1
Matsuda, Satoru, Hattori, Yasushi, Matsumiya, Kouta, McQuade, Paul, Yamashita, Tohru, Aida, Jumpei, Sandiego, Christine M, Gouasmat, Alexandra, Carroll, Vincent M, Barret, Olivier, Tamagnan, Gilles, Koike, Tatsuki, Kimura, Haruhide
Published in Journal of medicinal chemistry (09.09.2021)
Published in Journal of medicinal chemistry (09.09.2021)
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Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure–Activity Relationships of Novel 1‑(Imidazo[1,2‑a]pyridin-6-yl)pyridin-2(1H)‑one Derivatives
Igawa, Hideyuki, Takahashi, Masashi, Kakegawa, Keiko, Kina, Asato, Ikoma, Minoru, Aida, Jumpei, Yasuma, Tsuneo, Kawata, Yayoi, Ashina, Shuntaro, Yamamoto, Syunsuke, Kundu, Mrinalkanti, Khamrai, Uttam, Hirabayashi, Hideki, Nakayama, Masaharu, Nagisa, Yasutaka, Kasai, Shizuo, Maekawa, Tsuyoshi
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel non-basic 1-(2H-indazole-5-yl)pyridin-2(1H)-one derivatives and mitigation of mutagenicity in Ames test
Igawa, Hideyuki, Takahashi, Masashi, Ikoma, Minoru, Kaku, Hiromi, Kakegawa, Keiko, Kina, Asato, Aida, Jumpei, Okuda, Shoki, Kawata, Yayoi, Noguchi, Toshihiro, Hotta, Natsu, Yamamoto, Syunsuke, Nakayama, Masaharu, Nagisa, Yasutaka, Kasai, Shizuo, Maekawa, Tsuyoshi
Published in Bioorganic & medicinal chemistry (01.06.2016)
Published in Bioorganic & medicinal chemistry (01.06.2016)
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헤테로시클릭 NMDA 길항제
AIDA JUMPEI, NAKAMURA MINORU, YUKAWA TAKAFUMI, OGURO YUYA, YAMAGUCHI FUMIE, TAWARAISHI TAISUKE, IKEDA SHUHEI, KAMATA MAKOTO, IWANAGA KOUICHI, MURAKAMI MASATAKA, OCHIDA ATSUKO, OYABU NORIO, WAKABAYASHI TAKESHI, YAMAMOTO SATOSHI
Year of Publication 20.07.2022
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Year of Publication 20.07.2022
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Correction to Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure–Activity Relationships of Novel 1‑(Imidazo[1,2‑a]pyridin-6-yl)pyridin-2(1H)‑one Derivatives
Igawa, Hideyuki, Takahashi, Masashi, Kakegawa, Keiko, Kina, Asato, Ikoma, Minoru, Aida, Jumpei, Yasuma, Tsuneo, Kawata, Yayoi, Ashina, Shuntaro, Yamamoto, Syunsuke, Kundu, Mrinalkanti, Khamrai, Uttam, Hirabayashi, Hideki, Nakayama, Masaharu, Nagisa, Yasutaka, Kasai, Shizuo, Maekawa, Tsuyoshi
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
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Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition
Igawa, Hideyuki, Takahashi, Masashi, Shirasaki, Mikio, Kakegawa, Keiko, Kina, Asato, Ikoma, Minoru, Aida, Jumpei, Yasuma, Tsuneo, Okuda, Shoki, Kawata, Yayoi, Noguchi, Toshihiro, Yamamoto, Syunsuke, Fujioka, Yasushi, Kundu, Mrinalkanti, Khamrai, Uttam, Nakayama, Masaharu, Nagisa, Yasutaka, Kasai, Shizuo, Maekawa, Tsuyoshi
Published in Bioorganic & medicinal chemistry (01.06.2016)
Published in Bioorganic & medicinal chemistry (01.06.2016)
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헤테로시클릭 화합물
AIDA JUMPEI, OKAWA TOMOHIRO, TOKUHARA HIDEKAZU, NAKAMURA MINORU, MURAKAMI MASATAKA, SUGIYAMA HIDEYUKI, OGURO YUYA, IKEDA SHUHEI
Year of Publication 05.12.2018
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HETEROCYCLIC COMPOUND
MURAKAMI, Masataka, SUGIYAMA, Hideyuki, OGURO, Yuya, OKAWA, Tomohiro, TOKUHARA, Hidekazu, AIDA, Jumpei, NAKAMURA, Minoru, IKEDA, Shuhei
Year of Publication 05.10.2017
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Year of Publication 05.10.2017
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헤테로사이클릭 화합물 및 이의 용도
AIDA JUMPEI, NAKAMURA MINORU, TAKAMI KAZUAKI, MORIMOTO SHINJI, OGURO YUYA, ITO MITSUHIRO, TAWARAISHI TAISUKE, MIKAMI SATOSHI, TAKASHIMA SACHIE, MATSUMOTO SHIGEMITSU, WADA YASUFUMI, KAMATA MAKOTO, DAINI MASAKI, KAKEI HIROYUKI, KAMEI TAKU, MURAKAMI MASATAKA, IWANAGA KOUICHI, WAKABAYASHI TAKESHI, NAKAMURA SHINJI, TOKUNAGA NORIHITO, SETO MASAKI, YAMAMOTO SATOSHI
Year of Publication 08.12.2020
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Year of Publication 08.12.2020
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대사 장애의 치료를 위한 치환된 시클릴-아세트산 유도체
AIDA JUMPEI, MAEKAWA TSUYOSHI, FURUKAWA HIDEKI, TAKAKURA NOBUYUKI, HIRATA YASUHIRO, HITOMI YUKO, KOBAYASHI TOSHITAKE, NAKAYAMA YAYOI, MATSUMOTO SHIGEMITSU, MIWATASHI SEIJI, NOGUCHI NAOYOSHI, WATANABE KOJI, SASAKI SATOSHI, KASAI SHIZUO, MIYAMOTO YASUFUMI
Year of Publication 09.12.2019
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Year of Publication 09.12.2019
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HETEROCYCLIC COMPOUND
KAMATA, Makoto, SUGIYAMA, Hideyuki, FUSHIMI, Makoto, MIYAZAKI, Masako, TOKUHARA, Hidekazu, KOIKE, Tatsuki, AIDA, Jumpei, HATTORI, Yasushi, IKEDA, Shuhei, KUSUMOTO, Tomokazu
Year of Publication 06.10.2016
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Year of Publication 06.10.2016
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AROMATIC COMPOUND
TOKUNAGA, Norihito, FURUKAWA, Hideki, TAKAKURA, Nobuyuki, TAKAMI, Kazuaki, SHIBUYA, Akito, HITOMI, Yuko, MAEKAWA, Tsuyoshi, AIDA, Jumpei, KASAI, Shizuo, MIYAMOTO, Yasufumi, YOSHITOMI, Yayoi, MIWATASHI, Seiji, NOGUCHI, Naoyoshi, OKAWA, Tomohiro, WATANABE, Koji, KOBAYASHI, Toshitake, HIRATA, Yasuhiro
Year of Publication 04.10.2018
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Year of Publication 04.10.2018
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