Hypoglycemic Prodrugs of 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid
Aicher, Thomas D, Bebernitz, Gregory R, Bell, Philip A, Brand, Leonard J, Dain, Jeremy G, Deems, Rhonda, Fillers, William S, Foley, James E, Knorr, Douglas C, Nadelson, Jeffrey, Otero, Dario A, Simpson, Ronald, Strohschein, Robert J, Young, Douglas A
Published in Journal of medicinal chemistry (14.01.1999)
Published in Journal of medicinal chemistry (14.01.1999)
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Perhydroquinolylbenzamides as Novel Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1
Coppola, Gary M, Kukkola, Paivi J, Stanton, James L, Neubert, Alan D, Marcopulos, Nicholas, Bilci, Natalie A, Wang, Hua, Tomaselli, Hollis C, Tan, Jenny, Aicher, Thomas D, Knorr, Douglas C, Jeng, Arco Y, Dardik, Beatriz, Chatelain, Ricardo E
Published in Journal of medicinal chemistry (20.10.2005)
Published in Journal of medicinal chemistry (20.10.2005)
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Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK)
Aicher, Thomas D., Damon, Robert E., Koletar, Judit, Vinluan, Christine C., Brand, Leonard J., Gao, Jiaping, Shetty, Suraj S., Kaplan, Emma L., Mann, William R.
Published in Bioorganic & medicinal chemistry letters (02.08.1999)
Published in Bioorganic & medicinal chemistry letters (02.08.1999)
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Journal Article
Total synthesis of halichondrin B and norhalichondrin B
Aicher, Thomas D, Buszek, Keith R, Fang, Francis G, Forsyth, Craig J, Jung, Sun Ho, Kishi, Yoshito, Matelich, Michael C, Scola, Paul M, Spero, Denice M, Yoon, Suk Kyoon
Published in Journal of the American Chemical Society (01.04.1992)
Published in Journal of the American Chemical Society (01.04.1992)
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Journal Article
Substituted Tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and Tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones as Hypoglycemic Agents
Aicher, Thomas D, Balkan, Bork, Bell, Philip A, Brand, Leonard J, Cheon, S. H, Deems, Rhonda O, Fell, Jay B, Fillers, William S, Fraser, James D, Gao, Jiaping, Knorr, Douglas C, Kahle, Gerald G, Leone, Christina L, Nadelson, Jeffrey, Simpson, Ronald, Smith, Howard C
Published in Journal of medicinal chemistry (05.11.1998)
Published in Journal of medicinal chemistry (05.11.1998)
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Heterologously expressed inner lipoyl domain of dihydrolipoyl acetyltransferase inhibits ATP-dependent inactivation of pyruvate dehydrogenase complex. Identification of important amino acid residues
Jackson, J C, Vinluan, C C, Dragland, C J, Sundararajan, V, Yan, B, Gounarides, J S, Nirmala, N R, Topiol, S, Ramage, P, Blume, J E, Aicher, T D, Bell, P A, Mann, W R
Published in Biochemical journal (15.09.1998)
Published in Biochemical journal (15.09.1998)
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Journal Article
SYNTHETIC STUDIES TOWARDS HALICHONDRINS - SYNTHESIS OF THE C.27-C.38 SEGMENT
AICHER, TD, BUSZEK, KR, FANG, FG, FORSYTH, CJ, JUNG, SH, KISHI, Y, SCOLA, PM
Published in Tetrahedron letters (17.03.1992)
Published in Tetrahedron letters (17.03.1992)
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Journal Article
Secondary Amides of (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase
Aicher, Thomas D, Anderson, Robert C, Gao, Jiaping, Shetty, Suraj S, Coppola, Gary M, Stanton, James L, Knorr, Douglas C, Sperbeck, Donald M, Brand, Leonard J, Vinluan, Christine C, Kaplan, Emma L, Dragland, Carol J, Tomaselli, Hollis C, Islam, Amin, Lozito, Robert J, Liu, Xilin, Maniara, Wieslawa M, Fillers, William S, DelGrande, Dominick, Walter, R. Eric, Mann, William R
Published in Journal of medicinal chemistry (27.01.2000)
Published in Journal of medicinal chemistry (27.01.2000)
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Journal Article
Anilides of (R)-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase
Bebernitz, Gregory R, Aicher, Thomas D, Stanton, James L, Gao, Jiaping, Shetty, Suraj S, Knorr, Douglas C, Strohschein, Robert J, Tan, Jennifer, Brand, Leonard J, Liu, Charles, Wang, Wei H, Vinluan, Christine C, Kaplan, Emma L, Dragland, Carol J, DelGrande, Dominick, Islam, Amin, Lozito, Robert J, Liu, Xilin, Maniara, Wieslawa M, Mann, William R
Published in Journal of medicinal chemistry (01.06.2000)
Published in Journal of medicinal chemistry (01.06.2000)
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Journal Article
(R)-3,3,3-trifluoro-2-hydroxy-2-methyl-propionamides are orally active inhibitors of pyruvate dehydrogenase kinase
AICHER, T. D, ANDERSON, R. C, JIANPING GAO, VINLUAN, C. C, SHETTY, S. S, DRAGLAND, C, KAPLAN, E. L, DELGRANDE, D, ISLAM, A, XILIN LIU, LOZITO, R. J, MANIARA, W. M, BEBERNITZ, G. R, WALTER, R. E, MANN, W. R, COPPOLA, G. M, JEWELL, C. F, KNORR, D. C, LIU, C, SPERBECK, D. M, BRAND, L. J, STROHSCHEIN, R. J
Published in Journal of medicinal chemistry (1999)
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Published in Journal of medicinal chemistry (1999)
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Substituted tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and tetrahydropyrrolo[2,1-b]thiazol-5(6H)-one as hypoglycemic agents
AICHER, T. D, BALKAN, B, KNORR, D. C, KAHLE, G. G, LEONE, C. L, NADELSON, J, SIMPSON, R, SMITH, H. C, BELL, P. A, BRAND, L. J, CHEON, S. H, DEEMS, R. O, FELL, J. B, FILLERS, W. S, FRASER, J. D, JIAPINGGAO
Published in Journal of medicinal chemistry (1998)
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Published in Journal of medicinal chemistry (1998)
Journal Article
Synthesis of chiral tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones
Aicher, Thomas D., Knorr, Douglas C., Smith, Howard C.
Published in Tetrahedron letters (19.11.1998)
Published in Tetrahedron letters (19.11.1998)
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Journal Article
(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides Are Orally Active Inhibitors of Pyruvate Dehydrogenase Kinase
Aicher, Thomas D, Anderson, Robert C, Bebernitz, Gregory R, Coppola, Gary M, Jewell, Charles F, Knorr, Douglas C, Liu, Charles, Sperbeck, Donald M, Brand, Leonard J, Strohschein, Robert J, Gao, Jiaping, Vinluan, Christine C, Shetty, Suraj S, Dragland, Carol, Kaplan, Emma L, DelGrande, Dominick, Islam, Amin, Liu, Xilin, Lozito, Robert J, Maniara, Wieslawa M, Walter, R. Erik, Mann, William R
Published in Journal of medicinal chemistry (29.07.1999)
Published in Journal of medicinal chemistry (29.07.1999)
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Journal Article
(R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides are orally active inhibitors of pyruvate dehydrogenase kinase
Aicher, TD, Anderson, RC, Bebernitz, GR, Coppola, GM, Jewell, CF, Knorr, DC, Liu, C, Sperbeck, DM, Brand, LJ, Strohschein, RJ, Gao, JP, Vinluan, CC, Shetty, SS, Dragland, C, Kaplan, EL, DelGrande, D, Islam, A, Liu, XL, Lozito, RJ, Maniara, WM, Walter, RE, Mann, WR
Published in Journal of medicinal chemistry (29.07.1999)
Published in Journal of medicinal chemistry (29.07.1999)
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