Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase’s enzymatic cycle
Wang, Yingjie, V.S., Manu, Kim, Jonggul, Li, Geoffrey, Ahuja, Lalima G., Aoto, Philip, Taylor, Susan S., Veglia, Gianluigi
Published in Nature communications (18.02.2019)
Published in Nature communications (18.02.2019)
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Journal Article
A dynamic hydrophobic core orchestrates allostery in protein kinases
Kim, Jonggul, Ahuja, Lalima G, Chao, Fa-An, Xia, Youlin, McClendon, Christopher L, Kornev, Alexandr P, Taylor, Susan S, Veglia, Gianluigi
Published in Science advances (01.04.2017)
Published in Science advances (01.04.2017)
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Journal Article
Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases
Meharena, Hiruy S, Fan, Xiaorui, Ahuja, Lalima G, Keshwani, Malik M, McClendon, Christopher L, Chen, Angela M, Adams, Joseph A, Taylor, Susan S
Published in PLoS biology (30.11.2016)
Published in PLoS biology (30.11.2016)
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Journal Article
Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme
Zhang, Ping, Knape, Matthias J, Ahuja, Lalima G, Keshwani, Malik M, King, Charles C, Sastri, Mira, Herberg, Friedrich W, Taylor, Susan S
Published in PLoS biology (01.07.2015)
Published in PLoS biology (01.07.2015)
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Journal Article
Kinases and Pseudokinases: Lessons from RAF
Shaw, Andrey S., Kornev, Alexandr P., Hu, Jiancheng, Ahuja, Lalima G., Taylor, Susan S.
Published in Molecular and cellular biology (01.05.2014)
Published in Molecular and cellular biology (01.05.2014)
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Journal Article
Kinase Regulation by Hydrophobic Spine Assembly in Cancer
Hu, Jiancheng, Ahuja, Lalima G., Meharena, Hiruy S., Kannan, Natarajan, Kornev, Alexandr P., Taylor, Susan S., Shaw, Andrey S.
Published in Molecular and cellular biology (01.01.2015)
Published in Molecular and cellular biology (01.01.2015)
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Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP
Lu, Tsan-Wen, Wu, Jian, Aoto, Phillip C., Weng, Jui-Hung, Ahuja, Lalima G., Sun, Nicholas, Cheng, Cecilia Y., Zhang, Ping, Taylor, Susan S.
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2019)
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Corrigendum to “A Catalytically-Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation.” J. Mol. Biol. 430(6) (Mar 16 2018), 881–889
Meng, Yilin, Ahuja, Lalima G., Kornev, Alexandr P., Taylor, Susan S., Roux, Benoît
Published in Journal of molecular biology (19.10.2018)
Published in Journal of molecular biology (19.10.2018)
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Journal Article
Divalent Metal Ions Mg2+ and Ca2+ Have Distinct Effects on Protein Kinase A Activity and Regulation
Knape, Matthias J, Ahuja, Lalima G, Bertinetti, Daniela, Burghardt, Nicole C.G, Zimmermann, Bastian, Taylor, Susan S, Herberg, Friedrich W
Published in ACS chemical biology (16.10.2015)
Published in ACS chemical biology (16.10.2015)
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Journal Article
An Allosteric Region of Src Tyrosine Kinase Allows for Stabilization of Its Active-Like Conformation
Ahuja, Lalima G., Meng, Yilin, Kornev, Alexandr P., Roux, Benoit, Taylor, Susan
Published in Biophysical journal (02.02.2018)
Published in Biophysical journal (02.02.2018)
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Journal Article
Single Turnover Autophosphorylation Cycle of the PKA RII[Beta] Holoenzyme: e1002192
Zhang, Ping, Knape, Matthias J, Ahuja, Lalima G, Keshwani, Malik M, King, Charles C, Sastri, Mira, Herberg, Friedrich W, Taylor, Susan S
Published in PLoS biology (01.07.2015)
Published in PLoS biology (01.07.2015)
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Journal Article
Divalent Metal Ions Mg 2+ and Ca 2+ Have Distinct Effects on Protein Kinase A Activity and Regulation
Knape, Matthias J., Ahuja, Lalima G., Bertinetti, Daniela, Burghardt, Nicole C.G., Zimmermann, Bastian, Taylor, Susan S., Herberg, Friedrich W.
Published in ACS chemical biology (16.10.2015)
Published in ACS chemical biology (16.10.2015)
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