Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1
Flores-Otero, Jacqueline, Ahn, Kwang H., Delgado-Peraza, Francheska, Mackie, Ken, Kendall, Debra A., Yudowski, Guillermo A.
Published in Nature communications (01.08.2014)
Published in Nature communications (01.08.2014)
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Journal Article
Optimization of Chemical Functionalities of Indole-2-carboxamides To Improve Allosteric Parameters for the Cannabinoid Receptor 1 (CB1)
Khurana, Leepakshi, Ali, Hamed I, Olszewska, Teresa, Ahn, Kwang H, Damaraju, Aparna, Kendall, Debra A, Lu, Dai
Published in Journal of medicinal chemistry (10.04.2014)
Published in Journal of medicinal chemistry (10.04.2014)
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Journal Article
Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and Gi Protein-independent ERK1/2 Kinase Activation
Ahn, Kwang H., Mahmoud, Mariam M., Kendall, Debra A.
Published in The Journal of biological chemistry (06.04.2012)
Published in The Journal of biological chemistry (06.04.2012)
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Journal Article
Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)
Ahn, Kwang H., Mahmoud, Mariam M., Shim, Joong-Youn, Kendall, Debra A.
Published in The Journal of biological chemistry (05.04.2013)
Published in The Journal of biological chemistry (05.04.2013)
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Journal Article
Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor
Delgado-Peraza, Francheska, Ahn, Kwang H, Nogueras-Ortiz, Carlos, Mungrue, Imran N, Mackie, Ken, Kendall, Debra A, Yudowski, Guillermo A
Published in Molecular pharmacology (01.06.2016)
Published in Molecular pharmacology (01.06.2016)
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Journal Article
Structure–Activity Relationship in the Leucettine Family of Kinase Inhibitors
Tahtouh, Tania, Durieu, Emilie, Villiers, Benoît, Bruyère, Céline, Nguyen, Thu Lan, Fant, Xavier, Ahn, Kwang H, Khurana, Leepakshi, Deau, Emmanuel, Lindberg, Mattias F, Sévère, Elodie, Miege, Frédéric, Roche, Didier, Limanton, Emmanuelle, L’Helgoual’ch, Jean-Martial, Burgy, Guillaume, Guiheneuf, Solène, Herault, Yann, Kendall, Debra A, Carreaux, François, Bazureau, Jean-Pierre, Meijer, Laurent
Published in Journal of medicinal chemistry (27.01.2022)
Published in Journal of medicinal chemistry (27.01.2022)
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Journal Article
Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor
Qiao, Chang-Jiang, Ali, Hamed I., Ahn, Kwang H., Kolluru, Srikanth, Kendall, Debra A., Lu, Dai
Published in European journal of medicinal chemistry (04.10.2016)
Published in European journal of medicinal chemistry (04.10.2016)
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Journal Article
Molecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gαiβγ: identification of key CB1 contacts with the C-terminal helix α5 of Gαi
Shim, Joong-Youn, Ahn, Kwang H, Kendall, Debra A
Published in The Journal of biological chemistry (08.11.2013)
Published in The Journal of biological chemistry (08.11.2013)
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Journal Article
Structure–Activity Relationship Study of Indole-2-carboxamides Identifies a Potent Allosteric Modulator for the Cannabinoid Receptor 1 (CB1)
Mahmoud, Mariam M, Ali, Hamed I, Ahn, Kwang H, Damaraju, Aparna, Samala, Sushma, Pulipati, Venkata K, Kolluru, Srikanth, Kendall, Debra A, Lu, Dai
Published in Journal of medicinal chemistry (24.10.2013)
Published in Journal of medicinal chemistry (24.10.2013)
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Journal Article
Profiling two indole‐2‐carboxamides for allosteric modulation of the CB1 receptor
Ahn, Kwang H., Mahmoud, Mariam M., Samala, Sushma, Lu, Dai, Kendall, Debra A.
Published in Journal of neurochemistry (01.03.2013)
Published in Journal of neurochemistry (01.03.2013)
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Journal Article
Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding
Ahn, Kwang H., Scott, Caitlin E., Abrol, Ravinder, Goddard III, William A., Kendall, Debra A.
Published in Proteins, structure, function, and bioinformatics (01.08.2013)
Published in Proteins, structure, function, and bioinformatics (01.08.2013)
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Journal Article
Ligand binding sensitivity of the extracellular loop two of the cannabinoid receptor 1
Bertalovitz, Alexander C., Ahn, Kwang H., Kendall, Debra A.
Published in Drug development research (01.11.2010)
Published in Drug development research (01.11.2010)
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Journal Article
A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation
D'Antona, Aaron M., Ahn, Kwang H., Wang, Lei, Mierke, Dale F., Lucas-Lenard, Jean, Kendall, Debra A.
Published in Brain research (07.09.2006)
Published in Brain research (07.09.2006)
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