Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death
Ichim, Gabriel, Lopez, Jonathan, Ahmed, Shafiq U., Muthalagu, Nathiya, Giampazolias, Evangelos, Delgado, M. Eugenia, Haller, Martina, Riley, Joel S., Mason, Susan M., Athineos, Dimitris, Parsons, Melissa J., van de Kooij, Bert, Bouchier-Hayes, Lisa, Chalmers, Anthony J., Rooswinkel, Rogier W., Oberst, Andrew, Blyth, Karen, Rehm, Markus, Murphy, Daniel J., Tait, Stephen W.G.
Published in Molecular cell (05.03.2015)
Published in Molecular cell (05.03.2015)
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Journal Article
Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells
Ahmed, Shafiq U, Carruthers, Ross, Gilmour, Lesley, Yildirim, Salih, Watts, Colin, Chalmers, Anthony J
Published in Cancer research (Chicago, Ill.) (15.10.2015)
Published in Cancer research (Chicago, Ill.) (15.10.2015)
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Journal Article
Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells
Carruthers, Ross D, Ahmed, Shafiq U, Ramachandran, Shaliny, Strathdee, Karen, Kurian, Kathreena M, Hedley, Ann, Gomez-Roman, Natividad, Kalna, Gabriela, Neilson, Mathew, Gilmour, Lesley, Stevenson, Katrina H, Hammond, Ester M, Chalmers, Anthony J
Published in Cancer research (Chicago, Ill.) (01.09.2018)
Published in Cancer research (Chicago, Ill.) (01.09.2018)
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Journal Article
PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells
Kaur, Amanpreet, Denisova, Oxana V, Qiao, Xi, Jumppanen, Mikael, Peuhu, Emilia, Ahmed, Shafiq U, Raheem, Olayinka, Haapasalo, Hannu, Eriksson, John, Chalmers, Anthony J, Laakkonen, Pirjo, Westermarck, Jukka
Published in Cancer research (Chicago, Ill.) (01.12.2016)
Published in Cancer research (Chicago, Ill.) (01.12.2016)
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Journal Article
Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency
Hardcastle, Ian R, Liu, Junfeng, Valeur, Eric, Watson, Anna, Ahmed, Shafiq U, Blackburn, Timothy J, Bennaceur, Karim, Clegg, William, Drummond, Catherine, Endicott, Jane A, Golding, Bernard T, Griffin, Roger J, Gruber, Jan, Haggerty, Karen, Harrington, Ross W, Hutton, Claire, Kemp, Stuart, Lu, Xiaohong, McDonnell, James M, Newell, David R, Noble, Martin E. M, Payne, Sara L, Revill, Charlotte H, Riedinger, Christiane, Xu, Qing, Lunec, John
Published in Journal of medicinal chemistry (10.03.2011)
Published in Journal of medicinal chemistry (10.03.2011)
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Journal Article
SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53
Lynch, Cian J, Shah, Zahid H, Allison, Simon J, Ahmed, Shafiq U, Ford, Jack, Warnock, Lorna J, Li, Han, Serrano, Manuel, Milner, Jo
Published in PloS one (21.10.2010)
Published in PloS one (21.10.2010)
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Journal Article
Small-Molecule Inhibitors of the MDM2-p53 Protein−Protein Interaction Based on an Isoindolinone Scaffold
Hardcastle, Ian R, Ahmed, Shafiq U, Atkins, Helen, Farnie, Gillian, Golding, Bernard T, Griffin, Roger J, Guyenne, Sabrina, Hutton, Claire, Källblad, Per, Kemp, Stuart J, Kitching, Martin S, Newell, David R, Norbedo, Stefano, Northen, Julian S, Reid, Rebecca J, Saravanan, K, Willems, Henriëtte M. G, Lunec, John
Published in Journal of medicinal chemistry (19.10.2006)
Published in Journal of medicinal chemistry (19.10.2006)
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Journal Article
A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of Cancer-Related Genes
Shah, Zahid H., Ahmed, Shafiq U., Ford, Jack R., Allison, Simon J., Knight, John R. P., Milner, Jo
Published in Molecular and Cellular Biology (01.02.2012)
Published in Molecular and Cellular Biology (01.02.2012)
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Journal Article
Isoindolinone-based inhibitors of the MDM2–p53 protein–protein interaction
Hardcastle, Ian R., Ahmed, Shafiq U., Atkins, Helen, Calvert, A. Hilary, Curtin, Nicola J., Farnie, Gillian, Golding, Bernard T., Griffin, Roger J., Guyenne, Sabrina, Hutton, Claire, Källblad, Per, Kemp, Stuart J., Kitching, Martin S., Newell, David R., Norbedo, Stefano, Northen, Julian S., Reid, Rebecca J., Saravanan, K., Willems, Henriëtte M.G., Lunec, John
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
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Journal Article
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
Tardito, Saverio, Oudin, Anaïs, Ahmed, Shafiq U., Fack, Fred, Keunen, Olivier, Zheng, Liang, Miletic, Hrvoje, Sakariassen, Per Øystein, Weinstock, Adam, Wagner, Allon, Lindsay, Susan L., Hock, Andreas K., Barnett, Susan C., Ruppin, Eytan, Mørkve, Svein Harald, Lund-Johansen, Morten, Chalmers, Anthony J., Bjerkvig, Rolf, Niclou, Simone P., Gottlieb, Eyal
Published in Nature cell biology (01.12.2015)
Published in Nature cell biology (01.12.2015)
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Journal Article
Correction for Shah et al., "A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of Cancer-Related Genes"
Shah, Zahid H, Ahmed, Shafiq U, Ford, Jack R, Allison, Simon J, Knight, John R P, Milner, Jo
Published in Molecular and cellular biology (15.08.2017)
Published in Molecular and cellular biology (15.08.2017)
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Journal Article
Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death
Ichim, Gabriel, Lopez, Jonathan, Ahmed, Shafiq U., Muthalagu, Nathiya, Giampazolias, Evangelos, Delgado, M. Eugenia, Haller, Martina, Riley, Joel S., Mason, Susan M., Athineos, Dimitris, Parsons, Melissa J., van de Kooij, Bert, Bouchier-Hayes, Lisa, Chalmers, Anthony J., Rooswinkel, Rogier W., Oberst, Andrew, Blyth, Karen, Rehm, Markus, Murphy, Daniel J., Tait, Stephen W.G.
Published in Molecular cell (04.06.2015)
Published in Molecular cell (04.06.2015)
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