Directed differentiation of cholangiocytes from human pluripotent stem cells
Ogawa, Mina, Ogawa, Shinichiro, Bear, Christine E, Ahmadi, Saumel, Chin, Stephanie, Li, Bin, Grompe, Markus, Keller, Gordon, Kamath, Binita M, Ghanekar, Anand
Published in Nature biotechnology (01.08.2015)
Published in Nature biotechnology (01.08.2015)
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Journal Article
ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator Channel
Wu, Yu-Sheng, Jiang, Janet, Ahmadi, Saumel, Lew, Alexandria, Laselva, Onofrio, Xia, Sunny, Bartlett, Claire, Ip, Wan, Wellhauser, Leigh, Ouyang, Hong, Gonska, Tanja, Moraes, Theo J., Bear, Christine E.
Published in Molecular pharmacology (01.10.2019)
Published in Molecular pharmacology (01.10.2019)
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Journal Article
An organoid model to assay the role of CFTR in the human epididymis epithelium
Leir, Shih-Hsing, Yin, Shiyi, Kerschner, Jenny L., Xia, Sunny, Ahmadi, Saumel, Bear, Christine, Harris, Ann
Published in Cell and tissue research (01.08.2020)
Published in Cell and tissue research (01.08.2020)
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Journal Article
Activity of a novel antimicrobial peptide against Pseudomonas aeruginosa biofilms
Beaudoin, Trevor, Stone, Tracy A., Glibowicka, Miroslawa, Adams, Christina, Yau, Yvonne, Ahmadi, Saumel, Bear, Christine E., Grasemann, Hartmut, Waters, Valerie, Deber, Charles M.
Published in Scientific reports (03.10.2018)
Published in Scientific reports (03.10.2018)
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Journal Article
SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion
Ahmadi, Saumel, Xia, Sunny, Wu, Yu-Sheng, Di Paola, Michelle, Kissoon, Randolph, Luk, Catherine, Lin, Fan, Du, Kai, Rommens, Johanna, Bear, Christine E
Published in eLife (13.07.2018)
Published in eLife (13.07.2018)
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Journal Article
Orkambi® and amplifier co‐therapy improves function from a rare CFTR mutation in gene‐edited cells and patient tissue
Molinski, Steven V, Ahmadi, Saumel, Ip, Wan, Ouyang, Hong, Villella, Adriana, Miller, John P, Lee, Po‐Shun, Kulleperuma, Kethika, Du, Kai, Di Paola, Michelle, Eckford, Paul DW, Laselva, Onofrio, Huan, Ling Jun, Wellhauser, Leigh, Li, Ellen, Ray, Peter N, Pomès, Régis, Moraes, Theo J, Gonska, Tanja, Ratjen, Felix, Bear, Christine E
Published in EMBO molecular medicine (01.09.2017)
Published in EMBO molecular medicine (01.09.2017)
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Journal Article
Inhalational Anesthetics Induce Neuronal Protein Aggregation and Affect ER Trafficking
Coghlan, Matthew, Richards, Elizabeth, Shaik, Sadiq, Rossi, Pablo, Vanama, Ramesh Babu, Ahmadi, Saumel, Petroz, Christelle, Crawford, Mark, Maynes, Jason T.
Published in Scientific reports (27.03.2018)
Published in Scientific reports (27.03.2018)
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Journal Article
Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity
Malik, Firhan A, Meissner, Anja, Semenkov, Illya, Molinski, Steven, Pasyk, Stan, Ahmadi, Saumel, Bui, Hai H, Bear, Christine E, Lidington, Darcy, Bolz, Steffen-Sebastian
Published in PloS one (16.06.2015)
Published in PloS one (16.06.2015)
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Journal Article
Differential Diagnosis of Pediatric Multiple Sclerosis
Galardi, Maria Milagros, Gaudioso, Cristina, Ahmadi, Saumel, Evans, Emily, Gilbert, Laura, Mar, Soe
Published in Children (Basel) (03.06.2019)
Published in Children (Basel) (03.06.2019)
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Journal Article
Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia
Ahmadi, Saumel, Bozoky, Zoltan, Di Paola, Michelle, Xia, Sunny, Li, Canhui, Wong, Amy P., Wellhauser, Leigh, Molinski, Steven V., Ip, Wan, Ouyang, Hong, Avolio, Julie, Forman-Kay, Julie D., Ratjen, Felix, Hirota, Jeremy A., Rommens, Johanna, Rossant, Janet, Gonska, Tanja, Moraes, Theo J., Bear, Christine E.
Published in Npj genomic medicine (14.04.2017)
Published in Npj genomic medicine (14.04.2017)
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Journal Article
High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids
Xia, Sunny, Bozóky, Zoltán, Di Paola, Michelle, Laselva, Onofrio, Ahmadi, Saumel, Jiang, Jia Xin, Pitstick, Amy L, Jiang, Chong, Rotin, Daniela, Mayhew, Christopher N, Jones, Nicola L, Bear, Christine E
Published in Cells (Basel, Switzerland) (04.12.2021)
Published in Cells (Basel, Switzerland) (04.12.2021)
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Journal Article
VX-809 and Related Corrector Compounds Exhibit Secondary Activity Stabilizing Active F508del-CFTR after Its Partial Rescue to the Cell Surface
Eckford, Paul D.W., Ramjeesingh, Mohabir, Molinski, Steven, Pasyk, Stan, Dekkers, Johanna F., Li, Canhui, Ahmadi, Saumel, Ip, Wan, Chung, Timothy E., Du, Kai, Yeger, Herman, Beekman, Jeffrey, Gonska, Tanja, Bear, Christine E.
Published in Chemistry & biology (22.05.2014)
Published in Chemistry & biology (22.05.2014)
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Journal Article
Synergy of cAMP and calcium signaling pathways in CFTR regulation
Bozoky, Zoltan, Ahmadi, Saumel, Milman, Tal, Kim, Tae Hun, Du, Kai, Di Paola, Michelle, Pasyk, Stan, Pekhletski, Roman, Keller, Jacob P., Bear, Christine E., Forman-Kay, Julie D.
Published in Proceedings of the National Academy of Sciences - PNAS (14.03.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (14.03.2017)
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Journal Article
Lipophilicity of the Cystic Fibrosis Drug, Ivacaftor (VX-770), and Its Destabilizing Effect on the Major CF-causing Mutation: F508del
Chin, Stephanie, Hung, Maurita, Won, Amy, Wu, Yu-Sheng, Ahmadi, Saumel, Yang, Donghe, Elmallah, Salma, Toutah, Krimo, Hamilton, C. Michael, Young, Robert N., Viirre, Russell D., Yip, Christopher M., Bear, Christine E.
Published in Molecular pharmacology (01.08.2018)
Published in Molecular pharmacology (01.08.2018)
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Journal Article
Augmentation of Cystic Fibrosis Transmembrane Conductance Regulator Function in Human Bronchial Epithelial Cells via SLC6A14-Dependent Amino Acid Uptake. Implications for Treatment of Cystic Fibrosis
Ahmadi, Saumel, Wu, Yu-Sheng, Li, Mingyuan, Ip, Wan, Lloyd-Kuzik, Andrew, Di Paola, Michelle, Du, Kai, Xia, Sunny, Lew, Alexandria, Bozoky, Zoltan, Forman-Kay, Julie, Bear, Christine E, Gonska, Tanja
Published in American journal of respiratory cell and molecular biology (01.12.2019)
Published in American journal of respiratory cell and molecular biology (01.12.2019)
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Journal Article
SLC6A14 Is a Genetic Modifier of Cystic Fibrosis That Regulates Pseudomonas aeruginosa Attachment to Human Bronchial Epithelial Cells
Di Paola, Michelle, Park, Amber J, Ahmadi, Saumel, Roach, Elyse J, Wu, Yu-Sheng, Struder-Kypke, Michaela, Lam, Joseph S, Bear, Christine E, Khursigara, Cezar M
Published in mBio (19.12.2017)
Published in mBio (19.12.2017)
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Journal Article