Systemic immune challenge exacerbates neurodegeneration in a model of neurological lysosomal disease
Mandolfo, Oriana, Parker, Helen, Aguado, Èlia, Ishikawa Learmonth, Yuko, Liao, Ai Yin, O’Leary, Claire, Ellison, Stuart, Forte, Gabriella, Taylor, Jessica, Wood, Shaun, Searle, Rachel, Holley, Rebecca J, Boutin, Hervé, Bigger, Brian W
Published in EMBO molecular medicine (15.07.2024)
Published in EMBO molecular medicine (15.07.2024)
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Journal Article
MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage
Kalev, Peter, Hyer, Marc L., Gross, Stefan, Konteatis, Zenon, Chen, Chi-Chao, Fletcher, Mark, Lein, Max, Aguado-Fraile, Elia, Frank, Victoria, Barnett, Amelia, Mandley, Everton, Goldford, Joshua, Chen, Yue, Sellers, Katie, Hayes, Sebastian, Lizotte, Kate, Quang, Phong, Tuncay, Yesim, Clasquin, Michelle, Peters, Rachel, Weier, Jaclyn, Simone, Eric, Murtie, Joshua, Liu, Wei, Nagaraja, Raj, Dang, Lenny, Sui, Zhihua, Biller, Scott A., Travins, Jeremy, Marks, Kevin M., Marjon, Katya
Published in Cancer cell (08.02.2021)
Published in Cancer cell (08.02.2021)
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Journal Article
A Pilot Study Identifying a Set of microRNAs As Precise Diagnostic Biomarkers of Acute Kidney Injury
Aguado-Fraile, Elia, Ramos, Edurne, Conde, Elisa, Rodríguez, Macarena, Martín-Gómez, Laura, Lietor, Aurora, Candela, Ángel, Ponte, Belen, Liaño, Fernando, García-Bermejo, María Laura
Published in PloS one (16.06.2015)
Published in PloS one (16.06.2015)
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Journal Article
Systemic inflammation leads to neuronal loss and exacerbates behavioural deficits in a mouse model of MPS IIIA
Mandolfo, Oriana, Parker, Helen, Aguado, Èlia, Learmonth, Yuko Ishikawa, Liao, Aiyin, O'Leary, Claire, Ellison, Stuart M., Taylor, Jessica, Wood, Shaun R., Holley, Rebecca, Boutin, Herve, Bigger, Brian
Published in Molecular genetics and metabolism (01.02.2024)
Published in Molecular genetics and metabolism (01.02.2024)
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Journal Article
Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival
Conde, Elisa, Alegre, Laura, Blanco-Sánchez, Ignacio, Sáenz-Morales, David, Aguado-Fraile, Elia, Ponte, Belén, Ramos, Edurne, Sáiz, Ana, Jiménez, Carlos, Ordoñez, Angel, López-Cabrera, Manuel, del Peso, Luis, de Landázuri, Manuel O, Liaño, Fernando, Selgas, Rafael, Sanchez-Tomero, Jose Antonio, García-Bermejo, María Laura
Published in PloS one (14.03.2012)
Published in PloS one (14.03.2012)
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Journal Article
miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target
Aguado-Fraile, Elia, Ramos, Edurne, Sáenz-Morales, David, Conde, Elisa, Blanco-Sánchez, Ignacio, Stamatakis, Konstantinos, del Peso, Luis, Cuppen, Edwin, Brüne, Bernhard, Bermejo, María Laura García
Published in PloS one (04.09.2012)
Published in PloS one (04.09.2012)
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Journal Article
Mutual regulation of hypoxic and retinoic acid related signalling in tubular proximal cells
Fernández-Martínez, Ana Belén, Jiménez, María Isabel Arenas, Hernández, Irene Sánchez, García-Bermejo, María Laura, Manzano, Victoria Moreno, Fraile, Elia Aguado, de Lucio-Cazaña, Francisco Javier
Published in The international journal of biochemistry & cell biology (01.08.2011)
Published in The international journal of biochemistry & cell biology (01.08.2011)
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Journal Article
Interaction between intestinal dendritic cells and bacteria translocated from the gut in rats with cirrhosis
Muñoz, Leticia, José Borrero, María, Ubeda, María, Lario, Margaret, Díaz, David, Francés, Rubén, Monserrat, Jorge, Pastor, Óscar, Aguado-Fraile, Elia, Such, José, Álvarez-Mon, Melchor, Albillos, Agustín
Published in Hepatology (Baltimore, Md.) (01.11.2012)
Published in Hepatology (Baltimore, Md.) (01.11.2012)
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Journal Article
IDH1 mutation detection in plasma circulating tumor DNA (ctDNA) and association with clinical response in patients with advanced intrahepatic cholangiocarcinoma (IHC) from the phase III ClarIDHy study
Aguado, Elia, Abou-Alfa, Ghassan K., Zhu, Andrew X., Macarulla, Teresa, Fan, Bin, Nejad, Parham, Choe, Sung, Jiang, Liewen, Gliser, Camelia, Pandya, Shuchi Sumant, Wu, Bin
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Journal Article
EXTH-59. THE IDH1 MUTANT INHIBITOR AG-120 SHOWS STRONG INHIBITION OF 2-HG PRODUCTION IN AN ORTHOTOPIC IDH1 MUTANT GLIOMA MODEL IN VIVO
Nicolay, Brandon, Narayanaswamy, Rohini, Aguado, Elia, Nagaraja, Raj, Murtie, Josh, Liu, Guowen, Ishii, Yuko
Published in Neuro-oncology (Charlottesville, Va.) (06.11.2017)
Published in Neuro-oncology (Charlottesville, Va.) (06.11.2017)
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Journal Article
EXTH-34. COMBINED USE OF THE PAN-IDH MUTANT INHIBITOR AG-881 WITH RADIATION THERAPY SHOWS ADDED BENEFIT IN AN ORTHOTOPIC IDH1 MUTANT GLIOMA MODEL IN VIVO
Nicolay, Brandon, Narayanaswamy, Rohini, Amatangelo, Michael D, Aguado, Elia, Nagaraja, Raj, Murtie, Josh, Liu, Guowen, Ishii, Yuko
Published in Neuro-oncology (Charlottesville, Va.) (06.11.2017)
Published in Neuro-oncology (Charlottesville, Va.) (06.11.2017)
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Journal Article
Abstract 5650: RP-6306, a novel PKMYT1 inhibitor, demonstrates synthetic lethality as monotherapy and in combination with gemcitabine in CCNE1 amplified cancer cells
Fourtounis, Jimmy, Martino, John, Stocco, Rino, Baruah, Prasamit, Duffy, Nicole, Gallo, David, Fournier, Sarah, Li, JingJing, Li, Li, Aguado, Elia, Petrone, Adam, Roulston, Anne, Mamane, Yael, Morris, Stephen, Szychowski, Janek, Papp, Robert, Zinda, Mike, Marshall, C. Gary
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Genetic differences based on miRNAs of colorectal adenocarcinoma according to age and the presence or absence of MMR defect
Guillen-Ponce, Carmen, Conde Moreno, ELISA, Aguado, Elia, Soto, Jl, Alenda, Cristina, Castillejo, Adela, Barbera, Victor M, Salas, Dolores, Carrato, Alfredo, Garcia Bermejo, Maria LAURA
Published in Journal of clinical oncology (01.02.2012)
Published in Journal of clinical oncology (01.02.2012)
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Journal Article
Final Overall Survival Efficacy Results of Ivosidenib for Patients With Advanced Cholangiocarcinoma With IDH1 Mutation: The Phase 3 Randomized Clinical ClarIDHy Trial
Zhu, Andrew X, Macarulla, Teresa, Javle, Milind M, Kelley, R Kate, Lubner, Sam J, Adeva, Jorge, Cleary, James M, Catenacci, Daniel V T, Borad, Mitesh J, Bridgewater, John A, Harris, William P, Murphy, Adrian G, Oh, Do-Youn, Whisenant, Jonathan R, Lowery, Maeve A, Goyal, Lipika, Shroff, Rachna T, El-Khoueiry, Anthony B, Chamberlain, Christina X, Aguado-Fraile, Elia, Choe, Sung, Wu, Bin, Liu, Hua, Gliser, Camelia, Pandya, Shuchi S, Valle, Juan W, Abou-Alfa, Ghassan K
Published in JAMA oncology (01.11.2021)
Published in JAMA oncology (01.11.2021)
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Journal Article
Safety and activity of ivosidenib in patients with IDH1-mutant advanced cholangiocarcinoma: a phase 1 study
Lowery, Maeve A, Burris, 3rd, Howard A, Janku, Filip, Shroff, Rachna T, Cleary, James M, Azad, Nilofer S, Goyal, Lipika, Maher, Elizabeth A, Gore, Lia, Hollebecque, Antoine, Beeram, Muralidhar, Trent, Jonathan C, Jiang, Liewen, Fan, Bin, Aguado-Fraile, Elia, Choe, Sung, Wu, Bin, Gliser, Camelia, Agresta, Samuel V, Pandya, Shuchi S, Zhu, Andrew X, Abou-Alfa, Ghassan K
Published in The lancet. Gastroenterology & hepatology (01.09.2019)
Published in The lancet. Gastroenterology & hepatology (01.09.2019)
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Journal Article
Abstract 3510: IDH1-R132H tumor cells are not robustly sensitive to PARP inhibition in a 2-HG dependent manner
Aguado-Fraile, Elia, Hudson, Christine, Sleger, Taryn, Ronseaux, Sebastien, Narayanaswamy, Rohini, Choe, Sung, Wu, Bin, Kalev, Peter, Nicolay, Brandon
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
HIF-1α induction during reperfusion avoids maladaptive repair after renal ischemia/reperfusion involving miR127-3p
Conde, Elisa, Giménez-Moyano, Sara, Martín-Gómez, Laura, Rodríguez, Macarena, Ramos, M. Edurne, Aguado-Fraile, Elia, Blanco-Sanchez, Ignacio, Saiz, Ana, García-Bermejo, María Laura
Published in Scientific reports (20.01.2017)
Published in Scientific reports (20.01.2017)
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Journal Article
Molecular and morphological changes induced by ivosidenib correlate with efficacy in mutant- IDH1 cholangiocarcinoma
Aguado-Fraile, Elia, Tassinari, Ania, Ishii, Yuko, Sigel, Carlie, Lowery, Maeve A, Goyal, Lipika, Gliser, Camelia, Jiang, Liewen, Pandya, Shuchi S, Wu, Bin, Bardeesy, Nabeel, Choe, Sung, Deshpande, Vikram
Published in Future oncology (London, England) (01.06.2021)
Published in Future oncology (London, England) (01.06.2021)
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Journal Article
Abstract 2714: Targeting MAT2A in CDKN2A/MTAP-deleted cancers
Marjon, Katya, Kalev, Peter, Hyer, Marc, Fletcher, Mark, Zhang, Peili, Aguado-Fraile, Elia, Mandley, Everton, Konteatis, Zenon, Travins, Jeremy, Marks, Kevin
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 2275: Detection of IDH1 mutations in plasma cell-free circulating tumor DNA (ctDNA) from patients with cholangiocarcinoma
Aguado-Fraile, Elia, Choe, Sung, Gliser, Camelia, Steelman, Lori, Jiang, Liewen, Fan, Bin, Le, Kha, Lowery, Maeve A., Pandya, Susan, Wu, Bin
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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