Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis
Carrer, Alessandro, Trefely, Sophie, Zhao, Steven, Campbell, Sydney L, Norgard, Robert J, Schultz, Kollin C, Sidoli, Simone, Parris, Joshua L D, Affronti, Hayley C, Sivanand, Sharanya, Egolf, Shaun, Sela, Yogev, Trizzino, Marco, Gardini, Alessandro, Garcia, Benjamin A, Snyder, Nathaniel W, Stanger, Ben Z, Wellen, Kathryn E
Published in Cancer discovery (01.03.2019)
Published in Cancer discovery (01.03.2019)
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Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females
Fernandez, Sully, Viola, John M., Torres, AnnMarie, Wallace, Martina, Trefely, Sophie, Zhao, Steven, Affronti, Hayley C., Gengatharan, Jivani M., Guertin, David A., Snyder, Nathaniel W., Metallo, Christian M., Wellen, Kathryn E.
Published in Cell reports (Cambridge) (28.05.2019)
Published in Cell reports (Cambridge) (28.05.2019)
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Journal Article
Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy
Affronti, Hayley C., Rowsam, Aryn M., Pellerite, Anthony J., Rosario, Spencer R., Long, Mark D., Jacobi, Justine J., Bianchi-Smiraglia, Anna, Boerlin, Christoph S., Gillard, Bryan M., Karasik, Ellen, Foster, Barbara A., Moser, Michael, Wilton, John H., Attwood, Kristopher, Nikiforov, Mikhail A., Azabdaftari, Gissou, Pili, Roberto, Phillips, James G., Casero, Robert A., Smiraglia, Dominic J.
Published in Nature communications (07.01.2020)
Published in Nature communications (07.01.2020)
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Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer
Long, Mark D., Jacobi, Justine J., Singh, Prashant K., Llimos, Gerard, Wani, Sajad A., Rowsam, Aryn M., Rosario, Spencer R., Hoogstraat, Marlous, Linder, Simon, Kirk, Jason, Affronti, Hayley C., Bergman, Andries, Zwart, Wilbert, Campbell, Moray J., Smiraglia, Dominic J.
Published in Cell reports (Cambridge) (14.12.2021)
Published in Cell reports (Cambridge) (14.12.2021)
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Internally ratiometric fluorescent sensors for evaluation of intracellular GTP levels and distribution
Bianchi-Smiraglia, Anna, Rana, Mitra S, Foley, Colleen E, Paul, Leslie M, Lipchick, Brittany C, Moparthy, Sudha, Moparthy, Kalyana, Fink, Emily E, Bagati, Archis, Hurley, Edward, Affronti, Hayley C, Bakin, Andrei V, Kandel, Eugene S, Smiraglia, Dominic J, Feltri, Maria Laura, Sousa, Rui, Nikiforov, Mikhail A
Published in Nature methods (01.10.2017)
Published in Nature methods (01.10.2017)
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Dynamic patterns of DNA methylation in the normal prostate epithelial differentiation program are targets of aberrant methylation in prostate cancer
Long, Mark D., Dhiman, Vineet K., Affronti, Hayley C., Hu, Qiang, Liu, Song, Smiraglia, Dominic J.
Published in Scientific reports (01.06.2021)
Published in Scientific reports (01.06.2021)
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Journal Article
The essential role of methylthioadenosine phosphorylase in prostate cancer
Bistulfi, Gaia, Affronti, Hayley C, Foster, Barbara A, Karasik, Ellen, Gillard, Bryan, Morrison, Carl, Mohler, James, Phillips, James G, Smiraglia, Dominic J
Published in Oncotarget (22.03.2016)
Published in Oncotarget (22.03.2016)
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Journal Article
ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis
Bazilevsky, Gleb A., Affronti, Hayley C., Wei, Xuepeng, Campbell, Sydney L., Wellen, Kathryn E., Marmorstein, Ronen
Published in The Journal of biological chemistry (03.05.2019)
Published in The Journal of biological chemistry (03.05.2019)
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Journal Article
The Bidirectional Relationship Between Cancer Epigenetics and Metabolism
Izzo, Luke T, Affronti, Hayley C, Wellen, Kathryn E
Published in Annual review of cancer biology (04.03.2021)
Published in Annual review of cancer biology (04.03.2021)
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Journal Article
JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Rosario, Spencer R, Jacobi, Justine J, Long, Mark D, Affronti, Hayley C, Rowsam, Aryn M, Smiraglia, Dominic J
Published in Molecular cancer research (03.01.2023)
Published in Molecular cancer research (03.01.2023)
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Journal Article
ACLY alternative splicing correlates with cancer phenotypes
Supplee, Julianna G., Affronti, Hayley C., Duan, Richard, Brooks, Rebekah C., Stine, Zachary E., Nguyen, Phuong T.T., Pinheiro, Laura V., Noji, Michael C., Drummond, Jack M., Huang, Kevin, Schultz, Kollin, Dang, Chi V., Marmorstein, Ronen, Wellen, Kathryn E.
Published in The Journal of biological chemistry (01.07.2024)
Published in The Journal of biological chemistry (01.07.2024)
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Journal Article
Lactate supports a metabolic-epigenetic link in macrophage polarization
Noe, Jordan T, Rendon, Beatriz E, Geller, Anne E, Conroy, Lindsey R, Morrissey, Samantha M, Young, Lyndsay E A, Bruntz, Ronald C, Kim, Eun J, Wise-Mitchell, Ashley, Barbosa de Souza Rizzo, Mariana, Relich, Eric R, Baby, Becca V, Johnson, Lance A, Affronti, Hayley C, McMasters, Kelly M, Clem, Brian F, Gentry, Matthew S, Yan, Jun, Wellen, Kathryn E, Sun, Ramon C, Mitchell, Robert A
Published in Science advances (12.11.2021)
Published in Science advances (12.11.2021)
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Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma
Bianchi-Smiraglia, Anna, Bagati, Archis, Fink, Emily E, Affronti, Hayley C, Lipchick, Brittany C, Moparthy, Sudha, Long, Mark D, Rosario, Spencer R, Lightman, Shivana M, Moparthy, Kalyana, Wolff, David W, Yun, Dong Hyun, Han, Zhannan, Polechetti, Anthony, Roll, Matthew V, Gitlin, Ilya I, Leonova, Katerina I, Rowsam, Aryn M, Kandel, Eugene S, Gudkov, Andrei V, Bergsagel, P Leif, Lee, Kelvin P, Smiraglia, Dominic J, Nikiforov, Mikhail A
Published in The Journal of clinical investigation (01.10.2018)
Published in The Journal of clinical investigation (01.10.2018)
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Journal Article
Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model
Affronti, Hayley C, Long, Mark D, Rosario, Spencer R, Gillard, Bryan M, Karasik, Ellen, Boerlin, Christoph S, Pellerite, Anthony J, Foster, Barbara A, Attwood, Kristopher, Pili, Roberto, Wilton, John H, Campbell, Moray J, Smiraglia, Dominic J
Published in Oncotarget (28.11.2017)
Published in Oncotarget (28.11.2017)
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Journal Article
Abstract B052: Leveraging the metabolic stress of polyamine biosynthesis in prostate cancer towards a novel therapeutic approach
Affronti, Hayley C., Pellerite, Anthony J., Rowsam, Aryn, Rosario, Spencer R., Casero, Robert A., Nikiforov, Mikhail A., Phillips, James, Smiraglia, Dominic J.
Published in Cancer research (Chicago, Ill.) (15.08.2018)
Published in Cancer research (Chicago, Ill.) (15.08.2018)
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Journal Article
Abstract 3711: Molecular and cancer-related roles of ATP-citrate lyase exon 14
Supplee, Julianna G., Affronti, Hayley C., Duan, Richard, Brooks, Rebekah C., Nguyen, Phuong, Schultz, Kollin, Marmorstein, Ronen, Wellen, Kathryn E.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis
Carrer, Alessandro, Trefely, Sophie, Zhao, Steven, Campbell, Sydney L., Norgard, Robert J., Schulz, Kollin C., Sidoli, Simone, Parris, Joshua L. D., Affronti, Hayley C., Sivanand, Sharanya, Egolf, Shaun, Sela, Yogev, Trizzino, Marco, Gardini, Alessandro, Garcia, Benjamin A., Snyder, Nathaniel W., Stanger, Ben Z., Wellen, Kathryn E.
Published in Cancer discovery (09.01.2019)
Published in Cancer discovery (09.01.2019)
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